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This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
ATF1 (Activating Transcription Factor 1) is a Protein Coding gene. Diseases associated with ATF1 include Melanoma Of Soft Tissue and Fibrous Histiocytoma. Among its related pathways are Transcriptional misregulation in cancer and Interleukin-11 Signaling Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is CREB1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 1655749 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IEA,ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 1655749 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IEA,TAS | 2196176 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IEA,IDA | 8798441 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005667 | transcription factor complex | IEA,IBA | 21873635 |
GO:1990590 | ATF1-ATF4 transcription factor complex | IDA | 12871976 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
3 | ERK Signaling |
ERK Signaling
.61
MAPK Signaling
.58
|
ILK Signaling
.49
|
4 | IL-2 Pathway |
LPS Stimulated MAPK Signaling
.47
PACAP Signaling
.37
|
PI3K Signaling in B-Lymphocyte
.35
|
5 | Nuclear Events (kinase and transcription factor activation) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0010976 | positive regulation of neuron projection development | IEA | -- |
GO:0014070 | response to organic cyclic compound | IEA | -- |
GO:0032025 | response to cobalt ion | IEA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||
SP6: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ATF1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ATF1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ATF1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ATF1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ATF1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Atf1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Atf1 30 17 31 |
|
OneToOne | |
Atf1-ps 17 |
|
||||
Chicken (Gallus gallus) |
Aves | ATF1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ATF1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | atf1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | atf1 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CrebB-17A 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | crh-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.714 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2230674 | - | p.Pro191Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3629489 | CNV | loss | 21293372 |
nsv1069665 | CNV | deletion | 25765185 |
nsv1127269 | CNV | deletion | 24896259 |
nsv1138132 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
melanoma of soft tissue |
|
|
fibrous histiocytoma |
|
|
clear cell sarcoma |
|
|
myxoid liposarcoma |
|
|
ewing sarcoma |
|