ATF5 Gene (Protein Coding)

Activating Transcription Factor 5

GC19P049931
GIFtS:
36
See more...

Aliases for ATF5 Gene

Aliases for ATF5 Gene

  • Activating Transcription Factor 5 2 3 4 5
  • Cyclic AMP-Dependent Transcription Factor ATF-5 3 4
  • CAMP-Dependent Transcription Factor ATF-5 3 4
  • Transcription Factor ATFx 3 4
  • ATFX 3 4
  • HMFN0395 3
  • ATF5 5

External Ids for ATF5 Gene

Previous GeneCards Identifiers for ATF5 Gene

  • GC19P051090
  • GC19P050800
  • GC19P055108
  • GC19P055124
  • GC19P050431
  • GC19P046808

Summaries for ATF5 Gene

GeneCards Summary for ATF5 Gene

ATF5 (Activating Transcription Factor 5) is a Protein Coding gene. Diseases associated with ATF5 include Triple-Receptor Negative Breast Cancer and Glioblastoma Multiforme. Among its related pathways are Myometrial Relaxation and Contraction Pathways and IL-2 Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ATF4.

UniProtKB/Swiss-Prot Summary for ATF5 Gene

  • Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).

Gene Wiki entry for ATF5 Gene

Additional gene information for ATF5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATF5 Gene

Genomics for ATF5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ATF5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATF5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATF5

Top Transcription factor binding sites by QIAGEN in the ATF5 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • ISGF-3
  • MyoD
  • MZF-1
  • Pax-4a
  • Spz1

Genomic Locations for ATF5 Gene

Genomic Locations for ATF5 Gene
chr19:49,928,702-49,933,936
(GRCh38/hg38)
Size:
5,235 bases
Orientation:
Plus strand
chr19:50,431,959-50,437,193
(GRCh37/hg19)
Size:
5,235 bases
Orientation:
Plus strand

Genomic View for ATF5 Gene

Genes around ATF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ATF5 Gene

Proteins for ATF5 Gene

Products:

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  2. Protein
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  • Protein details for ATF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2D1-ATF5_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-5
    Protein Accession:
    Q9Y2D1
    Secondary Accessions:
    • B3KND3
    • Q9BSA1
    • Q9UNQ3

    Protein attributes for ATF5 Gene

    Size:
    282 amino acids
    Molecular mass:
    30674 Da
    Quaternary structure:
    • Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2 (PubMed:15358120). Interacts with HSPA1A or HSPA1B; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes. Interacts (via C-terminal region) with NPM1 (via C-terminal region); the interaction leads to loss of association between HSPA1A or HSPA1B and ATF5 and promotes ATF5 degradation via proteasome-dependent and caspase-dependent processes (PubMed:22528486, PubMed:24379400). Interacts with NLK; the interaction stabilizes ATF5 at the protein level in a kinase-independent manner (PubMed:25512613). Interacts with alpha-tubulin, gamma-tubulin members TUBGCP2 and TUBGCP4, PCNT; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385). Interacts with CEBPB and EP300; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity).

neXtProt entry for ATF5 Gene

Post-translational modifications for ATF5 Gene

  • Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. Cisplatin inhibits ubiquitination and proteasome-mediated degradation by inhibiting the interaction with CDC34 (PubMed:18458088). Ubiquitination and degradation by the proteasome are inhibited by NLK in a kinase-independent manner (PubMed:25512613).
  • Phosphorylated by NLK, probably at Ser-92, Thr-94, Ser-126 and Ser-190.
  • Acetylated at Lys-29 by EP300, the acetylation enhances the interaction with CEBPB, DNA-binding and transactivation activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATF5 Gene

Domains & Families for ATF5 Gene

Gene Families for ATF5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ATF5 Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
ProtoNet:

Suggested Antigen Peptide Sequences for ATF5 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor ATFx (ATF5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2D1

UniProtKB/Swiss-Prot:

ATF5_HUMAN :
  • Belongs to the bZIP family.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with ATF5: view

Function for ATF5 Gene

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  2. CRISPR
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Molecular function for ATF5 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).
UniProtKB/Swiss-Prot Induction:
Down-regulated by pro-apoptotic stimuli (PubMed:21212266). However, the pro-apoptotic cisplatin increases protein levels by inhibiting polyubiquitination (PubMed:18458088). IL1B increases protein levels through protein stabilization and increase of translation efficiency (PubMed:24379400).

Phenotypes From GWAS Catalog for ATF5 Gene

Gene Ontology (GO) - Molecular Function for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 15890932
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 16300731
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ATF5: view
genes like me logo Genes that share phenotypes with ATF5: view

Animal Models for ATF5 Gene

MGI Knock Outs for ATF5:
  • Atf5 Atf5<tm1(KOMP)Vlcg>
  • Atf5 Atf5<tm1Mrgr>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATF5 Gene

Localization for ATF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF5 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Actively transported to the centrosome and accumulated in the pericentriolar material (PCM) during G1 to M phase via a microtubule-dependent mechanism. During late telophase and cytokinesis, translocates from the centrosome to the midbody. {ECO:0000269 PubMed:26213385}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATF5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 2
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,IDA 22528486
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ATF5: view

Pathways & Interactions for ATF5 Gene

PathCards logo

SuperPathways for ATF5 Gene

SuperPathway Contained pathways
1 TNFR1 Pathway
TNF Signaling
.55
TNF Signaling
.34
2 ERK Signaling
MAPK Signaling
.58
ILK Signaling
.49
3 IL1 Signaling Pathway
IL1 Signaling Pathway
-
4 Ceramide Pathway
Ceramide Pathway
.32
5 Sertoli-Sertoli Cell Junction Dynamics
Epithelial Tight Junctions
.36
genes like me logo Genes that share pathways with ATF5: view

Pathways by source for ATF5 Gene

2 Sino Biological pathways for ATF5 Gene
9 Qiagen pathways for ATF5 Gene
  • Ceramide Pathway
  • Epithelial Tight Junctions
  • ILK Signaling
  • iNOS Signaling
  • ITK and TCR Signaling

SIGNOR curated interactions for ATF5 Gene

Activates:

Gene Ontology (GO) - Biological Process for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 20654631
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0007623 circadian rhythm IEA --
GO:0008285 negative regulation of cell proliferation IDA 22528486
GO:0009791 post-embryonic development IEA --
genes like me logo Genes that share ontologies with ATF5: view

Drugs & Compounds for ATF5 Gene

Products:

  1. Drug

(2) Drugs for ATF5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target, inhibitor 426
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with ATF5: view

Transcripts for ATF5 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for ATF5 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF5

Alternative Splicing Database (ASD) splice patterns (SP) for ATF5 Gene

No ASD Table

Relevant External Links for ATF5 Gene

GeneLoc Exon Structure for
ATF5

Expression for ATF5 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATF5 Gene

mRNA expression in normal human tissues for ATF5 Gene
mRNA expression by GTEx for ATF5 GenemRNA expression by BioGPS for ATF5 Gene

mRNA differential expression in normal tissues according to GTEx for ATF5 Gene

This gene is overexpressed in Liver (x34.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATF5

SOURCE GeneReport for Unigene cluster for ATF5 Gene:

Hs.9754

mRNA Expression by UniProt/SwissProt for ATF5 Gene:

Q9Y2D1-ATF5_HUMAN
Tissue specificity: Widely expressed with higher expression levels in liver.

Evidence on tissue expression from TISSUES for ATF5 Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Eye(2.9)
  • Muscle(2.8)
  • Pancreas(2.6)
  • Thyroid gland(2.5)
  • Intestine(2.3)
  • Kidney(2.3)
  • Blood(2.2)
  • Lung(2.2)
  • Skin(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with ATF5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF5 Gene

Orthologs for ATF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ATF5 30 31
  • 99.17 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ATF5 30 31
  • 85.13 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ATF5 30 31
  • 84.78 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Atf5 30 17 31
  • 84.16 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Atf5 30
  • 82.14 (n)
Lizard
(Anolis carolinensis)
 Reptilia ATF5 31
  • 45 (a)
 OneToOne
African clawed frog
(Xenopus laevis)
 Amphibia Xl.15540 30
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia Str.511 30
Zebrafish
(Danio rerio)
 Actinopterygii atf5a 31
  • 22 (a)
 OneToMany
atf5b 31
  • 19 (a)
 OneToMany
wufc14a10 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.2402 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.2035 31
  • 19 (a)
 OneToMany
Species where no ortholog for ATF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ATF5 Gene

ENSEMBL:
Gene Tree for ATF5 (if available)
TreeFam:
Gene Tree for ATF5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATF5: view image

Paralogs for ATF5 Gene

Paralogs for ATF5 Gene

genes like me logo Genes that share paralogs with ATF5: view

Variants for ATF5 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATF5 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
781515 Benign: not provided 49,932,498(+) C/A SYNONYMOUS_VARIANT
782656 Benign: not provided 49,930,940(+) C/T SYNONYMOUS_VARIANT
rs283526 - p.Pro121Leu

Additional dbSNP identifiers (rs#s) for ATF5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ATF5 Gene

Variant ID Type Subtype PubMed ID
dgv53n68 CNV loss 17160897
dgv54n68 CNV loss 17160897
esv3644630 CNV gain 21293372
nsv1058623 CNV gain 25217958
nsv1065648 CNV gain 25217958
nsv1140251 OTHER inversion 24896259
nsv458720 CNV gain 19166990
nsv579910 CNV gain 21841781
nsv579911 CNV gain 21841781
nsv7309 OTHER inversion 18451855
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for ATF5 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATF5 Gene

Human Gene Mutation Database (HGMD)
ATF5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATF5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF5 Gene

Disorders for ATF5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ATF5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
triple-receptor negative breast cancer
glioblastoma multiforme
  • adult glioblastoma multiforme
- elite association - COSMIC cancer census association via MalaCards
Search ATF5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ATF5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ATF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATF5 Gene

Publications for ATF5 Gene

  1. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PMID: 10373550) Pati D … Plon SE (Molecular and cellular biology 1999) 2 3 4
  2. ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole. (PMID: 26213385) Madarampalli B … Liu DX (Cell 2015) 3 4
  3. Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway. (PMID: 25512613) Zhang ZY … Zhang XD (Molecular and cellular biology 2015) 3 4
  4. N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization. (PMID: 24379400) Abe T … Takahashi Y (The Journal of biological chemistry 2014) 3 4
  5. p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation. (PMID: 24216764) Zhao Y … Li X (Molecular and cellular biology 2014) 3 4

ExternalLinks

View latest publications for ATF5 gene in Mastermind

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