Aliases for ATF3 Gene
Aliases for ATF3 Gene
External Ids for ATF3 Gene
- HGNC: 785
- Entrez Gene: 467
- Ensembl: ENSG00000162772
- OMIM: 603148
- UniProtKB: P18847
Previous GeneCards Identifiers for ATF3 Gene
- GC01P211461
- GC01P208625
- GC01P209398
- GC01P209838
- GC01P209170
- GC01P210805
- GC01P212738
- GC01P183415
Summaries for ATF3 Gene
-
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
GeneCards Summary for ATF3 Gene
ATF3 (Activating Transcription Factor 3) is a Protein Coding gene. Diseases associated with ATF3 include Hypospadias and Bone Cancer. Among its related pathways are ERK Signaling and HTLV-I infection. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is JDP2.
UniProtKB/Swiss-Prot for ATF3 Gene
-
This protein binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
Additional gene information for ATF3 Gene
- Monarch Initiative
- Search for ATF3 at DataMed
- Search for ATF3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF3 Gene
Genomics for ATF3 Gene
GeneHancer (GH) Regulatory Elements for ATF3 Gene
Promoters and enhancers for ATF3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J212605 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 662.9 | +42.5 | 42460 | 5.2 | MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 | ATF3 ANGEL2 FLVCR1 BATF3 GC01M212615 | |
| GH01J212565 | Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 650.7 | +1.8 | 1764 | 2.2 | PKNOX1 FOXA2 SMAD1 SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF213 ZNF207 | ATF3 GC01M212615 | |
| GH01J212615 | Promoter | 0.7 | EPDnew | 650.2 | +49.9 | 49910 | 0.1 | ZNF316 POLR2A USF2 | GC01M212615 ATF3 BATF3 | |
| GH01J212590 | Promoter | 0.6 | EPDnew | 650.3 | +25.0 | 25034 | 0.1 | ZNF316 | ATF3 GC01M212615 | |
| GH01J212481 | Enhancer | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 39.1 | -79.4 | -79417 | 8.2 | PKNOX1 SMAD1 FOXA2 ARNT NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF766 | LOC105372907 ATF3 ANGEL2 BATF3 RPL21P28 LOC105372908 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ATF3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ATF3 gene promoter:
Regulatory Element Products
Genomic Locations for ATF3 Gene
Genomic Locations for ATF3 Gene
- chr1:212,565,334-212,620,777
- (GRCh38/hg38)
- Size:
- 55,444 bases
- Orientation:
- Plus strand
- chr1:212,738,676-212,794,119
- (GRCh37/hg19)
Genomic View for ATF3 Gene
Genes around ATF3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.3 by Entrez Gene
- 1q32.3 by HGNC
- 1q32.3 by Ensembl
ATF3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ATF3 Gene
Proteins for ATF3 Gene
-
Protein details for ATF3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18847-ATF3_HUMAN
- Recommended name:
- Cyclic AMP-dependent transcription factor ATF-3
- Protein Accession:
- P18847
- Q5VTZ2
- Q6ICQ9
- Q7Z566
- Q8WYM6
Protein attributes for ATF3 Gene
- Size:
- 181 amino acids
- Molecular mass:
- 20576 Da
- Quaternary structure:
-
- Binds DNA as a homodimer or a heterodimer.
Protein Expression for ATF3 Gene
Post-translational modifications for ATF3 Gene
Other Protein References for ATF3 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ATF3
- Novus Biologicals Antibodies for ATF3
- Invitrogen Antibodies for ATF3
- antibodies-online: Search results for 126 available ATF3 Antibodies ranked by validation data
- Compare Top ATF3 Antibodies
-
Recommended
- 98 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 34 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 31 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex ATF3 Antibody for ATF3
-
Boster Bio Antibodies for ATF3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ATF3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ATF3
- Origene Custom Protein Services for ATF3
- ProSpec Recombinant Proteins for ATF3
- Search GeneTex for Proteins for ATF3
No data available for DME Specific Peptides for ATF3 Gene
Domains & Families for ATF3 Gene
Gene Families for ATF3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ATF3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ATF3 Gene
Graphical View of Domain Structure for InterPro Entry
P18847- Family:
-
- Belongs to the bZIP family. ATF subfamily.
Function for ATF3 Gene
Molecular function for ATF3 Gene
- UniProtKB/Swiss-Prot Function:
- This protein binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
Phenotypes From GWAS Catalog for ATF3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 24939851 |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 2516827 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | -- |
Phenotypes for ATF3 Gene
- MGI mutant phenotypes for ATF3:
-
inferred from 5 alleles
- respiratory system phenotype
- pigmentation phenotype
- vision/eye phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for ATF3:
Animal Models for ATF3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ATF3
-
CRISPR Products
-
OriGene CRISPR knockouts for ATF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATF3
- genomics-online: gRNA clones - Search results for 115 available ATF3 gene related products
- Overview of 115 available ATF3 gene related products
- Applied Biological Materials CRISPR for ATF3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ATF3
- GenScript: Design CRISPR guide RNA sequences for ATF3
miRNA for ATF3 Gene
- miRTarBase miRNAs that target ATF3
-
- hsa-mir-26b-5p (MIRT029081)
- hsa-mir-331-3p (MIRT043494)
- hsa-mir-17-5p (MIRT050819)
- hsa-mir-494-3p (MIRT053227)
- hsa-mir-505-5p (MIRT438584)
- hsa-mir-30e-3p (MIRT438585)
- hsa-mir-30a-3p (MIRT438586)
- hsa-mir-24-3p (MIRT528870)
- hsa-mir-3180-5p (MIRT528871)
- hsa-mir-6720-5p (MIRT528872)
- hsa-mir-6512-3p (MIRT528873)
- hsa-mir-4291 (MIRT528874)
- hsa-mir-377-3p (MIRT528875)
- hsa-mir-4277 (MIRT528876)
- hsa-mir-4267 (MIRT528877)
- hsa-mir-584-3p (MIRT528878)
- hsa-mir-7157-5p (MIRT528879)
- hsa-mir-4310 (MIRT528880)
- hsa-mir-216b-3p (MIRT528881)
- hsa-mir-5000-5p (MIRT528882)
- hsa-mir-3614-3p (MIRT528883)
- hsa-mir-1179 (MIRT528884)
- hsa-mir-590-5p (MIRT732444)
- hsa-mir-30c-2-3p (MIRT732675)
Targeted motifs for ATF3 Gene
HOMER Transcription Factor Regulatory Elements motif ATF3
- Consensus sequence: DATGASTCATHN Submotif: canonical Cell Type: GBM GEO ID: GSE33912
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ATF3
- Browse OriGene Inhibitory RNA Products For ATF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF3
- genomics-online: shRNA clones - Search results for 115 available ATF3 gene related products
- Overview of 115 available ATF3 gene related products
Clone Products
-
OriGene ORF clones in human for ATF3
- RC202897L1V
- RC202897L2V
- RC215620L1V
- RC215620L2V
- RC218939L1V
- RC218939L2V
- RC222638L1V
- RC222638L2V
- RC202897
- RC202897L1
- RC202897L2
- RG202897
- RC215620
- RC215620L1
- RC215620L2
- RG215620
- RC231726
- RG231726
- RC231648
- RG231648
- RC231727
- RG231727
- RC218939
- RC218939L1
- RC218939L2
- RG218939
- RC222638
- RC222638L1
- RC222638L2
- RG222638
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ATF3
- VectorBuilder custom plasmid, inducible vectors for ATF3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ATF3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ATF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATF3
- Applied Biological Materials Clones for ATF3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ATF3 Gene
Localization for ATF3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ATF3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
- Nucleoli (4)
- Nucleus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 8622660 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:1990622 | CHOP-ATF3 complex | IDA | 8622660 |
Pathways & Interactions for ATF3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | ERK Signaling |
.58
|
.49
|
| 2 | PERK regulates gene expression | ||
| 3 | HTLV-I infection | ||
| 4 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics | ||
| 5 | Glucose / Energy Metabolism | ||
Pathways by source for ATF3 Gene
7 BioSystems pathways for ATF3 Gene
4 Reactome pathways for ATF3 Gene
1 PharmGKB pathway for ATF3 Gene
1 KEGG pathway for ATF3 Gene
8 Qiagen pathways for ATF3 Gene
1 Cell Signaling Technology pathway for ATF3 Gene
Interacting Proteins for ATF3 Gene
Selected Interacting proteins:
P18847-ATF3_HUMAN
ENSP00000344352
for ATF3 Gene via
IID
UniProtKB
MINT
STRING
GPS-Prot Interaction Network for ATF3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 8622660 |
| GO:0006094 | gluconeogenesis | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | -- |
Transcripts for ATF3 Gene
mRNA/cDNA for ATF3 Gene
- (277) Selected AceView cDNA sequences:
- (11) Additional mRNA sequences :
- (10) REFSEQ mRNAs :
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000336937 482 bps (uc021piv.2)
- ENST00000341491 2033 bps (uc001hjh.4)
- ENST00000366981 680 bps (uc057pfw.1)
- ENST00000366983 858 bps (uc057pgb.1)
- ENST00000366985 516 bps (uc057pfz.1)
Unigene Clusters for ATF3 Gene
- Activating transcription factor 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ATF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATF3
- genomics-online: gRNA clones - Search results for 115 available ATF3 gene related products
- Overview of 115 available ATF3 gene related products
- Applied Biological Materials CRISPR for ATF3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ATF3
- GenScript: Design CRISPR guide RNA sequences for ATF3
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ATF3
- Browse OriGene Inhibitory RNA Products For ATF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF3
- genomics-online: shRNA clones - Search results for 115 available ATF3 gene related products
- Overview of 115 available ATF3 gene related products
Clone Products
-
OriGene ORF clones in human for ATF3
- RC202897L1V
- RC202897L2V
- RC215620L1V
- RC215620L2V
- RC218939L1V
- RC218939L2V
- RC222638L1V
- RC222638L2V
- RC202897
- RC202897L1
- RC202897L2
- RG202897
- RC215620
- RC215620L1
- RC215620L2
- RG215620
- RC231726
- RG231726
- RC231648
- RG231648
- RC231727
- RG231727
- RC218939
- RC218939L1
- RC218939L2
- RG218939
- RC222638
- RC222638L1
- RC222638L2
- RG222638
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ATF3
- VectorBuilder custom plasmid, inducible vectors for ATF3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ATF3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ATF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATF3
- Applied Biological Materials Clones for ATF3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b |
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| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP11: | - |
Expression for ATF3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Neural Ectoderm (Nervous System)
- Bone (Muscoskeletal System)
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
-
Liver (Hepatobiliary System)
-
Esophagus (Gastrointestinal Tract)
-
Adrenal Gland (Endocrine System)
-
Kidney (Urinary System)
-
Gall Bladder (Hepatobiliary System)
-
Thyroid (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Prostate (Endocrine System)
-
Uterus (Reproductive System)
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATF3 Gene
NURSA nuclear receptor signaling pathways regulating expression of ATF3 Gene:
ATF3SOURCE GeneReport for Unigene cluster for ATF3 Gene:
Hs.460Evidence on tissue expression from TISSUES for ATF3 Gene
- Lung(4.7)
- Nervous system(4.7)
- Muscle(4.5)
- Liver(2.9)
- Heart(2.7)
- Intestine(2.5)
- Kidney(2.5)
- Pancreas(2.3)
- Adrenal gland(2.1)
- Blood(2.1)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ATF3
-
OriGene qPCR primer pairs for ATF3
- genomics-online: primer clones - Search results for 115 available ATF3 gene related products
- Overview of 115 available ATF3 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF3 Gene
Orthologs for ATF3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ATF3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ATF3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ATF3 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ATF3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ATF3 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Atf3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Atf3 33 |
|
||
| chicken (Gallus gallus) |
Aves | ATF3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ATF3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | atf3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | atf3 34 33 |
|
OneToOne | |
| zgc55526 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ATF3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ATF3 Gene
- ENSEMBL:
- Gene Tree for ATF3 (if available)
- TreeFam:
- Gene Tree for ATF3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ATF3: view image
Paralogs for ATF3 Gene
Variants for ATF3 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000007038 | -- | 212,615,933(+) | G/A | intron_variant | |
| rs1000014351 | -- | 212,593,132(+) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000073434 | -- | 212,606,402(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000087672 | -- | 212,566,721(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000171183 | -- | 212,596,739(+) | A/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758996 | CNV | loss | 17122850 |
| esv3394920 | CNV | insertion | 20981092 |
| nsv549139 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.01;
20.77% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ATF3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF3 Gene
Disorders for ATF3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypospadias |
|
|
| bone cancer |
|
|
| wilms tumor 1 |
|
|
Search ATF3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ATF3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ATF3 Gene
Publications for ATF3 Gene
- ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. (PMID: 7515060) Chen BP … Hai T (The Journal of biological chemistry 1994) 2 3 4 22 58
- Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation? (PMID: 20215396) van der Zanden LF … Franke B (The Journal of clinical endocrinology and metabolism 2010) 3 22 44 58
- Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias. (PMID: 18426833) Beleza-Meireles A … Nordenskjöld A (European journal of endocrinology 2008) 3 22 44 58
- Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. (PMID: 12881527) Pan Y … Kilberg MS (The Journal of biological chemistry 2003) 3 4 22 58
- Activating transcription factor 3 is a positive regulator of human IFNG gene expression. (PMID: 20304822) Filén S … Lahesmaa R (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 22 58
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Sources for ATF3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
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- (84) Vector BioLabs
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- (97) antibodies-online
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- (100) SwitchGear Genomics
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- (103) GeneReviews
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