Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASPDH Gene

Aliases for ASPDH Gene

  • Aspartate Dehydrogenase Domain Containing 2 3 5
  • Aspartate Dehydrogenase Domain-Containing Protein 3 4
  • Putative L-Aspartate Dehydrogenase 3 4
  • EC 1.4.1.21 4

External Ids for ASPDH Gene

Previous GeneCards Identifiers for ASPDH Gene

  • GC19M055710
  • GC19M051014
  • GC19M047351

Summaries for ASPDH Gene

GeneCards Summary for ASPDH Gene

ASPDH (Aspartate Dehydrogenase Domain Containing) is a Protein Coding gene. Among its related pathways are NAD metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and aspartate dehydrogenase activity.

UniProtKB/Swiss-Prot for ASPDH Gene

  • Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.

Additional gene information for ASPDH Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASPDH Gene

Genomics for ASPDH Gene

GeneHancer (GH) Regulatory Elements for ASPDH Gene

Promoters and enhancers for ASPDH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J050513 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 610.7 +0.5 489 2.4 SP1 KAT8 RFX1 CEBPA GATAD2A PATZ1 KLF9 RFX3 BMI1 YY1 ASPDH JOSD2
GH19J050555 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.5 -42.0 -42011 1.8 CTCF ZNF148 ZNF121 GTF2F1 NFIB ZSCAN21 NCOA6 SP7 ELF1 KLF14 ENSG00000268231 ASPDH JOSD2 PTOV1 LINC01869 C19orf48 SNORD88C KLK4 SYT3 ACP4
GH19J050695 Promoter/Enhancer 1.3 FANTOM5 Ensembl 19 -180.4 -180411 1 ZNF652 ZNF148 ZNF560 ZNF600 ZSCAN4 POLR2A REST NRF1 EZH2 ZBTB26 ASPDH SYT3 KCNC3 LRRC4B SPACA6P-AS FUZ SHANK1 KLK6 PIR41386
GH19J050510 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +3.4 3390 2.6 MTA3 SP1 ELF3 ZFX SIX5 ZNF148 NKRF MLLT1 GTF2F1 CSDE1 JOSD2 NR1H2 RRAS PRR12 CTU1 PRMT1 NAPSB ENSG00000268047 CLEC11A ASPDH
GH19J050537 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.3 -23.2 -23211 0.6 CC2D1A CTCF ZNF687 ZSCAN21 SP7 ZNF639 RAD21 CREB1 GMEB1 ARID2 ASPDH JOSD2 LRRC4B GPR32 SNORD88A SNORD88B SNORD88C NAPSA NR1H2 LINC01869
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ASPDH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ASPDH gene promoter:
  • ATF
  • Egr-4
  • Pax-5
  • PPAR-alpha
  • ZIC2

Genomic Locations for ASPDH Gene

Genomic Locations for ASPDH Gene
chr19:50,511,600-50,514,690
(GRCh38/hg38)
Size:
3,091 bases
Orientation:
Minus strand
chr19:51,014,857-51,017,947
(GRCh37/hg19)
Size:
3,091 bases
Orientation:
Minus strand

Genomic View for ASPDH Gene

Genes around ASPDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASPDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASPDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASPDH Gene

Proteins for ASPDH Gene

  • Protein details for ASPDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ND91-ASPD_HUMAN
    Recommended name:
    Putative L-aspartate dehydrogenase
    Protein Accession:
    A6ND91
    Secondary Accessions:
    • Q6NZ37

    Protein attributes for ASPDH Gene

    Size:
    283 amino acids
    Molecular mass:
    29946 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

    Alternative splice isoforms for ASPDH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASPDH Gene

Post-translational modifications for ASPDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASPDH Gene

No data available for DME Specific Peptides for ASPDH Gene

Domains & Families for ASPDH Gene

Gene Families for ASPDH Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ASPDH Gene

Suggested Antigen Peptide Sequences for ASPDH Gene

GenScript: Design optimal peptide antigens:
  • Aspartate dehydrogenase domain-containing protein (ASPD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6ND91

UniProtKB/Swiss-Prot:

ASPD_HUMAN :
  • Belongs to the L-aspartate dehydrogenase family.
Family:
  • Belongs to the L-aspartate dehydrogenase family.
genes like me logo Genes that share domains with ASPDH: view

Function for ASPDH Gene

Molecular function for ASPDH Gene

UniProtKB/Swiss-Prot Function:
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate; Xref=Rhea:RHEA:11784, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.4.1.21;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate; Xref=Rhea:RHEA:11788, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.4.1.21;.

Enzyme Numbers (IUBMB) for ASPDH Gene

Phenotypes From GWAS Catalog for ASPDH Gene

Gene Ontology (GO) - Molecular Function for ASPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0033735 aspartate dehydrogenase activity IEA --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with ASPDH: view

Phenotypes for ASPDH Gene

genes like me logo Genes that share phenotypes with ASPDH: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ASPDH - Now 50% OFF >
  • * ASPDH as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ASPDH tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASPDH Gene

Localization for ASPDH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASPDH gene
Compartment Confidence
mitochondrion 2
nucleus 2
plasma membrane 1
cytosol 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ASPDH Gene

Pathways & Interactions for ASPDH Gene

PathCards logo

SuperPathways for ASPDH Gene

genes like me logo Genes that share pathways with ASPDH: view

Pathways by source for ASPDH Gene

UniProtKB/Swiss-Prot A6ND91-ASPD_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.

Gene Ontology (GO) - Biological Process for ASPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006742 NADP catabolic process IEA --
GO:0009435 NAD biosynthetic process IEA --
GO:0019363 pyridine nucleotide biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ASPDH: view

No data available for SIGNOR curated interactions for ASPDH Gene

Drugs & Compounds for ASPDH Gene

(4) Drugs for ASPDH Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia Approved Pharma 0
Water Approved Pharma 0
L-Aspartic acid Approved Nutra 0
NAD Experimental Pharma Full agonist, Agonist, Activator 0

(3) Additional Compounds for ASPDH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Iminoaspartic acid
  • Iminoaspartate
  • Iminosuccinate
  • Iminosuccinic acid
  • alpha-Iminosuccinate
  • imino-Butanedioate
79067-61-1
NADP
  • beta-Nicotinamide adenine dinucleotide phosphate
  • NADP+
  • Nicotinamide adenine dinucleotide phosphate
  • Oxidized nicotinamide-adenine dinucleotide phosphate
  • TPN
53-59-8
Oxalacetic acid
  • 2-Oxobutanedioic acid
  • 2-Oxosuccinic acid
  • 3-Carboxy-3-oxopropanoic acid
  • keto-Succinic acid
  • Ketosuccinic acid
328-42-7
genes like me logo Genes that share compounds with ASPDH: view

Transcripts for ASPDH Gene

mRNA/cDNA for ASPDH Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ASPDH Gene

Aspartate dehydrogenase domain containing:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ASPDH - Now 50% OFF >
  • * ASPDH as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ASPDH tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ASPDH Gene

No ASD Table

Relevant External Links for ASPDH Gene

GeneLoc Exon Structure for
ASPDH
ECgene alternative splicing isoforms for
ASPDH

Expression for ASPDH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASPDH Gene

mRNA differential expression in normal tissues according to GTEx for ASPDH Gene

This gene is overexpressed in Liver (x12.3).

Protein differential expression in normal tissues from HIPED for ASPDH Gene

This gene is overexpressed in Gallbladder (12.8), Nasal epithelium (9.7), Monocytes (8.4), Neutrophil (8.1), Esophagus (7.4), and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASPDH Gene



NURSA nuclear receptor signaling pathways regulating expression of ASPDH Gene:

ASPDH

SOURCE GeneReport for Unigene cluster for ASPDH Gene:

Hs.436338

Evidence on tissue expression from TISSUES for ASPDH Gene

  • Liver(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ASPDH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASPDH Gene

Orthologs for ASPDH Gene

This gene was present in the common ancestor of animals.

Orthologs for ASPDH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASPDH 35 34
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ASPDH 35 34
  • 87.43 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Aspdh 17 35 34
  • 86.09 (n)
cow
(Bos Taurus)
Mammalia ASPDH 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aspdh 34
  • 84.69 (n)
lizard
(Anolis carolinensis)
Reptilia ASPDH 35
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii aspdh 35 34
  • 53.33 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F17C8.9 34
  • 49.04 (n)
F17C8.9 35
  • 45 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToOne
Species where no ortholog for ASPDH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASPDH Gene

ENSEMBL:
Gene Tree for ASPDH (if available)
TreeFam:
Gene Tree for ASPDH (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ASPDH: view image

Paralogs for ASPDH Gene

No data available for Paralogs for ASPDH Gene

Variants for ASPDH Gene

Sequence variations from dbSNP and Humsavar for ASPDH Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000767299 -- 50,512,896(-) G/A intron_variant
rs1001688377 -- 50,514,533(-) T/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1002035677 -- 50,516,459(-) A/G upstream_transcript_variant
rs1003097628 -- 50,515,521(-) C/T upstream_transcript_variant
rs1003570295 -- 50,516,573(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ASPDH Gene

Variant ID Type Subtype PubMed ID
nsv1133010 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv1152956 OTHER inversion 26484159
nsv509750 CNV insertion 20534489
nsv953604 CNV deletion 24416366

Variation tolerance for ASPDH Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASPDH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASPDH

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASPDH Gene

Disorders for ASPDH Gene

Additional Disease Information for ASPDH

No disorders were found for ASPDH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASPDH Gene

Publications for ASPDH Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for ASPDH Gene

Sources for ASPDH Gene

Content
Loading form....