Aliases for ATF7 Gene
External Ids for ATF7 Gene
Previous GeneCards Identifiers for ATF7 Gene
GeneCards Summary for ATF7 Gene
ATF7 (Activating Transcription Factor 7) is a Protein Coding gene. Diseases associated with ATF7 include Pulmonary Systemic Sclerosis and Retinoblastoma. Among its related pathways are IL-2 Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ATF7-NPFF.
UniProtKB/Swiss-Prot Summary for ATF7 Gene
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.
Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.
Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.