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This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
ASGR2 (Asialoglycoprotein Receptor 2) is a Protein Coding gene. Diseases associated with ASGR2 include Hepatitis and Autoimmune Hepatitis. Among its related pathways are Transport to the Golgi and subsequent modification and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and asialoglycoprotein receptor activity. An important paralog of this gene is ASGR1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004873 | asialoglycoprotein receptor activity | TAS | 3863106 |
GO:0005515 | protein binding | IPI | 11408579 |
GO:0030246 | carbohydrate binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0044322 | endoplasmic reticulum quality control compartment | IDA | 11408579 |
GO:0048471 | perinuclear region of cytoplasm | IDA | 11408579 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of proteins | ||
2 | Aldosterone synthesis and secretion | ||
3 | Transport to the Golgi and subsequent modification |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006897 | endocytosis | IEA | -- |
GO:0007166 | cell surface receptor signaling pathway | TAS | 3863106 |
GO:0009100 | glycoprotein metabolic process | IEA | -- |
GO:0016032 | viral process | IEA | -- |
GO:0018279 | protein N-linked glycosylation via asparagine | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ASGR2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ASGR2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ASGR2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Asgr2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Asgr2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-283g2.2 31 |
|
ManyToMany | |
si:ch73-361h17.1 31 |
|
ManyToMany | |||
si:ch211-283g2.3 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2422288 | CNV | deletion | 17116639 |
esv2665200 | CNV | deletion | 23128226 |
esv3639859 | CNV | loss | 21293372 |
esv3639860 | CNV | gain | 21293372 |
nsv1071366 | CNV | deletion | 25765185 |
nsv1131297 | CNV | deletion | 24896259 |
nsv1138495 | CNV | deletion | 24896259 |
nsv457659 | CNV | loss | 19166990 |
nsv574322 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatitis |
|
|
autoimmune hepatitis |
|
|
hepatitis b |
|
|
hepatitis e |
|
|