Aliases for ASMT Gene
External Ids for ASMT Gene
Previous GeneCards Identifiers for ASMT Gene
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
GeneCards Summary for ASMT Gene
ASMT (Acetylserotonin O-Methyltransferase) is a Protein Coding gene. Diseases associated with ASMT include Pineoblastoma and Retinoblastoma. Among its related pathways are Tryptophan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and methyltransferase activity. An important paralog of this gene is ASMTL.
UniProtKB/Swiss-Prot Summary for ASMT Gene
Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.