Aliases for ASF1A Gene
External Ids for ASF1A Gene
Previous GeneCards Identifiers for ASF1A Gene
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]
GeneCards Summary for ASF1A Gene
ASF1A (Anti-Silencing Function 1A Histone Chaperone) is a Protein Coding gene. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is ASF1B.
UniProtKB/Swiss-Prot for ASF1A Gene
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.