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This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
ATF3 (Activating Transcription Factor 3) is a Protein Coding gene. Diseases associated with ATF3 include Bone Cancer and Hypospadias. Among its related pathways are Photodynamic therapy-induced unfolded protein response and PERK regulates gene expression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is JDP2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J212605 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 612.9 | +42.9 | 42860 | 6 | RNF2 CEBPG HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 REST | ATF3 lnc-BATF3-8 ANGEL2 DTL FLVCR1 BATF3 FAM71A | |
GH01J212565 | Promoter/Enhancer | 1.7 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +1.8 | 1764 | 2.2 | RNF2 SP1 PRDM10 ZNF629 ZNF512 LEF1 ZNF692 BACH1 JUND FOXA1 | ATF3 lnc-BATF3-8 FAM71A | |
GH01J212615 | Promoter | 0.6 | EPDnew | 600.3 | +49.9 | 49910 | 0.1 | ZNF316 POLR2A USF2 | AB372749-001 NONHSAG004237.2 lnc-BATF3-5 ATF3 BATF3 FAM71A | |
GH01J212590 | Promoter | 0.4 | EPDnew | 600.3 | +25.0 | 25034 | 0.1 | ZNF316 | ATF3 lnc-BATF3-8 FAM71A | |
GH01J212481 | Enhancer | 1.5 | FANTOM5 ENCODE dbSUPER | 39.1 | -79.4 | -79417 | 8.2 | CREB1 ATF7 PRDM10 ZNF629 RFX1 LEF1 ZNF692 BACH1 JUND FOXA1 | lnc-TMEM206-7 LINC02771 ATF3 ANGEL2 BATF3 RPL21P28 lnc-NENF-5 NENF |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 8622660 |
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 2516827 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IDA | 8622660 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:1990622 | CHOP-ATF3 complex | IDA | 8622660 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | TNFR1 Pathway |
TNF Signaling
.55
|
.34
|
2 | ERK Signaling |
MAPK Signaling
.58
|
ILK Signaling
.49
|
3 | PERK regulates gene expression | ||
4 | Glucose / Energy Metabolism | ||
5 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 8622660 |
GO:0006094 | gluconeogenesis | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0008284 | positive regulation of cell proliferation | IEA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||||||||||
SP9: | - | ||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP11: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ATF3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ATF3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ATF3 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ATF3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ATF3 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Atf3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Atf3 30 |
|
||
Chicken (Gallus gallus) |
Aves | ATF3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ATF3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | atf3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | atf3 30 31 |
|
OneToOne | |
zgc55526 30 |
|
||||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
741892 | Benign: not provided | 212,619,384(+) | T/C | SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT | |
rs11571541 | - | p.Thr38Met | |||
VAR_081532 | - | p.Asn168Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758996 | CNV | loss | 17122850 |
esv3394920 | CNV | insertion | 20981092 |
nsv549139 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
bone cancer |
|
|
hypospadias |
|
|
cockayne syndrome b |
|
|
pulmonary systemic sclerosis |
|
|
wilms tumor 1 |
|
|