This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] See more...

Aliases for ATE1 Gene

Aliases for ATE1 Gene

  • Arginyltransferase 1 2 3 4 5
  • Arginine-TRNA--Protein Transferase 1 3 4
  • Arginyl-TRNA--Protein Transferase 1 3 4
  • R-Transferase 1 3 4
  • EC 2.3.2.8 4 51
  • Arginyl-TRNA-Protein Transferase 3
  • ATE1 5

External Ids for ATE1 Gene

Previous GeneCards Identifiers for ATE1 Gene

  • GC10M122522
  • GC10M122745
  • GC10M123633
  • GC10M123167
  • GC10M123492
  • GC10M117133

Summaries for ATE1 Gene

Entrez Gene Summary for ATE1 Gene

  • This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for ATE1 Gene

ATE1 (Arginyltransferase 1) is a Protein Coding gene. Diseases associated with ATE1 include Chromosome 10Q26 Deletion Syndrome and Beare-Stevenson Cutis Gyrata Syndrome. Gene Ontology (GO) annotations related to this gene include arginyltransferase activity.

UniProtKB/Swiss-Prot Summary for ATE1 Gene

  • Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATE1 Gene

Genomics for ATE1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ATE1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J121926 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 612.7 0.0 -4 5.2 HNRNPL GATAD2A PRDM10 SIX5 IKZF1 NFKBIZ KDM1A ZNF692 POLR2A NFRKB ATE1-AS1 ATE1 NSMCE4A lnc-TACC2-9
GH10J121854 Enhancer 1.1 Ensembl ENCODE 14.1 +74.3 74280 2.2 GATAD2A REST SOX13 NFKBIZ RCOR2 RXRB IRF2 SP1 CEBPA KMT2B ATE1 ATE1-AS1 NSMCE4A ENSG00000201884 KR153194-024 lnc-NSMCE4A-4 FGFR2
GH10J121900 Enhancer 0.8 Ensembl ENCODE 16.7 +28.1 28070 0.5 CTCF ZNF692 REST RAD21 TRIM22 ZBTB44 BCLAF1 USF1 SMC3 PRDM4 lnc-NSMCE4A-4 ATE1-AS1 ATE1 NSMCE4A KR153194-024 FGFR2
GH10J121935 Enhancer 1 Ensembl ENCODE 12.2 -7.2 -7219 1.6 GATAD2A REST SOX13 RCOR2 RXRB IRF2 SP1 SOX6 NRF1 ETS1 ATE1-AS1 ATE1 lnc-TACC2-9 lnc-ATE1-1 NSMCE4A
GH10J121910 Enhancer 0.8 Ensembl ENCODE 14 +17.8 17802 1.5 BACH1 RELA RELB NFE2 ZNF316 MAFF MAFK MAFG JUNB IRF4 ATE1 NSMCE4A ATE1-AS1 lnc-NSMCE4A-4 FGFR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATE1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATE1

Top Transcription factor binding sites by QIAGEN in the ATE1 gene promoter:
  • ATF-2
  • c-Jun

Genomic Locations for ATE1 Gene

Genomic Locations for ATE1 Gene
chr10:121,740,421-121,928,801
(GRCh38/hg38)
Size:
188,381 bases
Orientation:
Minus strand
chr10:123,499,939-123,688,316
(GRCh37/hg19)
Size:
188,378 bases
Orientation:
Minus strand

Genomic View for ATE1 Gene

Genes around ATE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATE1 Gene

Proteins for ATE1 Gene

  • Protein details for ATE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95260-ATE1_HUMAN
    Recommended name:
    Arginyl-tRNA--protein transferase 1
    Protein Accession:
    O95260
    Secondary Accessions:
    • O95261
    • Q5SQQ3
    • Q8WW04

    Protein attributes for ATE1 Gene

    Size:
    518 amino acids
    Molecular mass:
    59090 Da
    Quaternary structure:
    • Monomer. Interacts with LIAT1 (By similarity).

    Alternative splice isoforms for ATE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATE1 Gene

Selected DME Specific Peptides for ATE1 Gene

O95260:
  • LLCPETY
  • YDPDYSFLSLG
  • VGVIDILP
  • GYGSFHQ
  • TCCPQYTIR

Post-translational modifications for ATE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ATE1
  • Boster Bio Antibodies for ATE1

Domains & Families for ATE1 Gene

Gene Families for ATE1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ATE1 Gene

Suggested Antigen Peptide Sequences for ATE1 Gene

GenScript: Design optimal peptide antigens:
  • Arginine-tRNA--protein transferase 1 (ATE1_HUMAN)
  • cDNA FLJ42678 fis, clone BRAMY2038887, highly similar to Arginyl-tRNA--protein transferase 1 (EC 2.3.2.8) (B3KWA3_HUMAN)
  • Arginine-tRNA--protein transferase 1 (B4DK25_HUMAN)
  • Arginine-tRNA--protein transferase 1 (B4E107_HUMAN)
  • Arginine-tRNA--protein transferase 1 (F5GXE4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95260

UniProtKB/Swiss-Prot:

ATE1_HUMAN :
  • Belongs to the R-transferase family.
Family:
  • Belongs to the R-transferase family.
genes like me logo Genes that share domains with ATE1: view

Function for ATE1 Gene

Molecular function for ATE1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg); Xref=Rhea:RHEA:10208, Rhea:RHEA-COMP:9658, Rhea:RHEA-COMP:9673, Rhea:RHEA-COMP:10636, Rhea:RHEA-COMP:10638, ChEBI:CHEBI:15378, ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:78597, ChEBI:CHEBI:83562; EC=2.3.2.8;.

Enzyme Numbers (IUBMB) for ATE1 Gene

Phenotypes From GWAS Catalog for ATE1 Gene

Gene Ontology (GO) - Molecular Function for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004057 arginyltransferase activity IEA,TAS 9858543
GO:0005515 protein binding IPI 23455924
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with ATE1: view
genes like me logo Genes that share phenotypes with ATE1: view

Animal Models for ATE1 Gene

MGI Knock Outs for ATE1:

Animal Model Products

CRISPR Products

miRNA for ATE1 Gene

miRTarBase miRNAs that target ATE1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATE1

Clone Products

  • Addgene plasmids for ATE1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATE1 Gene

Localization for ATE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATE1 Gene

[Isoform ATE1-1]: Nucleus. Cytoplasm.
[Isoform ATE1-2]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATE1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
cytoskeleton 1
lysosome 1
peroxisome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9858543
GO:0005737 cytoplasm IBA,IDA 9858543
genes like me logo Genes that share ontologies with ATE1: view

Pathways & Interactions for ATE1 Gene

PathCards logo

SuperPathways for ATE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010498 proteasomal protein catabolic process IMP 25970626
GO:0016598 protein arginylation IEA,NAS 9858543
genes like me logo Genes that share ontologies with ATE1: view

No data available for Pathways by source and SIGNOR curated interactions for ATE1 Gene

Drugs & Compounds for ATE1 Gene

(1) Drugs for ATE1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ATE1: view

Transcripts for ATE1 Gene

mRNA/cDNA for ATE1 Gene

5 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATE1

Clone Products

  • Addgene plasmids for ATE1

Alternative Splicing Database (ASD) splice patterns (SP) for ATE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - -
SP5:
SP6: - - - -
SP7: - - -
SP8: - -
SP9: - - - -
SP10: -

ExUns: 18d · 18e · 18f · 18g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ATE1 Gene

GeneLoc Exon Structure for
ATE1

Expression for ATE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATE1 Gene

This gene is overexpressed in Adrenal (17.0), Peripheral blood mononuclear cells (13.3), and Testis (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATE1 Gene



Protein tissue co-expression partners for ATE1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATE1

SOURCE GeneReport for Unigene cluster for ATE1 Gene:

Hs.632080

Evidence on tissue expression from TISSUES for ATE1 Gene

  • Nervous system(2.9)
  • Muscle(2.5)
  • Heart(2.3)
  • Kidney(2.3)
  • Skin(2)
genes like me logo Genes that share expression patterns with ATE1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATE1 Gene

Orthologs for ATE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATE1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ATE1 30 31
  • 99.29 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ATE1 30 31
  • 89.94 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ATE1 30 31
  • 85.24 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ate1 30 17 31
  • 84.9 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ate1 30
  • 81.85 (n)
Oppossum
(Monodelphis domestica)
Mammalia ATE1 31
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 70 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 24 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ATE1 30 31
  • 72.64 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ATE1 31
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ate1 30
  • 63.79 (n)
Zebrafish
(Danio rerio)
Actinopterygii ate1 30 31
  • 61.33 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Ate1 30 31 32
  • 49.3 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010373 30
  • 49.07 (n)
Worm
(Caenorhabditis elegans)
Secernentea CELE_K07A1.9 30
  • 50.45 (n)
K07A1.9 31
  • 37 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATE1 31 33
  • 22 (a)
OneToOne
Rice
(Oryza sativa)
Liliopsida Os.18844 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7900 31
  • 45 (a)
OneToOne
Species where no ortholog for ATE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ATE1 Gene

ENSEMBL:
Gene Tree for ATE1 (if available)
TreeFam:
Gene Tree for ATE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATE1: view image

Paralogs for ATE1 Gene

No data available for Paralogs for ATE1 Gene

Variants for ATE1 Gene

Additional dbSNP identifiers (rs#s) for ATE1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ATE1 Gene

Variant ID Type Subtype PubMed ID
esv2665421 CNV deletion 23128226
esv2675411 CNV deletion 23128226
esv3305561 CNV mobile element insertion 20981092
esv3354144 CNV insertion 20981092
esv3358854 CNV insertion 20981092
esv3624760 CNV loss 21293372
esv3624761 CNV loss 21293372
nsv475443 CNV novel sequence insertion 20440878

Variation tolerance for ATE1 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATE1 Gene

Human Gene Mutation Database (HGMD)
ATE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATE1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATE1 Gene

Disorders for ATE1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ATE1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ATE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ATE1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ATE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATE1 Gene

Publications for ATE1 Gene

  1. Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. (PMID: 9858543) Kwon YT … Varshavsky A (Molecular and cellular biology 1999) 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41
  4. Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms. (PMID: 16943202) Hu RG … Varshavsky A (The Journal of biological chemistry 2006) 2 3
  5. Identification of mammalian arginyltransferases that modify a specific subset of protein substrates. (PMID: 16002466) Rai R … Kashina A (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3

Products for ATE1 Gene

Sources for ATE1 Gene