ATF1 Gene (Protein Coding)

Activating Transcription Factor 1

GC12P050763
GIFtS:
46
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible doma... See more...

Aliases for ATF1 Gene

Aliases for ATF1 Gene

  • Activating Transcription Factor 1 2 3 4 5
  • Cyclic AMP-Dependent Transcription Factor ATF-1 3 4
  • CAMP-Dependent Transcription Factor ATF-1 3 4
  • TREB36 2 3
  • Protein TREB36 4
  • FUS/ATF-1 3
  • EWS-ATF1 3
  • ATF1 5

External Ids for ATF1 Gene

Previous GeneCards Identifiers for ATF1 Gene

  • GC12P051390
  • GC12P051189
  • GC12P050874
  • GC12P049444
  • GC12P048190

Summaries for ATF1 Gene

Entrez Gene Summary for ATF1 Gene

  • This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

GeneCards Summary for ATF1 Gene

ATF1 (Activating Transcription Factor 1) is a Protein Coding gene. Diseases associated with ATF1 include Melanoma Of Soft Tissue and Fibrous Histiocytoma. Among its related pathways are Transcriptional misregulation in cancer and Interleukin-11 Signaling Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is CREB1.

UniProtKB/Swiss-Prot Summary for ATF1 Gene

  • This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

Gene Wiki entry for ATF1 Gene

Additional gene information for ATF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATF1 Gene

Genomics for ATF1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ATF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATF1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATF1

Top Transcription factor binding sites by QIAGEN in the ATF1 gene promoter:
  • ATF-2
  • TBP
  • TFIID

Genomic Locations for ATF1 Gene

Genomic Locations for ATF1 Gene
chr12:50,763,682-50,821,162
(GRCh38/hg38)
Size:
57,481 bases
Orientation:
Plus strand
chr12:51,157,493-51,214,943
(GRCh37/hg19)
Size:
57,451 bases
Orientation:
Plus strand

Genomic View for ATF1 Gene

Genes around ATF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ATF1 Gene

Proteins for ATF1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ATF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18846-ATF1_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-1
    Protein Accession:
    P18846
    Secondary Accessions:
    • B4DRF9
    • P25168
    • Q9H4A8

    Protein attributes for ATF1 Gene

    Size:
    271 amino acids
    Molecular mass:
    29233 Da
    Quaternary structure:
    • Binds DNA as a dimer. Interacts with HIPK2 and CDK3.
    SequenceCaution:
    • Sequence=CAC15058.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ATF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATF1 Gene

Protein Expression for ATF1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ATF1 Gene

  • Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
  • Ubiquitination at Lys260
  • Modification sites at PhosphoSitePlus

Other Protein References for ATF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ATF1

No data available for DME Specific Peptides for ATF1 Gene

Domains & Families for ATF1 Gene

Gene Families for ATF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ATF1 Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
  • cAMP response element binding (CREB) protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for ATF1 Gene

GenScript: Design optimal peptide antigens:
  • Protein TREB36 (ATF1_HUMAN)
  • cDNA FLJ57141, highly similar to Cyclic AMP-dependent transcription factor ATF-1 (B4DRF9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P18846

UniProtKB/Swiss-Prot:

ATF1_HUMAN :
  • Belongs to the bZIP family. ATF subfamily.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with ATF1: view

Function for ATF1 Gene

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  2. CRISPR
  3. miRNA
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Molecular function for ATF1 Gene

UniProtKB/Swiss-Prot Function:
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
GENATLAS Biochemistry:
activating transcription factor,cAMP regulated,mediating the E1A responsiveness and heterodimerizing with members of the JUN/FOS family,ubiquitous,with main expression in hippocampus and dentate gyrus,involved in malignant melanoma of soft tissues with translocation t(12;22)(q13;q12) (see EWSR1)

Phenotypes From GWAS Catalog for ATF1 Gene

Gene Ontology (GO) - Molecular Function for ATF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 1655749
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IEA,ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 1655749
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,TAS 2196176
genes like me logo Genes that share ontologies with ATF1: view
genes like me logo Genes that share phenotypes with ATF1: view

Animal Models for ATF1 Gene

MGI Knock Outs for ATF1:

Animal Model Products

CRISPR Products

Targeted motifs for ATF1 Gene
HOMER Transcription Factor Regulatory Elements motif ATF1
  • Consensus sequence: GATGACGTCA Submotif: canonical Cell Type: K562 GEO ID: GSE31477

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ATF1 Gene

Localization for ATF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATF1 gene
Compartment Confidence
nucleus 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IDA 8798441
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IEA,IBA 21873635
GO:1990590 ATF1-ATF4 transcription factor complex IDA 12871976
genes like me logo Genes that share ontologies with ATF1: view

Pathways & Interactions for ATF1 Gene

genes like me logo Genes that share pathways with ATF1: view

Pathways by source for ATF1 Gene

4 GeneGo (Thomson Reuters) pathways for ATF1 Gene
  • Beta-2 adrenergic-dependent CFTR expression
  • Development EDNRB signaling
  • Development Thrombopoietin-regulated cell processes
  • DNA damage_Role of Brca1 and Brca2 in DNA repair
1 R&D Systems pathway for ATF1 Gene
18 Qiagen pathways for ATF1 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • BRCA1 Pathway
  • cAMP Pathway
  • Ceramide Pathway

SIGNOR curated interactions for ATF1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ATF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0014070 response to organic cyclic compound IEA --
GO:0032025 response to cobalt ion IEA --
genes like me logo Genes that share ontologies with ATF1: view

Drugs & Compounds for ATF1 Gene

Products:

  1. Drug

(11) Drugs for ATF1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target, inhibitor 426
cyclic amp Experimental Pharma 0

(9) Additional Compounds for ATF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ATF1: view

Transcripts for ATF1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ATF1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF1

Alternative Splicing Database (ASD) splice patterns (SP) for ATF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - -
SP6: - -

Relevant External Links for ATF1 Gene

GeneLoc Exon Structure for
ATF1

Expression for ATF1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATF1 Gene

mRNA expression in normal human tissues for ATF1 Gene
mRNA expression by GTEx for ATF1 GenemRNA expression by BioGPS for ATF1 Gene

Protein differential expression in normal tissues from HIPED for ATF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATF1 Gene



Protein tissue co-expression partners for ATF1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATF1

SOURCE GeneReport for Unigene cluster for ATF1 Gene:

Hs.648565

Evidence on tissue expression from TISSUES for ATF1 Gene

  • Bone marrow(4.3)
  • Muscle(2.4)
  • Nervous system(2.4)
  • Lymph node(2.2)
  • Liver(2.2)
  • Kidney(2.2)
  • Adrenal gland(2.1)
  • Heart(2.1)
  • Spleen(2.1)
  • Blood(2.1)
  • Intestine(2.1)
  • Lung(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with ATF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF1 Gene

Orthologs for ATF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATF1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ATF1 30 31
  • 99.75 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ATF1 30 31
  • 93.7 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia ATF1 31
  • 92 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ATF1 30 31
  • 90.99 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia ATF1 31
  • 90 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Atf1 30
  • 86.82 (n)
Mouse
(Mus musculus)
 Mammalia Atf1 30 17 31
  • 86.74 (n)
 OneToOne
Atf1-ps 17
Chicken
(Gallus gallus)
 Aves ATF1 30 31
  • 80.3 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ATF1 31
  • 68 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia atf1 30
  • 72.05 (n)
Zebrafish
(Danio rerio)
 Actinopterygii atf1 30 31
  • 66.82 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CrebB-17A 31
  • 22 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea crh-1 31
  • 21 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.714 31
  • 36 (a)
 OneToMany
Species where no ortholog for ATF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ATF1 Gene

ENSEMBL:
Gene Tree for ATF1 (if available)
TreeFam:
Gene Tree for ATF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATF1: view image

Paralogs for ATF1 Gene

Paralogs for ATF1 Gene

(82) SIMAP similar genes for ATF1 Gene using alignment to 6 proteins:

  • ATF1_HUMAN
  • B4DRF9_HUMAN
  • F8VRN2_HUMAN
  • F8VS03_HUMAN
  • F8VYE5_HUMAN
  • F8VYN3_HUMAN

Pseudogenes.org Pseudogenes for ATF1 Gene

genes like me logo Genes that share paralogs with ATF1: view

Variants for ATF1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATF1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs2230674 - p.Pro191Ala

Additional dbSNP identifiers (rs#s) for ATF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ATF1 Gene

Variant ID Type Subtype PubMed ID
esv3629489 CNV loss 21293372
nsv1069665 CNV deletion 25765185
nsv1127269 CNV deletion 24896259
nsv1138132 CNV deletion 24896259

Variation tolerance for ATF1 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATF1 Gene

Human Gene Mutation Database (HGMD)
ATF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF1 Gene

Disorders for ATF1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for ATF1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma of soft tissue
  • clear cell sarcoma of the tendons and aponeuroses
fibrous histiocytoma
  • benign fibrous histiocytoma
clear cell sarcoma
  • adult soft part clear cell sarcoma
myxoid liposarcoma
  • liposarcoma
ewing sarcoma
  • es
- elite association - COSMIC cancer census association via MalaCards
Search ATF1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ATF1_HUMAN
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.

Additional Disease Information for ATF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ATF1: view

No data available for Genatlas for ATF1 Gene

Publications for ATF1 Gene

  1. Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. (PMID: 15884099) Hallor KH … Panagopoulos I (Genes, chromosomes & cancer 2005) 3 4 23
  2. EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. (PMID: 8401579) Zucman J … Thomas G (Nature genetics 1993) 2 3 23
  3. The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. (PMID: 1655749) Rehfuss RP … Goodman RH (The Journal of biological chemistry 1991) 3 4 23
  4. Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. (PMID: 2196176) Yoshimura T … Yoshida M (The EMBO journal 1990) 3 4 23
  5. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 41

ExternalLinks

View latest publications for ATF1 gene in Mastermind

Products for ATF1 Gene

  • Addgene plasmids for ATF1

Sources for ATF1 Gene