Aliases for ASPG Gene

Aliases for ASPG Gene

  • Asparaginase 2 3 5
  • Lysophospholipase-Transacylase 3 4
  • 60 KDa Lysophospholipase 3 4
  • C14orf76 3 4
  • Asparaginase Homolog (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 76 2
  • 60-KDa-Lysophospholipase 2
  • Wild-Type L-Asparaginase 3
  • Asparaginase Homolog 3
  • EC 3.1.1.5 4
  • GPA/WT 3
  • LYSOLP 3
  • LysoLP 4
  • ASPG 5

External Ids for ASPG Gene

Previous HGNC Symbols for ASPG Gene

  • C14orf76

Previous GeneCards Identifiers for ASPG Gene

  • GC14P103622
  • GC14P104552
  • GC14P084732

Summaries for ASPG Gene

GeneCards Summary for ASPG Gene

ASPG (Asparaginase) is a Protein Coding gene. Diseases associated with ASPG include Cerebral Sinovenous Thrombosis and Testicular Leukemia. Among its related pathways are Viral mRNA Translation and Metabolism. Gene Ontology (GO) annotations related to this gene include lysophospholipase activity and asparaginase activity.

UniProtKB/Swiss-Prot Summary for ASPG Gene

  • Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ASPG Gene

Genomics for ASPG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ASPG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J104084 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 621.7 +0.2 242 1.4 SP1 EZH2 KLF8 VEZF1 MAX TAF1 CTCF ASPG lnc-KIF26A-1 KIF26A
GH14J104085 Enhancer 0.3 dbSUPER 631.6 -1.2 -1229 0.5 NR2F2 YY1 ASPG ATP5MPL LOC105370691
GH14J104088 Enhancer 1 Ensembl ENCODE dbSUPER 31.5 +2.2 2171 2.1 PKNOX1 SP1 ZNF341 FOXA2 ATF3 YY1 GABPA ZBTB33 JUND NR2F2 ASPG ATP5MPL lnc-KIF26A-1 KIF26A
GH14J104082 Enhancer 0.8 Ensembl ENCODE dbSUPER 25.5 -2.9 -2857 1.2 FOXA1 NFIC NFIB NRF1 MAX ASPG LOC105370691
GH14J104137 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 6.6 +53.5 53506 3.8 CTCF KDM1A ZNF692 TARDBP ZNF143 ZIC2 PATZ1 REST RAD21 ZNF501 ENSG00000258748 LOC105370708 KIF26A ASPG MIR203A ATP5MPL lnc-ASPG-3 C14orf180
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ASPG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ASPG

Top Transcription factor binding sites by QIAGEN in the ASPG gene promoter:
  • ATF-2
  • c-Myb
  • CRE-BP1
  • CREB
  • deltaCREB
  • FOXF2
  • HNF-4alpha1
  • LCR-F1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for ASPG Gene

Genomic Locations for ASPG Gene
chr14:104,085,658-104,115,582
(GRCh38/hg38)
Size:
29,925 bases
Orientation:
Plus strand
chr14:104,552,016-104,579,098
(GRCh37/hg19)
Size:
27,083 bases
Orientation:
Plus strand

Genomic View for ASPG Gene

Genes around ASPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASPG Gene

Proteins for ASPG Gene

  • Protein details for ASPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U10-LPP60_HUMAN
    Recommended name:
    60 kDa lysophospholipase
    Protein Accession:
    Q86U10
    Secondary Accessions:
    • B9EGQ2
    • Q8IV80

    Protein attributes for ASPG Gene

    Size:
    573 amino acids
    Molecular mass:
    60883 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=CAD62331.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: May be due to a competing acceptor splice site.

    Alternative splice isoforms for ASPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASPG Gene

Post-translational modifications for ASPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASPG Gene

Domains & Families for ASPG Gene

Gene Families for ASPG Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ASPG Gene

GenScript: Design optimal peptide antigens:
  • 60 kDa lysophospholipase (LPP60_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86U10

UniProtKB/Swiss-Prot:

LPP60_HUMAN :
  • In the N-terminal section; belongs to the asparaginase 1 family.
Family:
  • In the N-terminal section; belongs to the asparaginase 1 family.
genes like me logo Genes that share domains with ASPG: view

Function for ASPG Gene

Molecular function for ASPG Gene

UniProtKB/Swiss-Prot Function:
Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + L-asparagine = L-aspartate + NH4(+); Xref=Rhea:RHEA:21016, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:58048; EC=3.5.1.1; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:17777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707; EC=3.1.1.47; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40879, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + octadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40887, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:25629, ChEBI:CHEBI:73858; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40807, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28610, ChEBI:CHEBI:30823; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:40891, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73004, ChEBI:CHEBI:143890; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:40895, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74971, ChEBI:CHEBI:143890; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40899, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998, ChEBI:CHEBI:73004, ChEBI:CHEBI:73005; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40827, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:32395, ChEBI:CHEBI:76079; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40903, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:76078; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40907, ChEBI:CHEBI:16870, ChEBI:CHEBI:72999, ChEBI:CHEBI:76078; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41320, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:78044, ChEBI:CHEBI:78045; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:41352, ChEBI:CHEBI:16870, ChEBI:CHEBI:64771, ChEBI:CHEBI:64874, ChEBI:CHEBI:72998; Evidence={ECO:0000250|UniProtKB:O88202};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40959, ChEBI:CHEBI:16870, ChEBI:CHEBI:60657, ChEBI:CHEBI:76079; Evidence={ECO:0000250|UniProtKB:O88202};.

Enzyme Numbers (IUBMB) for ASPG Gene

Phenotypes From GWAS Catalog for ASPG Gene

Gene Ontology (GO) - Molecular Function for ASPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA --
GO:0004067 asparaginase activity IEA,TAS --
GO:0004622 lysophospholipase activity ISS --
GO:0005515 protein binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with ASPG: view
genes like me logo Genes that share phenotypes with ASPG: view

Animal Model Products

CRISPR Products

miRNA for ASPG Gene

miRTarBase miRNAs that target ASPG

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASPG

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASPG Gene

Localization for ASPG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASPG gene
Compartment Confidence
cytosol 5
mitochondrion 3
plasma membrane 2
extracellular 2
nucleus 2
lysosome 2
golgi apparatus 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for ASPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASPG: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ASPG Gene

Pathways & Interactions for ASPG Gene

genes like me logo Genes that share pathways with ASPG: view

Pathways by source for ASPG Gene

Gene Ontology (GO) - Biological Process for ASPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process IEA --
GO:0006530 asparagine catabolic process IBA --
GO:0006629 lipid metabolic process IEA --
GO:0008652 cellular amino acid biosynthetic process TAS --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with ASPG: view

No data available for SIGNOR curated interactions for ASPG Gene

Drugs & Compounds for ASPG Gene

(12) Drugs for ASPG Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Procaine Approved, Investigational, Vet_approved Pharma Channel blocker, Target, inhibitor 52
acetic acid Approved Pharma Agonist, Full agonist 139
Ammonia Approved Pharma 0
Palmitic Acid Approved Pharma Agonist, Full agonist 27
Stearic acid Approved, Experimental Pharma 0

(39) Additional Compounds for ASPG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
  • Eicosanoic acid
506-30-9
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6
LysoPC(0:0/18:0)
  • (2R)-3-Hydroxy-2-(stearoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
  • 2-Octadecanoyl-sn-glycero-3-phosphocholine
  • 2-Stearoyllysophosphatidylcholine
  • LPC (18:0)
  • PC(0:0/18:0)
4421-58-3
LysoPC(10:0)
  • 1-Capryl-2-lysophosphatidylcholine
  • 1-Capryl-L-alpha-phosphorylcholine
  • 1-Decanoyl-sn-glycero-3-phosphocholine
  • 1-Decanoyl-sn-glycerol-3-phosphorylcholine
  • 1-Decanoyllysolecithin
22248-63-1
genes like me logo Genes that share compounds with ASPG: view

Transcripts for ASPG Gene

mRNA/cDNA for ASPG Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASPG

Alternative Splicing Database (ASD) splice patterns (SP) for ASPG Gene

No ASD Table

Relevant External Links for ASPG Gene

GeneLoc Exon Structure for
ASPG

Expression for ASPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ASPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASPG Gene

This gene is overexpressed in Liver (x20.2) and Heart - Atrial Appendage (x14.1).

Protein differential expression in normal tissues from HIPED for ASPG Gene

This gene is overexpressed in Liver (28.3), Kidney (16.1), Gallbladder (11.1), and Esophagus (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASPG Gene



Protein tissue co-expression partners for ASPG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ASPG

SOURCE GeneReport for Unigene cluster for ASPG Gene:

Hs.146239

Evidence on tissue expression from TISSUES for ASPG Gene

  • Kidney(4.4)
  • Liver(2.7)
  • Blood(2.4)
  • Nervous system(2.2)
  • Bone marrow(2.2)
  • Skin(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with ASPG: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASPG Gene

Orthologs for ASPG Gene

This gene was present in the common ancestor of animals.

Orthologs for ASPG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ASPG 30 31
  • 98.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ASPG 30 31
  • 85.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ASPG 30 31
  • 83.43 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Aspg 30 17 31
  • 80.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Aspg 30
  • 79.79 (n)
Oppossum
(Monodelphis domestica)
Mammalia ASPG 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ASPG 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ASPG 31
  • 49 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 50 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii aspg 31
  • 43 (a)
OneToMany
ASPG (3 of 3) 31
  • 23 (a)
OneToMany
ASPG (2 of 3) 31
  • 15 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG6428 31
  • 36 (a)
OneToMany
CG8526 31
  • 33 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C27A7.5 31
  • 30 (a)
OneToOne
Species where no ortholog for ASPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ASPG Gene

ENSEMBL:
Gene Tree for ASPG (if available)
TreeFam:
Gene Tree for ASPG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ASPG: view image

Paralogs for ASPG Gene

(4) SIMAP similar genes for ASPG Gene using alignment to 4 proteins:

  • LPP60_HUMAN
  • G3V1Y8_HUMAN
  • H0YHD3_HUMAN
  • H0YHG5_HUMAN
genes like me logo Genes that share paralogs with ASPG: view

No data available for Paralogs for ASPG Gene

Variants for ASPG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ASPG Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
725758 Likely Benign: not provided 104,092,711(+) G/A MISSENSE_VARIANT
732429 Likely Benign: not provided 104,105,417(+) G/A SYNONYMOUS_VARIANT
786627 Benign: not provided 104,103,591(+) C/T SYNONYMOUS_VARIANT
rs1744284 - p.Leu96Val
rs1770984 - p.Cys95Arg

Additional dbSNP identifiers (rs#s) for ASPG Gene

Structural Variations from Database of Genomic Variants (DGV) for ASPG Gene

Variant ID Type Subtype PubMed ID
dgv276e201 CNV deletion 23290073
dgv277e201 CNV deletion 23290073
esv2749179 CNV deletion 23290073
esv2749180 CNV deletion 23290073
esv2749181 CNV deletion 23290073
esv2749183 CNV deletion 23290073
esv2749189 CNV deletion 23290073
esv3635614 CNV gain 21293372
esv3635616 CNV gain 21293372
nsv1047990 CNV gain 25217958
nsv1050479 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv1071175 CNV deletion 25765185
nsv470674 CNV loss 18288195
nsv519605 CNV loss 19592680
nsv526680 CNV gain 19592680
nsv566029 CNV loss 21841781
nsv566030 CNV gain 21841781
nsv566031 CNV loss 21841781
nsv952262 CNV deletion 24416366

Variation tolerance for ASPG Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.97; 95.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASPG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASPG Gene

Disorders for ASPG Gene

MalaCards: The human disease database

(7) MalaCards diseases for ASPG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebral sinovenous thrombosis
  • csvt
testicular leukemia
childhood acute lymphocytic leukemia
  • childhood acute lymphoblastic leukemia
adult acute lymphocytic leukemia
  • adult acute lymphoid leukemia
aspartylglucosaminuria
  • agu
- elite association - COSMIC cancer census association via MalaCards
Search ASPG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ASPG

genes like me logo Genes that share disorders with ASPG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ASPG Gene

Publications for ASPG Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. (PMID: 30652415) Liu Y … Chen L (Cancer medicine 2019) 3
  3. Symptomatic Cerebral Sinovenous Thrombosis Associated With L-Asparaginase In Children With Acute Lymphoblastic Leukemia: A Single Institution Experience Over 17 Years. (PMID: 29554021) Malhotra P … Kapoor G (Journal of pediatric hematology/oncology 2018) 3
  4. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin SY … Soranzo N (Nature genetics 2014) 3
  5. Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis. (PMID: 24768817) Nomme J … Lavie A (Journal of molecular biology 2014) 3

Products for ASPG Gene

Sources for ASPG Gene