Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASF1B Gene

Aliases for ASF1B Gene

  • Anti-Silencing Function 1B Histone Chaperone 2 3 5
  • Anti-Silencing Function Protein 1 Homolog B 3 4
  • CCG1-Interacting Factor A-II 3 4
  • HCIA-II 3 4
  • CIA-II 3 4
  • HAsf1b 3 4
  • HAsf1 3 4
  • ASF1 Anti-Silencing Function 1 Homolog B (S. Cerevisiae) 2
  • ASF1 Anti-Silencing Function 1 Homolog B 3
  • Histone Chaperone ASF1B 3

External Ids for ASF1B Gene

Previous GeneCards Identifiers for ASF1B Gene

  • GC19M014597
  • GC19M014075
  • GC19M014091
  • GC19M014230
  • GC19M013801

Summaries for ASF1B Gene

Entrez Gene Summary for ASF1B Gene

  • This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASF1B Gene

ASF1B (Anti-Silencing Function 1B Histone Chaperone) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include histone binding. An important paralog of this gene is ASF1A.

UniProtKB/Swiss-Prot for ASF1B Gene

  • Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis.

Gene Wiki entry for ASF1B Gene

Additional gene information for ASF1B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASF1B Gene

Genomics for ASF1B Gene

GeneHancer (GH) Regulatory Elements for ASF1B Gene

Promoters and enhancers for ASF1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014135 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 -1.1 -1128 5.5 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 ASF1B LOC100507373 DDX39A DCAF15 RFX1 CCDC130 PRKACA ZNF333 PALM3 PIR43598
GH19J014216 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.3 -80.4 -80373 1.5 HDGF SIN3A ZNF2 GTF3C2 ZNF121 ZNF213 ARID2 ZNF207 ZNF143 KLF13 CCDC130 DCAF15 DDX39A RFX1 MRI1 ZNF333 ZSWIM4 ASF1B ADGRL1 RN7SL231P
GH19J014111 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.3 +20.8 20822 9.3 HDGF PKNOX1 ARNT ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B YY1 ZNF766 PRKACA CCDC130 DDX39A TRMT1 DCAF15 ZNF333 LOC284454 RFX1 ADGRE5 PALM3
GH19J014126 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +8.9 8928 2.7 PKNOX1 SAP130 MLX EBF1 RARA YY1 POLR2A SCRT2 EED RUNX3 PRKACA ASF1B PIR34894
GH19J014134 Enhancer 0.4 Ensembl 0.7 +2.4 2355 0.8 PRDM10 ZBTB33 ASF1B PIR34894
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ASF1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ASF1B gene promoter:
  • TBP
  • CP2
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • Nkx2-5
  • GATA-3
  • STAT1beta
  • STAT1alpha

Genomic Locations for ASF1B Gene

Genomic Locations for ASF1B Gene
chr19:14,119,509-14,136,956
(GRCh38/hg38)
Size:
17,448 bases
Orientation:
Minus strand
chr19:14,230,321-14,247,768
(GRCh37/hg19)
Size:
17,448 bases
Orientation:
Minus strand

Genomic View for ASF1B Gene

Genes around ASF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASF1B Gene

Proteins for ASF1B Gene

  • Protein details for ASF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVP2-ASF1B_HUMAN
    Recommended name:
    Histone chaperone ASF1B
    Protein Accession:
    Q9NVP2
    Secondary Accessions:
    • Q53G51
    • Q9NVZ0

    Protein attributes for ASF1B Gene

    Size:
    202 amino acids
    Molecular mass:
    22434 Da
    Quaternary structure:
    • Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with HAT1, NASP, TAF1, TLK1 and TLK2. Interacts with CDAN1. Found in a cytosolic complex with CDAN1, ASF1A, IPO4 and histones H3.1 and H4. Interacts with CREBBP.

    Three dimensional structures from OCA and Proteopedia for ASF1B Gene

neXtProt entry for ASF1B Gene

Post-translational modifications for ASF1B Gene

Other Protein References for ASF1B Gene

No data available for DME Specific Peptides for ASF1B Gene

Domains & Families for ASF1B Gene

Gene Families for ASF1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ASF1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ASF1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVP2

UniProtKB/Swiss-Prot:

ASF1B_HUMAN :
  • Belongs to the ASF1 family.
Family:
  • Belongs to the ASF1 family.
genes like me logo Genes that share domains with ASF1B: view

Function for ASF1B Gene

Molecular function for ASF1B Gene

UniProtKB/Swiss-Prot Function:
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis.

Gene Ontology (GO) - Molecular Function for ASF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16980972
GO:0042393 histone binding IEA --
genes like me logo Genes that share ontologies with ASF1B: view
genes like me logo Genes that share phenotypes with ASF1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASF1B

Clone Products

  • Addgene plasmids for ASF1B

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASF1B Gene

Localization for ASF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASF1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASF1B gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ASF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 14718166
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0032991 protein-containing complex IDA 14718166
genes like me logo Genes that share ontologies with ASF1B: view

Pathways & Interactions for ASF1B Gene

genes like me logo Genes that share pathways with ASF1B: view

Pathways by source for ASF1B Gene

1 Cell Signaling Technology pathway for ASF1B Gene

Gene Ontology (GO) - Biological Process for ASF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006333 chromatin assembly or disassembly IEA --
GO:0006334 nucleosome assembly IEA --
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with ASF1B: view

No data available for SIGNOR curated interactions for ASF1B Gene

Drugs & Compounds for ASF1B Gene

No Compound Related Data Available

Transcripts for ASF1B Gene

mRNA/cDNA for ASF1B Gene

Unigene Clusters for ASF1B Gene

ASF1 anti-silencing function 1 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASF1B

Clone Products

  • Addgene plasmids for ASF1B

Alternative Splicing Database (ASD) splice patterns (SP) for ASF1B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - - -

Relevant External Links for ASF1B Gene

GeneLoc Exon Structure for
ASF1B
ECgene alternative splicing isoforms for
ASF1B

Expression for ASF1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASF1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASF1B Gene

This gene is overexpressed in Testis (x9.8) and Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for ASF1B Gene

This gene is overexpressed in Pancreas (33.0), Lung (14.7), Fetal Liver (6.5), and Ovary (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ASF1B Gene



NURSA nuclear receptor signaling pathways regulating expression of ASF1B Gene:

ASF1B

SOURCE GeneReport for Unigene cluster for ASF1B Gene:

Hs.26516

mRNA Expression by UniProt/SwissProt for ASF1B Gene:

Q9NVP2-ASF1B_HUMAN
Tissue specificity: Highly expressed in testis and at lower levels in colon, small intestine and thymus.
genes like me logo Genes that share expression patterns with ASF1B: view

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASF1B Gene

Orthologs for ASF1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASF1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASF1B 34 33
  • 99.17 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 95 (a)
OneToMany
ASF1B 33
  • 90.22 (n)
cow
(Bos Taurus)
Mammalia ASF1B 34 33
  • 90.92 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASF1B 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asf1b 16 34 33
  • 87.62 (n)
rat
(Rattus norvegicus)
Mammalia Asf1b 33
  • 86.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ASF1B 34
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASF1B 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4526 33
zebrafish
(Danio rerio)
Actinopterygii asf1bb 34
  • 77 (a)
OneToMany
asf1ba 34 34
  • 76 (a)
OneToMany
wufb20g03 33
fruit fly
(Drosophila melanogaster)
Insecta asf1 34
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea asfl-1 34
  • 35 (a)
ManyToMany
unc-85 34
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ASF1 36 34
  • 35 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9876 33
barley
(Hordeum vulgare)
Liliopsida Hv.2277 33
corn
(Zea mays)
Liliopsida Zm.13729 33
bread mold
(Neurospora crassa)
Ascomycetes NCU09436 33
  • 59.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToMany
Species where no ortholog for ASF1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ASF1B Gene

ENSEMBL:
Gene Tree for ASF1B (if available)
TreeFam:
Gene Tree for ASF1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ASF1B: view image

Paralogs for ASF1B Gene

Paralogs for ASF1B Gene

(1) SIMAP similar genes for ASF1B Gene using alignment to 5 proteins:

  • ASF1B_HUMAN
  • K7EIL9_HUMAN
  • K7ELW9_HUMAN
  • K7EM93_HUMAN
  • K7ES22_HUMAN
genes like me logo Genes that share paralogs with ASF1B: view

Variants for ASF1B Gene

Sequence variations from dbSNP and Humsavar for ASF1B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000082286 -- 14,136,940(-) T/C upstream_transcript_variant
rs1000478318 -- 14,126,449(-) T/C intron_variant
rs1000525362 -- 14,132,314(-) C/T intron_variant
rs1000632395 -- 14,137,350(-) C/T upstream_transcript_variant
rs1000746775 -- 14,137,449(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ASF1B Gene

Variant ID Type Subtype PubMed ID
dgv49n68 CNV loss 17160897
esv22154 CNV gain 19812545
esv2718213 CNV deletion 23290073
nsv517436 CNV loss 19592680
nsv578642 CNV gain 21841781
nsv578663 CNV loss 21841781
nsv828452 CNV loss 20364138
nsv833761 CNV loss 17160897
nsv953980 CNV deletion 24416366

Variation tolerance for ASF1B Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASF1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASF1B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASF1B Gene

Disorders for ASF1B Gene

Additional Disease Information for ASF1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ASF1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASF1B Gene

Publications for ASF1B Gene

  1. Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis. (PMID: 12842904) Umehara T … Horikoshi M (The Journal of biological chemistry 2003) 3 4 22 58
  2. Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway. (PMID: 11897662) Mello JA … Almouzni G (EMBO reports 2002) 2 3 4 58
  3. Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. (PMID: 11470414) Silljé HH … Nigg EA (Current biology : CB 2001) 2 3 4 58
  4. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. (PMID: 22407294) Ask K … Groth A (The EMBO journal 2012) 3 4 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for ASF1B Gene

Sources for ASF1B Gene

Content
Loading form....