Aliases for ASIP Gene
Aliases for ASIP Gene
External Ids for ASIP Gene
- HGNC: 745
- Entrez Gene: 434
- Ensembl: ENSG00000101440
- OMIM: 600201
- UniProtKB: P42127
Previous HGNC Symbols for ASIP Gene
- AGTIL
Previous GeneCards Identifiers for ASIP Gene
- GC20P032606
- GC20P033516
- GC20P033563
- GC20P032312
- GC20P032848
- GC20P029629
- GC20P032783
- GC20P032785
- GC20P032790
Summaries for ASIP Gene
-
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
GeneCards Summary for ASIP Gene
ASIP (Agouti Signaling Protein) is a Protein Coding gene. Diseases associated with ASIP include Skin/Hair/Eye Pigmentation, Variation In, 9 and Melanoma, Cutaneous Malignant 1. Among its related pathways are Adipogenesis and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and type 4 melanocortin receptor binding.
UniProtKB/Swiss-Prot for ASIP Gene
-
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Additional gene information for ASIP Gene
- Monarch Initiative
- Search for ASIP at DataMed
- Search for ASIP at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASIP Gene
Genomics for ASIP Gene
GeneHancer (GH) Regulatory Elements for ASIP Gene
Promoters and enhancers for ASIP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ASIP on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ASIP Gene
Genomic Locations for ASIP Gene
- chr20:34,186,493-34,269,344
- (GRCh38/hg38)
- Size:
- 82,852 bases
- Orientation:
- Plus strand
- chr20:32,782,375-32,857,150
- (GRCh37/hg19)
Genomic View for ASIP Gene
Genes around ASIP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.22 by Entrez Gene
- 20q11.22 by HGNC
- 20q11.22 by Ensembl
ASIP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASIP Gene
Proteins for ASIP Gene
-
Protein details for ASIP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P42127-ASIP_HUMAN
- Recommended name:
- Agouti-signaling protein
- Protein Accession:
- P42127
- Q3SXL2
Protein attributes for ASIP Gene
- Size:
- 132 amino acids
- Molecular mass:
- 14515 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for ASIP Gene
Other Protein References for ASIP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ASIP
- Invitrogen Antibodies for ASIP
- Search GeneTex for Antibodies for ASIP
Protein Products
- R&D Systems Proteins and Enzymes for ASIP
-
OriGene Purified Proteins for ASIP
- Search Origene for MassSpec and Protein Over-expression Lysates for ASIP
- Origene Custom Protein Services for ASIP
- Search GeneTex for Proteins for ASIP
Assay Products
No data available for DME Specific Peptides for ASIP Gene
Domains & Families for ASIP Gene
Gene Families for ASIP Gene
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for ASIP Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASIP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P42127UniProtKB/Swiss-Prot:
ASIP_HUMAN :- The presence of a disulfide through disulfide knot structurally defines this protein as a knottin.
- Domain:
-
- The presence of a disulfide through disulfide knot structurally defines this protein as a knottin.
Function for ASIP Gene
Molecular function for ASIP Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
- GENATLAS Biochemistry:
- murine agouti (A) signaling protein,homolog,also antagonizing MC4R,predominantly expressed in skin,testis,ovary,heart,melanocortin receptor (MC1R) antagonist
Phenotypes From GWAS Catalog for ASIP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | TAS | 7757071 |
| GO:0031779 | melanocortin receptor binding | IEA | -- |
| GO:0031781 | type 3 melanocortin receptor binding | IEA | -- |
| GO:0031782 | type 4 melanocortin receptor binding | IEA | -- |
Phenotypes for ASIP Gene
- MGI mutant phenotypes for ASIP:
-
inferred from 85 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- pigmentation phenotype
- vision/eye phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for ASIP:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASIP
-
CRISPR Products
-
OriGene CRISPR knockouts for ASIP
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- genomics-online: gRNA clones - Search results for available ASIP gene related products
- Applied Biological Materials CRISPR for ASIP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASIP
- GenScript: Design CRISPR guide RNA sequences for ASIP
miRNA for ASIP Gene
- miRTarBase miRNAs that target ASIP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ASIP
- Browse OriGene Inhibitory RNA Products For ASIP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASIP
- genomics-online: shRNA clones - Search results for available ASIP gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ASIP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASIP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ASIP
- genomics-online: cdna clones - Search results for available ASIP gene related products
- orf clones - Search results for available ASIP gene related products
- Applied Biological Materials Clones for ASIP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ASIP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASIP Gene
Localization for ASIP Gene
Subcellular locations from UniProtKB/Swiss-Prot for ASIP Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | TAS | 7937887 |
| GO:0005622 | intracellular | IEA | -- |
Pathways & Interactions for ASIP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Aldosterone synthesis and secretion |
.41
|
|
| 2 | Adipogenesis | ||
| 3 | Insulin-mediated glucose transport | ||
Pathways by source for ASIP Gene
2 BioSystems pathways for ASIP Gene
1 KEGG pathway for ASIP Gene
Interacting Proteins for ASIP Gene
GPS-Prot Interaction Network for ASIP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006091 | generation of precursor metabolites and energy | TAS,IEA | -- |
| GO:0007165 | signal transduction | TAS | 7757071 |
| GO:0007267 | cell-cell signaling | TAS | 7757071 |
| GO:0008343 | adult feeding behavior | IEA | -- |
| GO:0009755 | hormone-mediated signaling pathway | IEA | -- |
Drugs & Compounds for ASIP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cyclic amp | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for ASIP Gene
mRNA/cDNA for ASIP Gene
- (8) Selected AceView cDNA sequences:
- (4) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000374954 586 bps (uc002xah.2)
- ENST00000568305 610 bps (uc061wig.1)
Unigene Clusters for ASIP Gene
CRISPR Products
-
OriGene CRISPR knockouts for ASIP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ASIP
- genomics-online: gRNA clones - Search results for available ASIP gene related products
- Applied Biological Materials CRISPR for ASIP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASIP
- GenScript: Design CRISPR guide RNA sequences for ASIP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ASIP
- Browse OriGene Inhibitory RNA Products For ASIP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASIP
- genomics-online: shRNA clones - Search results for available ASIP gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ASIP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASIP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ASIP
- genomics-online: cdna clones - Search results for available ASIP gene related products
- orf clones - Search results for available ASIP gene related products
- Applied Biological Materials Clones for ASIP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ASIP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ASIP Gene
This gene is overexpressed in Ovary (x19.0) and Heart - Left Ventricle (x9.3).
NURSA nuclear receptor signaling pathways regulating expression of ASIP Gene:
ASIPSOURCE GeneReport for Unigene cluster for ASIP Gene:
Hs.659995mRNA Expression by UniProt/SwissProt for ASIP Gene:
P42127-ASIP_HUMAN
Tissue specificity:
Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.
Evidence on tissue expression from TISSUES for ASIP Gene
- Skin(2.3)
Primer Products
-
OriGene qPCR primer pairs for ASIP
- genomics-online: primer clones - Search results for available ASIP gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASIP Gene
Orthologs for ASIP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ASIP 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ASIP 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ASIP 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | a 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Asip 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ASIP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ASIP 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | asip 34 |
|
OneToOne |
- Species where no ortholog for ASIP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ASIP Gene
- ENSEMBL:
- Gene Tree for ASIP (if available)
- TreeFam:
- Gene Tree for ASIP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ASIP: view image
Paralogs for ASIP Gene
No data available for Paralogs for ASIP Gene
Variants for ASIP Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for ASIP Gene
- ASIP_HUMAN-P42127
- Genetic variants in ASIP define the skin/hair/eye pigmentation variation locus 9 (SHEP9) [MIM:611742]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair.
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs6058017 | association, Skin/hair/eye pigmentation, variation in, 9 | 34,269,192(+) | A/G | 3_prime_UTR_variant | |
| rs1000030908 | -- | 34,199,384(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000123331 | -- | 34,269,080(+) | A/C/G | coding_sequence_variant, synonymous_variant | |
| rs1000165443 | -- | 34,188,351(+) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000184697 | -- | 34,244,051(+) | T/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1059756 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.79;
16.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ASIP Gene
SNP Genotyping and Copy Number Assay Products
Disorders for ASIP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| skin/hair/eye pigmentation, variation in, 9 |
|
|
| melanoma, cutaneous malignant 1 |
|
|
| body mass index quantitative trait locus 11 |
|
Search ASIP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ASIP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ASIP Gene
Publications for ASIP Gene
- A polymorphism in the agouti signaling protein gene is associated with human pigmentation. (PMID: 11833005) Kanetsky PA … Rebbeck TR (American journal of human genetics 2002) 3 4 22 44 58
- Structure and function of ASP, the human homolog of the mouse agouti gene. (PMID: 7757071) Wilson BD … Barsh GS (Human molecular genetics 1995) 2 3 4 22 58
- Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma. (PMID: 19710684) Duffy DL … Montgomery GW (The Journal of investigative dermatology 2010) 3 22 44 58
- Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. (PMID: 19384953) Nan H … Han J (International journal of cancer 2009) 3 22 44 58
- The contribution of melanocortin 1 receptor gene polymorphisms and the agouti signalling protein gene 8818A>G polymorphism to cutaneous melanoma and basal cell carcinoma in a Polish population. (PMID: 18637131) Brudnik U … Kanas P (Experimental dermatology 2009) 3 22 44 58
Products for ASIP Gene
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- Browse R&D Systems for biochemical assays
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- Novus Biologicals proteins and lysates for ASIP
- Novus Biologicals
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- Browse Antibodies
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- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for ASIP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASIP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 21 available ASIP Antibodies ranked by validation data
- Compare Top ASIP Antibodies
- antibodies-online: Search results for 10 available ASIP Elisa Kits ranked by validation data
- Compare Top ASIP Elisa Kits
- antibodies-online: Search results for 27 available ASIP Proteins ranked by validation data
- Compare Top ASIP Proteins
- Search GeneTex for Antibodies for ASIP
- Search GeneTex for Proteins for ASIP
- Horizon Cell Lines for ASIP
- genomics-online: cdna clones - Search results for available ASIP gene related products
- orf clones - Search results for available ASIP gene related products
- genomics-online: gRNA clones - Search results for available ASIP gene related products
- genomics-online: primer clones - Search results for available ASIP gene related products
- genomics-online: shRNA clones - Search results for available ASIP gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ASIP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ASIP
- GeneCopoeia miRNA 3'UTR Target clone products for ASIP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASIP
Sources for ASIP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
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