Aliases for ASMTL Gene
External Ids for ASMTL Gene
Previous GeneCards Identifiers for ASMTL Gene
The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
GeneCards Summary for ASMTL Gene
ASMTL (Acetylserotonin O-Methyltransferase Like) is a Protein Coding gene. Diseases associated with ASMTL include Melanotic Neurilemmoma and Patau Syndrome. Gene Ontology (GO) annotations related to this gene include O-methyltransferase activity. An important paralog of this gene is ASMT.
UniProtKB/Swiss-Prot for ASMTL Gene
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable).