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Aliases for ASNSD1 Gene

Aliases for ASNSD1 Gene

  • Asparagine Synthetase Domain Containing 1 2 3 5
  • HCV NS3-Transactivated Protein 1 3 4
  • NS3TP1 3 4
  • Asparagine Synthetase Domain-Containing Protein 1 3
  • NBLA00058 3

External Ids for ASNSD1 Gene

Previous GeneCards Identifiers for ASNSD1 Gene

  • GC02P190234
  • GC02P190526
  • GC02P182385

Summaries for ASNSD1 Gene

GeneCards Summary for ASNSD1 Gene

ASNSD1 (Asparagine Synthetase Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include asparagine synthase (glutamine-hydrolyzing) activity.

Additional gene information for ASNSD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASNSD1 Gene

Genomics for ASNSD1 Gene

GeneHancer (GH) Regulatory Elements for ASNSD1 Gene

Promoters and enhancers for ASNSD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I189660 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 558.8 +0.5 500 2.3 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ASNSD1 ORMDL1 ANKAR
GH02I189761 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.2 +101.5 101534 2.5 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B ENSG00000273240 OSGEPL1 OSGEPL1-AS1 ORMDL1 MSTN ASNSD1 ANKAR
GH02I189573 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 5.8 -81.7 -81661 11.5 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B SLC40A1 HNRNPCP2 ORMDL1 NEMP2 ASNSD1 LOC100420666
GH02I189782 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5.8 +122.6 122641 3.6 HDGF PKNOX1 SMAD1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ORMDL1 PMS1 ANKAR HNRNPCP2 OSGEPL1-AS1 OSGEPL1 WDR75 NEMP2 ASNSD1 ENSG00000273240
GH02I189638 Enhancer 0.6 ENCODE 15.4 -21.9 -21906 1.8 KLF1 JUN CEBPB EP300 OSR2 ZNF335 HIC1 ZNF629 ZXDB TRIM28 ORMDL1 ASNSD1 ENSG00000276828
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ASNSD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ASNSD1 gene promoter:

Genomic Locations for ASNSD1 Gene

Genomic Locations for ASNSD1 Gene
chr2:189,661,385-189,670,831
(GRCh38/hg38)
Size:
9,447 bases
Orientation:
Plus strand
chr2:190,526,111-190,535,557
(GRCh37/hg19)

Genomic View for ASNSD1 Gene

Genes around ASNSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASNSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASNSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASNSD1 Gene

Proteins for ASNSD1 Gene

  • Protein details for ASNSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWL6-ASND1_HUMAN
    Recommended name:
    Asparagine synthetase domain-containing protein 1
    Protein Accession:
    Q9NWL6
    Secondary Accessions:
    • D3DPH6
    • Q3LIC3
    • Q4ZG45

    Protein attributes for ASNSD1 Gene

    Size:
    643 amino acids
    Molecular mass:
    72080 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ASNSD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASNSD1 Gene

Post-translational modifications for ASNSD1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ASNSD1 Gene

Domains & Families for ASNSD1 Gene

Gene Families for ASNSD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ASNSD1 Gene

Suggested Antigen Peptide Sequences for ASNSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ASNSD1: view

No data available for UniProtKB/Swiss-Prot for ASNSD1 Gene

Function for ASNSD1 Gene

Phenotypes From GWAS Catalog for ASNSD1 Gene

Gene Ontology (GO) - Molecular Function for ASNSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity IBA,IEA --
GO:0042803 protein homodimerization activity IBA --
genes like me logo Genes that share ontologies with ASNSD1: view

Phenotypes for ASNSD1 Gene

genes like me logo Genes that share phenotypes with ASNSD1: view

miRNA for ASNSD1 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASNSD1 Gene

Localization for ASNSD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASNSD1 gene
Compartment Confidence
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ASNSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ASNSD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASNSD1 Gene

Pathways & Interactions for ASNSD1 Gene

SuperPathways for ASNSD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ASNSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006529 asparagine biosynthetic process IBA,IEA --
GO:0006541 glutamine metabolic process IEA --
GO:0008150 biological_process ND --
GO:0008652 cellular amino acid biosynthetic process IEA --
genes like me logo Genes that share ontologies with ASNSD1: view

No data available for Pathways by source and SIGNOR curated interactions for ASNSD1 Gene

Drugs & Compounds for ASNSD1 Gene

No Compound Related Data Available

Transcripts for ASNSD1 Gene

Unigene Clusters for ASNSD1 Gene

Asparagine synthetase domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASNSD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2:
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7:

Relevant External Links for ASNSD1 Gene

GeneLoc Exon Structure for
ASNSD1
ECgene alternative splicing isoforms for
ASNSD1

Expression for ASNSD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASNSD1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ASNSD1 Gene



Protein tissue co-expression partners for ASNSD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ASNSD1 Gene:

ASNSD1

SOURCE GeneReport for Unigene cluster for ASNSD1 Gene:

Hs.101364

Evidence on tissue expression from TISSUES for ASNSD1 Gene

  • Nervous system(4.2)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with ASNSD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASNSD1 Gene

Orthologs for ASNSD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASNSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASNSD1 33 34
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia ASNSD1 33 34
  • 86.47 (n)
dog
(Canis familiaris)
Mammalia ASNSD1 33 34
  • 86.12 (n)
mouse
(Mus musculus)
Mammalia Asnsd1 33 16 34
  • 80.78 (n)
rat
(Rattus norvegicus)
Mammalia Asnsd1 33
  • 80.09 (n)
oppossum
(Monodelphis domestica)
Mammalia ASNSD1 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASNSD1 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASNSD1 33 34
  • 66.93 (n)
lizard
(Anolis carolinensis)
Reptilia ASNSD1 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asnsd1 33
  • 62.3 (n)
Str.15869 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.20871 33
zebrafish
(Danio rerio)
Actinopterygii asnsd1 33 34
  • 58.76 (n)
sidz211o13.6 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8980 33
fruit fly
(Drosophila melanogaster)
Insecta CG17486 33 34
  • 49.58 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010492 33
  • 46.91 (n)
worm
(Caenorhabditis elegans)
Secernentea M18.3 33 34
  • 49.1 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10285g 33
  • 47.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YML096W 33
  • 45.86 (n)
-- 34
  • 29 (a)
OneToOne
-- 36
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL350C 33
  • 44.18 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G03667 33
  • 51.07 (n)
rice
(Oryza sativa)
Liliopsida Os12g0574900 33
  • 48.72 (n)
Os.47110 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4F6.11c 33
  • 46.35 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07300 33
  • 43.7 (n)
Species where no ortholog for ASNSD1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASNSD1 Gene

ENSEMBL:
Gene Tree for ASNSD1 (if available)
TreeFam:
Gene Tree for ASNSD1 (if available)

Paralogs for ASNSD1 Gene

No data available for Paralogs for ASNSD1 Gene

Variants for ASNSD1 Gene

Sequence variations from dbSNP and Humsavar for ASNSD1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000015422 -- 189,662,949(+) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000087038 -- 189,663,243(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000359822 -- 189,669,463(+) T/C intron_variant
rs1000529587 -- 189,664,746(+) C/A intron_variant
rs1001810915 -- 189,660,762(+) A/G upstream_transcript_variant

Variation tolerance for ASNSD1 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASNSD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASNSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ASNSD1 Gene

Disorders for ASNSD1 Gene

Additional Disease Information for ASNSD1

No disorders were found for ASNSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASNSD1 Gene

Publications for ASNSD1 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Identification and characterization of sORF-encoded polypeptides. (PMID: 25857697) Chu Q … Saghatelian A (Critical reviews in biochemistry and molecular biology 2015) 4 58
  4. Direct detection of alternative open reading frames translation products in human significantly expands the proteome. (PMID: 23950983) Vanderperre B … Roucou X (PloS one 2013) 4 58
  5. Peptidomic discovery of short open reading frame-encoded peptides in human cells. (PMID: 23160002) Slavoff SA … Saghatelian A (Nature chemical biology 2013) 4 58

Products for ASNSD1 Gene

Sources for ASNSD1 Gene

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