This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5.... See more...

Aliases for ASPM Gene

Aliases for ASPM Gene

  • Assembly Factor For Spindle Microtubules 2 3 5
  • Abnormal Spindle-Like Microcephaly-Associated Protein 3 4
  • Abnormal Spindle Microtubule Assembly 2 3
  • Calmbp1 2 3
  • MCPH5 3 4
  • ASP 2 3
  • Asp (Abnormal Spindle) Homolog, Microcephaly Associated (Drosophila) 2
  • Asp (Abnormal Spindle)-Like, Microcephaly Associated (Drosophila) 2
  • Asp (Abnormal Spindle) Homolog, Microcephaly Associated 3
  • Microcephaly, Primary Autosomal Recessive 5 2
  • Abnormal Spindle Protein Homolog 4
  • Asp Homolog 4
  • FLJ10517 2
  • FLJ10549 2
  • ASPM 5

External Ids for ASPM Gene

Previous HGNC Symbols for ASPM Gene

  • MCPH5

Previous GeneCards Identifiers for ASPM Gene

  • GC01U990488
  • GC01M192511
  • GC01M193519
  • GC01M194341
  • GC01M193785
  • GC01M195319
  • GC01M197053
  • GC01M168210

Summaries for ASPM Gene

Entrez Gene Summary for ASPM Gene

  • This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

GeneCards Summary for ASPM Gene

ASPM (Assembly Factor For Spindle Microtubules) is a Protein Coding gene. Diseases associated with ASPM include Microcephaly 5, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly. Gene Ontology (GO) annotations related to this gene include binding and calmodulin binding. An important paralog of this gene is EHBP1.

UniProtKB/Swiss-Prot Summary for ASPM Gene

  • Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.

Gene Wiki entry for ASPM Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ASPM Gene

Genomics for ASPM Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ASPM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J197144 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.9 894 4 TBP SP1 MXD4 MNT SMAD5 IRF2 MBD2 ZNF217 BRCA1 CEBPB ASPM lnc-ZBTB41-8 CRB1 CFHR3 ZBTB41 lnc-ZBTB41-2 SEPTIN14P12 lnc-ZBTB41-1 F13B
GH01J197173 Enhancer 1 Ensembl ENCODE 12.1 -27.5 -27538 1.7 CEBPA HOMEZ KDM6A THAP11 CEBPB FOXA2 SMAD4 SAP130 EP300 RXRA ASPM CRB1 ZBTB41 CFHR3 HSALNG0009432 lnc-ZBTB41-1
GH01J197178 Enhancer 0.7 ENCODE 12.1 -32.4 -32430 0.9 REST EP300 RXRA RAD21 ZNF316 NFE2 BATF NFE2L2 CTCF SMARCA4 ASPM CRB1 ZBTB41 CFHR3 lnc-ZBTB41-1 HSALNG0009432
GH01J197198 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 -53.4 -53406 5.8 TBP ZBTB10 SP1 MXD4 CEBPA MNT IKZF1 SMAD5 IRF2 ZFP64 CRB1 ZBTB41 lnc-CRB1-2 CFHR3 lnc-ZBTB41-1 HSALNG0009432 ASPM
GH01J197141 Promoter 0.7 Ensembl 0.7 +4.8 4793 0.2 ZNF316 ZKSCAN1 ZNF24 CHAMP1 POLR2A CBX3 DPF2 F13B ZBTB41 CRB1 ASPM SEPTIN14P12 lnc-ZBTB41-2 lnc-ZBTB41-8 lnc-ZBTB41-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ASPM on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ASPM

Top Transcription factor binding sites by QIAGEN in the ASPM gene promoter:
  • AML1a
  • E2F
  • E2F-1
  • FOXD3
  • GATA-1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for ASPM Gene

Latest Assembly
chr1:197,084,121-197,146,694
(GRCh38/hg38)
Size:
62,574 bases
Orientation:
Minus strand

Previous Assembly
chr1:197,053,257-197,115,799
(GRCh37/hg19 by Entrez Gene)
Size:
62,543 bases
Orientation:
Minus strand

chr1:197,053,258-197,115,824
(GRCh37/hg19 by Ensembl)
Size:
62,567 bases
Orientation:
Minus strand

Genomic View for ASPM Gene

Genes around ASPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASPM Gene

Proteins for ASPM Gene

  • Protein details for ASPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZT6-ASPM_HUMAN
    Recommended name:
    Abnormal spindle-like microcephaly-associated protein
    Protein Accession:
    Q8IZT6
    Secondary Accessions:
    • Q4G1H1
    • Q5VYL3
    • Q86UX4
    • Q8IUL2
    • Q8IZJ7
    • Q8IZJ8
    • Q8IZJ9
    • Q8N4D1
    • Q9NVS1
    • Q9NVT6

    Protein attributes for ASPM Gene

    Size:
    3477 amino acids
    Molecular mass:
    409800 Da
    Quaternary structure:
    • Interacts with KATNA1 and KATNB1; katanin complex formation KATNA1:KATNB1 is required for the association.
    SequenceCaution:
    • Sequence=AAH34607.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91676.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ASPM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASPM Gene

Post-translational modifications for ASPM Gene

  • Ubiquitination at Lys177, Lys1349, Lys3061, Lys1519, Lys1537, Lys3169, Lys3404, Lys1830, Lys1843, Lys3446, Lys1875, Lys1903, Lys2002, Lys2053, Lys2171, and Lys2358
  • Modification sites at PhosphoSitePlus

Other Protein References for ASPM Gene

No data available for DME Specific Peptides for ASPM Gene

Domains & Families for ASPM Gene

Gene Families for ASPM Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ASPM Gene

InterPro:
Blocks:
  • IQ calmodulin-binding region
  • Calponin-like actin-binding
ProtoNet:

Suggested Antigen Peptide Sequences for ASPM Gene

GenScript: Design optimal peptide antigens:
  • Abnormal spindle protein homolog (ASPM_HUMAN)
  • Abnormal spindle-like microcephaly associated splice variant 2 (Q4G1H0_HUMAN)
  • Abnormal spindle-like microcephaly associated splice variant 1 (Q4G1H1_HUMAN)
  • Abnormal spindle-like microcephaly associated splice variant 3 (Q4G1H2_HUMAN)
genes like me logo Genes that share domains with ASPM: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ASPM Gene

Function for ASPM Gene

Molecular function for ASPM Gene

UniProtKB/Swiss-Prot Function:
Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.

Phenotypes From GWAS Catalog for ASPM Gene

Gene Ontology (GO) - Molecular Function for ASPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with ASPM: view
genes like me logo Genes that share phenotypes with ASPM: view

Human Phenotype Ontology for ASPM Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ASPM Gene

MGI Knock Outs for ASPM:
  • Aspm Aspm<tm1.2Kxi>
  • Aspm Aspm<tm1a(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASPM

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ASPM Gene

Localization for ASPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASPM Gene

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity). Localizes to spindle poles during mitosis (PubMed:19690332). Associates with microtubule minus ends (By similarity). {ECO:0000250 UniProtKB:Q8CJ27}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASPM gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
cytosol 4
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ASPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA --
GO:0005634 nucleus IDA 21044324
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with ASPM: view

Pathways & Interactions for ASPM Gene

PathCards logo

SuperPathways for ASPM Gene

No Data Available

SIGNOR curated interactions for ASPM Gene

Activates:

Gene Ontology (GO) - Biological Process for ASPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IMP --
GO:0002052 positive regulation of neuroblast proliferation IMP --
GO:0007049 cell cycle IEA --
GO:0007051 spindle organization IEA,IMP 21044324
GO:0007283 spermatogenesis IMP --
genes like me logo Genes that share ontologies with ASPM: view

No data available for Pathways by source for ASPM Gene

Drugs & Compounds for ASPM Gene

No Compound Related Data Available

Transcripts for ASPM Gene

mRNA/cDNA for ASPM Gene

2 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASPM

Alternative Splicing Database (ASD) splice patterns (SP) for ASPM Gene

No ASD Table

Relevant External Links for ASPM Gene

GeneLoc Exon Structure for
ASPM

Expression for ASPM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ASPM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASPM Gene

This gene is overexpressed in Esophagus - Mucosa (x4.0).

Protein differential expression in normal tissues from HIPED for ASPM Gene

This gene is overexpressed in Urine (29.7), Esophagus (15.8), and Platelet (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ASPM Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ASPM

SOURCE GeneReport for Unigene cluster for ASPM Gene:

Hs.121028

Evidence on tissue expression from TISSUES for ASPM Gene

  • Nervous system(4.5)
  • Kidney(4.3)
  • Blood(2.1)
  • Liver(2.1)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ASPM Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • chin
  • cranial nerve
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • kidney
Pelvis:
  • pelvis
  • ureter
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with ASPM: view

Primer products for research

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ASPM Gene

Orthologs for ASPM Gene

This gene was present in the common ancestor of animals.

Orthologs for ASPM Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ASPM 30 31
  • 99.52 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ASPM 30 31
  • 86.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ASPM 30 31
  • 80.43 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Aspm 30 17 31
  • 74.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Aspm 30
  • 73.63 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ASPM 31
  • 65 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ASPM 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ASPM 30 31
  • 61.32 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ASPM 31
  • 47 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia aspm 30
  • 54.75 (n)
Str.15458 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7778 30
Zebrafish
(Danio rerio)
Actinopterygii aspm 30 31
  • 50.51 (n)
OneToOne
Dr.19463 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12308 30
Fruit Fly
(Drosophila melanogaster)
Insecta asp 31
  • 25 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea aspm-1 31
  • 18 (a)
OneToOne
Species where no ortholog for ASPM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ASPM Gene

ENSEMBL:
Gene Tree for ASPM (if available)
TreeFam:
Gene Tree for ASPM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ASPM: view image

Paralogs for ASPM Gene

Paralogs for ASPM Gene

genes like me logo Genes that share paralogs with ASPM: view

Variants for ASPM Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ASPM Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
873870 Uncertain Significance: Primary autosomal recessive microcephaly 5 197,100,515(-) A/G
NM_018136.5(ASPM):c.8736T>C (p.Ser2912=)
SYNONYMOUS_VARIANT,INTRON
873986 Uncertain Significance: Primary autosomal recessive microcephaly 5 197,103,558(-) T/A
NM_018136.5(ASPM):c.5693A>T (p.His1898Leu)
MISSENSE_VARIANT,INTRON
874053 Uncertain Significance: Primary autosomal recessive microcephaly 5 197,104,934(-) C/T
NM_018136.5(ASPM):c.4317G>A (p.Met1439Ile)
MISSENSE_VARIANT,INTRON
874054 Uncertain Significance: Primary autosomal recessive microcephaly 5 197,105,045(-) C/T
NM_018136.5(ASPM):c.4206G>A (p.Arg1402=)
SYNONYMOUS_VARIANT,INTRON
874104 Uncertain Significance: Primary autosomal recessive microcephaly 5 197,124,256(-) T/C
NM_018136.5(ASPM):c.3244A>G (p.Thr1082Ala)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ASPM Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ASPM Gene

Variant ID Type Subtype PubMed ID
esv2758990 CNV gain+loss 17122850
nsv528460 CNV gain 19592680
nsv548871 CNV loss 21841781
nsv826053 CNV loss 20364138
nsv946564 CNV duplication 23825009
nsv946565 CNV duplication 23825009

Variation tolerance for ASPM Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.00; 96.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASPM Gene

Human Gene Mutation Database (HGMD)
ASPM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASPM

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASPM Gene

Disorders for ASPM Gene

MalaCards: The human disease database

(34) MalaCards diseases for ASPM Gene - From: OMI, CVR, GTR, ORP, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search ASPM in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ASPM_HUMAN
  • Microcephaly 5, primary, autosomal recessive (MCPH5) [MIM:608716]: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder. {ECO:0000269 PubMed:12355089, ECO:0000269 PubMed:14574646, ECO:0000269 PubMed:22989186}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for ASPM

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ASPM: view

No data available for Genatlas for ASPM Gene

Publications for ASPM Gene

  1. ASPM is a major determinant of cerebral cortical size. (PMID: 12355089) Bond J … Woods CG (Nature genetics 2002) 3 4 23 74
  2. Sex-dependent association of common variants of microcephaly genes with brain structure. (PMID: 20080800) Rimol LM … Alzheimer's Disease Neuroimaging Initiative (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 23 41
  3. A common SNP of MCPH1 is associated with cranial volume variation in Chinese population. (PMID: 18204051) Wang JK … Su B (Human molecular genetics 2008) 3 4 41
  4. No evidence that polymorphisms of brain regulator genes Microcephalin and ASPM are associated with general mental ability, head circumference or altruism. (PMID: 17251122) Rushton JP … Bons TA (Biology letters 2007) 3 23 41
  5. The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein. (PMID: 15972725) Kouprina N … Larionov V (Human molecular genetics 2005) 3 4 23

Products for ASPM Gene

Sources for ASPM Gene