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Aliases for ATAD2 Gene

Aliases for ATAD2 Gene

  • ATPase Family, AAA Domain Containing 2 2 3 5
  • AAA Nuclear Coregulator Cancer-Associated Protein 2 3 4
  • ANCCA 3 4
  • ATPase Family AAA Domain-Containing Protein 2 3
  • EC 3.6.1.3 4
  • PRO2000 3
  • CT137 3

External Ids for ATAD2 Gene

Previous GeneCards Identifiers for ATAD2 Gene

  • GC08M124292
  • GC08M124401
  • GC08M119657
  • GC08M124332

Summaries for ATAD2 Gene

Entrez Gene Summary for ATAD2 Gene

  • A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATAD2 Gene

ATAD2 (ATPase Family, AAA Domain Containing 2) is a Protein Coding gene. Diseases associated with ATAD2 include Trichomoniasis and Anogenital Venereal Wart. Among its related pathways are Gene Expression and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. Gene Ontology (GO) annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is ATAD2B.

UniProtKB/Swiss-Prot for ATAD2 Gene

  • May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

Additional gene information for ATAD2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD2 Gene

Genomics for ATAD2 Gene

GeneHancer (GH) Regulatory Elements for ATAD2 Gene

Promoters and enhancers for ATAD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I123394 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 552.3 +20.5 20500 3 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ATAD2 FAM91A1 DERL1 C8orf76 WDYHV1 ZHX1 IMPDH1P6 GC08M123342
GH08I123415 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.6 -591 2.3 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF143 WDYHV1 ATAD2 LOC105375737 DERL1 C8orf76 GC08P123445
GH08I123534 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -122.2 -122215 9 PKNOX1 ARID4B SIN3A FEZF1 ZBTB7B GLIS2 ZNF213 SP3 MXD4 KAT8 FBXO32 LOC105375738 ANXA13 RNF139-AS1 WDYHV1 ATAD2 GC08M123523
GH08I123688 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 -275.6 -275601 6 FOXA2 NFRKB RAD21 RARA RFX5 ZNF143 RUNX3 DEK SMARCA5 ZNF362 ANXA13 TATDN1 KLHL38 ATAD2 WDYHV1 LOC105375738 FBXO32 DUTP2 RNU6-875P MIR548AA1
GH08I123546 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.8 -131.3 -131308 3 PKNOX1 NEUROD1 BATF IRF4 RFX5 SCRT2 FOS RCOR1 IKZF2 SMARCC1 GC08P123547 LOC105375738 ANXA13 KLHL38 WDYHV1 ATAD2 ENSG00000254113
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATAD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATAD2 gene promoter:

Genomic Locations for ATAD2 Gene

Genomic Locations for ATAD2 Gene
chr8:123,319,850-123,416,350
(GRCh38/hg38)
Size:
96,501 bases
Orientation:
Minus strand
chr8:124,332,090-124,428,590
(GRCh37/hg19)

Genomic View for ATAD2 Gene

Genes around ATAD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATAD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD2 Gene

Proteins for ATAD2 Gene

  • Protein details for ATAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PL18-ATAD2_HUMAN
    Recommended name:
    ATPase family AAA domain-containing protein 2
    Protein Accession:
    Q6PL18
    Secondary Accessions:
    • Q14CR1
    • Q658P2
    • Q68CQ0
    • Q6PJV6
    • Q8N890
    • Q9UHS5

    Protein attributes for ATAD2 Gene

    Size:
    1390 amino acids
    Molecular mass:
    158554 Da
    Quaternary structure:
    • Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro).
    SequenceCaution:
    • Sequence=AAF22032.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part (676-679).; Evidence={ECO:0000305}; Sequence=AAH19909.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATAD2 Gene

    Alternative splice isoforms for ATAD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATAD2 Gene

Post-translational modifications for ATAD2 Gene

  • Ubiquitination at Lys175, Lys311, Lys489, Lys931, and posLast=10421042
  • Modification sites at PhosphoSitePlus

Other Protein References for ATAD2 Gene

No data available for DME Specific Peptides for ATAD2 Gene

Domains & Families for ATAD2 Gene

Gene Families for ATAD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ATAD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PL18

UniProtKB/Swiss-Prot:

ATAD2_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with ATAD2: view

Function for ATAD2 Gene

Molecular function for ATAD2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated in breast, uterus, colon, ovary, and stomach tumors. Induced in breast cancer cells overexpressing NCOA3 or treated with estrogen. Down-regulated in 5-fluorouracil-resistant derivatives of the colon cancer cell line HCT 116.

Enzyme Numbers (IUBMB) for ATAD2 Gene

Phenotypes From GWAS Catalog for ATAD2 Gene

Gene Ontology (GO) - Molecular Function for ATAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding IPI 17998543
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity IEA,IDA 17998543
genes like me logo Genes that share ontologies with ATAD2: view

Phenotypes for ATAD2 Gene

genes like me logo Genes that share phenotypes with ATAD2: view

Clone Products

  • Addgene plasmids for ATAD2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATAD2 Gene

Localization for ATAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATAD2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with ATAD2: view

Pathways & Interactions for ATAD2 Gene

genes like me logo Genes that share pathways with ATAD2: view

Gene Ontology (GO) - Biological Process for ATAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS --
GO:0031936 negative regulation of chromatin silencing IBA --
genes like me logo Genes that share ontologies with ATAD2: view

No data available for SIGNOR curated interactions for ATAD2 Gene

Drugs & Compounds for ATAD2 Gene

(3) Drugs for ATAD2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for ATAD2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ATAD2: view

Transcripts for ATAD2 Gene

Unigene Clusters for ATAD2 Gene

ATPase family, AAA domain containing 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for ATAD2

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 17b · 17c ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -

Relevant External Links for ATAD2 Gene

GeneLoc Exon Structure for
ATAD2
ECgene alternative splicing isoforms for
ATAD2

Expression for ATAD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATAD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATAD2 Gene

This gene is overexpressed in Lung (21.7), Testis (17.3), Ovary (12.6), and Synovial fluid (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATAD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ATAD2 Gene:

ATAD2

SOURCE GeneReport for Unigene cluster for ATAD2 Gene:

Hs.370834

mRNA Expression by UniProt/SwissProt for ATAD2 Gene:

Q6PL18-ATAD2_HUMAN
Tissue specificity: Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.

Evidence on tissue expression from TISSUES for ATAD2 Gene

  • Lymph node(4.4)
  • Liver(4.3)
  • Nervous system(4.3)
  • Spleen(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ATAD2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATAD2 Gene

Orthologs for ATAD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATAD2 34 33
  • 99.16 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATAD2 33 34
  • 91.63 (n)
cow
(Bos Taurus)
Mammalia ATAD2 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atad2 33
  • 86.02 (n)
mouse
(Mus musculus)
Mammalia Atad2 16 34 33
  • 85.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATAD2 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATAD2 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATAD2 33 34
  • 66.64 (n)
lizard
(Anolis carolinensis)
Reptilia ATAD2 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atad2 33
  • 67.29 (n)
Str.3073 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25675 33
zebrafish
(Danio rerio)
Actinopterygii wu:fi16e04 33
  • 60.11 (n)
ATAD2 34
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lex-1 34
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTA7 34 36
  • 23 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.8886 33
corn
(Zea mays)
Liliopsida Zm.12719 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToMany
Species where no ortholog for ATAD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATAD2 Gene

ENSEMBL:
Gene Tree for ATAD2 (if available)
TreeFam:
Gene Tree for ATAD2 (if available)

Paralogs for ATAD2 Gene

Paralogs for ATAD2 Gene

(6) SIMAP similar genes for ATAD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATAD2: view

Variants for ATAD2 Gene

Sequence variations from dbSNP and Humsavar for ATAD2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000001617 -- 123,341,104(-) A/C intron_variant
rs1000010368 -- 123,383,599(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000043399 -- 123,333,052(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000076686 -- 123,324,380(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000081233 -- 123,390,281(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATAD2 Gene

Variant ID Type Subtype PubMed ID
esv3572974 CNV loss 25503493
nsv1109989 CNV deletion 24896259
nsv831449 CNV loss 17160897

Variation tolerance for ATAD2 Gene

Residual Variation Intolerance Score: 2.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATAD2 Gene

Human Gene Mutation Database (HGMD)
ATAD2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATAD2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATAD2 Gene

Disorders for ATAD2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ATAD2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
trichomoniasis
  • trichomonas infection
anogenital venereal wart
  • anogenital human papilloma virus infectious disease
charcot-marie-tooth disease and deafness
  • hmsn1
- elite association - COSMIC cancer census association via MalaCards
Search ATAD2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ATAD2

genes like me logo Genes that share disorders with ATAD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATAD2 Gene

Publications for ATAD2 Gene

  1. Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells. (PMID: 26459632) Morozumi Y … Khochbin S (Journal of molecular cell biology 2016) 2 3 58
  2. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. (PMID: 17998543) Zou JX … Chen HW (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ATAD2 Gene

  • Addgene plasmids for ATAD2

Sources for ATAD2 Gene

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