Aliases for ASRGL1 Gene
External Ids for ASRGL1 Gene
Previous GeneCards Identifiers for ASRGL1 Gene
GeneCards Summary for ASRGL1 Gene
ASRGL1 (Asparaginase And Isoaspartyl Peptidase 1) is a Protein Coding gene. Diseases associated with ASRGL1 include Aspartylglucosaminuria and Immunodeficiency 48. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and asparaginase activity. An important paralog of this gene is TASP1.
UniProtKB/Swiss-Prot Summary for ASRGL1 Gene
Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.