Free for academic non-profit institutions. Other users need a Commercial license
ATF7 (Activating Transcription Factor 7) is a Protein Coding gene. Diseases associated with ATF7 include Pulmonary Systemic Sclerosis and Retinoblastoma. Among its related pathways are IL-2 Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ATF7-NPFF.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | NAS | 1694576 |
GO:0005515 | protein binding | IPI | 10376527 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | NAS | 8288576 |
GO:0005654 | nucleoplasm | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0034399 | nuclear periphery | IDA | 17264123 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | TNFR1 Pathway |
TNF Signaling
.55
|
.34
|
2 | ERK Signaling |
MAPK Signaling
.58
|
ILK Signaling
.49
|
3 | Ceramide Pathway |
Ceramide Pathway
.32
|
|
4 | Sertoli-Sertoli Cell Junction Dynamics |
Epithelial Tight Junctions
.36
|
|
5 | Toll Comparative Pathway |
iNOS Signaling
.34
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IDA | 8288576 |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0016032 | viral process | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ATF7 30 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
ATF7 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
ATF7 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | ATF7 31 |
|
ManyToMany | |
Atf7 30 17 31 |
|
ManyToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Atf7 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
ATF7 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | atf7 30 |
|
||
Str.18007 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | atf7a 30 31 |
|
ManyToMany | |
atf7b 31 |
|
ManyToMany | |||
wufa97a09 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9788 30 |
|
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
776711 | Benign: not provided | 53,524,654(-) | T/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2672386 | CNV | deletion | 23128226 |
esv2673908 | CNV | deletion | 23128226 |
esv2745909 | CNV | deletion | 23290073 |
esv3629542 | CNV | loss | 21293372 |
esv3629543 | CNV | loss | 21293372 |
esv3629544 | CNV | loss | 21293372 |
nsv1113484 | CNV | deletion | 24896259 |
nsv1122736 | CNV | deletion | 24896259 |
nsv526791 | CNV | gain | 19592680 |
nsv53289 | CNV | insertion | 16902084 |
nsv715 | CNV | deletion | 18451855 |
nsv973988 | CNV | duplication | 23825009 |
nsv975496 | CNV | duplication | 23825009 |
nsv983486 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
pulmonary systemic sclerosis |
|
|
retinoblastoma |
|
|
penicilliosis |
|
|
familial atrial fibrillation |
|
|
fetal akinesia deformation sequence 1 |
|
|