This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and ... See more...

Aliases for ATF2 Gene

Aliases for ATF2 Gene

  • Activating Transcription Factor 2 2 3 4 5
  • HB16 2 3 4
  • Cyclic AMP-Dependent Transcription Factor ATF-2 3 4
  • Cyclic AMP-Responsive Element-Binding Protein 2 3 4
  • CAMP Response Element-Binding Protein CRE-BP1 3 4
  • CAMP-Dependent Transcription Factor ATF-2 3 4
  • Histone Acetyltransferase ATF2 3 4
  • CRE-BP1 2 3
  • CREB-2 3 4
  • CREB2 3 4
  • TREB7 2 3
  • Activating Transcription Factor 2 Splice Variant ATF2-Var2 3
  • CAMP Responsive Element Binding Protein 2, Formerly 3
  • CAMP Responsive Element Binding Protein 2 2
  • CAMP-Responsive Element-Binding Protein 2 4
  • EC 2.3.1.48 4
  • CREBP1 4
  • ATF2 5

External Ids for ATF2 Gene

Previous HGNC Symbols for ATF2 Gene

  • CREB2

Previous GeneCards Identifiers for ATF2 Gene

  • GC02M173991
  • GC02M174600
  • GC02M175903
  • GC02M176141
  • GC02M175762
  • GC02M175645
  • GC02M167819
  • GC02M175937

Summaries for ATF2 Gene

Entrez Gene Summary for ATF2 Gene

  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

GeneCards Summary for ATF2 Gene

ATF2 (Activating Transcription Factor 2) is a Protein Coding gene. Diseases associated with ATF2 include Eccrine Porocarcinoma and Cardiomyopathy, Familial Hypertrophic, 25. Among its related pathways are ATM Pathway and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ATF7.

UniProtKB/Swiss-Prot Summary for ATF2 Gene

  • Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

Gene Wiki entry for ATF2 Gene

Additional gene information for ATF2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATF2 Gene

Genomics for ATF2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ATF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J175180 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 600.4 -12.9 -12918 2.6 SP1 CREB1 GATAD2A HNRNPL PRDM10 ZNF629 ZNF512 LEF1 IKZF1 NFKBIZ lnc-ATF2-1 lnc-SCRN3-10 piR-59456 ATF2 ATP5MC3 HOXD9 HOXD4 CHN1 OLA1 CIR1
GH02J175165 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.0 978 4.4 BRCA1 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 ATF2 ENSG00000229750 MIR933 lnc-ATF2-5 ATP5MC3 piR-56451-063 CHN1
GH02J176129 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 -966.1 -966133 13.8 ZNF221 RNF2 GATAD2A CTCF PRDM10 ZNF629 ZNF512 IKZF1 KDM1A ZNF692 HOXD4 HOXD8 HOXD-AS2 HOXD3 LOC401021 HOXD1 HAGLR HOXD9 HAGLROS HOXD11
GH02J175061 Enhancer 1.1 Ensembl ENCODE 10.3 +105.7 105678 2.6 GATAD2A ATF7 TFE3 SOX13 NFKBIZ RCOR2 FOXA1 RBFOX2 RXRB IRF2 lnc-ATF2-2 ATP5MC3 CHRNA1 CHN1 ATF2 ENSG00000229750 MIR933 lnc-CHN1-5
GH02J176106 Promoter 1.1 Ensembl 9.8 -938.3 -938319 1.4 PRDM10 ZNF629 ZNF692 PRDM1 ZIC2 PATZ1 EZH2 ZNF600 GTF2F1 ZNF341 HSALNG0020587 LOC107985805 HOXD4 ATF2 HOXD11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATF2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATF2

Top Transcription factor binding sites by QIAGEN in the ATF2 gene promoter:
  • AREB6
  • ATF
  • ATF-2
  • FAC1
  • HOXA5
  • p300

Genomic Locations for ATF2 Gene

Genomic Locations for ATF2 Gene
chr2:175,072,250-175,168,382
(GRCh38/hg38)
Size:
96,133 bases
Orientation:
Minus strand
chr2:175,936,978-176,033,110
(GRCh37/hg19)
Size:
96,133 bases
Orientation:
Minus strand

Genomic View for ATF2 Gene

Genes around ATF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF2 Gene

Proteins for ATF2 Gene

  • Protein details for ATF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15336-ATF2_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-2
    Protein Accession:
    P15336
    Secondary Accessions:
    • A1L3Z2
    • A4D7U4
    • A4D7U5
    • A4D7V1
    • D3DPE9
    • G8JLM5
    • Q13000
    • Q3B7B7
    • Q4ZFU9
    • Q53RY2
    • Q8TAR1
    • Q96JT8

    Protein attributes for ATF2 Gene

    Size:
    505 amino acids
    Molecular mass:
    54537 Da
    Quaternary structure:
    • Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Heterodimerization is essential for its transcriptional activity. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity. Interacts with the HK1/VDAC1 complex. Interacts with NBN, MRE11, XPO1, KAT5 and CUL3.
    SequenceCaution:
    • Sequence=AAY17203.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAY17207.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATF2 Gene

    Alternative splice isoforms for ATF2 Gene

neXtProt entry for ATF2 Gene

Post-translational modifications for ATF2 Gene

  • Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4. ATM-mediated phosphorylation at Ser-490 and Ser-498 stimulates its function in DNA damage response. Phosphorylation at Ser-62, Thr-73 and Ser-121 activates its transcriptional activity. Phosphorylation at Thr-69 or Thr-71 enhances its histone acetyltransferase (HAT) activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ATF2

Protein Products

  • Abcam proteins for ATF2

No data available for DME Specific Peptides for ATF2 Gene

Domains & Families for ATF2 Gene

Gene Families for ATF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ATF2 Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
ProtoNet:

Suggested Antigen Peptide Sequences for ATF2 Gene

GenScript: Design optimal peptide antigens:
  • Activating transcription factor 2 splice variant ATF2-var7 (A4D7U3_HUMAN)
  • Activating transcription factor 2 splice variant ATF2-var5 (A4D7U4_HUMAN)
  • Activating transcription factor 2 splice variant ATF2-var4 (A4D7U7_HUMAN)
  • Activating transcription factor 2 splice variant ATF2-var9 (A4D7U9_HUMAN)
  • Activating transcription factor 2 splice variant ATF2-var12 (A4D7V5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P15336

UniProtKB/Swiss-Prot:

ATF2_HUMAN :
  • The nuclear export signal 1 (N-NES) negatively regulates its nuclear localization and transcriptional activity.
  • Belongs to the bZIP family. ATF subfamily.
Domain:
  • The nuclear export signal 1 (N-NES) negatively regulates its nuclear localization and transcriptional activity.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with ATF2: view

Function for ATF2 Gene

Molecular function for ATF2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000269|PubMed:10821277};.
GENATLAS Biochemistry:
activating transcription factor 2,cAMP response element binding protein

Enzyme Numbers (IUBMB) for ATF2 Gene

Phenotypes From GWAS Catalog for ATF2 Gene

Gene Ontology (GO) - Molecular Function for ATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 2516827
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 19861239
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IC,ISM 19274049
GO:0000987 proximal promoter sequence-specific DNA binding IDA 2196176
GO:0001102 RNA polymerase II activating transcription factor binding IPI 19861239
genes like me logo Genes that share ontologies with ATF2: view
genes like me logo Genes that share phenotypes with ATF2: view

Animal Models for ATF2 Gene

MGI Knock Outs for ATF2:
  • Atf2 Atf2<tm1b(EUCOMM)Hmgu>
  • Atf2 Atf2<tm1Sis>
  • Atf2 Atf2<tm2Nicj>
  • Atf2 Atf2<tm1Nicj>

Animal Model Products

CRISPR Products

Transcription Factor Targets for ATF2 Gene

Selected GeneGlobe predicted Target genes for ATF2
Targeted motifs for ATF2 Gene
HOMER Transcription Factor Regulatory Elements motif ATF2
  • Consensus sequence: NRRTGACGTCAT Submotif: canonical Cell Type: 3T3L1 GEO ID: GSE56872

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF2

Clone Products

  • Addgene plasmids for ATF2

No data available for Human Phenotype Ontology for ATF2 Gene

Localization for ATF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF2 Gene

Nucleus. Cytoplasm. Mitochondrion outer membrane. Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATF2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IDA 8798441
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA,IDA 22304920
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ATF2: view

Pathways & Interactions for ATF2 Gene

genes like me logo Genes that share pathways with ATF2: view

Pathways by source for ATF2 Gene

21 GeneGo (Thomson Reuters) pathways for ATF2 Gene
  • Cell cycle ESR1 regulation of G1/S transition
  • Development A1 receptor signaling
  • Development A2A receptor signaling
  • Development Angiotensin signaling via PYK2
  • Development FGFR signaling pathway
34 Qiagen pathways for ATF2 Gene
  • 4-1BB Pathway
  • Antioxidant Action of Vitamin-C
  • ATM Pathway
  • BMP Pathway
  • Cardiomyocyte Differentiation through BMP Receptors
1 Cell Signaling Technology pathway for ATF2 Gene
3 GeneTex pathways for ATF2 Gene

SIGNOR curated interactions for ATF2 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0003151 outflow tract morphogenesis IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IMP 22304920
GO:0006357 regulation of transcription by RNA polymerase II IEA,IDA 19861239
GO:0006970 response to osmotic stress IDA 21098032
genes like me logo Genes that share ontologies with ATF2: view

Drugs & Compounds for ATF2 Gene

(31) Drugs for ATF2 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target, inhibitor 426
Fentanyl Approved, Illicit, Investigational, Vet_approved Pharma Agonist, Full agonist, Partial agonist 1229
cyclic amp Experimental Pharma 0

(14) Additional Compounds for ATF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ATF2: view

Transcripts for ATF2 Gene

mRNA/cDNA for ATF2 Gene

6 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF2

Clone Products

  • Addgene plasmids for ATF2

Alternative Splicing Database (ASD) splice patterns (SP) for ATF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - -
SP14: - - - - - - - -
SP15: -
SP16: - - - - - - - - - - - - - - - -
SP17: -

Relevant External Links for ATF2 Gene

GeneLoc Exon Structure for
ATF2

Expression for ATF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATF2 Gene

This gene is overexpressed in Liver (55.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATF2 Gene



Protein tissue co-expression partners for ATF2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATF2

SOURCE GeneReport for Unigene cluster for ATF2 Gene:

Hs.592510

mRNA Expression by UniProt/SwissProt for ATF2 Gene:

P15336-ATF2_HUMAN
Tissue specificity: Ubiquitously expressed, with more abundant expression in the brain.

Evidence on tissue expression from TISSUES for ATF2 Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Muscle(4.5)
  • Heart(2.6)
  • Kidney(2.5)
  • Blood(2.4)
  • Spleen(2.4)
  • Intestine(2.4)
  • Lung(2.4)
  • Skin(2.2)
  • Lymph node(2.2)
  • Thyroid gland(2.2)
  • Pancreas(2.1)
  • Bone marrow(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with ATF2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF2 Gene

Orthologs for ATF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CHN1 31
  • 100 (a)
OneToOne
ATF2 30
  • 99.76 (n)
Dog
(Canis familiaris)
Mammalia ATF2 30 31
  • 96.37 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ATF2 31
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ATF2 30 31
  • 95.84 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ATF2 31
  • 95 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Atf2 30 17 31
  • 94.39 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Atf2 30
  • 93.57 (n)
Chicken
(Gallus gallus)
Aves ATF2 30 31
  • 85.37 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ATF2 31
  • 93 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia atf2 30
  • 80.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia atf2-A 30
Zebrafish
(Danio rerio)
Actinopterygii atf2 30 31
  • 68.79 (n)
OneToOne
Species where no ortholog for ATF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ATF2 Gene

ENSEMBL:
Gene Tree for ATF2 (if available)
TreeFam:
Gene Tree for ATF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATF2: view image

Paralogs for ATF2 Gene

Paralogs for ATF2 Gene

(2) SIMAP similar genes for ATF2 Gene using alignment to 12 proteins:

  • ATF2_HUMAN
  • A4D7U3_HUMAN
  • A4D7U7_HUMAN
  • A4D7U9_HUMAN
  • A4D7V5_HUMAN
  • B8ZZU6_HUMAN
  • C9JCI8_HUMAN
  • E9PBF9_HUMAN
  • E9PEK8_HUMAN
  • F2Z2K2_HUMAN
  • F5H629_HUMAN
  • H7C2N6_HUMAN
genes like me logo Genes that share paralogs with ATF2: view

Variants for ATF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATF2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
750476 Likely Benign: not provided 175,074,624(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
775788 Benign: not provided 175,074,807(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
775789 Benign: not provided 175,093,202(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs138225471 Uncertain Significance: not specified 175,093,233(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs17223647 Uncertain Significance: not provided 175,093,160(-) A/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for ATF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ATF2 Gene

Variant ID Type Subtype PubMed ID
esv3390245 CNV insertion 20981092
esv3575313 CNV gain 25503493
nsv1012709 CNV gain 25217958
nsv3044 CNV deletion 18451855

Variation tolerance for ATF2 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF2 Gene

Disorders for ATF2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ATF2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eccrine porocarcinoma
  • eccrine porocarcinoma of skin
cardiomyopathy, familial hypertrophic, 25
  • cmh25
retinoblastoma
  • rb1
t-cell lymphoblastic leukemia/lymphoma
  • t-cell leukemia
pick disease of brain
  • lobar atrophy of brain
- elite association - COSMIC cancer census association via MalaCards
Search ATF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ATF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
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genes like me logo Genes that share disorders with ATF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATF2 Gene

Publications for ATF2 Gene

  1. Phosphorylation of Activation Transcription Factor-2 at Serine 121 by Protein Kinase C Controls c-Jun-mediated Activation of Transcription. (PMID: 19176525) Yamasaki T … Yokoyama KK (The Journal of biological chemistry 2009) 3 4 23
  2. Regulation of TIP60 by ATF2 modulates ATM activation. (PMID: 18397884) Bhoumik A … Ronai ZA (The Journal of biological chemistry 2008) 3 4 23
  3. ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities. (PMID: 18677098) Bhoumik A … Ronai Z (Cell cycle (Georgetown, Tex.) 2008) 3 4 23
  4. ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. (PMID: 15916964) Bhoumik A … Ronai Z (Molecular cell 2005) 3 4 23
  5. Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. (PMID: 15105425) Sevilla A … Lazo PA (The Journal of biological chemistry 2004) 3 4 23

Products for ATF2 Gene