This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding pro... See more...

Aliases for ATF4 Gene

Aliases for ATF4 Gene

  • Activating Transcription Factor 4 2 3 4 5
  • CREB-2 2 3 4
  • Tax-Responsive Enhancer Element-Binding Protein 67 3 4
  • Cyclic AMP-Dependent Transcription Factor ATF-4 3 4
  • Cyclic AMP-Responsive Element-Binding Protein 2 3 4
  • CAMP-Dependent Transcription Factor ATF-4 3 4
  • CAMP-Responsive Element-Binding Protein 2 3 4
  • Tax-Responsive Enhancer Element B67 2 3
  • TAXREB67 2 3
  • CREB2 3 4
  • TXREB 3 4
  • Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) 2
  • CAMP Response Element-Binding Protein 2 3
  • DNA-Binding Protein TAXREB67 3
  • TaxREB67 4
  • ATF4 5

External Ids for ATF4 Gene

Previous HGNC Symbols for ATF4 Gene

  • TXREB

Previous GeneCards Identifiers for ATF4 Gene

  • GC22P036531
  • GC22P038158
  • GC22P038159
  • GC22P038241
  • GC22P039916
  • GC22P022881
  • GC22P039519

Summaries for ATF4 Gene

Entrez Gene Summary for ATF4 Gene

  • This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

GeneCards Summary for ATF4 Gene

ATF4 (Activating Transcription Factor 4) is a Protein Coding gene. Diseases associated with ATF4 include Coffin-Lowry Syndrome and Leukoencephalopathy With Vanishing White Matter. Among its related pathways are ATM Pathway and NGF Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is ATF5.

UniProtKB/Swiss-Prot Summary for ATF4 Gene

  • Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and acts both as a regulator of normal metabolic and redox processes, and as a master transcription factor during the integrated stress response (ISR) (PubMed:1847461, PubMed:16682973, PubMed:31444471, PubMed:32132707). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress, such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress (PubMed:32132707). During the ISR, ATF4 protein is translated in response to eIF-2-alpha/EIF2S1 phosphorylation caused by stress, and acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (PubMed:32132707). Protects cells against metabolic consequences of ER oxidation by promoting expression of genes linked to amino acid sufficiency and resistance to oxidative stress (By similarity). Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to amino acid deprivation or endoplasmic reticulum (ER) stress (PubMed:11960987). Together with DDIT3/CHOP, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (By similarity). ATF4 and DDIT3/CHOP activate the transcription of TRIB3 and promote ER stress-induced neuronal cell-death by regulating the expression of BBC3/PUMA (PubMed:15775988, PubMed:18940792). During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088). Activates expression of genes required to promote cell recovery in response to mitochondrial stress (PubMed:32132706, PubMed:32132707). Independently of the ISR, also required for normal metabolic processes: plays a key role in embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (PubMed:15109498). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). Activates transcription of SIRT4 (By similarity). Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (By similarity). Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (By similarity). Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471).
  • (Microbial infection) Binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.

Gene Wiki entry for ATF4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATF4 Gene

Genomics for ATF4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ATF4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J039518 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 633.6 +9.9 9864 12.3 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 ZNF629 ATF4 ENSG00000272834 TAB1 RPL3 SNORD83B ENSG00000230912 ENSG00000228274 CBY1 SNORD83A ENSG00000273076
GH22J039514 Enhancer 0.8 ENCODE dbSUPER 600.7 +0.1 67 0.2 CTCF ZNF143 RBFOX2 RAD21 TRIM22 CEBPB ZNF444 SMC3 RBM22 ARNT ATF4 piR-37505 piR-53104 piR-45170 MGAT3 SYNGR1 MIEF1 RPS19BP1
GH22J039515 Enhancer 0.3 Ensembl 600.7 +0.7 707 0.4 CTCF RBM22 ATF4 piR-37505 piR-53104 piR-45170 MGAT3 SYNGR1 piR-56777-002 MIEF1 RPS19BP1
GH22J039516 Enhancer 0.2 Ensembl 600.7 +1.2 1207 0.2 ATF4 piR-37505 piR-53104 piR-45170 MGAT3 SYNGR1 piR-56777-002 MIEF1 RPS19BP1
GH22J039530 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 24.6 +18.6 18602 4.6 SP1 HNRNPL GATAD2A CTCF TEAD4 PRDM10 ZNF629 TFE3 NFKBIZ KDM1A RPS19BP1 piR-35811 lnc-RPL3-2 ATF4 RPL3 TNRC6B CACNA1I FAM83F MGAT3 ENSG00000228274
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATF4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATF4

Top Transcription factor binding sites by QIAGEN in the ATF4 gene promoter:
  • AP-1
  • ATF-2
  • ATF6
  • C/EBPbeta
  • CREB
  • deltaCREB

Genomic Locations for ATF4 Gene

Genomic Locations for ATF4 Gene
chr22:39,514,494-39,522,686
(GRCh38/hg38)
Size:
8,193 bases
Orientation:
Plus strand
chr22:39,915,700-39,918,691
(GRCh37/hg19)
Size:
2,992 bases
Orientation:
Plus strand

Genomic View for ATF4 Gene

Genes around ATF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF4 Gene

Proteins for ATF4 Gene

  • Protein details for ATF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18848-ATF4_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-4
    Protein Accession:
    P18848
    Secondary Accessions:
    • Q96AQ3
    • Q9UH31

    Protein attributes for ATF4 Gene

    Size:
    351 amino acids
    Molecular mass:
    38590 Da
    Quaternary structure:
    • Binds DNA as a homodimer and as a heterodimer (PubMed:11018027). Heterodimer; heterodimerizes with CEBPB (PubMed:11018027). Heterodimer; heterodimerizes with DDIT3/CHOP (PubMed:18940792). Interacts with CEP290 (via an N-terminal region) (PubMed:16682973). Interacts with NEK6, DAPK2 (isoform 2) and ZIPK/DAPK3 (PubMed:20873783, PubMed:21408167). Interacts (via its leucine zipper domain) with GABBR1 and GABBR2 (via their C-termini) (By similarity). Forms a heterodimer with TXLNG in osteoblasts (PubMed:15911876). Interacts (via its DNA binding domain) with FOXO1 (C-terminal half); the interaction occurs in osteoblasts and regulates glucose homeostasis through suppression of beta-cell proliferation and a decrease in insulin production (By similarity). Interacts with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Interacts with ABRAXAS2 (PubMed:22974638). Interacts with TRIB3, inhibiting the transactivation activity of ATF4 (By similarity). Interacts with DISC1; which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (By similarity). Interacts with EP300/p300; EP300/p300 stabilizes ATF4 and increases its transcriptional activity independently of its catalytic activity by preventing its ubiquitination (PubMed:16219772).

    Three dimensional structures from OCA and Proteopedia for ATF4 Gene

neXtProt entry for ATF4 Gene

Post-translational modifications for ATF4 Gene

  • Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4 (PubMed:11238952). Interaction with EP300/p300 inhibits ubiquitination by SCF(BTRC) (PubMed:16219772).
  • Phosphorylation at Ser-245 by RPS6KA3/RSK2 in osteoblasts enhances transactivation activity and promotes osteoblast differentiation (PubMed:15109498). Phosphorylated on the betaTrCP degron motif at Ser-219, followed by phosphorylation at Thr-213, Ser-224, Ser-231, Ser-235 and Ser-248, promoting interaction with BTRC and ubiquitination (By similarity). Phosphorylation is promoted by mTORC1 (By similarity). Phosphorylation at Ser-215 by CK2 decreases its stability (PubMed:23123191). Phosphorylated by NEK6 (PubMed:20873783).
  • Hydroxylated by PHD3, leading to decreased protein stability.
  • Ubiquitination at Lys329
  • Modification sites at PhosphoSitePlus

Other Protein References for ATF4 Gene

Antibody Products

  • Abcam antibodies for ATF4

No data available for DME Specific Peptides for ATF4 Gene

Domains & Families for ATF4 Gene

Gene Families for ATF4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ATF4 Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
ProtoNet:

Suggested Antigen Peptide Sequences for ATF4 Gene

GenScript: Design optimal peptide antigens:
  • Tax-responsive enhancer element-binding protein 67 (ATF4_HUMAN)
  • ATF4 protein (Q6ICP0_HUMAN)
  • Activating transcription factor 4 (Tax-responsive enhancer element B67), isoform CRA_a (Q96AQ3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P18848

UniProtKB/Swiss-Prot:

ATF4_HUMAN :
  • The BetaTrCP degron motif promotes binding to BTRC when phosphorylated.
  • Belongs to the bZIP family.
Domain:
  • The BetaTrCP degron motif promotes binding to BTRC when phosphorylated.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with ATF4: view

Function for ATF4 Gene

Molecular function for ATF4 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and acts both as a regulator of normal metabolic and redox processes, and as a master transcription factor during the integrated stress response (ISR) (PubMed:1847461, PubMed:16682973, PubMed:31444471, PubMed:32132707). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress, such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress (PubMed:32132707). During the ISR, ATF4 protein is translated in response to eIF-2-alpha/EIF2S1 phosphorylation caused by stress, and acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (PubMed:32132707). Protects cells against metabolic consequences of ER oxidation by promoting expression of genes linked to amino acid sufficiency and resistance to oxidative stress (By similarity). Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to amino acid deprivation or endoplasmic reticulum (ER) stress (PubMed:11960987). Together with DDIT3/CHOP, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (By similarity). ATF4 and DDIT3/CHOP activate the transcription of TRIB3 and promote ER stress-induced neuronal cell-death by regulating the expression of BBC3/PUMA (PubMed:15775988, PubMed:18940792). During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088). Activates expression of genes required to promote cell recovery in response to mitochondrial stress (PubMed:32132706, PubMed:32132707). Independently of the ISR, also required for normal metabolic processes: plays a key role in embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (PubMed:15109498). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). Activates transcription of SIRT4 (By similarity). Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (By similarity). Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (By similarity). Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.
UniProtKB/Swiss-Prot Induction:
Specifically produced in response to various stress, such as endoplasmic reticulum (ER) stress, amino acid starvation, or oxidative stress (PubMed:27629041). In absence of stress, some upstream open reading frame (uORF) of this transcript is translated, thereby preventing its translation (PubMed:27629041). In response to stress and subsequent eIF-2-alpha/EIF2S1 phosphorylation, preferentially translated (PubMed:27629041).
GENATLAS Biochemistry:
activation transcription factor 4,cAMP dependent,for a tax responsive enhancer element B67 in the long terminal repeat of human T cell leukemia virus type I

Phenotypes From GWAS Catalog for ATF4 Gene

Gene Ontology (GO) - Molecular Function for ATF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA, TAS 23392669
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISS --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IDA,ISM 19274049
GO:0001085 RNA polymerase II transcription factor binding IPI 11478948
genes like me logo Genes that share ontologies with ATF4: view
genes like me logo Genes that share phenotypes with ATF4: view

Animal Models for ATF4 Gene

MGI Knock Outs for ATF4:

Animal Model Products

CRISPR Products

miRNA for ATF4 Gene

Targeted motifs for ATF4 Gene
HOMER Transcription Factor Regulatory Elements motif ATF4
  • Consensus sequence: MTGATGCAAT Submotif: canonical Cell Type: MEF GEO ID: GSE35681

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ATF4 Gene

Localization for ATF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF4 Gene

Nucleus. Nucleus speckle. Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783). Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772). {ECO:0000250 UniProtKB:Q9ES19, ECO:0000269 PubMed:16219772, ECO:0000269 PubMed:20873783}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATF4 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
plasma membrane 3
endoplasmic reticulum 3
cytosol 3
extracellular 2
mitochondrion 2
peroxisome 2
lysosome 2
golgi apparatus 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005623 cell IEA --
GO:0005634 nucleus IDA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with ATF4: view

Pathways & Interactions for ATF4 Gene

PathCards logo

SuperPathways for ATF4 Gene

SuperPathway Contained pathways
1 Aldosterone synthesis and secretion
2 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
3 CREB Pathway
.68
.68
.63
.50
4 Relaxin signaling pathway
5 nNOS Signaling in Skeletal Muscle
.44
.44
.01
genes like me logo Genes that share pathways with ATF4: view

Pathways by source for ATF4 Gene

1 R&D Systems pathway for ATF4 Gene
53 Qiagen pathways for ATF4 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Akt Signaling
  • ATM Pathway
1 Cell Signaling Technology pathway for ATF4 Gene
1 GeneTex pathway for ATF4 Gene

SIGNOR curated interactions for ATF4 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ATF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis ISS --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006366 transcription by RNA polymerase II ISS --
GO:0006874 cellular calcium ion homeostasis IEA --
genes like me logo Genes that share ontologies with ATF4: view

Drugs & Compounds for ATF4 Gene

(22) Drugs for ATF4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target, inhibitor 426
cyclic amp Experimental Pharma 0

(10) Additional Compounds for ATF4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ATF4: view

Transcripts for ATF4 Gene

mRNA/cDNA for ATF4 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF4

Alternative Splicing Database (ASD) splice patterns (SP) for ATF4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3
SP1: -
SP2:

Relevant External Links for ATF4 Gene

GeneLoc Exon Structure for
ATF4

Expression for ATF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATF4 Gene

This gene is overexpressed in Platelet (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ATF4 Gene



Protein tissue co-expression partners for ATF4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATF4

SOURCE GeneReport for Unigene cluster for ATF4 Gene:

Hs.496487

Evidence on tissue expression from TISSUES for ATF4 Gene

  • Lung(5)
  • Intestine(4.9)
  • Nervous system(4.9)
  • Liver(4.8)
  • Blood(4.5)
  • Eye(4.5)
  • Kidney(4.4)
  • Pancreas(4.4)
  • Muscle(4.3)
  • Skin(4.2)
  • Stomach(3.8)
  • Bone(3.6)
  • Heart(3.5)
  • Bone marrow(3.4)
  • Adrenal gland(3)
  • Lymph node(2.9)
  • Spleen(2.9)
  • Thyroid gland(2.9)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with ATF4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF4 Gene

Orthologs for ATF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ATF4 30 31
  • 99.43 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ATF4 30 31
  • 90.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ATF4 30 31
  • 88.05 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Atf4 30 17 31
  • 86.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Atf4 30
  • 86.46 (n)
Oppossum
(Monodelphis domestica)
Mammalia ATF4 31
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ATF4 31
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ATF4 30 31
  • 68.4 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ATF4 31
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia atf4 30
  • 63.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68539 30
Zebrafish
(Danio rerio)
Actinopterygii atf4b2 30 31
  • 49.2 (n)
OneToMany
atf4b1 31
  • 35 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.832 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2035 31
  • 21 (a)
OneToMany
Species where no ortholog for ATF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ATF4 Gene

ENSEMBL:
Gene Tree for ATF4 (if available)
TreeFam:
Gene Tree for ATF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATF4: view image

Paralogs for ATF4 Gene

Paralogs for ATF4 Gene

Pseudogenes.org Pseudogenes for ATF4 Gene

genes like me logo Genes that share paralogs with ATF4: view

Variants for ATF4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATF4 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
709309 Benign: not provided 39,521,939(+) T/C SYNONYMOUS_VARIANT
717867 Likely Benign: not provided 39,522,125(+) G/A SYNONYMOUS_VARIANT
725766 Benign: not provided 39,521,452(+) G/A MISSENSE_VARIANT
726550 Benign: not provided 39,522,044(+) C/T SYNONYMOUS_VARIANT
736103 Likely Benign: not provided 39,522,458(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ATF4 Gene

Structural Variations from Database of Genomic Variants (DGV) for ATF4 Gene

Variant ID Type Subtype PubMed ID
nsv3629 CNV insertion 18451855
nsv834199 CNV loss 17160897
nsv964633 CNV duplication 23825009

Variation tolerance for ATF4 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.54; 88.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATF4 Gene

Human Gene Mutation Database (HGMD)
ATF4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATF4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF4 Gene

Disorders for ATF4 Gene

MalaCards: The human disease database

(11) MalaCards diseases for ATF4 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ATF4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ATF4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ATF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATF4 Gene

Publications for ATF4 Gene

  1. Associations of ATF4 gene polymorphisms with schizophrenia in male patients. (PMID: 18163433) Qu M … Zhang D (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 41
  2. Lithium response and genetic variation in the CREB family of genes. (PMID: 18189280) Mamdani F … Turecki G (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 41
  3. Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor. (PMID: 17684156) Köditz J … Katschinski DM (Blood 2007) 3 4 23
  4. Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder. (PMID: 17346882) Kakiuchi C … Kato T (Neuroscience letters 2007) 3 23 41
  5. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. (PMID: 15775988) Ohoka N … Hayashi H (The EMBO journal 2005) 3 4 23

Products for ATF4 Gene

  • Addgene plasmids for ATF4

Sources for ATF4 Gene