Aliases for ASIP Gene
External Ids for ASIP Gene
Previous HGNC Symbols for ASIP Gene
Previous GeneCards Identifiers for ASIP Gene
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
GeneCards Summary for ASIP Gene
ASIP (Agouti Signaling Protein) is a Protein Coding gene. Diseases associated with ASIP include Skin/Hair/Eye Pigmentation, Variation In, 9 and Skin Carcinoma. Among its related pathways are Insulin-mediated glucose transport and Adipogenesis. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and type 4 melanocortin receptor binding. An important paralog of this gene is AGRP.
UniProtKB/Swiss-Prot Summary for ASIP Gene
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.