Aliases for ATF3 Gene
External Ids for ATF3 Gene
Previous GeneCards Identifiers for ATF3 Gene
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
GeneCards Summary for ATF3 Gene
ATF3 (Activating Transcription Factor 3) is a Protein Coding gene. Diseases associated with ATF3 include Bone Cancer and Hypospadias. Among its related pathways are Ceramide Pathway and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is JDP2.
UniProtKB/Swiss-Prot Summary for ATF3 Gene
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter.
[Isoform 2]: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters.