Aliases for ATAD2 Gene
External Ids for ATAD2 Gene
Previous GeneCards Identifiers for ATAD2 Gene
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATAD2 Gene
ATAD2 (ATPase Family, AAA Domain Containing 2) is a Protein Coding gene. Diseases associated with ATAD2 include Trichomoniasis and Anogenital Venereal Wart. Among its related pathways are Gene Expression and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. Gene Ontology (GO) annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is ATAD2B.
UniProtKB/Swiss-Prot for ATAD2 Gene
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.