Aliases for ATF1 Gene
Aliases for ATF1 Gene
External Ids for ATF1 Gene
- HGNC: 783
- Entrez Gene: 466
- Ensembl: ENSG00000123268
- OMIM: 123803
- UniProtKB: P18846
Previous GeneCards Identifiers for ATF1 Gene
- GC12P051390
- GC12P051189
- GC12P050874
- GC12P049444
- GC12P048190
Summaries for ATF1 Gene
-
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
GeneCards Summary for ATF1 Gene
ATF1 (Activating Transcription Factor 1) is a Protein Coding gene. Diseases associated with ATF1 include Melanoma Of Soft Tissue and Fibrous Histiocytoma. Among its related pathways are ERK Signaling and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is CREB1.
UniProtKB/Swiss-Prot for ATF1 Gene
-
This protein binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Additional gene information for ATF1 Gene
- Monarch Initiative
- Search for ATF1 at DataMed
- Search for ATF1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF1 Gene
Genomics for ATF1 Gene
GeneHancer (GH) Regulatory Elements for ATF1 Gene
Promoters and enhancers for ATF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ATF1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ATF1 gene promoter:
-
- TBP
- TFIID
- ATF-2
Regulatory Element Products
Genomic Locations for ATF1 Gene
Genomic Locations for ATF1 Gene
- chr12:50,763,710-50,821,167
- (GRCh38/hg38)
- Size:
- 57,458 bases
- Orientation:
- Plus strand
- chr12:51,157,493-51,214,943
- (GRCh37/hg19)
- Size:
- 57,451 bases
- Orientation:
- Plus strand
Genomic View for ATF1 Gene
Genes around ATF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.12 by Entrez Gene
- 12q13.12 by HGNC
- 12q13.12 by Ensembl
ATF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ATF1 Gene
Proteins for ATF1 Gene
-
Protein details for ATF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18846-ATF1_HUMAN
- Recommended name:
- Cyclic AMP-dependent transcription factor ATF-1
- Protein Accession:
- P18846
- B4DRF9
- P25168
- Q9H4A8
Protein attributes for ATF1 Gene
- Size:
- 271 amino acids
- Molecular mass:
- 29233 Da
- Quaternary structure:
-
- Binds DNA as a dimer. Interacts with HIPK2 and CDK3.
- SequenceCaution:
-
- Sequence=CAC15058.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ATF1 Gene
Post-translational modifications for ATF1 Gene
- Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
- Ubiquitination at posLast=260260
- Modification sites at PhosphoSitePlus
Other Protein References for ATF1 Gene
Antibody Products
- R&D Systems Antibodies for ATF1 (ATF1)
-
Custom Antibody ServicesOriGene Antibodies for ATF1
- Novus Biologicals Antibodies for ATF1
- Invitrogen Antibodies for ATF1
- GeneTex ATF1 Antibody for ATF1
-
Boster Bio Antibodies for ATF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ATF1
- Sino Biological Antibodies for ATF1
Protein Products
-
OriGene Purified Proteins for ATF1
- Search Origene for MassSpec and Protein Over-expression Lysates for ATF1
- Origene Custom Protein Services for ATF1
- ProSpec Recombinant Proteins for ATF1
- Search GeneTex for Proteins for ATF1
-
ProSci Proteins for ATF1
No data available for DME Specific Peptides for ATF1 Gene
Domains & Families for ATF1 Gene
Gene Families for ATF1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ATF1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ATF1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P18846- Family:
-
- Belongs to the bZIP family. ATF subfamily.
Function for ATF1 Gene
Molecular function for ATF1 Gene
- UniProtKB/Swiss-Prot Function:
- This protein binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
- GENATLAS Biochemistry:
- activating transcription factor,cAMP regulated,mediating the E1A responsiveness and heterodimerizing with members of the JUN/FOS family,ubiquitous,with main expression in hippocampus and dentate gyrus,involved in malignant melanoma of soft tissues with translocation t(12;22)(q13;q12) (see EWSR1)
Phenotypes From GWAS Catalog for ATF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 1655749 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 1655749 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IEA,TAS | 2196176 |
Phenotypes for ATF1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ATF1
-
CRISPR Products
-
OriGene CRISPR knockouts for ATF1
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- genomics-online: gRNA clones - Search results for 107 available AFT1 gene related products
- Overview of 107 available AFT1 gene related products
- Applied Biological Materials CRISPR for ATF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ATF1
- GenScript: Design CRISPR guide RNA sequences for ATF1
miRNA for ATF1 Gene
- miRTarBase miRNAs that target ATF1
Targeted motifs for ATF1 Gene
HOMER Transcription Factor Regulatory Elements motif ATF1
- Consensus sequence: GATGACGTCA Submotif: canonical Cell Type: K562 GEO ID: GSE31477
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATF1
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF1
- genomics-online: shRNA clones - Search results for 107 available AFT1 gene related products
- Overview of 107 available AFT1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ATF1
- VectorBuilder custom plasmid, inducible vectors for ATF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ATF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ATF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATF1
- Applied Biological Materials Clones for ATF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ATF1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ATF1 Gene
Localization for ATF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ATF1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 8798441 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005667 | transcription factor complex | IBA,IEA | -- |
| GO:1990590 | ATF1-ATF4 transcription factor complex | IDA | 12871976 |
Pathways & Interactions for ATF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | IL-2 Pathway |
.37
|
|
| 5 | Nuclear Events (kinase and transcription factor activation) | ||
Pathways by source for ATF1 Gene
2 Sino Biological pathways for ATF1 Gene
8 BioSystems pathways for ATF1 Gene
26 Reactome pathways for ATF1 Gene
3 KEGG pathways for ATF1 Gene
4 GeneGo (Thomson Reuters) pathways for ATF1 Gene
1 R&D Systems pathway for ATF1 Gene
18 Qiagen pathways for ATF1 Gene
Interacting Proteins for ATF1 Gene
Selected Interacting proteins:
P18846-ATF1_HUMAN
ENSP00000262053
for ATF1 Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for ATF1
SIGNOR curated interactions for ATF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0010976 | positive regulation of neuron projection development | IEA | -- |
Transcripts for ATF1 Gene
mRNA/cDNA for ATF1 Gene
- (10) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (118) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000262053 2181 bps (uc001rww.5)
- ENST00000549612 568 bps (uc058nyo.1)
- ENST00000551831 970 bps (uc058nyp.1)
- ENST00000552487 745 bps (uc058nyq.1)
- ENST00000552510 549 bps (uc058nyn.1)
Unigene Clusters for ATF1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ATF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATF1
- genomics-online: gRNA clones - Search results for 107 available AFT1 gene related products
- Overview of 107 available AFT1 gene related products
- Applied Biological Materials CRISPR for ATF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ATF1
- GenScript: Design CRISPR guide RNA sequences for ATF1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATF1
- Browse OriGene Inhibitory RNA Products For ATF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF1
- genomics-online: shRNA clones - Search results for 107 available AFT1 gene related products
- Overview of 107 available AFT1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ATF1
- VectorBuilder custom plasmid, inducible vectors for ATF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ATF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ATF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATF1
- Applied Biological Materials Clones for ATF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||
| SP6: | - | - |
Expression for ATF1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (68.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATF1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ATF1 Gene:
ATF1SOURCE GeneReport for Unigene cluster for ATF1 Gene:
Hs.648565Evidence on tissue expression from TISSUES for ATF1 Gene
- Bone marrow(4.2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ATF1
-
OriGene qPCR primer pairs for ATF1
- genomics-online: primer clones - Search results for 107 available AFT1 gene related products
- Overview of 107 available AFT1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF1 Gene
Orthologs for ATF1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ATF1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ATF1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ATF1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ATF1 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ATF1 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Atf1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Atf1 34 33 |
|
OneToOne | |
| Atf1-ps 16 |
|
||||
| chicken (Gallus gallus) |
Aves | ATF1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ATF1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | atf1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | atf1 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CrebB-17A 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | crh-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.714 34 |
|
OneToMany |
- Species where no ortholog for ATF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ATF1 Gene
- ENSEMBL:
- Gene Tree for ATF1 (if available)
- TreeFam:
- Gene Tree for ATF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ATF1: view image
Paralogs for ATF1 Gene
(82) SIMAP similar genes for ATF1 Gene using alignment to 6 proteins:
- ATF1_HUMAN
- B4DRF9_HUMAN
- F8VRN2_HUMAN
- F8VS03_HUMAN
- F8VYE5_HUMAN
- F8VYN3_HUMAN
- EWSR1/ATF1 fusion
- BEAN1
- CREB1
- LOC101929849
- IRF2
- TMEM78
- HINFP
- AAR2
- SLC35E3
- PPP2R5C
- PACRG
- PFKFB3
- pp12301
- PTPLAD1
- NEK4
- CDK10
- TBCB
- ADCK1
- ABI2
- ZNF180
- VPS33A
- SUN3
- RRM2B
- NR5A2
- HC6
- EIF3G
- CREM
- ZNF114
- PUS1
- ZNF799
- TUBA1C
- SLC38A6
- PTPN22
- PPP5D1
- MLL5
- C21orf37
- ZNF28
- SLMO1
- NDC80
- CATSPERD
- ARL6IP5
- AAMDC
- UBE2V2
- SNRPF
- NUP93
- IDNK
- TNNT1
- RARS
- NLN
- LSM12
- GNB2L1
- ZMAT1
- TM4SF19
- SLC16A3
- NLRC5
- NFYC
- MAP4K1
- CCDC122
- C13orf45
- ZNF559
- SEPSECS
- CREB3L1
- ZNF66
- UBXN4
- TP63
- TMX3
- GEMIN6
- EEF1E1
- DYNC2LI1
- DYNC1LI1
- NOSTRIN
- UTY
- FBLN5
- CCNJL
- C3orf33
- FTSJ2
- LINC00999
- LINC00269
- C4BPB
- RPGRIP1L
- GCDH
- CASC4
Pseudogenes.org Pseudogenes for ATF1 Gene
Variants for ATF1 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000027016 | -- | 50,773,535(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000058315 | -- | 50,773,119(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000105244 | -- | 50,795,295(+) | G/A | intron_variant | |
| rs1000136423 | -- | 50,794,944(+) | AAAAAAAAA/AAAAAAAA | intron_variant | |
| rs1000141638 | -- | 50,779,458(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1138132 | CNV | deletion | 24896259 |
| nsv1127269 | CNV | deletion | 24896259 |
| nsv1069665 | CNV | deletion | 25765185 |
| esv3629489 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.06;
37.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ATF1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF1 Gene
Disorders for ATF1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melanoma of soft tissue |
|
|
| fibrous histiocytoma |
|
|
| clear cell sarcoma |
|
|
| histiocytoma |
|
|
| sarcomatosis |
|
|
Search ATF1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ATF1_HUMAN- Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.
Additional Disease Information for ATF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ATF1 Gene
Publications for ATF1 Gene
- Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. (PMID: 15884099) Hallor KH … Panagopoulos I (Genes, chromosomes & cancer 2005) 3 4 22 58
- EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. (PMID: 8401579) Zucman J … Thomas G (Nature genetics 1993) 2 3 22 58
- The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. (PMID: 1655749) Rehfuss RP … Goodman RH (The Journal of biological chemistry 1991) 3 4 22 58
- Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. (PMID: 2196176) Yoshimura T … Yoshida M (The EMBO journal 1990) 3 4 22 58
- GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 44 58
Products for ATF1 Gene
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- OriGene qPCR primer pairs for ATF1
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- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ATF1
- Sino Biological Human cDNA Clone for ATF1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for ATF1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ATF1
- Novus Biologicals lysates and proteins for ATF1
- Novus Biologicals ELISA Kits for ATF1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for ATF1
- VectorBuilder custom plasmid, inducible vectors for ATF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ATF1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ATF1
- antibodies-online: Search results for 155 available AFT1 Antibodies ranked by validation data
- Compare Top AFT1 Antibodies
- antibodies-online: Search results for 28 available AFT1 Elisa Kits ranked by validation data
- Compare Top AFT1 Elisa Kits
- antibodies-online: Search results for 14 available AFT1 Proteins ranked by validation data
- Compare Top AFT1 Proteins
- GeneTex ATF1 Antibody for ATF1
- Search GeneTex for Proteins for ATF1
- Santa Cruz Biotechnology (SCBT) Antibodies for ATF1
- Search Santa Cruz Biotechnology (SCBT) for ATF1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ATF1
- Search for ATF1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ATF1
- Horizon Cell Lines for ATF1
- genomics-online: cdna clones - Search results for 107 available AFT1 gene related products
- Overview of 107 available AFT1 gene related products
- orf clones - Search results for 107 available AFT1 gene related products
- Overview of 107 available AFT1 gene related products
- genomics-online: gRNA clones - Search results for 107 available AFT1 gene related products
- Overview of 107 available AFT1 gene related products
- genomics-online: primer clones - Search results for 107 available AFT1 gene related products
- Overview of 107 available AFT1 gene related products
- genomics-online: shRNA clones - Search results for 107 available AFT1 gene related products
- Overview of 107 available AFT1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATF1
- GeneCopoeia miRNA 3'UTR Target clone products for ATF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF1
- Boster Bio Antibodies for ATF1
- Browse Boster Bio ELISA Kits
Sources for ATF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147)