Aliases for ATF7 Gene

Aliases for ATF7 Gene

  • Activating Transcription Factor 7 2 3 4 5
  • ATFA 2 3 4
  • Cyclic AMP-Dependent Transcription Factor ATF-7 3 4
  • Transcription Factor ATF-A 3 4
  • CAMP-Dependent Transcription Factor ATF-7 4
  • ATF7 5

External Ids for ATF7 Gene

Previous GeneCards Identifiers for ATF7 Gene

  • GC12M053905
  • GC12M054022
  • GC12M053626
  • GC12M052196
  • GC12M050945
  • GC12M053508
  • GC12M053510
  • GC12M053517

Summaries for ATF7 Gene

GeneCards Summary for ATF7 Gene

ATF7 (Activating Transcription Factor 7) is a Protein Coding gene. Diseases associated with ATF7 include Pulmonary Systemic Sclerosis and Retinoblastoma. Among its related pathways are IL-2 Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ATF7-NPFF.

UniProtKB/Swiss-Prot Summary for ATF7 Gene

  • Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.
  • Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.
  • Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Gene Wiki entry for ATF7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATF7 Gene

Genomics for ATF7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ATF7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J053622 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 620.6 +1.3 1280 5 BRCA1 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 ATF7 ATF7-NPFF lnc-ATP5MC2-1 SP1 EIF4B ENSG00000258344 ATP5MC2 AAAS ITGB7 PCBP2
GH12J053971 Promoter/Enhancer 2.7 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 76.2 -376.9 -376897 63 ZNF221 RNF2 CREB1 GATAD2A CTCF ZBTB33 HNRNPL TEAD4 PRDM10 ZNF629 HOTAIR HOXC8 HOXC-AS1 HOXC11 HOXC4 HOXC9 HOXC6 HOXC10 HOXC5 HNRNPA1
GH12J053524 Promoter 0.3 EPDnew 609.9 +101.4 101412 0.1 ATF7 ENSG00000285692 lnc-NPFF-2 piR-35674-105 TARBP2 MAP3K12 AMHR2 ATP5MC2 NPFF ATF7-NPFF
GH12J053515 Promoter 0.3 EPDnew 600.1 +110.8 110777 0.1 ENSG00000257550 LOC100652999 ATF7 MYG1 AMHR2 ATP5MC2 PFDN5 NPFF lnc-NPFF-2 ATF7-NPFF
GH12J053179 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 64.9 +444.7 444697 4.8 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 ZNF512 SIX5 ZNF692 POLR2A ZNF740 CSAD ATF7 PCBP2 ENSG00000257550 SP1 AAAS CALCOCO1 EIF4B SOAT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATF7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATF7

Top Transcription factor binding sites by QIAGEN in the ATF7 gene promoter:
  • AREB6
  • ATF
  • CUTL1
  • FOXO4
  • HOXA5
  • HSF2
  • MEF-2
  • Pax-4a
  • TBP

Genomic Locations for ATF7 Gene

Genomic Locations for ATF7 Gene
chr12:53,507,856-53,626,415
(GRCh38/hg38)
Size:
118,560 bases
Orientation:
Minus strand
chr12:53,901,640-54,020,199
(GRCh37/hg19)
Size:
118,560 bases
Orientation:
Minus strand

Genomic View for ATF7 Gene

Genes around ATF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF7 Gene

Proteins for ATF7 Gene

  • Protein details for ATF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17544-ATF7_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-7
    Protein Accession:
    P17544
    Secondary Accessions:
    • A5D6Y4
    • B2RMP1
    • B4DQL4
    • Q13814
    • Q8IVR8
    • Q9UD83

    Protein attributes for ATF7 Gene

    Size:
    494 amino acids
    Molecular mass:
    52967 Da
    Quaternary structure:
    • Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members. Interacts with JNK2; the interaction does not phosphorylate ATF7 but acts as a docking site for other ATF-associated partners such as JUN family members. Interacts (via its transactivation domain) with TAF12 (isoforms TAFII15 and TAFII20); the interaction potentiates the transactivation activity (isoform TAFII20 only) and is inhibited by ATF7 sumoylation. Interacts with TAF4; the interaction inhibits the TAF12-dependent transactivation. Interacts with MAPK9; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN.
    • (Microbial infection) Interacts with adenovirus 2 E1A; the interaction enhances the ATF7-mediated viral transactivation activity which requires the zinc-binding domains of both E1A and ATF7.

    Alternative splice isoforms for ATF7 Gene

neXtProt entry for ATF7 Gene

Post-translational modifications for ATF7 Gene

  • On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity.
  • Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12. RANBP2 appears to be the specific E3 ligase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATF7 Gene

Domains & Families for ATF7 Gene

Gene Families for ATF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ATF7 Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
ProtoNet:

Suggested Antigen Peptide Sequences for ATF7 Gene

GenScript: Design optimal peptide antigens:
  • ATF7 protein (A5D6Y4_HUMAN)
  • Transcription factor ATF-A (ATF7_HUMAN)
  • ATF7 protein (Q8IVR8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17544

UniProtKB/Swiss-Prot:

ATF7_HUMAN :
  • Belongs to the bZIP family.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with ATF7: view

Function for ATF7 Gene

Molecular function for ATF7 Gene

UniProtKB/Swiss-Prot Function:
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.
UniProtKB/Swiss-Prot Function:
Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.
UniProtKB/Swiss-Prot Function:
Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Phenotypes From GWAS Catalog for ATF7 Gene

Gene Ontology (GO) - Molecular Function for ATF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS 1694576
GO:0005515 protein binding IPI 10376527
genes like me logo Genes that share ontologies with ATF7: view
genes like me logo Genes that share phenotypes with ATF7: view

Animal Models for ATF7 Gene

MGI Knock Outs for ATF7:
  • Atf7 Atf7<tm1Sis>
  • Atf7 Atf7<tm2b(EUCOMM)Hmgu>
  • Atf7 Atf7<tm1Nicj>

Animal Model Products

CRISPR Products

Targeted motifs for ATF7 Gene
HOMER Transcription Factor Regulatory Elements motif ATF7
  • Consensus sequence: NGRTGACGTCAY Submotif: canonical Cell Type: 3T3L1 GEO ID: GSE56872

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ATF7 Gene

Localization for ATF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF7 Gene

Nucleus. Nucleus, nucleoplasm. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.
[Isoform 5]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATF7 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus NAS 8288576
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm IEA --
GO:0034399 nuclear periphery IDA 17264123
genes like me logo Genes that share ontologies with ATF7: view

Pathways & Interactions for ATF7 Gene

PathCards logo

SuperPathways for ATF7 Gene

SuperPathway Contained pathways
1 TNFR1 Pathway
.55
2 ERK Signaling
.58
.49
3 Ceramide Pathway
.32
4 Sertoli-Sertoli Cell Junction Dynamics
.36
5 Toll Comparative Pathway
.34
genes like me logo Genes that share pathways with ATF7: view

Pathways by source for ATF7 Gene

1 Sino Biological pathway for ATF7 Gene
1 BioSystems pathway for ATF7 Gene
9 Qiagen pathways for ATF7 Gene
  • Ceramide Pathway
  • Epithelial Tight Junctions
  • ILK Signaling
  • iNOS Signaling
  • ITK and TCR Signaling

SIGNOR curated interactions for ATF7 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ATF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 8288576
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with ATF7: view

Drugs & Compounds for ATF7 Gene

(3) Drugs for ATF7 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target, inhibitor 426
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with ATF7: view

Transcripts for ATF7 Gene

mRNA/cDNA for ATF7 Gene

11 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF7

Alternative Splicing Database (ASD) splice patterns (SP) for ATF7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5:
SP6: -

Relevant External Links for ATF7 Gene

GeneLoc Exon Structure for
ATF7

Expression for ATF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATF7 Gene

Protein differential expression in normal tissues from HIPED for ATF7 Gene

This gene is overexpressed in NK cells (15.7), Fetal testis (13.4), Fetal ovary (12.3), and Testis (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATF7 Gene



Protein tissue co-expression partners for ATF7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATF7

SOURCE GeneReport for Unigene cluster for ATF7 Gene:

Hs.12286

mRNA Expression by UniProt/SwissProt for ATF7 Gene:

P17544-ATF7_HUMAN
Tissue specificity: Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.

Evidence on tissue expression from TISSUES for ATF7 Gene

  • Nervous system(4.7)
  • Intestine(4.4)
  • Liver(4.4)
  • Skin(2.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with ATF7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF7 Gene

Orthologs for ATF7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ATF7 30 31
  • 99.93 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 99 (a)
OneToMany
ATF7 30
  • 94.96 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 98 (a)
OneToMany
ATF7 30
  • 94.81 (n)
Mouse
(Mus musculus)
Mammalia ATF7 31
  • 97 (a)
ManyToMany
Atf7 30 17 31
  • 92.62 (n)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Atf7 30
  • 91.65 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 62 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 56 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 91 (a)
OneToMany
ATF7 30
  • 78.26 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 90 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia atf7 30
  • 73.59 (n)
Str.18007 30
Zebrafish
(Danio rerio)
Actinopterygii atf7a 30 31
  • 68.57 (n)
ManyToMany
atf7b 31
  • 61 (a)
ManyToMany
wufa97a09 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9788 30
Species where no ortholog for ATF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ATF7 Gene

ENSEMBL:
Gene Tree for ATF7 (if available)
TreeFam:
Gene Tree for ATF7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATF7: view image

Paralogs for ATF7 Gene

Paralogs for ATF7 Gene

(2) SIMAP similar genes for ATF7 Gene using alignment to 4 proteins:

  • ATF7_HUMAN
  • F8VWG7_HUMAN
  • K7EKZ7_HUMAN
  • K7ESA4_HUMAN
genes like me logo Genes that share paralogs with ATF7: view

Variants for ATF7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATF7 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
776711 Benign: not provided 53,524,654(-) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ATF7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ATF7 Gene

Variant ID Type Subtype PubMed ID
esv2672386 CNV deletion 23128226
esv2673908 CNV deletion 23128226
esv2745909 CNV deletion 23290073
esv3629542 CNV loss 21293372
esv3629543 CNV loss 21293372
esv3629544 CNV loss 21293372
nsv1113484 CNV deletion 24896259
nsv1122736 CNV deletion 24896259
nsv526791 CNV gain 19592680
nsv53289 CNV insertion 16902084
nsv715 CNV deletion 18451855
nsv973988 CNV duplication 23825009
nsv975496 CNV duplication 23825009
nsv983486 CNV duplication 23825009

Variation tolerance for ATF7 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATF7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF7 Gene

Disorders for ATF7 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ATF7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pulmonary systemic sclerosis
  • lung disease with systemic sclerosis
retinoblastoma
  • rb1
penicilliosis
familial atrial fibrillation
  • atrial fibrillation, familial, 1
fetal akinesia deformation sequence 1
  • fads1
- elite association - COSMIC cancer census association via MalaCards
Search ATF7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ATF7

genes like me logo Genes that share disorders with ATF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATF7 Gene

Publications for ATF7 Gene

  1. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PMID: 15735663) Hamard PJ … Chatton B (Oncogene 2005) 3 4 23
  2. Role of the ATFa/JNK2 complex in Jun activation. (PMID: 10376527) De Graeve F … Chatton B (Oncogene 1999) 3 4 23
  3. Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells. (PMID: 1694576) Gaire M … Kedinger C (Nucleic acids research 1990) 2 3 4
  4. A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity. (PMID: 21858082) Diring J … Chatton B (PloS one 2011) 3 4
  5. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 41

Products for ATF7 Gene

Sources for ATF7 Gene