Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms ... See more...
Aliases for ATF3 Gene
Aliases for ATF3 Gene
External Ids for ATF3 Gene
- HGNC: 785
- Entrez Gene: 467
- Ensembl: ENSG00000162772
- OMIM: 603148
- UniProtKB: P18847
Previous GeneCards Identifiers for ATF3 Gene
- GC01P211461
- GC01P208625
- GC01P209398
- GC01P209838
- GC01P209170
- GC01P210805
- GC01P212738
- GC01P183415
Summaries for ATF3 Gene
-
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
GeneCards Summary for ATF3 Gene
ATF3 (Activating Transcription Factor 3) is a Protein Coding gene. Diseases associated with ATF3 include Bone Cancer and Hypospadias. Among its related pathways are Direct p53 effectors and Ceramide Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is JDP2.
UniProtKB/Swiss-Prot Summary for ATF3 Gene
-
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
Additional gene information for ATF3 Gene
- Monarch Initiative
- Search for ATF3 at DataMed
- Search for ATF3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATF3 Gene
Genomics for ATF3 Gene
GeneHancer (GH) Regulatory Elements for ATF3 Gene
Promoters and enhancers for ATF3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J212605 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 512.9 | +42.9 | 42860 | 6 | FOXK2 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A NRF1 TCF12 MYC | ATF3 lnc-BATF3-8 ANGEL2 RPL21P28 ENSG00000229832 FLVCR1 BATF3 | |
| GH01J212565 | Promoter/Enhancer | 1.7 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 500.7 | +1.8 | 1764 | 2.2 | RXRA ZBTB40 EP300 ZSCAN5C SIN3A SP1 JUND FOS ZNF639 ZNF10 | ATF3 ANGEL2 FLVCR1 lnc-BATF3-8 | |
| GH01J212615 | Promoter | 0.6 | EPDnew | 500.3 | +49.9 | 49910 | 0.1 | ZNF316 POLR2A USF2 RBFOX2 | AB372749-001 NONHSAG004237.2 lnc-BATF3-5 ATF3 BATF3 | |
| GH01J212590 | Promoter | 0.4 | EPDnew | 500.3 | +25.0 | 25034 | 0.1 | ZNF316 | ATF3 lnc-BATF3-8 | |
| GH01J212481 | Enhancer | 1.5 | FANTOM5 ENCODE dbSUPER | 39.1 | -79.4 | -79417 | 8.2 | TCF12 USF1 GTF2E2 JUND FOS ZNF639 ZNF10 EP300 ZIC2 POLR2A | lnc-TMEM206-7 LINC02771 ATF3 ANGEL2 BATF3 lnc-NENF-5 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ATF3 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATF3
- Top Transcription factor binding sites by QIAGEN in the ATF3 gene promoter:
-
- ATF
- C/EBPalpha
- CREB
- deltaCREB
Genomic Locations for ATF3 Gene
Genomic Locations for ATF3 Gene
- chr1:212,565,334-212,620,777
- (GRCh38/hg38)
- Size:
- 55,444 bases
- Orientation:
- Plus strand
- chr1:212,738,676-212,794,119
- (GRCh37/hg19)
- Size:
- 55,444 bases
- Orientation:
- Plus strand
Genomic View for ATF3 Gene
Genes around ATF3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.3 by HGNC
- 1q32.3 by Entrez Gene
- 1q32.3 by Ensembl
ATF3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ATF3 Gene
Proteins for ATF3 Gene
-
Protein details for ATF3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18847-ATF3_HUMAN
- Recommended name:
- Cyclic AMP-dependent transcription factor ATF-3
- Protein Accession:
- P18847
- Q5VTZ2
- Q6ICQ9
- Q7Z566
- Q8WYM6
Protein attributes for ATF3 Gene
- Size:
- 181 amino acids
- Molecular mass:
- 20576 Da
- Quaternary structure:
-
- Binds DNA as a homodimer or a heterodimer.
- Miscellaneous:
-
- [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
- [Isoform 3]: Stress-induced isoform, counteracts the transcriptional repression of isoform 1.
Protein Expression for ATF3 Gene
Post-translational modifications for ATF3 Gene
Other Protein References for ATF3 Gene
Antibody Products
- NSJ Bioreagents ATF3 Antibody
- Creative Diagnostics Anti-ATF3 (aa 1-90) polyclonal antibody
- Creative Biolabs Recombinant Anti-Human ATF3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for ATF3
- Novus Biologicals Antibodies for ATF3
-
Abcam antibodies for ATF3
- Invitrogen Antibodies for ATF3 (AFLGC-ATF3)
- antibodies-online: Show 30 available ATF3 Antibodies ranked by validation data
- Compare Top ATF3 Antibodies
-
Recommended
- 110 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 ICC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 41 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 35 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Boster Bio Antibodies for ATF3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ATF3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ATF3
- Origene Custom Protein Services for ATF3
- ProSpec Recombinant Proteins for ATF3
-
Signalway Proteins for ATF3
-
Abcam proteins for ATF3
Assay Products
- Aviva Systems Biology ATF3 ELISA Kit (Human) (OKCD01658)
- Novus Biologicals ELISA Kits for ATF3
-
Boster Bio ELISA Kits for ATF3
-
Signalway ELISA kits for ATF3
No data available for DME Specific Peptides for ATF3 Gene
Domains & Families for ATF3 Gene
Gene Families for ATF3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ATF3 Gene
Suggested Antigen Peptide Sequences for ATF3 Gene
- GenScript: Design optimal peptide antigens:
-
- Activating transcription factor 3 (ATF3_HUMAN)
- cDNA, FLJ93461, Homo sapiens activating transcription factor 3 (ATF3), mRNA (Q6ICQ9_HUMAN)
- cDNA FLJ57271, highly similar to Cyclic AMP-dependent transcription factorATF-3 (Q7Z567_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P18847- Family:
-
- Belongs to the bZIP family. ATF subfamily.
Function for ATF3 Gene
Molecular function for ATF3 Gene
- UniProtKB/Swiss-Prot Function:
- This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
Phenotypes From GWAS Catalog for ATF3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 24939851 |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 2516827 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA | -- |
Phenotypes for ATF3 Gene
- MGI mutant phenotypes for ATF3:
-
inferred from 5 alleles
- respiratory system phenotype
- vision/eye phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- skeleton phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for ATF3:
Animal Models for ATF3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ATF3 - Select products 50% OFF >
- * ATF3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ATF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATF3
- genomics-online: gRNA clones - Search for available ATF3 gRNA products
- Overview of 135 available ATF3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ATF3
miRNA for ATF3 Gene
- miRTarBase miRNAs that target ATF3
-
- hsa-mir-26b-5p (MIRT029081)
- hsa-mir-331-3p (MIRT043494)
- hsa-mir-17-5p (MIRT050819)
- hsa-mir-494-3p (MIRT053227)
- hsa-mir-505-5p (MIRT438584)
- hsa-mir-30e-3p (MIRT438585)
- hsa-mir-30a-3p (MIRT438586)
- hsa-mir-24-3p (MIRT528870)
- hsa-mir-3180-5p (MIRT528871)
- hsa-mir-6720-5p (MIRT528872)
- hsa-mir-6512-3p (MIRT528873)
- hsa-mir-4291 (MIRT528874)
- hsa-mir-377-3p (MIRT528875)
- hsa-mir-4277 (MIRT528876)
- hsa-mir-4267 (MIRT528877)
- hsa-mir-584-3p (MIRT528878)
- hsa-mir-7157-5p (MIRT528879)
- hsa-mir-4310 (MIRT528880)
- hsa-mir-216b-3p (MIRT528881)
- hsa-mir-5000-5p (MIRT528882)
- hsa-mir-3614-3p (MIRT528883)
- hsa-mir-1179 (MIRT528884)
- hsa-mir-590-5p (MIRT732444)
- hsa-mir-30c-2-3p (MIRT732675)
Targeted motifs for ATF3 Gene
HOMER Transcription Factor Regulatory Elements motif ATF3
- Consensus sequence: DATGASTCATHN Submotif: canonical Cell Type: GBM GEO ID: GSE33912
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATF3
- Browse OriGene Inhibitory RNA Products For ATF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF3
- genomics-online: shRNA clones - Search for available ATF3 shRNA products
- Overview of 135 available ATF3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ATF3 - Select products 50% OFF >
- * ATF3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201634
- MR201634
- MR201634L1
- MR201634L2
- MR201634L3
- MR201634L4
- RC202897
- RC202897L1
- RC202897L2
- RC202897L3
- RC202897L4
- RC215620
- RC215620L1
- RC215620L2
- RC215620L3
- RC215620L4
- RC218939
- RC218939L1
- RC218939L2
- RC218939L3
- RC218939L4
- RC222638
- RC222638L3
- RC222638L4
- RC231648
- RC231726
- RC231727
- RG202897
- RG215620
- RG218939
- RG222638
- RG231648
- RG231726
- RG231727
- RR212713
- RR212713L3
- RR212713L4
- MR201634L1V
- MR201634L2V
- MR201634L3V
- MR201634L4V
- RC202897L1V
- RC202897L2V
- RC202897L3V
- RC202897L4V
- RC215620L1V
- RC215620L2V
- RC215620L3V
- RC215620L4V
- RC218939L1V
- RC218939L2V
- RC218939L3V
- RC218939L4V
- RC222638L3V
- RC222638L4V
- RR212713L3V
- RR212713L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ATF3
- Addgene plasmids for ATF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATF3
- genomics-online: cdna clones - Search for available ATF3 CDNA products
- Overview of 135 available ATF3 gene related products
- orf clones - Search for available ATF3 ORF products
- Overview of 135 available ATF3 gene related products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ATF3 Gene
Localization for ATF3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ATF3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| endoplasmic reticulum | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Nucleoli (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IDA,IBA | 8622660 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:1990622 | CHOP-ATF3 complex | IDA | 8622660 |
Pathways & Interactions for ATF3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | ERK Signaling |
MAPK Signaling
.58
|
ILK Signaling
.49
|
| 2 | PERK regulates gene expression | ||
| 3 | Glucose / Energy Metabolism | ||
| 4 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics | ||
| 5 | Ceramide Pathway |
Ceramide Pathway
.32
|
|
Pathways by source for ATF3 Gene
7 BioSystems pathways for ATF3 Gene
4 Reactome pathways for ATF3 Gene
1 PharmGKB pathway for ATF3 Gene
8 Qiagen pathways for ATF3 Gene
- Ceramide Pathway
- ILK Signaling
- iNOS Signaling
- ITK and TCR Signaling
- MAPK Signaling
1 Cell Signaling Technology pathway for ATF3 Gene
Interacting Proteins for ATF3 Gene
Selected Interacting proteins:
P18847-ATF3_HUMAN
ENSP00000344352
for ATF3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ATF3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 8622660 |
| GO:0006094 | gluconeogenesis | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
Transcripts for ATF3 Gene
mRNA/cDNA for ATF3 Gene
- 8 REFSEQ mRNAs :
- 27 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000336937 482 bps (ENST00000336937.8)
- ENST00000341491 1940 bps (ENST00000341491.9)
- ENST00000366981 680 bps (ENST00000366981.8)
- ENST00000366983 858 bps (ENST00000366983.5)
- ENST00000366985 516 bps (ENST00000366985.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ATF3 - Select products 50% OFF >
- * ATF3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ATF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATF3
- genomics-online: gRNA clones - Search for available ATF3 gRNA products
- Overview of 135 available ATF3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ATF3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATF3
- Browse OriGene Inhibitory RNA Products For ATF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF3
- genomics-online: shRNA clones - Search for available ATF3 shRNA products
- Overview of 135 available ATF3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ATF3 - Select products 50% OFF >
- * ATF3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201634
- MR201634
- MR201634L1
- MR201634L2
- MR201634L3
- MR201634L4
- RC202897
- RC202897L1
- RC202897L2
- RC202897L3
- RC202897L4
- RC215620
- RC215620L1
- RC215620L2
- RC215620L3
- RC215620L4
- RC218939
- RC218939L1
- RC218939L2
- RC218939L3
- RC218939L4
- RC222638
- RC222638L3
- RC222638L4
- RC231648
- RC231726
- RC231727
- RG202897
- RG215620
- RG218939
- RG222638
- RG231648
- RG231726
- RG231727
- RR212713
- RR212713L3
- RR212713L4
- MR201634L1V
- MR201634L2V
- MR201634L3V
- MR201634L4V
- RC202897L1V
- RC202897L2V
- RC202897L3V
- RC202897L4V
- RC215620L1V
- RC215620L2V
- RC215620L3V
- RC215620L4V
- RC218939L1V
- RC218939L2V
- RC218939L3V
- RC218939L4V
- RC222638L3V
- RC222638L4V
- RR212713L3V
- RR212713L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ATF3
- Addgene plasmids for ATF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATF3
- genomics-online: cdna clones - Search for available ATF3 CDNA products
- Overview of 135 available ATF3 gene related products
- orf clones - Search for available ATF3 ORF products
- Overview of 135 available ATF3 gene related products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP11: | - |
Relevant External Links for ATF3 Gene
- GeneLoc Exon Structure for
- ATF3
Expression for ATF3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
- Bone (Muscoskeletal System)
- Neural Ectoderm (Nervous System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATF3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATF3
SOURCE GeneReport for Unigene cluster for ATF3 Gene:
Hs.460Evidence on tissue expression from TISSUES for ATF3 Gene
- Lung(4.7)
- Nervous system(4.7)
- Muscle(4.5)
- Liver(2.9)
- Heart(2.7)
- Intestine(2.5)
- Kidney(2.5)
- Pancreas(2.3)
- Adrenal gland(2.1)
- Blood(2.1)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for ATF3
-
OriGene qPCR primer pairs and template standards for ATF3
- genomics-online: primer clones - Search for available ATF3 Primer products
- Overview of 135 available ATF3 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF3 Gene
Orthologs for ATF3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ATF3 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ATF3 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ATF3 31 30 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ATF3 31 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ATF3 31 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Atf3 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Atf3 30 |
|
||
| chicken (Gallus gallus) |
Aves | ATF3 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ATF3 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | atf3 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | atf3 31 30 |
|
OneToOne | |
| zgc55526 30 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for ATF3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ATF3 Gene
- ENSEMBL:
- Gene Tree for ATF3 (if available)
- TreeFam:
- Gene Tree for ATF3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ATF3: view image
Paralogs for ATF3 Gene
Variants for ATF3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATF3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 741892 | Benign: not provided | 212,619,384(+) | T/C | SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT | |
| rs11571541 | - | p.Thr38Met | |||
| VAR_081532 | - | p.Asn168Thr |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758996 | CNV | loss | 17122850 |
| esv3394920 | CNV | insertion | 20981092 |
| nsv549139 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.01;
20.77% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ATF3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF3 Gene
Disorders for ATF3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bone cancer |
|
|
| hypospadias |
|
|
| wilms tumor 3 |
|
|
| cockayne syndrome b |
|
|
| pulmonary systemic sclerosis |
|
|
Search ATF3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ATF3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ATF3 Gene
Publications for ATF3 Gene
- ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. (PMID: 7515060) Chen BP … Hai T (The Journal of biological chemistry 1994) 2 3 4 23 54
- Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation? (PMID: 20215396) van der Zanden LF … Franke B (The Journal of clinical endocrinology and metabolism 2010) 3 23 41 54
- Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias. (PMID: 18426833) Beleza-Meireles A … Nordenskjöld A (European journal of endocrinology 2008) 3 23 41 54
- Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. (PMID: 12881527) Pan Y … Kilberg MS (The Journal of biological chemistry 2003) 3 4 23 54
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
ExternalLinks
Products for ATF3 Gene
- Custom Antibody ServicesOriGene Antibodies for ATF3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ATF3
- Origene Custom Protein Services for ATF3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATF3
- Browse OriGene Inhibitory RNA Products For ATF3
- OriGene qPCR primer pairs for ATF3
- OriGene qPCR primer pairs and template standards for ATF3
- OriGene CRISPR knockouts for ATF3
- MG201634
- MR201634
- MR201634L1
- MR201634L2
- MR201634L3
- MR201634L4
- RC202897
- RC202897L1
- RC202897L2
- RC202897L3
- RC202897L4
- RC215620
- RC215620L1
- RC215620L2
- RC215620L3
- RC215620L4
- RC218939
- RC218939L1
- RC218939L2
- RC218939L3
- RC218939L4
- RC222638
- RC222638L3
- RC222638L4
- RC231648
- RC231726
- RC231727
- RG202897
- RG215620
- RG218939
- RG222638
- RG231648
- RG231726
- RG231727
- RR212713
- RR212713L3
- RR212713L4
- MR201634L1V
- MR201634L2V
- MR201634L3V
- MR201634L4V
- RC202897L1V
- RC202897L2V
- RC202897L3V
- RC202897L4V
- RC215620L1V
- RC215620L2V
- RC215620L3V
- RC215620L4V
- RC218939L1V
- RC218939L2V
- RC218939L3V
- RC218939L4V
- RC222638L3V
- RC222638L4V
- RR212713L3V
- RR212713L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ATF3
- Sino Biological Human cDNA Clone for ATF3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ATF3
- Novus Biologicals proteins and lysates for ATF3
- Novus Biologicals ELISA Kits for ATF3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ATF3
- Abcam proteins for ATF3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for ATF3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ATF3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ATF3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ATF3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ATF3
- Addgene plasmids for ATF3
- antibodies-online: Show 30 available ATF3 Antibodies ranked by validation data
- Compare Top ATF3 Antibodies
- Recommended
- 110 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 ICC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 41 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 35 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 23 available ATF3 Elisa Kits ranked by validation data
- Compare Top ATF3 Elisa Kits
- antibodies-online: Show 14 available ATF3 Proteins ranked by validation data
- Compare Top ATF3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ATF3
- Search Santa Cruz Biotechnology (SCBT) for ATF3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ATF3
- Horizon Cell Lines for ATF3
- genomics-online: cdna clones - Search for available ATF3 CDNA products
- Overview of 135 available ATF3 gene related products
- orf clones - Search for available ATF3 ORF products
- Overview of 135 available ATF3 gene related products
- genomics-online: gRNA clones - Search for available ATF3 gRNA products
- Overview of 135 available ATF3 gene related products
- genomics-online: primer clones - Search for available ATF3 Primer products
- Overview of 135 available ATF3 gene related products
- genomics-online: shRNA clones - Search for available ATF3 shRNA products
- Overview of 135 available ATF3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATF3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ATF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF3
Sources for ATF3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN