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ATF5 (Activating Transcription Factor 5) is a Protein Coding gene. Diseases associated with ATF5 include Triple-Receptor Negative Breast Cancer and Schizophrenia 1. Among its related pathways are Myometrial Relaxation and Contraction Pathways and TNFR1 Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ATF4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | ISS | -- |
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IMP | 15890932 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IBA,IDA | 16300731 |
GO:0003677 | DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | ISA | -- |
GO:0005634 | nucleus | IBA,IDA | 22528486 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005667 | transcription factor complex | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | TNFR1 Pathway |
TNF Signaling
.55
|
.34
|
2 | ERK Signaling |
MAPK Signaling
.58
|
ILK Signaling
.49
|
3 | IL1 Signaling Pathway | ||
4 | Ceramide Pathway |
Ceramide Pathway
.32
|
|
5 | Sertoli-Sertoli Cell Junction Dynamics |
Epithelial Tight Junctions
.36
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IDA | 20654631 |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
GO:0007623 | circadian rhythm | IEA | -- |
GO:0008285 | negative regulation of cell proliferation | IDA | 22528486 |
GO:0009791 | post-embryonic development | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ATF5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ATF5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ATF5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Atf5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Atf5 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | ATF5 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.15540 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.511 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | atf5a 31 |
|
OneToMany | |
atf5b 31 |
|
OneToMany | |||
wufc14a10 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2402 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2035 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv53n68 | CNV | loss | 17160897 |
dgv54n68 | CNV | loss | 17160897 |
esv3644630 | CNV | gain | 21293372 |
nsv1058623 | CNV | gain | 25217958 |
nsv1065648 | CNV | gain | 25217958 |
nsv1140251 | OTHER | inversion | 24896259 |
nsv458720 | CNV | gain | 19166990 |
nsv579910 | CNV | gain | 21841781 |
nsv579911 | CNV | gain | 21841781 |
nsv7309 | OTHER | inversion | 18451855 |
nsv953600 | CNV | deletion | 24416366 |
nsv9739 | CNV | gain+loss | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
triple-receptor negative breast cancer |
|
|
schizophrenia 1 |
|
|