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Aliases for ATF5 Gene
Aliases for ATF5 Gene
External Ids for ATF5 Gene
- HGNC: 790
- NCBI Entrez Gene: 22809
- Ensembl: ENSG00000169136
- OMIM®: 606398
- UniProtKB/Swiss-Prot: Q9Y2D1
Previous GeneCards Identifiers for ATF5 Gene
- GC19P051090
- GC19P050800
- GC19P055108
- GC19P055124
- GC19P050431
- GC19P046808
Summaries for ATF5 Gene
GeneCards Summary for ATF5 Gene
ATF5 (Activating Transcription Factor 5) is a Protein Coding gene. Diseases associated with ATF5 include Triple-Receptor Negative Breast Cancer and Schizophrenia 1. Among its related pathways are Ceramide Pathway and Toll Comparative Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ATF4.
UniProtKB/Swiss-Prot Summary for ATF5 Gene
-
Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).
Additional gene information for ATF5 Gene
- HGNC (790)
- NCBI Entrez Gene (22809)
- Ensembl (ENSG00000169136)
- OMIM® (606398)
- UniProtKB/Swiss-Prot (Q9Y2D1)
- Open Targets Platform(ENSG00000169136)
- Alliance of Genome Resources
- Search for ATF5 at DataMed
- Search for ATF5 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATF5 Gene
Genomics for ATF5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ATF5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ATF5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATF5
- Top Transcription factor binding sites by QIAGEN in the ATF5 gene promoter:
-
- AML1a
- AP-1
- ATF-2
- c-Jun
- ISGF-3
- MyoD
- MZF-1
- Pax-4a
- Spz1
Genomic Locations for ATF5 Gene
Latest Assembly
- chr19:49,928,702-49,933,935
- (GRCh38/hg38)
- Size:
- 5,234 bases
- Orientation:
- Plus strand
Previous Assembly
- chr19:50,431,959-50,437,193
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 5,235 bases
- Orientation:
- Plus strand
Genomic View for ATF5 Gene
Genes around ATF5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
ATF5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ATF5 Gene
Proteins for ATF5 Gene
-
Protein details for ATF5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2D1-ATF5_HUMAN
- Recommended name:
- Cyclic AMP-dependent transcription factor ATF-5
- Protein Accession:
- Q9Y2D1
- B3KND3
- Q9BSA1
- Q9UNQ3
Protein attributes for ATF5 Gene
- Size:
- 282 amino acids
- Molecular mass:
- 30674 Da
- Quaternary structure:
-
- Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2 (PubMed:15358120). Interacts with HSPA1A or HSPA1B; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes. Interacts (via C-terminal region) with NPM1 (via C-terminal region); the interaction leads to loss of association between HSPA1A or HSPA1B and ATF5 and promotes ATF5 degradation via proteasome-dependent and caspase-dependent processes (PubMed:22528486, PubMed:24379400). Interacts with NLK; the interaction stabilizes ATF5 at the protein level in a kinase-independent manner (PubMed:25512613). Interacts with alpha-tubulin, gamma-tubulin members TUBGCP2 and TUBGCP4, PCNT; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385). Interacts with CEBPB and EP300; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity).
Post-translational modifications for ATF5 Gene
- Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. Cisplatin inhibits ubiquitination and proteasome-mediated degradation by inhibiting the interaction with CDC34 (PubMed:18458088). Ubiquitination and degradation by the proteasome are inhibited by NLK in a kinase-independent manner (PubMed:25512613).
- Phosphorylated by NLK, probably at Ser-92, Thr-94, Ser-126 and Ser-190.
- Acetylated at Lys-29 by EP300, the acetylation enhances the interaction with CEBPB, DNA-binding and transactivation activity.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ATF5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences ATF5 Antibody and ATF5 Monoclonal Antibody
- G Biosciences Immunotag™ ATF5 Antibody
-
Custom Antibody ServicesOriGene Antibodies for ATF5
- Novus Biologicals Antibodies for ATF5
-
Abcam antibodies for ATF5
- Invitrogen Antibodies for ATF5 (AFLGC-Atf5)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ATF5
- Sino Biological Antibodies for ATF5
Protein products for research
-
OriGene Purified Proteins for ATF5
- Search Origene for MassSpec and Protein Over-expression Lysates for ATF5
- Origene Custom Protein Services for ATF5
- Novus Biologicals proteins for ATF5
-
Abcam proteins for ATF5
No data available for DME Specific Peptides for ATF5 Gene
Domains & Families for ATF5 Gene
Gene Families for ATF5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Suggested Antigen Peptide Sequences for ATF5 Gene
- GenScript: Design optimal peptide antigens:
-
- Transcription factor ATFx (ATF5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y2D1- Family:
-
- Belongs to the bZIP family.
Function for ATF5 Gene
Molecular function for ATF5 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by pro-apoptotic stimuli (PubMed:21212266). However, the pro-apoptotic cisplatin increases protein levels by inhibiting polyubiquitination (PubMed:18458088). IL1B increases protein levels through protein stabilization and increase of translation efficiency (PubMed:24379400).
Phenotypes From GWAS Catalog for ATF5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | ISS | -- |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IMP | 15890932 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IBA,IDA | 16300731 |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for ATF5 Gene
- MGI mutant phenotypes for ATF5:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ATF5:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ATF5 - Starting at $85 >
- * ATF5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ATF5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATF5
-
Santa Cruz Biotechnology (SCBT) CRISPR for ATF5
miRNA for ATF5 Gene
- miRTarBase miRNAs that target ATF5
-
- hsa-miR-7-5p (MIRT025724)
- hsa-miR-222-3p (MIRT046831)
- hsa-miR-142-3p (MIRT151995)
- hsa-miR-519e-5p (MIRT716531)
- hsa-miR-515-5p (MIRT716532)
- hsa-miR-4749-3p (MIRT716533)
- hsa-miR-5695 (MIRT716534)
- hsa-miR-519d-5p (MIRT716535)
- hsa-miR-6892-3p (MIRT716536)
- hsa-miR-6769a-3p (MIRT716537)
- hsa-miR-6856-3p (MIRT716538)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATF5
- Browse OriGene Inhibitory RNA Products For ATF5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF5
Clone products for research
- Applied Biological Materials (abm): Clones for ATF5 - Starting at $45 >
- * ATF5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ATF5
- Addgene plasmids for ATF5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATF5
Cell Lines for research
-
Horizon Cell Lines for ATF5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATF5 Gene
Localization for ATF5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ATF5 Gene
- Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Actively transported to the centrosome and accumulated in the pericentriolar material (PCM) during G1 to M phase via a microtubule-dependent mechanism. During late telophase and cytokinesis, translocates from the centrosome to the midbody. {ECO:0000269 PubMed:26213385}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA,IDA | 22528486 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for ATF5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TNFR1 Pathway |
TNF Signaling
.55
|
.34
|
| 2 | ERK Signaling |
MAPK Signaling
.58
|
ILK Signaling
.49
|
| 3 | IL1 Signaling Pathway | ||
| 4 | Ceramide Pathway |
Ceramide Pathway
.32
|
|
| 5 | Sertoli-Sertoli Cell Junction Dynamics |
Epithelial Tight Junctions
.36
|
|
Pathways by source for ATF5 Gene
2 Sino Biological pathways for ATF5 Gene
3 BioSystems pathways for ATF5 Gene
9 Qiagen pathways for ATF5 Gene
- Ceramide Pathway
- Epithelial Tight Junctions
- ILK Signaling
- iNOS Signaling
- ITK and TCR Signaling
Interacting Proteins for ATF5 Gene
Selected Interacting proteins:
Q9Y2D1-ATF5_HUMAN
ENSP00000396954
for ATF5 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ATF5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 20654631 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
| GO:0007623 | circadian rhythm | IEA | -- |
| GO:0008285 | negative regulation of cell proliferation | IDA | 22528486 |
| GO:0009791 | post-embryonic development | IEA | -- |
Transcripts for ATF5 Gene
mRNA/cDNA for ATF5 Gene
- 3 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000423777 2007 nts (view in UCSC)
- ENST00000595125 1637 nts (view in UCSC)
- ENST00000596658 722 nts (view in UCSC)
- ENST00000597227 828 nts (view in UCSC)
- ENST00000600336 682 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ATF5 - Starting at $85 >
- * ATF5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ATF5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATF5
-
Santa Cruz Biotechnology (SCBT) CRISPR for ATF5
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATF5
- Browse OriGene Inhibitory RNA Products For ATF5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF5
Clone products for research
- Applied Biological Materials (abm): Clones for ATF5 - Starting at $45 >
- * ATF5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ATF5
- Addgene plasmids for ATF5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATF5
Relevant External Links for ATF5 Gene
- GeneLoc Exon Structure for
- ATF5
Expression for ATF5 Gene
mRNA differential expression in normal tissues according to GTEx for ATF5 Gene
This gene is overexpressed in Liver (x34.1).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATF5
SOURCE GeneReport for Unigene cluster for ATF5 Gene:
Hs.9754mRNA Expression by UniProt/SwissProt for ATF5 Gene:
Q9Y2D1-ATF5_HUMAN
Tissue specificity:
Widely expressed with higher expression levels in liver.
Evidence on tissue expression from TISSUES for ATF5 Gene
- Nervous system(4.6)
- Liver(4.1)
- Eye(2.8)
- Muscle(2.7)
- Pancreas(2.5)
- Thyroid gland(2.5)
- Intestine(2.2)
- Kidney(2.2)
- Blood(2.1)
- Lung(2)
Primer products for research
-
OriGene qPCR primer pairs for ATF5
-
OriGene qPCR primer pairs and template standards for ATF5
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF5 Gene
Orthologs for ATF5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ATF5 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ATF5 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ATF5 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Atf5 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Atf5 29 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | ATF5 30 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15540 29 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.511 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | atf5a 30 |
|
OneToMany | |
| atf5b 30 |
|
OneToMany | |||
| wufc14a10 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2402 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2035 30 |
|
OneToMany |
- Species where no ortholog for ATF5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ATF5 Gene
- ENSEMBL:
- Gene Tree for ATF5 (if available)
- TreeFam:
- Gene Tree for ATF5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ATF5: view image
- Alliance of Genome Resources:
- Additional Orthologs for ATF5
Paralogs for ATF5 Gene
Variants for ATF5 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv53n68 | CNV | loss | 17160897 |
| dgv54n68 | CNV | loss | 17160897 |
| esv3644630 | CNV | gain | 21293372 |
| nsv1058623 | CNV | gain | 25217958 |
| nsv1065648 | CNV | gain | 25217958 |
| nsv1140251 | OTHER | inversion | 24896259 |
| nsv458720 | CNV | gain | 19166990 |
| nsv579910 | CNV | gain | 21841781 |
| nsv579911 | CNV | gain | 21841781 |
| nsv7309 | OTHER | inversion | 18451855 |
| nsv953600 | CNV | deletion | 24416366 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.83;
47.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ATF5 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF5 Gene
Disorders for ATF5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| triple-receptor negative breast cancer |
|
|
| schizophrenia 1 |
|
|
Search ATF5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ATF5
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ATF5 Gene
Publications for ATF5 Gene
- Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PMID: 10373550) Pati D … Plon SE (Molecular and cellular biology 1999) 2 3 4
- ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole. (PMID: 26213385) Madarampalli B … Liu DX (Cell 2015) 3 4
- Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway. (PMID: 25512613) Zhang ZY … Zhang XD (Molecular and cellular biology 2015) 3 4
- N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization. (PMID: 24379400) Abe T … Takahashi Y (The Journal of biological chemistry 2014) 3 4
- p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation. (PMID: 24216764) Zhao Y … Li X (Molecular and cellular biology 2014) 3 4
ExternalLinks
Products for ATF5 Gene
- Custom Antibody ServicesOriGene Antibodies for ATF5
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ATF5
- Search Origene for MassSpec and Protein Over-expression Lysates for ATF5
- Origene Custom Protein Services for ATF5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATF5
- Browse OriGene Inhibitory RNA Products For ATF5
- OriGene qPCR primer pairs for ATF5
- OriGene qPCR primer pairs and template standards for ATF5
- OriGene CRISPR knockouts for ATF5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ATF5
- Sino Biological Human cDNA Clone for ATF5
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for ATF5
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ATF5
- Novus Biologicals proteins for ATF5
- Novus Biologicals ELISA Kits for ATF5
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ATF5
- Abcam proteins for ATF5
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for ATF5 (AFLGC-Atf5)
- VectorBuilder Custom and pre-made DNA vectors for ATF5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ATF5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ATF5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ATF5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ATF5
- Addgene plasmids for ATF5
- antibodies-online: Show 23 available ATF5 Antibodies ranked by validation data
- Compare Top ATF5 Antibodies
- antibodies-online: Show 10 available ATF5 Elisa Kits ranked by validation data
- Compare Top ATF5 Elisa Kits
- antibodies-online: Show 4 available ATF5 Proteins ranked by validation data
- Compare Top ATF5 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ATF5
- Search Santa Cruz Biotechnology (SCBT) for ATF5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ATF5
- Horizon Cell Lines for ATF5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATF5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATF5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ATF5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF5
Sources for ATF5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources