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Aliases for ATE1 Gene

Aliases for ATE1 Gene

  • Arginyltransferase 1 2 3 4 5
  • Arginine-TRNA--Protein Transferase 1 3 4
  • R-Transferase 1 3 4
  • Arginyl-TRNA--Protein Transferase 1 3
  • Arginyl-TRNA-Protein Transferase 3
  • EC 2.3.2.8 4

External Ids for ATE1 Gene

Previous GeneCards Identifiers for ATE1 Gene

  • GC10M122522
  • GC10M122745
  • GC10M123633
  • GC10M123167
  • GC10M123492
  • GC10M117133

Summaries for ATE1 Gene

Entrez Gene Summary for ATE1 Gene

  • This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for ATE1 Gene

ATE1 (Arginyltransferase 1) is a Protein Coding gene. Diseases associated with ATE1 include Chromosome 10Q26 Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include arginyltransferase activity.

UniProtKB/Swiss-Prot for ATE1 Gene

  • Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).

Additional gene information for ATE1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATE1 Gene

Genomics for ATE1 Gene

GeneHancer (GH) Regulatory Elements for ATE1 Gene

Promoters and enhancers for ATE1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J121926 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 662.8 0.0 -4 5.2 HDGF PKNOX1 FOXA2 ARNT SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ATE1-AS1 ATE1 GC10M121925 ENSG00000224250 RPL19P16 LINC01153 FAM24A NSMCE4A C10orf120 GC10P121933
GH10J121854 Enhancer 0.9 ENCODE 14.1 +73.8 73796 1.3 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 NFKBIZ RXRA SP5 MXD4 ATE1 ATE1-AS1 ENSG00000201884 GC10P121871
GH10J121935 Enhancer 0.9 ENCODE 12.2 -7.2 -7235 1.6 FOXA2 ARID4B DMAP1 ZNF48 ETS1 YY1 ZNF121 RXRA REST PPARG ATE1-AS1 ATE1 GC10P121933 GC10M121942
GH10J121987 Promoter/Enhancer 1.3 EPDnew ENCODE 8.2 -59.9 -59878 1.9 PKNOX1 FOXA2 INSM2 KLF17 SIN3A GLI4 RAD21 GTF3C2 EGR1 SCRT2 TACC2 NSMCE4A ATE1 ATE1-AS1
GH10J121910 Enhancer 0.7 ENCODE 14 +17.8 17802 1.5 BACH1 BATF IRF4 RELA ZNF316 NFE2 IKZF2 MAFK NFE2L2 ZNF639 ATE1 NSMCE4A ATE1-AS1 GC10M121895 GC10M121896 GC10M121913
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATE1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATE1 gene promoter:
  • ATF-2
  • c-Jun

Genomic Locations for ATE1 Gene

Genomic Locations for ATE1 Gene
chr10:121,740,421-121,928,801
(GRCh38/hg38)
Size:
188,381 bases
Orientation:
Minus strand
chr10:123,499,939-123,688,316
(GRCh37/hg19)
Size:
188,378 bases
Orientation:
Minus strand

Genomic View for ATE1 Gene

Genes around ATE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATE1 Gene

Proteins for ATE1 Gene

  • Protein details for ATE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95260-ATE1_HUMAN
    Recommended name:
    Arginyl-tRNA--protein transferase 1
    Protein Accession:
    O95260
    Secondary Accessions:
    • O95261
    • Q5SQQ3
    • Q8WW04

    Protein attributes for ATE1 Gene

    Size:
    518 amino acids
    Molecular mass:
    59090 Da
    Quaternary structure:
    • Monomer. Interacts with LIAT1 (By similarity).

    Alternative splice isoforms for ATE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATE1 Gene

Post-translational modifications for ATE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATE1 Gene

Domains & Families for ATE1 Gene

Gene Families for ATE1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

O95260

UniProtKB/Swiss-Prot:

ATE1_HUMAN :
  • Belongs to the R-transferase family.
Family:
  • Belongs to the R-transferase family.
genes like me logo Genes that share domains with ATE1: view

Function for ATE1 Gene

Molecular function for ATE1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein].

Enzyme Numbers (IUBMB) for ATE1 Gene

Phenotypes From GWAS Catalog for ATE1 Gene

Gene Ontology (GO) - Molecular Function for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004057 arginyltransferase activity TAS 9858543
GO:0005515 protein binding IPI 23455924
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with ATE1: view
genes like me logo Genes that share phenotypes with ATE1: view

Animal Models for ATE1 Gene

MGI Knock Outs for ATE1:

Animal Model Products

miRNA for ATE1 Gene

miRTarBase miRNAs that target ATE1

Clone Products

  • Addgene plasmids for ATE1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATE1 Gene

Localization for ATE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATE1 Gene

Isoform ATE1-1: Nucleus. Cytoplasm.
Isoform ATE1-2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATE1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 9858543
GO:0005737 cytoplasm IDA,IEA 9858543
genes like me logo Genes that share ontologies with ATE1: view

Pathways & Interactions for ATE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010498 proteasomal protein catabolic process IMP 25970626
GO:0016598 protein arginylation NAS,IEA 9858543
genes like me logo Genes that share ontologies with ATE1: view

No data available for Pathways by source and SIGNOR curated interactions for ATE1 Gene

Drugs & Compounds for ATE1 Gene

(1) Drugs for ATE1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ATE1: view

Transcripts for ATE1 Gene

Unigene Clusters for ATE1 Gene

Arginyltransferase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for ATE1

Alternative Splicing Database (ASD) splice patterns (SP) for ATE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - -
SP5:
SP6: - - - -
SP7: - - -
SP8: - -
SP9: - - - -
SP10: -

ExUns: 18d · 18e · 18f · 18g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ATE1 Gene

GeneLoc Exon Structure for
ATE1
ECgene alternative splicing isoforms for
ATE1

Expression for ATE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATE1 Gene

Protein differential expression in normal tissues from HIPED for ATE1 Gene

This gene is overexpressed in Adrenal (17.0), Peripheral blood mononuclear cells (13.3), and Testis (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATE1 Gene



Protein tissue co-expression partners for ATE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ATE1 Gene:

ATE1

SOURCE GeneReport for Unigene cluster for ATE1 Gene:

Hs.632080

Evidence on tissue expression from TISSUES for ATE1 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ATE1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATE1 Gene

Orthologs for ATE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATE1 34 33
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATE1 34 33
  • 89.94 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ATE1 34 33
  • 85.24 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ate1 16 34 33
  • 84.9 (n)
rat
(Rattus norvegicus)
Mammalia Ate1 33
  • 81.85 (n)
oppossum
(Monodelphis domestica)
Mammalia ATE1 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
OneToMany
-- 34
  • 58 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
chicken
(Gallus gallus)
Aves ATE1 34 33
  • 72.64 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATE1 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ate1 33
  • 63.79 (n)
zebrafish
(Danio rerio)
Actinopterygii ate1 34 33
  • 61.33 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ate1 34 35 33
  • 49.3 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010373 33
  • 49.07 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_K07A1.9 33
  • 50.45 (n)
K07A1.9 34
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATE1 36 34
  • 22 (a)
rice
(Oryza sativa)
Liliopsida Os.18844 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7900 34
  • 45 (a)
OneToOne
Species where no ortholog for ATE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATE1 Gene

ENSEMBL:
Gene Tree for ATE1 (if available)
TreeFam:
Gene Tree for ATE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATE1: view image

Paralogs for ATE1 Gene

No data available for Paralogs for ATE1 Gene

Variants for ATE1 Gene

Sequence variations from dbSNP and Humsavar for ATE1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000027516 -- 121,835,377(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000032107 -- 121,912,343(-) T/A intron_variant
rs1000039739 -- 121,783,384(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000049246 -- 121,740,752(-) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000086373 -- 121,762,369(-) G/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATE1 Gene

Variant ID Type Subtype PubMed ID
esv2665421 CNV deletion 23128226
esv2675411 CNV deletion 23128226
esv3305561 CNV mobile element insertion 20981092
esv3354144 CNV insertion 20981092
esv3358854 CNV insertion 20981092
esv3624760 CNV loss 21293372
esv3624761 CNV loss 21293372
nsv475443 CNV novel sequence insertion 20440878

Variation tolerance for ATE1 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATE1 Gene

Human Gene Mutation Database (HGMD)
ATE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATE1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATE1 Gene

Disorders for ATE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATE1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
chromosome 10q26 deletion syndrome
  • terminal chromosome 10q26 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ATE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ATE1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ATE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATE1 Gene

Publications for ATE1 Gene

  1. Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. (PMID: 9858543) Kwon YT … Varshavsky A (Molecular and cellular biology 1999) 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  4. Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms. (PMID: 16943202) Hu RG … Varshavsky A (The Journal of biological chemistry 2006) 2 3 58
  5. Identification of mammalian arginyltransferases that modify a specific subset of protein substrates. (PMID: 16002466) Rai R … Kashina A (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 58

Products for ATE1 Gene

Sources for ATE1 Gene

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