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Aliases for ATAD2B Gene

Aliases for ATAD2B Gene

  • ATPase Family, AAA Domain Containing 2B 2 3 5
  • ATPase Family AAA Domain-Containing Protein 2B 3
  • KIAA1240 4

External Ids for ATAD2B Gene

Previous GeneCards Identifiers for ATAD2B Gene

  • GC02M023825
  • GC02M023971

Summaries for ATAD2B Gene

Entrez Gene Summary for ATAD2B Gene

  • The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for ATAD2B Gene

ATAD2B (ATPase Family, AAA Domain Containing 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is ATAD2.

Additional gene information for ATAD2B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD2B Gene

Genomics for ATAD2B Gene

GeneHancer (GH) Regulatory Elements for ATAD2B Gene

Promoters and enhancers for ATAD2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J023924 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 662.6 +0.5 549 3.7 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 UBXN2A ATAD2B FAM228B MFSD2B SF3B6 FKBP1B PFN4 RPS13P4 GC02P023754
GH02J024045 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 38.6 -119.8 -119819 2.5 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 WDCP RNU6-370P ATAD2B FAM228B PFN4 ITSN2 ENSG00000271936 FAM228A MFSD2B GC02P023754
GH02J024489 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 28.9 -564.9 -564856 5.7 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS KLF13 SP3 NCOA1 ATAD2B ITSN2 ENSG00000271936 PTRHD1 WDCP ADCY3 DNAJC27 GC02M024526
GH02J023938 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 30.1 -13.5 -13509 3.4 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 IRF4 YY1 SLC30A9 POLR2B UBXN2A MFSD2B ATAD2B ITSN2 PFN4 GC02P023938 SDHCP3 GC02P023754
GH02J024791 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 23.6 -866.3 -866300 4.8 MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC GLIS1 PTRHD1 CENPO LOC105369164 ATAD2B DNMT3A ITSN2 WDCP FAM228B ADCY3 NCOA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATAD2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATAD2B gene promoter:

Genomic Locations for ATAD2B Gene

Genomic Locations for ATAD2B Gene
chr2:23,685,229-23,927,114
(GRCh38/hg38)
Size:
241,886 bases
Orientation:
Minus strand
chr2:23,971,534-24,149,984
(GRCh37/hg19)

Genomic View for ATAD2B Gene

Genes around ATAD2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATAD2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATAD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD2B Gene

Proteins for ATAD2B Gene

  • Protein details for ATAD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULI0-ATD2B_HUMAN
    Recommended name:
    ATPase family AAA domain-containing protein 2B
    Protein Accession:
    Q9ULI0
    Secondary Accessions:
    • B9ZVQ5
    • Q6ZNA6
    • Q8N9E7

    Protein attributes for ATAD2B Gene

    Size:
    1458 amino acids
    Molecular mass:
    164914 Da
    Quaternary structure:
    • Binds acetylated lysine residues in histone H1.4, H2A, H2B, H3 and H4 (in vitro).
    SequenceCaution:
    • Sequence=BAD18469.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATAD2B Gene

    Alternative splice isoforms for ATAD2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATAD2B Gene

Post-translational modifications for ATAD2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATAD2B Gene

Domains & Families for ATAD2B Gene

Gene Families for ATAD2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ATAD2B Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULI0

UniProtKB/Swiss-Prot:

ATD2B_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with ATAD2B: view

Function for ATAD2B Gene

Phenotypes From GWAS Catalog for ATAD2B Gene

Gene Ontology (GO) - Molecular Function for ATAD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IBA --
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with ATAD2B: view
genes like me logo Genes that share phenotypes with ATAD2B: view

Animal Models for ATAD2B Gene

MGI Knock Outs for ATAD2B:
  • Atad2b Atad2b<tm1b(EUCOMM)Hmgu>

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATAD2B Gene

Localization for ATAD2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAD2B Gene

Nucleus. Note=Partially localizes to replication sites.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATAD2B gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATAD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 24561620
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ATAD2B: view

Pathways & Interactions for ATAD2B Gene

SuperPathways for ATAD2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATAD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031936 negative regulation of chromatin silencing IBA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with ATAD2B: view

No data available for Pathways by source and SIGNOR curated interactions for ATAD2B Gene

Drugs & Compounds for ATAD2B Gene

No Compound Related Data Available

Transcripts for ATAD2B Gene

mRNA/cDNA for ATAD2B Gene

(1) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(17) REFSEQ mRNAs :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATAD2B Gene

ATPase family, AAA domain containing 2B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: -
SP5:

Relevant External Links for ATAD2B Gene

GeneLoc Exon Structure for
ATAD2B
ECgene alternative splicing isoforms for
ATAD2B

Expression for ATAD2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATAD2B Gene

Protein differential expression in normal tissues from HIPED for ATAD2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.4), CD8 Tcells (13.0), and Monocytes (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATAD2B Gene



Protein tissue co-expression partners for ATAD2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATAD2B Gene:

ATAD2B

SOURCE GeneReport for Unigene cluster for ATAD2B Gene:

Hs.467862

Evidence on tissue expression from TISSUES for ATAD2B Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ATAD2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATAD2B Gene

Orthologs for ATAD2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATAD2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATAD2B 34 33
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATAD2B 34 33
  • 94.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ATAD2B 34 33
  • 94.29 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATAD2B 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atad2b 16 34 33
  • 88.27 (n)
oppossum
(Monodelphis domestica)
Mammalia ATAD2B 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATAD2B 34 33
  • 81.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATAD2B 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atad2b 33
  • 70.95 (n)
Str.7080 33
zebrafish
(Danio rerio)
Actinopterygii atad2b 34 33
  • 61.8 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lex-1 34
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTA7 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
Cin.869 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.869 33
Species where no ortholog for ATAD2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATAD2B Gene

ENSEMBL:
Gene Tree for ATAD2B (if available)
TreeFam:
Gene Tree for ATAD2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATAD2B: view image

Paralogs for ATAD2B Gene

Paralogs for ATAD2B Gene

(12) SIMAP similar genes for ATAD2B Gene using alignment to 6 proteins:

  • ATD2B_HUMAN
  • C9J1G9_HUMAN
  • C9JG15_HUMAN
  • H7BYF1_HUMAN
  • H7C475_HUMAN
  • Q8IWJ3_HUMAN
genes like me logo Genes that share paralogs with ATAD2B: view

Variants for ATAD2B Gene

Sequence variations from dbSNP and Humsavar for ATAD2B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000006475 -- 23,773,456(-) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000021922 -- 23,903,661(-) T/G intron_variant
rs1000043481 -- 23,882,598(-) G/A intron_variant
rs1000075843 -- 23,697,369(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000087184 -- 23,771,177(-) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATAD2B Gene

Variant ID Type Subtype PubMed ID
dgv3741n100 CNV loss 25217958
esv1080283 CNV deletion 17803354
esv1350131 CNV insertion 17803354
esv2659738 CNV deletion 23128226
esv33590 CNV loss 17666407
esv3553789 CNV deletion 23714750
esv3583668 CNV loss 25503493
esv3590060 CNV loss 21293372
nsv1004502 CNV gain 25217958
nsv1008906 CNV loss 25217958
nsv1143933 CNV deletion 24896259
nsv214066 CNV deletion 16902084
nsv2640 CNV deletion 18451855
nsv507003 OTHER sequence alteration 20534489
nsv511769 CNV loss 21212237
nsv524917 CNV loss 19592680
nsv527636 CNV gain 19592680
nsv961018 CNV duplication 23825009
nsv997445 CNV gain 25217958

Variation tolerance for ATAD2B Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATAD2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATAD2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATAD2B Gene

Disorders for ATAD2B Gene

Additional Disease Information for ATAD2B

No disorders were found for ATAD2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATAD2B Gene

Publications for ATAD2B Gene

  1. Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components. (PMID: 24561620) Alabert C … Groth A (Nature cell biology 2014) 3 4 58
  2. Histone recognition and large-scale structural analysis of the human bromodomain family. (PMID: 22464331) Filippakopoulos P … Knapp S (Cell 2012) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  5. Biological function and histone recognition of family IV bromodomain-containing proteins. (PMID: 28500727) Lloyd JT … Glass KC (Journal of cellular physiology 2018) 3 58

Products for ATAD2B Gene

Sources for ATAD2B Gene

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