Aliases for ASIC4 Gene
External Ids for ASIC4 Gene
Previous HGNC Symbols for ASIC4 Gene
Previous GeneCards Identifiers for ASIC4 Gene
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]
GeneCards Summary for ASIC4 Gene
ASIC4 (Acid Sensing Ion Channel Subunit Family Member 4) is a Protein Coding gene. Diseases associated with ASIC4 include Branchiootic Syndrome. Among its related pathways are Ion channel transport and Development Endothelin-1/EDNRA signaling. Gene Ontology (GO) annotations related to this gene include ion channel activity and sodium ion transmembrane transporter activity. An important paralog of this gene is ASIC1.
UniProtKB/Swiss-Prot for ASIC4 Gene
Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity.
Acid-sensing ion channels (ASIC) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels and are widely expressed in neurons of the central and peripheral nervous system.