This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multipl... See more...

Aliases for ASGR1 Gene

Aliases for ASGR1 Gene

  • Asialoglycoprotein Receptor 1 2 3 4 5
  • CLEC4H1 2 3 4
  • C-Type Lectin Domain Family 4 Member H1 3 4
  • Hepatic Lectin H1 3 4
  • HL-1 3 4
  • ASGP-R 1 4
  • ASGPR 1 4
  • ASGPR1 3
  • ASGPR 3
  • ASGR1 5

External Ids for ASGR1 Gene

Previous GeneCards Identifiers for ASGR1 Gene

  • GC17M007468
  • GC17P007746
  • GC17M007020
  • GC17M007277
  • GC17M007017
  • GC17M006970

Summaries for ASGR1 Gene

Entrez Gene Summary for ASGR1 Gene

  • This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASGR1 Gene

ASGR1 (Asialoglycoprotein Receptor 1) is a Protein Coding gene. Diseases associated with ASGR1 include Hepatitis and Hepatitis B. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and asialoglycoprotein receptor activity. An important paralog of this gene is ASGR2.

UniProtKB/Swiss-Prot Summary for ASGR1 Gene

  • Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ASGR1 Gene

Genomics for ASGR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ASGR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007179 Promoter 0.9 EPDnew 250.7 +0.2 174 0.1 CHD2 FOXA2 SAP130 RXRA KMT2B DMAP1 ZBTB33 TBP KAT7 CREM ASGR1 lnc-DLG4-2 ASGR2
GH17J006710 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 29.6 +467.1 467060 3.8 CEBPA PLRG1 FOXA1 CTCF HOMEZ THAP11 SMAD4 SAP130 NBN RXRA SLC13A5 HSALNG0114214 DVL2 ASGR1 SNORD10 WRAP53 SNORA48 POLR2A ASGR2 MIR324
GH17J007130 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +47.4 47372 3.9 SP1 BCL11A NR2C1 IKZF1 THAP11 CTCF IRF4 SMAD4 SAP130 RXRA LOC105371512 piR-31655-002 CLEC10A SLC16A11 ASGR1 BCL6B EIF5A RPL7AP64 TRAPPC1 CD68
GH17J007144 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 11.6 +33.8 33763 3.2 ZNF341 RARA RFX1 ZNF384 ZNF121 piR-55985-073 ASGR2 SLC16A11 ASGR1 CLEC10A CLDN7 ENSG00000202251 DVL2 PHF23 GABARAP
GH17J007176 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 5.6 +2.1 2063 2.6 ZBTB10 MXD4 CTCF ZBTB7B ZIC2 SIN3A ZNF740 ZNF521 VEZF1 TRIM22 lnc-DLG4-2 DVL2 CNTROB WRAP53 POLR2A CYB5D1 SNORD10 SNORA48 MIR324 ELP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ASGR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ASGR1

Top Transcription factor binding sites by QIAGEN in the ASGR1 gene promoter:
  • ARP-1
  • ATF
  • c-Myb
  • HSF1 (long)
  • HSF1short
  • Pax-6
  • SREBP-1a
  • ZID

Genomic Locations for ASGR1 Gene

Latest Assembly
chr17:7,173,431-7,179,564
(GRCh38/hg38)
Size:
6,134 bases
Orientation:
Minus strand

Previous Assembly
chr17:7,076,750-7,082,689
(GRCh37/hg19 by Entrez Gene)
Size:
5,940 bases
Orientation:
Minus strand

chr17:7,076,750-7,082,883
(GRCh37/hg19 by Ensembl)
Size:
6,134 bases
Orientation:
Minus strand

Genomic View for ASGR1 Gene

Genes around ASGR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASGR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASGR1 Gene

Proteins for ASGR1 Gene

  • Protein details for ASGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07306-ASGR1_HUMAN
    Recommended name:
    Asialoglycoprotein receptor 1
    Protein Accession:
    P07306
    Secondary Accessions:
    • I3L1X1

    Protein attributes for ASGR1 Gene

    Size:
    291 amino acids
    Molecular mass:
    33186 Da
    Quaternary structure:
    • Interacts with LASS2.
    • (Microbial infection) Interacts with hepatitis E virus capsid protein ORF2.
    Miscellaneous:
    • Calcium is required for ligand binding.

    Three dimensional structures from OCA and Proteopedia for ASGR1 Gene

    Alternative splice isoforms for ASGR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASGR1 Gene

Post-translational modifications for ASGR1 Gene

  • Phosphorylated on a cytoplasmic Ser residue.
  • Glycosylation at Asn79 and Asn147
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ASGR1 Gene

Domains & Families for ASGR1 Gene

Gene Families for ASGR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ASGR1 Gene

InterPro:
Blocks:
  • Type II antifreeze protein signature
  • Hepatic lectin, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for ASGR1 Gene

GenScript: Design optimal peptide antigens:
  • Hepatic lectin H1 (ASGR1_HUMAN)
  • Asialoglycoprotein receptor 1, isoform CRA_a (Q6FGQ5_HUMAN)
genes like me logo Genes that share domains with ASGR1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ASGR1 Gene

Function for ASGR1 Gene

Molecular function for ASGR1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
GENATLAS Biochemistry:
asialoglycoprotein receptor 1

Phenotypes From GWAS Catalog for ASGR1 Gene

Gene Ontology (GO) - Molecular Function for ASGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004873 asialoglycoprotein receptor activity TAS,IEA --
GO:0005515 protein binding IPI 21988832
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ASGR1: view
genes like me logo Genes that share phenotypes with ASGR1: view

Animal Models for ASGR1 Gene

MGI Knock Outs for ASGR1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASGR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASGR1 Gene

Localization for ASGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASGR1 Gene

[Isoform H1a]: Membrane. Single-pass type II membrane protein.
[Isoform H1b]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASGR1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ASGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10734069
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ASGR1: view

Pathways & Interactions for ASGR1 Gene

genes like me logo Genes that share pathways with ASGR1: view

Pathways by source for ASGR1 Gene

Gene Ontology (GO) - Biological Process for ASGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0016032 viral process IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0031668 cellular response to extracellular stimulus IEA --
genes like me logo Genes that share ontologies with ASGR1: view

No data available for SIGNOR curated interactions for ASGR1 Gene

Drugs & Compounds for ASGR1 Gene

(2) Drugs for ASGR1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6876
genes like me logo Genes that share compounds with ASGR1: view

Transcripts for ASGR1 Gene

mRNA/cDNA for ASGR1 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASGR1

Alternative Splicing Database (ASD) splice patterns (SP) for ASGR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5:
SP6: -

Relevant External Links for ASGR1 Gene

GeneLoc Exon Structure for
ASGR1

Expression for ASGR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ASGR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASGR1 Gene

This gene is overexpressed in Liver (x45.7).

Protein differential expression in normal tissues from HIPED for ASGR1 Gene

This gene is overexpressed in Liver (30.0), Fetal Liver (22.6), and Gallbladder (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASGR1 Gene



Protein tissue co-expression partners for ASGR1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ASGR1

SOURCE GeneReport for Unigene cluster for ASGR1 Gene:

Hs.12056

mRNA Expression by UniProt/SwissProt for ASGR1 Gene:

P07306-ASGR1_HUMAN
Tissue specificity: Expressed exclusively in hepatic parenchymal cells.

Evidence on tissue expression from TISSUES for ASGR1 Gene

  • Liver(4.8)
  • Blood(2.7)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with ASGR1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ASGR1 Gene

Orthologs for ASGR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASGR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ASGR1 30 31
  • 99.87 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ASGR1 30
  • 85.92 (n)
-- 31
  • 26 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia ASGR1 30 31
  • 84.93 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Asgr1 30 17 31
  • 81.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Asgr1 30
  • 81.69 (n)
Oppossum
(Monodelphis domestica)
Mammalia ASGR1 31
  • 58 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 39 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-283g2.2 31
  • 30 (a)
ManyToMany
si:ch73-361h17.1 31
  • 27 (a)
ManyToMany
si:ch211-283g2.3 31
  • 22 (a)
ManyToMany
Species where no ortholog for ASGR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ASGR1 Gene

ENSEMBL:
Gene Tree for ASGR1 (if available)
TreeFam:
Gene Tree for ASGR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ASGR1: view image

Paralogs for ASGR1 Gene

(15) SIMAP similar genes for ASGR1 Gene using alignment to 7 proteins:

  • ASGR1_HUMAN
  • I3L129_HUMAN
  • I3L1F8_HUMAN
  • I3L2S9_HUMAN
  • J3QSZ2_HUMAN
  • K7EPS5_HUMAN
  • Q6FGQ5_HUMAN
genes like me logo Genes that share paralogs with ASGR1: view

Variants for ASGR1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ASGR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ASGR1 Gene

Variant ID Type Subtype PubMed ID
dgv1683e59 CNV duplication 20981092
dgv1684e59 CNV duplication 20981092
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv28478 CNV loss 19812545
nsv1077836 CNV duplication 25765185
nsv1124750 CNV duplication 24896259
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for ASGR1 Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASGR1 Gene

Human Gene Mutation Database (HGMD)
ASGR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASGR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ASGR1 Gene

Disorders for ASGR1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ASGR1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hepatitis
  • acute and subacute liver necrosis
hepatitis b
  • chronic hepatitis b
acute gonococcal cervicitis
  • acute gonorrhea of cervix
acute cervicitis
amelogenesis imperfecta, type ib
  • ai1b
- elite association - COSMIC cancer census association via MalaCards
Search ASGR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ASGR1

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ASGR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ASGR1 Gene

Publications for ASGR1 Gene

  1. Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2. (PMID: 27155063) Zhang L … Wang Y (Journal of medical virology 2016) 3 4
  2. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers JC … Kooner JS (Nature genetics 2011) 3 41
  3. A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes. (PMID: 20886072) Liu J … Yang D (PloS one 2010) 3 4
  4. Potentiation of proliferation of some but not all human colon carcinoma cell lines by immobilized hepatic asialoglycoprotein receptor 1. (PMID: 19725223) Fang J … Irimura T (Oncology research 2009) 3 23
  5. Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. (PMID: 16475991) Yang J … Wang SQ (Journal of viral hepatitis 2006) 3 23

Products for ASGR1 Gene

Sources for ASGR1 Gene