Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multipl... See more...
Aliases for ASGR2 Gene
Aliases for ASGR2 Gene
External Ids for ASGR2 Gene
- HGNC: 743
- NCBI Entrez Gene: 433
- Ensembl: ENSG00000161944
- OMIM®: 108361
- UniProtKB/Swiss-Prot: P07307
Previous GeneCards Identifiers for ASGR2 Gene
- GC17M007393
- GC17M007735
- GC17M006949
- GC17M007205
- GC17M006945
- GC17M007004
- GC17M006898
Summaries for ASGR2 Gene
-
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for ASGR2 Gene
ASGR2 (Asialoglycoprotein Receptor 2) is a Protein Coding gene. Diseases associated with ASGR2 include Hepatitis and Autoimmune Hepatitis. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and asialoglycoprotein receptor activity. An important paralog of this gene is ASGR1.
UniProtKB/Swiss-Prot Summary for ASGR2 Gene
-
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Additional gene information for ASGR2 Gene
- HGNC (743)
- NCBI Entrez Gene (433)
- Ensembl (ENSG00000161944)
- OMIM® (108361)
- UniProtKB/Swiss-Prot (P07307)
- Open Targets Platform(ENSG00000161944)
- Search for ASGR2 at DataMed
- Search for ASGR2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ASGR2 Gene
Genomics for ASGR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ASGR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ASGR2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ASGR2
- Top Transcription factor binding sites by QIAGEN in the ASGR2 gene promoter:
-
- COUP
- COUP-TF
- COUP-TF1
- HNF-4alpha1
- Nkx2-5
Genomic Locations for ASGR2 Gene
Latest Assembly
- chr17:7,101,322-7,115,700
- (GRCh38/hg38)
- Size:
- 14,379 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:7,004,641-7,018,130
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 13,490 bases
- Orientation:
- Minus strand
- chr17:7,004,641-7,019,019
- (GRCh37/hg19 by Ensembl)
- Size:
- 14,379 bases
- Orientation:
- Minus strand
Genomic View for ASGR2 Gene
Genes around ASGR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by HGNC
- 17p13.1 by Entrez Gene
- 17p13.1 by Ensembl
ASGR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASGR2 Gene
Proteins for ASGR2 Gene
-
Protein details for ASGR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07307-ASGR2_HUMAN
- Recommended name:
- Asialoglycoprotein receptor 2
- Protein Accession:
- P07307
- A6NLV8
- A8MT12
- D3DTM9
- D3DTN0
- O00448
- Q03969
Protein attributes for ASGR2 Gene
- Size:
- 311 amino acids
- Molecular mass:
- 35092 Da
- Quaternary structure:
-
- The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2.
- (Microbial infection) Interacts with hepatitis E virus capsid protein ORF2.
- Miscellaneous:
-
- Calcium is required for ligand binding.
Protein Expression for ASGR2 Gene
Post-translational modifications for ASGR2 Gene
Other Protein References for ASGR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for ASGR2
- Invitrogen Antibodies for ASGR2 (AFLGC-ASGR2)
-
Biorbyt antibodies for ASGR2
-
Boster Bio Antibodies for ASGR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ASGR2
- Sino Biological Antibodies for ASGR2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for ASGR2
- Origene Custom Protein Services for ASGR2
- Sino Biological Recombinant Proteins for ASGR2
- Sino Biological Cell Lysates for ASGR2
- ProSpec Recombinant Proteins for ASGR2
-
Abcam proteins for ASGR2
Assay products for research
- RayBiotech Custom Human ASGP-R 2/ASGR2 ELISA
- Novus Biologicals ELISA Kits for ASGR2
No data available for DME Specific Peptides for ASGR2 Gene
Domains & Families for ASGR2 Gene
Gene Families for ASGR2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ASGR2 Gene
- InterPro:
- Blocks:
-
- Type II antifreeze protein signature
- Hepatic lectin, N-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for ASGR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Hepatic lectin H2 (ASGR2_HUMAN)
- cDNA FLJ60040, highly similar to Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant 2, mRNA (B4E1D2_HUMAN)
- Asialoglycoprotein receptor 2, isoform CRA_a (D3DTN0_HUMAN)
- HBxAg-binding protein (Q7Z4G9_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ASGR2 Gene
Function for ASGR2 Gene
Molecular function for ASGR2 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Phenotypes From GWAS Catalog for ASGR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004873 | asialoglycoprotein receptor activity | TAS | 3863106 |
| GO:0005515 | protein binding | IPI | 11408579 |
| GO:0030246 | carbohydrate binding | IEA | -- |
Phenotypes for ASGR2 Gene
- MGI mutant phenotypes for ASGR2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ASGR2:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability
- Decreased viability in pancreas lineage
- Inconclusive
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased HPV16-GFP infection
- Decreased Salmonella proliferation
- Decreased epidermal growth factor (EGF) endocytosis
Animal Models for ASGR2 Gene
- MGI Knock Outs for ASGR2:
-
- Asgr2 Asgr2<tm1Her>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ASGR2 - Starting at $85 >
- * ASGR2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ASGR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ASGR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASGR2
miRNA for ASGR2 Gene
- miRTarBase miRNAs that target ASGR2
-
- hsa-miR-2467-3p (MIRT488736)
- hsa-miR-3197 (MIRT488737)
- hsa-miR-4673 (MIRT488738)
- hsa-miR-6847-5p (MIRT488739)
- hsa-miR-4645-5p (MIRT488740)
- hsa-miR-6511a-5p (MIRT488741)
- hsa-miR-1910-3p (MIRT488742)
- hsa-miR-4695-5p (MIRT488743)
- hsa-miR-527 (MIRT504321)
- hsa-miR-518a-5p (MIRT504322)
- hsa-miR-548aw (MIRT504323)
- hsa-miR-137 (MIRT504324)
- hsa-miR-4468 (MIRT504325)
- hsa-miR-92b-3p (MIRT504326)
- hsa-miR-92a-3p (MIRT504327)
- hsa-miR-367-3p (MIRT504328)
- hsa-miR-363-3p (MIRT504329)
- hsa-miR-32-5p (MIRT504330)
- hsa-miR-25-3p (MIRT504331)
- hsa-miR-6838-5p (MIRT504332)
- hsa-miR-497-5p (MIRT504333)
- hsa-miR-424-5p (MIRT504334)
- hsa-miR-195-5p (MIRT504335)
- hsa-miR-16-5p (MIRT504336)
- hsa-miR-15b-5p (MIRT504337)
- hsa-miR-15a-5p (MIRT504338)
- hsa-miR-451b (MIRT504339)
- hsa-miR-5586-3p (MIRT504340)
- hsa-miR-3133 (MIRT504341)
- hsa-miR-1276 (MIRT504342)
- hsa-miR-4514 (MIRT569489)
- hsa-miR-4692 (MIRT569490)
- hsa-miR-632 (MIRT646682)
- hsa-miR-4288 (MIRT646683)
- hsa-miR-6828-3p (MIRT646684)
- hsa-miR-346 (MIRT646685)
- hsa-miR-3120-5p (MIRT646686)
- hsa-miR-767-3p (MIRT646687)
- hsa-miR-5695 (MIRT646688)
- hsa-miR-6769a-3p (MIRT646689)
- hsa-miR-1294 (MIRT737168)
- hsa-miR-4316 (MIRT743990)
- hsa-miR-4446-3p (MIRT744605)
- hsa-miR-4675 (MIRT746874)
- hsa-miR-4677-3p (MIRT746903)
- hsa-miR-4721 (MIRT747544)
- hsa-miR-4741 (MIRT748111)
- hsa-miR-7974 (MIRT759974)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ASGR2
- Browse OriGene Inhibitory RNA Products For ASGR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASGR2
Clone products for research
- Applied Biological Materials (abm): Clones for ASGR2 - Starting at $45 >
- * ASGR2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204202
- MR204202
- MR204202L3
- MR204202L4
- RC205695
- RC205695L1
- RC205695L2
- RC205695L3
- RC205695L4
- RC213607
- RC213607L1
- RC213607L2
- RC213607L3
- RC213607L4
- RC217541
- RC217541L1
- RC217541L2
- RC217541L3
- RC217541L4
- RC218606
- RC218606L3
- RC218606L4
- RC232441
- RG205695
- RG213607
- RG217541
- RG218606
- RG232441
- RR215219
- RR215219L3
- RR215219L4
- MR204202L3V
- MR204202L4V
- RC205695L1V
- RC205695L2V
- RC205695L3V
- RC205695L4V
- RC213607L1V
- RC213607L2V
- RC213607L3V
- RC213607L4V
- RC217541L1V
- RC217541L2V
- RC217541L3V
- RC217541L4V
- RC218606L3V
- RC218606L4V
- RR215219L3V
- RR215219L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ASGR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ASGR2
Cell Lines for research
-
Horizon Cell Lines for ASGR2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASGR2 Gene
Localization for ASGR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ASGR2 Gene
- Membrane. Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 5 |
| extracellular | 2 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0044322 | endoplasmic reticulum quality control compartment | IDA | 11408579 |
| GO:0048471 | perinuclear region of cytoplasm | IDA | 11408579 |
Pathways & Interactions for ASGR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of proteins | ||
| 2 | Aldosterone synthesis and secretion | ||
| 3 | Transport to the Golgi and subsequent modification | ||
Pathways by source for ASGR2 Gene
3 Reactome pathways for ASGR2 Gene
1 KEGG pathway for ASGR2 Gene
Interacting Proteins for ASGR2 Gene
Selected Interacting proteins:
P07307-ASGR2_HUMAN
ENSP00000347140
for ASGR2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ASGR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006897 | endocytosis | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | TAS | 3863106 |
| GO:0009100 | glycoprotein metabolic process | IEA | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0018279 | protein N-linked glycosylation via asparagine | TAS | -- |
No data available for SIGNOR curated interactions for ASGR2 Gene
Drugs & Compounds for ASGR2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for ASGR2 Gene
mRNA/cDNA for ASGR2 Gene
- 5 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000254850 1396 nts (view in UCSC)
- ENST00000355035 1386 nts (view in UCSC)
- ENST00000446679 879 nts (view in UCSC)
- ENST00000450034 932 nts (view in UCSC)
- ENST00000574868 1202 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ASGR2 - Starting at $85 >
- * ASGR2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ASGR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ASGR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASGR2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ASGR2
- Browse OriGene Inhibitory RNA Products For ASGR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASGR2
Clone products for research
- Applied Biological Materials (abm): Clones for ASGR2 - Starting at $45 >
- * ASGR2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204202
- MR204202
- MR204202L3
- MR204202L4
- RC205695
- RC205695L1
- RC205695L2
- RC205695L3
- RC205695L4
- RC213607
- RC213607L1
- RC213607L2
- RC213607L3
- RC213607L4
- RC217541
- RC217541L1
- RC217541L2
- RC217541L3
- RC217541L4
- RC218606
- RC218606L3
- RC218606L4
- RC232441
- RG205695
- RG213607
- RG217541
- RG218606
- RG232441
- RR215219
- RR215219L3
- RR215219L4
- MR204202L3V
- MR204202L4V
- RC205695L1V
- RC205695L2V
- RC205695L3V
- RC205695L4V
- RC213607L1V
- RC213607L2V
- RC213607L3V
- RC213607L4V
- RC217541L1V
- RC217541L2V
- RC217541L3V
- RC217541L4V
- RC218606L3V
- RC218606L4V
- RR215219L3V
- RR215219L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ASGR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ASGR2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: |
Relevant External Links for ASGR2 Gene
- GeneLoc Exon Structure for
- ASGR2
Expression for ASGR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for ASGR2 Gene
This gene is overexpressed in Liver (x46.7).
This gene is overexpressed in Serum (33.7), Plasma (14.8), and Fetal Liver (11.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ASGR2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ASGR2
SOURCE GeneReport for Unigene cluster for ASGR2 Gene:
Hs.654440mRNA Expression by UniProt/SwissProt for ASGR2 Gene:
P07307-ASGR2_HUMAN
Tissue specificity:
Expressed exclusively in hepatic parenchymal cells.
Evidence on tissue expression from TISSUES for ASGR2 Gene
- Liver(4.7)
- Bone marrow(4.2)
Primer products for research
-
OriGene qPCR primer pairs for ASGR2
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ASGR2 Gene
Orthologs for ASGR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ASGR2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ASGR2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ASGR2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Asgr2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Asgr2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-283g2.2 31 |
|
ManyToMany | |
| si:ch73-361h17.1 31 |
|
ManyToMany | |||
| si:ch211-283g2.3 31 |
|
ManyToMany |
- Species where no ortholog for ASGR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ASGR2 Gene
- ENSEMBL:
- Gene Tree for ASGR2 (if available)
- TreeFam:
- Gene Tree for ASGR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ASGR2: view image
Paralogs for ASGR2 Gene
Paralogs for ASGR2 Gene
(10) SIMAP similar genes for ASGR2 Gene using alignment to 2 proteins:
- ASGR2_HUMAN
- I3L1H2_HUMAN
Variants for ASGR2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ASGR2 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs140278403 | Benign: not provided | 7,101,587(-) |
G/A NM_080912.3(ASGR2):c.924C>T (p.Gly308=) |
SYNONYMOUS | |
| rs143467270 | Benign: not provided | 7,101,590(-) |
G/A NM_080912.3(ASGR2):c.921C>T (p.Thr307=) |
SYNONYMOUS | |
| rs2304978 | - |
p.Gly85Arg |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422288 | CNV | deletion | 17116639 |
| esv2665200 | CNV | deletion | 23128226 |
| esv3639859 | CNV | loss | 21293372 |
| esv3639860 | CNV | gain | 21293372 |
| nsv1071366 | CNV | deletion | 25765185 |
| nsv1131297 | CNV | deletion | 24896259 |
| nsv1138495 | CNV | deletion | 24896259 |
| nsv457659 | CNV | loss | 19166990 |
| nsv574322 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.83;
79.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ASGR2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ASGR2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASGR2 Gene
Disorders for ASGR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatitis |
|
|
| autoimmune hepatitis |
|
|
| hepatitis b |
|
|
| liver cirrhosis |
|
|
| primary biliary cholangitis |
|
|
Search ASGR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ASGR2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ASGR2 Gene
Publications for ASGR2 Gene
- Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution. (PMID: 3863106) Spiess M … Lodish HF (Proceedings of the National Academy of Sciences of the United States of America 1985) 2 3 4
- Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2. (PMID: 27155063) Zhang L … Wang Y (Journal of medical virology 2016) 3 4
- An internalizing antibody specific for the human asialoglycoprotein receptor. (PMID: 19663694) Trahtenherts A … Benhar I (Hybridoma (2005) 2009) 3 23
- Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA--revival of a disease-activity marker in autoimmune hepatitis. (PMID: 19576873) Hausdorf G … Klein R (Clinica chimica acta; international journal of clinical chemistry 2009) 3 23
- Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. (PMID: 18855599) Li Y … Wiebe LI (Current drug delivery 2008) 3 23
ExternalLinks
Products for ASGR2 Gene
- View all 10 R&D Systems ASGR2 (ASGR2) Products
- View all R&D Systems ASGR2 (ASGR2) Proteins and Enzymes
- View all 8 R&D Systems ASGR2 (ASGR2) Primary Antibodies
- View all R&D Systems ASGR2 (ASGR2) cDNA Clones
- Learn more about R&D Systems custom ASGR2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for ASGR2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ASGR2
- Origene Custom Protein Services for ASGR2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ASGR2
- Browse OriGene Inhibitory RNA Products For ASGR2
- OriGene qPCR primer pairs for ASGR2
- OriGene CRISPR knockouts for ASGR2
- MG204202
- MR204202
- MR204202L3
- MR204202L4
- RC205695
- RC205695L1
- RC205695L2
- RC205695L3
- RC205695L4
- RC213607
- RC213607L1
- RC213607L2
- RC213607L3
- RC213607L4
- RC217541
- RC217541L1
- RC217541L2
- RC217541L3
- RC217541L4
- RC218606
- RC218606L3
- RC218606L4
- RC232441
- RG205695
- RG213607
- RG217541
- RG218606
- RG232441
- RR215219
- RR215219L3
- RR215219L4
- MR204202L3V
- MR204202L4V
- RC205695L1V
- RC205695L2V
- RC205695L3V
- RC205695L4V
- RC213607L1V
- RC213607L2V
- RC213607L3V
- RC213607L4V
- RC217541L1V
- RC217541L2V
- RC217541L3V
- RC217541L4V
- RC218606L3V
- RC218606L4V
- RR215219L3V
- RR215219L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ASGR2
- Sino Biological Human cDNA Clone for ASGR2
- Sino Biological Recombinant Proteins for ASGR2
- Sino Biological Cell Lysates for ASGR2
- Sino Biological Antibodies for ASGR2
- Browse Sino Biological Assays
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ASGR2
- Novus Biologicals proteins and lysates for ASGR2
- Novus Biologicals ELISA Kits for ASGR2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for ASGR2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for ASGR2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ASGR2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ASGR2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ASGR2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ASGR2
- antibodies-online: Show 14 available Asialoglycoprotein Receptor 2 Antibodies ranked by validation data
- Compare Top Asialoglycoprotein Receptor 2 Antibodies
- antibodies-online: Show 26 available Asialoglycoprotein Receptor 2 Elisa Kits ranked by validation data
- Compare Top Asialoglycoprotein Receptor 2 Elisa Kits
- antibodies-online: Show 12 available Asialoglycoprotein Receptor 2 Proteins ranked by validation data
- Compare Top Asialoglycoprotein Receptor 2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ASGR2
- Search Santa Cruz Biotechnology (SCBT) for ASGR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ASGR2
- Horizon Cell Lines for ASGR2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ASGR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ASGR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ASGR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASGR2
- Boster Bio Antibodies for ASGR2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for ASGR2
Sources for ASGR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB