ASMT Gene - Acetylserotonin O-Methyltransferase

Protein Coding (Updated: Nov 13, 2025)
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 20... See more...

Aliases for ASMT Gene

Aliases for ASMT Gene

  • GeneCards Symbol: ASMT 2
  • Acetylserotonin O-Methyltransferase 2 3 4 5
  • HIOMT 2 3 4 5
  • HIOMTY 2 3 5
  • ASMTY 2 3 5
  • Hydroxyindole O-Methyltransferase 3 4
  • Acetylserotonin Methyltransferase (Y Chromosome) 3
  • Acetylserotonin N-Methyltransferase 3
  • EC 2.1.1.4 4

External Ids for ASMT Gene

Previous GeneCards Identifiers for ASMT Gene

  • GC0XP001185
  • GC0XP001125
  • GC0XP001294
  • GC0XP001359
  • GC0XP001356
  • GC0YP001758
  • GC0XP001758
  • GC0XP001674
  • GC0XP001714
  • GC0XP001595
  • GC0XP002067
  • GC0XP002150
  • GC0XP002242
  • GC0XP002340
  • GC0XP002442
  • GC0XP002536
  • GC0XP002690
  • GC0XP002811
  • GC0XP002912
  • GC0XP003081

Summaries for ASMT Gene

NCBI Gene Summary for ASMT Gene

  • This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for ASMT Gene

ASMT (Acetylserotonin O-Methyltransferase) is a Protein Coding gene. Diseases associated with ASMT include Pineocytoma and Pineoblastoma. Among its related pathways are Biogenic amine synthesis and superpathway of tryptophan utilization. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and methyltransferase activity. An important paralog of this gene is ASMTL.

UniProtKB/Swiss-Prot Summary for ASMT Gene

[Isoform 1]: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). ( ASMT_HUMAN,P46597 )

[Isoform 2]: Does not show Acetylserotonin O-methyltransferase activity. ( ASMT_HUMAN,P46597 )

[Isoform 3]: Does not show Acetylserotonin O-methyltransferase activity. ( ASMT_HUMAN,P46597 )

Gene Wiki entry for ASMT Gene

PharmGKB Summary for ASMT Gene

Additional gene information for ASMT Gene

No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for ASMT Gene

Genomics for ASMT Gene

Subsections:

  1. Promoters/Enhancers
  2. Location

GeneHancer (GH) Regulatory Elements (see citations)

Download GeneHancer 2017 data
Promoters and enhancers for ASMT Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ001614 Promoter 0.2 EPDnew 300.70 75.18 -0.1 0 0.1 ASMT AKAP17A
GH0XJ001615 Promoter 0.2 EPDnew 300.70 75.18 +0.1 0 0.1 ASMT AKAP17A piR-43107-307 DHRSX
GH0XJ001391 Promoter/Enhancer 2.1 RefSeq EPDnew Ensembl CraniofacialAtlas 12.30 25.95 -222.8 23 2.5 SREBF2 KLF6 SP1 MIER1 MGA ZBTB26 PRDM1 KLF17 POLR2A HCFC1 LINC00106 SLC25A6 LOC124900597 AKAP17A ASMT P2RY8
GH0XJ002608 Promoter/Enhancer 1.9 RefSeq EPDnew Ensembl CraniofacialAtlas 12.20 23.33 +994.1 91 2.4 ZBTB26 PRDM1 UBTF ZNF580 MAZ MLLT1 CTCF POLR2A ZMYM3 TBP CD99P1 LINC03112 MIR6089 lnc-CD99-2-001 ASMT CD99 piR-48790 lnc-DHRSX-3 ZBED1
GH0XJ000856 Enhancer 0.7 RefSeq 12.30 8.62 -749.5 121 18.8 PRDM1 ZNF146 ATF2 CREB1 ZSCAN4 ZNF544 U2AF2 ZNF512 CDC5L ZNF114 piR-32287-181 ASMT AKAP17A LINC00106 piR-56480-109 HSALNG0151027 SHOX CRLF2

GeneHancers around ASMT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from The Signaling Pathways Project (SPP) (The Signaling Pathways Project) for ASMT

Top Transcription factor binding sites by QIAGEN in the ASMT gene promoter:
  • NF-kappaB
  • NF-kappaB1
  • p53
  • PPAR-alpha
  • RelA

Genomic Locations for ASMT Gene

Latest Assembly
chrX:1,615,059-1,643,081
(GRCh38/hg38)
Size:
28,023 bases
Orientation:
Plus strand

Previous Assembly
chrX:1,714,348-1,761,974
(GRCh37/hg19 by NCBI Gene)
Size:
47,627 bases
Orientation:
Plus strand

chrX:1,733,894-1,761,974
(GRCh37/hg19 by Ensembl)
Size:
28,081 bases
Orientation:
Plus strand

Genomic View for ASMT Gene

Genes around ASMT on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19)

Cytogenetic band:
ASMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or NCBI Gene and/or Ensembl if different)
Genomic Location for ASMT Gene
Genomic Neighborhood
•
Exon Structure
•
Gene Densities

RefSeq DNA sequence for ASMT Gene

Proteins for ASMT Gene

Subsections:

  1. 3D Structures
  2. Alternative Splicing
  3. Protein References
  4. Post-Translational Modifications

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  • Protein details for ASMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46597-ASMT_HUMAN
    Recommended name:
    Acetylserotonin O-methyltransferase
    Protein Accession:
    P46597
    Secondary Accessions:
    • B2RC33
    • Q16598
    • Q5JQ72
    • Q5JQ73

    Protein attributes for ASMT Gene

    Size:
    345 amino acids
    Molecular mass:
    38453 Da
    Protein existence level:
    PE1
    Quaternary structure:

    • Homodimer.
    Miscellaneous:

    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Three dimensional structures from PDB (representative) and AlphaFold (predicted) for ASMT Gene

    Model Confidence:
    Very high (pLDDT > 90)
    Confident (90 > pLDDT > 70)
    Low (70 > pLDDT > 50)
    Very low (pLDDT < 50)
    Identifier Method Resolution PDBe RCSB-PDB OCA Proteopedia
    GeneCards.Business.Types.Common.LinkDto X-ray 2.4 (3D) (3D) (3D)
    GeneCards.Business.Types.Common.LinkDto X-ray 2.7 (3D) (3D) (3D)
    GeneCards.Business.Types.Common.LinkDto Predicted

    Alternative splice isoforms for ASMT Gene from UniProtKB/Swiss-Prot

    produced by Alternative splicing
    Isoform Note
    P46597-1
    P46597-2
    P46597-3 Includes part of a LINE-1 element.

Protein Expression for ASMT Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ASMT Gene

No Post-translational modifications

Other Protein References for ASMT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASMT Gene

Domains & Families for ASMT Gene

Gene Families for ASMT Gene

HGNC:
The Human Protein Atlas (HPA):
  • Enzymes
  • Metabolic proteins
  • Predicted intracellular proteins

Protein Domains for ASMT Gene

InterPro:
Blocks:
  • O-methyltransferase, family 2

Suggested Antigen Peptide Sequences for ASMT Gene

GenScript: Design optimal peptide antigens:
  • Acetylserotonin O-methyltransferase (HIOM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P46597

UniProtKB/Swiss-Prot:

ASMT_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Genes that share domains with ASMT: view

Function for ASMT Gene

Subsections:

  1. GO Terms
  2. MGI/GenomeRNAi Phenotypes

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  3. Inhibitory RNAs
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Molecular function for ASMT Gene according to UniProtKB/Swiss-Prot

Function:
  • [Isoform 1]: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). ASMT_HUMAN,P46597
  • [Isoform 2]: Does not show Acetylserotonin O-methyltransferase activity. ASMT_HUMAN,P46597
  • [Isoform 3]: Does not show Acetylserotonin O-methyltransferase activity. ASMT_HUMAN,P46597
CatalyticActivity:
Induction:
  • By all-trans-, 9-cis- and 13-cis-retinoic acid and by serum treatment, following starvation, in the retinoblastoma cell line Y79. ASMT_HUMAN,P46597

Molecular function for ASMT Gene according to GENATLAS

Biochemistry:
  • methyltransferase,hydroxyindole-O,catalyzing the final step of melatonin synthesis,expressed in the pineal gland ASMT
  • methyltransferase,hydroxyindole-O ASMT

Enzyme Numbers (IUBMB) for ASMT Gene

Gene Ontology (GO) - Molecular Function for ASMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 3 5 enables methyltransferase activity IEA
GO:0008171 3 5 enables O-methyltransferase activity TAS, IEA 8397829
GO:0008172 3 5 enables S-methyltransferase activity TAS
GO:0016740 3 5 enables transferase activity IEA
GO:0017096 3 5 enables acetylserotonin O-methyltransferase activity IDA, IBA, IEA
Genes that share ontologies with ASMT: view
Genes that share phenotypes with ASMT: view

miRNA for ASMT Gene

miRTarBase miRNAs that target ASMT

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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , NCBI Functional elements , Transcription Factor Targeted Genes and HOMER Transcription for ASMT Gene

Localization for ASMT Gene

Subsections:

  1. Cellular Components

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASMT gene
Compartment Confidence
cytosol 4
mitochondrion 3
endoplasmic reticulum 2
nucleus 2
peroxisome 2
extracellular 2
plasma membrane 2
golgi apparatus 1
lysosome 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ASMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 3 5 located_in cytosol TAS
Genes that share ontologies with ASMT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ASMT Gene

Pathways & Interactions for ASMT Gene

Subsections:

  1. SuperPathways
  2. String Interactions
  3. Interacting Proteins
  4. GO Terms
Genes that share pathways with ASMT: view

UniProtKB/Swiss-Prot ASMT_HUMAN

  • Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.

Additional Pathway Information for ASMT Gene

Gene Ontology (GO) - Biological Process for ASMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 3 5 involved_in translation TAS 8397829
GO:0006629 3 5 involved_in lipid metabolic process IEA
GO:0030187 3 5 involved_in melatonin biosynthetic process IDA, IBA, IEA
GO:0032259 3 5 involved_in methylation IBA, IEA
GO:0046219 3 5 involved_in indolalkylamine biosynthetic process TAS
Genes that share ontologies with ASMT: view

No data available for SIGNOR curated interactions for ASMT Gene

Drugs & Compounds for ASMT Gene

Subsections:

  1. Drugs
  2. Inferred drugs
  3. Compounds
  4. Inferred compounds

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  1. Drug products

(7) Drugs for ASMT Gene - From DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Melatonin 21 23 24 Approved, Investigational, Vet_approved Nutra substrate, Enzyme Melatonin receptors MT inhibitor, Hypnotics And Sedatives, Small Molecule, Endogenous hormone; agonist at MT1 and MT2
Nortriptyline 91 Approved, Investigational 23 Pharma Blocker Small Molecule, Antidepressive Agents, Tricyclic
N-acetylserotonin 24 Experimental 23 Pharma an agonist at the melatonin receptors MT1, MT2, and MT3
S-adenosyl-L-homocysteine 24 Experimental 23 Pharma intermediate in the synthesis of cysteine and adenosine
VU0134992 91 Pharma Blocker

(2) Inferred Drugs for ASMT Gene

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclic adenosine monophosphate 21 Investigational 23 Pharma
Serotonin 21 Investigational Nutra

(1) Additional Compounds for ASMT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Methoxyindoleacetate
  • (5-Methoxy-1H-indol-3-yl)acetic acid
  • 2-(5-Methoxy-1H-indol-3-yl)acetic acid
  • 2-(5-Methoxy-1H-indol-3-yl)ethanoate
  • 2-(5-Methoxy-1H-indol-3-yl)ethanoic acid
  • 2-(5-Methoxy-3-indolyl)acetic acid
 3471-31-6

(4) Additional Inferred Compounds for ASMT Gene

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arylalkylamine
butyrate
dbc-amp
Oligonucleotide
Genes that share compounds with ASMT: view

Transcripts for ASMT Gene

Subsections:

  1. Alternative Splicing

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mRNA/cDNA for ASMT Gene

4 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

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Alternative Splicing Database (ASD) splice patterns (SP) for ASMT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4:

Exon structure for ASMT gene

Exon Structure

Expression for ASMT Gene

Subsections:

  1. Expression in stem cells
  2. Protein expression
  3. Co-Expression partners

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ASMT Gene

mRNA expression in normal human tissues for ASMT Gene
mRNA expression by GTEx for ASMT GenemRNA expression by BioGPS for ASMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Inner Cell Mass (Early Embryonic Tissues)
    • Line H1 (WA01)
    • Human embryonic stem cells (family)

Protein differential expression in normal tissues from HIPED for ASMT Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASMT Gene



Protein tissue co-expression partners for ASMT Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ASMT

mRNA Expression by UniProt/SwissProt for ASMT Gene:

P46597-ASMT_HUMAN
Tissue specificity: Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683).

Evidence on tissue expression from TISSUES for ASMT Gene

  • Nervous system(4.7)
  • Eye(4.6)
  • Intestine(3.2)
  • Lung(2.5)
  • Liver(2.1)
  • Blood(2)

Bgee gene expression patterns for ASMT gene:

  • Expressed in male germ line stem cell (sensu Vertebrata) in testis, adenohypophysis, oocyte and 95 other cell types or tissues.
Genes that share expression patterns with ASMT: view

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No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASMT Gene

Orthologs for ASMT Gene

Subsections:

  1. CladeOScope co-evolved genes

This gene was present in the common ancestor of animals and fungi.

Orthologs for ASMT Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)		 Mammalia ASMT 27 28
  • 76.81 (n)
OneToOne
Chicken
(Gallus gallus)		 Aves ASMT 27 28
  • 62.51 (n)
OneToOne
Zebrafish
(Danio rerio)		 Actinopterygii asmt 27 28
  • 61.11 (n)
OneToOne
Cow
(Bos Taurus)		 Mammalia ASMT 28
  • 61 (a)
OneToOne
Rat
(Rattus norvegicus)		 Mammalia Asmt 27
  • 60.2 (n)
Species where no ortholog for ASMT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ASMT Gene

ENSEMBL:
Gene Tree for ASMT (if available)
TreeFam:
Gene Tree for ASMT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ASMT: view image
Alliance of Genome Resources:
Additional Orthologs for ASMT

CladeOScope co-evolved genes for ASMT gene

Clade Top 10 Co-Evolved Genes Normalized Phylogenetic Profile HeatMap (PPH)
Top Genes From All Clades
Archelosauria
Ascomycota
Basidiomycota
Chordata
Eudicotyledons
Eukaryota
Fungi
Fungi Incertae Sedis
Liliopsida
Mammalia
Stramenopiles
Viridiplantae

Paralogs for ASMT Gene

Paralogs for ASMT Gene

(1) SIMAP paralogs for ASMT Gene using alignment to 2 proteins:

  • ASMT_HUMAN
  • I7HFW6_HUMAN
Genes that share paralogs with ASMT: view

Variants for ASMT Gene

Subsections:

  1. Variation Tolerance
  2. External Links

Sequence variations, with clinical significance, from ClinVar and UniProt Humsavar, with links to dbSNP and Ensembl, for ASMT Gene

Accession rsID Clinical significance and condition Chr 0X pos Variation Name Ref/Alt AA Chg Type
2688617 5 rs148855515

Conflicting interpretations of pathogenicity: not provided

1,629,941(+) NM_001171038.2(ASMT):c.562+2T>C T/C splice donor variant
2688614 5 rs17149149

Uncertain significance: not provided

Likely benign: ASMT-related disorder

1,615,250(+) NM_001171038.2(ASMT):c.51C>A (p.Asn17Lys) C/A N17K missense variant
2688615 5 rs2521893473

Uncertain significance: not provided

1,636,446(+) NM_001171038.2(ASMT):c.796T>G (p.Phe266Val) T/G F266V missense variant
2688616 5 rs143524297

Uncertain significance: not provided

1,633,190(+) NM_001171038.2(ASMT):c.687C>A (p.Tyr229Ter) C/A intron variant,nonsense
285309 5 rs199647924

Uncertain significance: not provided

1,623,156(+) NM_001171038.2(ASMT):c.87C>A (p.Cys29Ter) C/A C29* nonsense

Identifiers for variants without clinical significance from dbSNP and UniProt Humsavar for ASMT Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ASMT Gene

Variant ID Type Subtype PubMed ID
nsv4323028 OTHER sequence alteration 32461652
esv29996 CNV loss 17803354
nsv4037834 CNV duplication 32461652
nsv510811 CNV deletion 20534489
nsv4037527 CNV duplication 32461652
SVs/CNVs around ASMT on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19)

Variation tolerance for ASMT Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.85; 83.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASMT Gene

Human Gene Mutation Database (HGMD)
ASMT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASMT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASMT Gene

Disorders for ASMT Gene

Subsections:

  1. External links

1 diseases for ASMT Gene - From: GTR

(click the icon to the left of a disorder to see descriptions and symptoms)

Disorder Aliases PubMed IDs
Alacrima, Achalasia, And Impaired Intellectual Development Syndrome 99
  • AAMR
  • Alacrima, Achalasia, And Mental Retardation Syndrome
  • Alacrima, Achalasia, And Intellectual Disability Syndrome
  • Intellectual Disability
- elite association - COSMIC cancer census association via MalaCards
Search ASMT in MalaCards View complete list of genes associated with diseases

13 text mining disease associations for ASMT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
Pineocytoma 21 63
  • Pinealocytoma
  • Pinealoma
  • Benign Pinealoma
  • Pineocytoma, Benign
  • Pineal Gland Neoplasm
  • Tumor Of The Pineal Region
 10831155 16825954
Pineoblastoma 21 63
  • Pineal Pnet
  • Pineal Gland Primitive Neuroectodermal Tumour
  • Pineal Primitive Neuroectodermal Tumour
  • Pinealoblastoma
  • Pineoblastoma, Malignant
  • Primitive Neuroectodermal Tumour Of Pineal Gland
  • Primitive Neuroectodermal Tumour Of The Pineal Gland
  • Pinealoma
  • Pineal Gland Neoplasm
  • Pineocytoma
  • Tumor Of The Pineal Region
 10831155 16825954
Advanced Sleep Phase Syndrome, Familial, 1 63
  • Advanced Sleep Phase Syndrome 1
  • FASPS1
  • Familial Advanced Sleep Phase Syndrome 1
Delayed Sleep Phase Disorder 63
  • Delayed Sleep Phase Syndrome
  • DSPD
  • Delayed Sleep Phase Syndrome, Susceptibility To
  • Delayed Sleep Phase Disorder, Susceptibility To
  • DSPS
Retinoblastoma 1 21
  • RB
  • Rb - Retinoblastoma
  • RB1
  • Neuroblastoma Of Retina
  • Retina Tumor
  • Retina Tumour
  • Retinoblastoma - Morphology
  • Retinoblastoma, Malignant
  • Retinoblastoma, Somatic
  • Glioma, Retinal
  • Non-Hereditary Retinoblastoma
  • Childhood Cancer Retinoblastoma
  • Trilateral Retinoblastoma
  • Malignant Neoplasm Of Retina
  • Retinal Neoplasms
 10496148 8842389 2162375 8574683
- COSMIC cancer census association via MalaCards
Search ASMT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ASMT

Human Genome Epidemiology Literature Finder
(Human Genome Epidemiology Literature Finder)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
Open Targets Platform
Open Targets Platform
The FABRIC Cancer Portal
(FABRIC)
Genes that share disorders with ASMT: view

No data available for UniProtKB/Swiss-Prot and GENATLAS for ASMT Gene

Publications for ASMT Gene

Publications for ASMT from NCBI Gene, PubMed, Novoseek, ClinVar, GAD, HMDB, UniProtKB/Swiss-Prot, HGNC, SIGNOR

(click the icon to the left of a publication to see abstract and related MeSH terms)

Title Association Year # Cit
Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway.
(Journal of pineal research) Botros HG … Bourgeron T (22775292) 		GeneVariant 107 Publication 49 Protein 4 Gene 3 Interaction 94 2013 35
Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder.
(Human molecular genetics) Etain B … Jamain S (22694957) 		GeneVariant 107 Publication 49 Protein 4 Gene 3 2012 43
Abnormal melatonin synthesis in autism spectrum disorders.
(Molecular psychiatry) Melke J … Bourgeron T (17505466) 		GeneVariant 107 Publication 49 Protein 4 Gene 3 2008 186
Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters.
(The Journal of biological chemistry) Rodriguez IR … Chader GJ (7989373) 		Protein 4 Gene 3 2 21* 1994 27
Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA.
(DNA and cell biology) Donohue SJ … Klein DC (8397829) 		Protein 4 Gene 3 2 21* 1993 12
Sequencing ASMT identifies rare mutations in Chinese Han patients with autism.
(PloS one) Wang L … Zhang D (23349736) 		Publication 49 Protein 4 Gene 3 2013 24
Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders.
(Journal of pineal research) Chaste P … Bourgeron T (21615493) 		GeneVariant 107 Protein 4 Gene 3 2011 23
Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations.
(Molecular psychiatry) Toma C … International Molecular Genetic Study of Autism Consortium (17957233) 		Publication 49 Protein 4 Gene 3 2007 19
Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder.
(Journal of pineal research) Gałecki P … Karbownik-Lewińska M (20433639) 		Gene 38 3 21* 2010 24
A novel signature predicts recurrence risk and therapeutic response in breast cancer patients.
(International journal of cancer) Tran QH … Nguyen MN (33586202) 		Publication 49 Gene 3 2021 2

Products for ASMT Gene

  • Sino Biological Clones for ASMT

Sources for ASMT Gene