Aliases for ASTL Gene
External Ids for ASTL Gene
Previous GeneCards Identifiers for ASTL Gene
GeneCards Summary for ASTL Gene
ASTL (Astacin Like Metalloendopeptidase) is a Protein Coding gene. Diseases associated with ASTL include Powassan Encephalitis and Colorado Tick Fever. Gene Ontology (GO) annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is MEP1B.
UniProtKB/Swiss-Prot Summary for ASTL Gene
Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity).