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This gene encodes a protein containing a plant homeodomain (PHD) zinc finger domain that plays a role in the regulation of gene transcription. The encoded protein has been shown to negatively regulate lipogenesis by binding to and inhibiting the transcriptional activity of two nuclear hormone receptors, oxysterols receptor LXR-alpha (LXRalpha) and thyroid hormone receptor beta ... See more...
Aliases for ASXL3 Gene
Aliases for ASXL3 Gene
- ASXL Transcriptional Regulator 3 2 3 5
- KIAA1713 2 3 4
- Additional Sex Combs Like 3, Transcriptional Regulator 2 3
- Putative Polycomb Group Protein ASXL3 3 4
- Additional Sex Combs-Like Protein 3 3 4
- Additional Sex Combs Like Transcriptional Regulator 3 3
- Additional Sex Combs Like 3 (Drosophila) 2
- ASXL3 5
- BRPS 3
External Ids for ASXL3 Gene
- HGNC: 29357
- NCBI Entrez Gene: 80816
- Ensembl: ENSG00000141431
- OMIM®: 615115
- UniProtKB/Swiss-Prot: Q9C0F0
Previous HGNC Symbols for ASXL3 Gene
- KIAA1713
Previous GeneCards Identifiers for ASXL3 Gene
- GC18P029413
- GC18P031158
- GC18P028018
Summaries for ASXL3 Gene
-
This gene encodes a protein containing a plant homeodomain (PHD) zinc finger domain that plays a role in the regulation of gene transcription. The encoded protein has been shown to negatively regulate lipogenesis by binding to and inhibiting the transcriptional activity of two nuclear hormone receptors, oxysterols receptor LXR-alpha (LXRalpha) and thyroid hormone receptor beta (TRbeta). The encoded protein may also inhibit histone deubiquitination. Mutations in this gene have been identified in human patients with Bainbridge-Ropers syndrome, which is characterized by feeding difficulties, developmental delay and other features. [provided by RefSeq, May 2017]
GeneCards Summary for ASXL3 Gene
ASXL3 (ASXL Transcriptional Regulator 3) is a Protein Coding gene. Diseases associated with ASXL3 include Bainbridge-Ropers Syndrome and Alacrima, Achalasia, And Mental Retardation Syndrome. An important paralog of this gene is ASXL2.
UniProtKB/Swiss-Prot Summary for ASXL3 Gene
-
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity).
Additional gene information for ASXL3 Gene
- HGNC (29357)
- NCBI Entrez Gene (80816)
- Ensembl (ENSG00000141431)
- OMIM® (615115)
- UniProtKB/Swiss-Prot (Q9C0F0)
- Open Targets Platform(ENSG00000141431)
- Monarch Initiative
- Search for ASXL3 at DataMed
- Search for ASXL3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ASXL3 Gene
Genomics for ASXL3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ASXL3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH18J033577 | Promoter/Enhancer | 1.8 | Ensembl ENCODE CraniofacialAtlas | 250.7 | +1.2 | 1218 | 5.2 | ZSCAN16 ZBTB10 FEZF1 ZEB1 ZIC2 ZNF610 ZNF513 ZNF639 KLF7 ZNF341 | ASXL3 ENSG00000267642 HSALNG0120815 lnc-NOL4-3 NOL4 | |
| GH18J033600 | Enhancer | 0.3 | Ensembl | 11.8 | +22.7 | 22682 | 0.6 | PRDM6 TRIM28 | ASXL3 HSALNG0120815 lnc-NOL4-3 NOL4 | |
| GH18J033575 | Enhancer | 0.3 | Ensembl | 0.7 | -2.3 | -2319 | 1.4 | SCRT1 MZF1 | ASXL3 ENSG00000267642 HSALNG0120814 CCDC178 | |
| GH18J033584 | Enhancer | 0.5 | Ensembl | 0.4 | +6.8 | 6781 | 2 | SP1 PKNOX1 NANOG ZNF558 PRDM10 ZBTB20 PRDM1 ZNF10 | ASXL3 HSALNG0120815 lnc-NOL4-3 NOL4 | |
| GH18J033595 | Enhancer | 0.6 | Ensembl ENCODE | 0.4 | +18.2 | 18248 | 1.3 | ZNF366 FOS ZNF335 | ASXL3 HSALNG0120815 lnc-NOL4-3 NOL4 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ASXL3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ASXL3
- Top Transcription factor binding sites by QIAGEN in the ASXL3 gene promoter:
-
- C/EBPalpha
- FOXI1
- GR
- GR-alpha
- GR-beta
- HFH-3
- Hlf
- RSRFC4
Genomic Locations for ASXL3 Gene
Latest Assembly
- chr18:33,578,219-33,751,195
- (GRCh38/hg38)
- Size:
- 172,977 bases
- Orientation:
- Plus strand
Previous Assembly
- chr18:31,158,183-31,331,159
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 172,977 bases
- Orientation:
- Plus strand
- chr18:31,158,579-31,331,156
- (GRCh37/hg19 by Ensembl)
- Size:
- 172,578 bases
- Orientation:
- Plus strand
Genomic View for ASXL3 Gene
Genes around ASXL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q12.1 by HGNC
- 18q12.1 by Entrez Gene
- 18q12.1 by Ensembl
ASXL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASXL3 Gene
Proteins for ASXL3 Gene
-
Protein details for ASXL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9C0F0-ASXL3_HUMAN
- Recommended name:
- Putative Polycomb group protein ASXL3
- Protein Accession:
- Q9C0F0
- Q6ZMX6
- Q96MU3
- Q9UFC5
Protein attributes for ASXL3 Gene
- Size:
- 2248 amino acids
- Molecular mass:
- 241919 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB71186.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAD18599.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAB61377.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Protein Expression for ASXL3 Gene
Post-translational modifications for ASXL3 Gene
Other Protein References for ASXL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ASXL3
- Origene Custom Protein Services for ASXL3
Assay products for research
No data available for DME Specific Peptides for ASXL3 Gene
Domains & Families for ASXL3 Gene
Gene Families for ASXL3 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for ASXL3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASXL3 Gene
- GenScript: Design optimal peptide antigens:
-
- Additional sex combs-like protein 3 (ASXL3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9C0F0- Family:
-
- Belongs to the Asx family.
Function for ASXL3 Gene
Molecular function for ASXL3 Gene
- UniProtKB/Swiss-Prot Function:
- Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity).
Phenotypes From GWAS Catalog for ASXL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IBA | 21873635 |
| GO:0042975 | peroxisome proliferator activated receptor binding | IBA | 21873635 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ASXL3 Gene
- MGI mutant phenotypes for ASXL3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ASXL3:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ASXL3 - Starting at $85 >
- * ASXL3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ASXL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ASXL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASXL3
miRNA for ASXL3 Gene
- miRTarBase miRNAs that target ASXL3
-
- mmu-miR-301b-3p (MIRT007928)
- mmu-miR-19b-3p (MIRT012479)
- mmu-miR-9-5p (MIRT015416)
- hsa-miR-221-3p (MIRT024184)
- hsa-miR-26b-5p (MIRT029464)
- hsa-miR-6780b-5p (MIRT460723)
- hsa-miR-4725-3p (MIRT460724)
- hsa-miR-4271 (MIRT460725)
- hsa-miR-5196-5p (MIRT460726)
- hsa-miR-4747-5p (MIRT460727)
- hsa-miR-4533 (MIRT460728)
- hsa-miR-6722-3p (MIRT460729)
- hsa-miR-1909-3p (MIRT460730)
- hsa-miR-6783-5p (MIRT460731)
- hsa-miR-4779 (MIRT460732)
- hsa-miR-6510-5p (MIRT460733)
- hsa-miR-3120-3p (MIRT460734)
- hsa-miR-6891-5p (MIRT460735)
- hsa-miR-3173-3p (MIRT460736)
- hsa-miR-1305 (MIRT624638)
- hsa-miR-4659b-3p (MIRT624639)
- hsa-miR-4659a-3p (MIRT624640)
- hsa-miR-6875-3p (MIRT624641)
- hsa-miR-498 (MIRT624642)
- hsa-miR-4465 (MIRT624643)
- hsa-miR-26a-5p (MIRT624644)
- hsa-miR-6715b-3p (MIRT624645)
- hsa-miR-1297 (MIRT624646)
- hsa-miR-676-5p (MIRT624647)
- hsa-miR-7844-5p (MIRT624648)
- hsa-miR-708-3p (MIRT624649)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ASXL3
- Browse OriGene Inhibitory RNA Products For ASXL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASXL3
Clone products for research
- Applied Biological Materials (abm): Clones for ASXL3 - Starting at $45 >
- * ASXL3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ASXL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ASXL3
Cell Lines for research
-
Horizon Cell Lines for ASXL3
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ASXL3 Gene
Localization for ASXL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ASXL3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0035517 | PR-DUB complex | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ASXL3 Gene
Pathways & Interactions for ASXL3 Gene
Interacting Proteins for ASXL3 Gene
GPS-Prot Interaction Network for ASXL3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0009887 | animal organ morphogenesis | IBA | 21873635 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0051055 | negative regulation of lipid biosynthetic process | IDA | 25450400 |
No data available for Pathways by source and SIGNOR curated interactions for ASXL3 Gene
Transcripts for ASXL3 Gene
mRNA/cDNA for ASXL3 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000269197 11760 nts (view in UCSC)
- ENST00000585426 653 nts (view in UCSC)
- ENST00000586327 559 nts (view in UCSC)
- ENST00000586948 468 nts (view in UCSC)
- ENST00000588038 572 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ASXL3 - Starting at $85 >
- * ASXL3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ASXL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ASXL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASXL3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ASXL3
- Browse OriGene Inhibitory RNA Products For ASXL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASXL3
Clone products for research
- Applied Biological Materials (abm): Clones for ASXL3 - Starting at $45 >
- * ASXL3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ASXL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ASXL3
Relevant External Links for ASXL3 Gene
- GeneLoc Exon Structure for
- ASXL3
Expression for ASXL3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for ASXL3 Gene
This gene is overexpressed in Testis (x4.2).
This gene is overexpressed in Bone (33.5), Liver, secretome (18.6), and Pancreatic juice (11.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASXL3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ASXL3
SOURCE GeneReport for Unigene cluster for ASXL3 Gene:
Hs.464876mRNA Expression by UniProt/SwissProt for ASXL3 Gene:
Q9C0F0-ASXL3_HUMAN
Tissue specificity:
Expressed in pancreatic islets, testis, neuroblastoma, head and neck tumor.
Evidence on tissue expression from TISSUES for ASXL3 Gene
- Nervous system(4.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ASXL3 Gene
Germ Layers:
- ectoderm
Systems:
- integumentary
- nervous
- skeleton
Regions:
Head and neck:
- brain
- face
- forehead
- head
- nose
General:
- hair
- skin
Primer products for research
-
OriGene qPCR primer pairs for ASXL3
Gene Expression Assays for research
Orthologs for ASXL3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ASXL3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ASXL3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ASXL3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Asxl3 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ASXL3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ASXL3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ASXL3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ASXL3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | asxl3 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Asx 31 |
|
OneToMany |
- Species where no ortholog for ASXL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for ASXL3 Gene
- ENSEMBL:
- Gene Tree for ASXL3 (if available)
- TreeFam:
- Gene Tree for ASXL3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ASXL3: view image
Paralogs for ASXL3 Gene
Variants for ASXL3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ASXL3 Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 429913 | Pathogenic/Likely Pathogenic: Bainbridge-Ropers syndrome; not provided | 33,742,954(+) |
C/T NM_030632.3(ASXL3):c.3106C>T (p.Arg1036Ter) |
NONSENSE | |
| 858551 | Uncertain Significance: not provided | 33,683,564(+) |
G/A NM_030632.3(ASXL3):c.875G>A (p.Arg292Lys) |
MISSENSE | |
| 870738 | Uncertain Significance: not provided | 33,732,029(+) |
A/G NM_030632.3(ASXL3):c.941A>G (p.Tyr314Cys) |
MISSENSE | |
| 870739 | Uncertain Significance: not provided | 33,744,186(+) |
G/T NM_030632.3(ASXL3):c.4338G>T (p.Arg1446Ser) |
MISSENSE | |
| 915370 | Uncertain Significance: Bainbridge-Ropers syndrome | 33,745,427(+) |
TCATCAGTTCCGG/T NM_030632.3(ASXL3):c.5587_5598del (p.Ser1863_Ser1866del) |
INFRAME_DELETION |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
5.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.08;
68.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ASXL3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASXL3 Gene
Disorders for ASXL3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bainbridge-ropers syndrome |
|
|
| alacrima, achalasia, and mental retardation syndrome |
|
|
| disease of mental health |
|
|
| sleep disorder |
|
|
| asxl3-related disorder |
|
|
Search ASXL3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ASXL3_HUMAN- Bainbridge-Ropers syndrome (BRPS) [MIM:615485]: A syndrome characterized by psychomotor retardation, feeding problems, severe postnatal growth retardation in some patients, arched eyebrows, anteverted nares, and ulnar deviation of the hands. {ECO:0000269 PubMed:23383720}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for ASXL3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for ASXL3 Gene
Publications for ASXL3 Gene
- De novo truncating mutations in ASXL3 are associated with a novel clinical phenotype with similarities to Bohring-Opitz syndrome. (PMID: 23383720) Bainbridge MN … Ropers HH (Genome medicine 2013) 3 4 74
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Identification and characterization of ASXL3 gene in silico. (PMID: 15138607) Katoh M … Katoh M (International journal of oncology 2004) 3 4
ExternalLinks
Products for ASXL3 Gene
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- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ASXL3
- Origene Custom Protein Services for ASXL3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ASXL3
- Browse OriGene Inhibitory RNA Products For ASXL3
- OriGene qPCR primer pairs for ASXL3
- OriGene CRISPR knockouts for ASXL3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ASXL3
- Sino Biological Human cDNA Clone for ASXL3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for ASXL3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ASXL3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ASXL3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ASXL3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ASXL3
- antibodies-online: Search results for available ASXL3 related products ranked by validation data
- antibodies-online: Search results for available ASXL3 related products ranked by validation data
- antibodies-online: Search results for available ASXL3 related products ranked by validation data
- Horizon Cell Lines for ASXL3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ASXL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ASXL3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ASXL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASXL3
Sources for ASXL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB