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Aliases for ASF1A Gene

Aliases for ASF1A Gene

  • Anti-Silencing Function 1A Histone Chaperone 2 3 5
  • Anti-Silencing Function Protein 1 Homolog A 3 4
  • CCG1-Interacting Factor A 3 4
  • HAsf1a 3 4
  • HAsf1 3 4
  • HCIA 3 4
  • CIA 3 4
  • ASF1 Anti-Silencing Function 1 Homolog A (S. Cerevisiae) 2
  • ASF1 Anti-Silencing Function 1 Homolog A 3
  • Histone Chaperone ASF1A 3
  • HSPC146 3
  • CGI-98 3

External Ids for ASF1A Gene

Previous GeneCards Identifiers for ASF1A Gene

  • GC06P119157
  • GC06P119202
  • GC06P119192
  • GC06P119263
  • GC06P116797
  • GC06P119215

Summaries for ASF1A Gene

Entrez Gene Summary for ASF1A Gene

  • This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASF1A Gene

ASF1A (Anti-Silencing Function 1A Histone Chaperone) is a Protein Coding gene. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is ASF1B.

UniProtKB/Swiss-Prot for ASF1A Gene

  • Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Gene Wiki entry for ASF1A Gene

Additional gene information for ASF1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASF1A Gene

Genomics for ASF1A Gene

GeneHancer (GH) Regulatory Elements for ASF1A Gene

Promoters and enhancers for ASF1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J118890 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 651.8 +0.2 155 6.8 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ASF1A MCM9 CEP85L ENSG00000253194 FAM184A
GH06J118659 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.9 -233.9 -233859 1.3 HDGF PKNOX1 SMAD1 NFIB MZF1 ZNF195 FEZF1 YY1 NCOA2 ZNF335 SSXP10 ASF1A MCM9 NUS1 CEP85L
GH06J118800 Enhancer 1 Ensembl ENCODE 11.1 -93.4 -93401 1.3 ELF3 ARNT ARID4B ZNF2 RAD21 ZNF335 ZNF614 ZNF143 ATF7 MIXL1 ASF1A MCM9 CEP85L SELENOKP3
GH06J118807 Enhancer 1 FANTOM5 Ensembl ENCODE 11.1 -84.5 -84537 3.2 PKNOX1 ATF2 GABPA GABPB1 NFATC1 ETV6 RUNX3 BCLAF1 SPI1 MCM9 CEP85L ASF1A FAM184A SELENOKP3
GH06J118844 Enhancer 0.5 ENCODE 11.2 -49.1 -49084 0.2 FOXA2 POLR2A CBFB ETV6 ATF2 IRF4 CREM MCM9 ASF1A SELENOKP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ASF1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ASF1A gene promoter:
  • TBP
  • HFH-3
  • FOXI1
  • FOXD3
  • Evi-1
  • Nkx2-5
  • S8
  • AP-1
  • TFIID

Genomic Locations for ASF1A Gene

Genomic Locations for ASF1A Gene
chr6:118,894,077-118,909,171
(GRCh38/hg38)
Size:
15,095 bases
Orientation:
Plus strand
chr6:119,215,241-119,230,336
(GRCh37/hg19)
Size:
15,096 bases
Orientation:
Plus strand

Genomic View for ASF1A Gene

Genes around ASF1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASF1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASF1A Gene

Proteins for ASF1A Gene

  • Protein details for ASF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y294-ASF1A_HUMAN
    Recommended name:
    Histone chaperone ASF1A
    Protein Accession:
    Q9Y294
    Secondary Accessions:
    • Q6IA08
    • Q9P014

    Protein attributes for ASF1A Gene

    Size:
    204 amino acids
    Molecular mass:
    22969 Da
    Quaternary structure:
    • Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Interacts with CDAN1. Found in a cytosolic complex with CDAN1, ASF1B, IPO4 and histones H3.1 and H4. Interacts with CREBBP.

    Three dimensional structures from OCA and Proteopedia for ASF1A Gene

neXtProt entry for ASF1A Gene

Post-translational modifications for ASF1A Gene

  • Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASF1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASF1A Gene

Domains & Families for ASF1A Gene

Gene Families for ASF1A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ASF1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ASF1A Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y294

UniProtKB/Swiss-Prot:

ASF1A_HUMAN :
  • Belongs to the ASF1 family.
Family:
  • Belongs to the ASF1 family.
genes like me logo Genes that share domains with ASF1A: view

Function for ASF1A Gene

Molecular function for ASF1A Gene

UniProtKB/Swiss-Prot Function:
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Phenotypes From GWAS Catalog for ASF1A Gene

Gene Ontology (GO) - Molecular Function for ASF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA,NAS 10759893
GO:0005515 protein binding IPI 16980972
GO:0042393 histone binding IDA 10759893
genes like me logo Genes that share ontologies with ASF1A: view
genes like me logo Genes that share phenotypes with ASF1A: view

Animal Models for ASF1A Gene

MGI Knock Outs for ASF1A:
  • Asf1a Asf1a<tm1b(KOMP)Wtsi>

Animal Model Products

Clone Products

  • Addgene plasmids for ASF1A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASF1A Gene

Localization for ASF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASF1A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASF1A gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ASF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 14718166
GO:0005634 nucleus IDA,NAS 10759893
GO:0005654 nucleoplasm TAS --
GO:0032991 protein-containing complex IDA 14718166
genes like me logo Genes that share ontologies with ASF1A: view

Pathways & Interactions for ASF1A Gene

genes like me logo Genes that share pathways with ASF1A: view

Pathways by source for ASF1A Gene

Gene Ontology (GO) - Biological Process for ASF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0006281 DNA repair IDA 11897662
GO:0006325 chromatin organization IEA --
GO:0006333 chromatin assembly or disassembly IEA --
GO:0006334 nucleosome assembly IDA 11897662
genes like me logo Genes that share ontologies with ASF1A: view

No data available for SIGNOR curated interactions for ASF1A Gene

Drugs & Compounds for ASF1A Gene

No Compound Related Data Available

Transcripts for ASF1A Gene

mRNA/cDNA for ASF1A Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASF1A Gene

ASF1 anti-silencing function 1 homolog A (S. cerevisiae):
Representative Sequences:

Clone Products

  • Addgene plasmids for ASF1A

Alternative Splicing Database (ASD) splice patterns (SP) for ASF1A Gene

No ASD Table

Relevant External Links for ASF1A Gene

GeneLoc Exon Structure for
ASF1A
ECgene alternative splicing isoforms for
ASF1A

Expression for ASF1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASF1A Gene

Protein differential expression in normal tissues from HIPED for ASF1A Gene

This gene is overexpressed in Breast (16.3), Peripheral blood mononuclear cells (7.2), Fetal ovary (7.2), and Rectum (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ASF1A Gene



Protein tissue co-expression partners for ASF1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ASF1A Gene:

ASF1A

SOURCE GeneReport for Unigene cluster for ASF1A Gene:

Hs.292316

mRNA Expression by UniProt/SwissProt for ASF1A Gene:

Q9Y294-ASF1A_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ASF1A Gene

  • Nervous system(4.8)
  • Blood(4.1)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ASF1A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASF1A Gene

Orthologs for ASF1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASF1A Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia ASF1A 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASF1A 34 33
  • 97.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ASF1A 34 33
  • 96.08 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASF1A 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asf1a 16 34 33
  • 94.77 (n)
chimpanzee
(Pan troglodytes)
Mammalia ASF1A 34 33
  • 94.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asf1a 33
  • 91.99 (n)
chicken
(Gallus gallus)
Aves ASF1A 34 33
  • 90.2 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASF1A 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asf1b 33
  • 68.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia asf1a-prov 33
zebrafish
(Danio rerio)
Actinopterygii asf1bb 33
  • 67.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005920 33
  • 64.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta asf1 34 33
  • 60.24 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea asfl-1 34 33
  • 54.98 (n)
ManyToMany
unc-85 34
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ASF1 34 33
  • 59.07 (n)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ASF1B 33
  • 60.59 (n)
rice
(Oryza sativa)
Liliopsida Os05g0553800 33
  • 62.96 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToMany
Species where no ortholog for ASF1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASF1A Gene

ENSEMBL:
Gene Tree for ASF1A (if available)
TreeFam:
Gene Tree for ASF1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ASF1A: view image

Paralogs for ASF1A Gene

Paralogs for ASF1A Gene

(1) SIMAP similar genes for ASF1A Gene using alignment to 1 proteins:

  • ASF1A_HUMAN
genes like me logo Genes that share paralogs with ASF1A: view

Variants for ASF1A Gene

Sequence variations from dbSNP and Humsavar for ASF1A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000068399 -- 118,901,193(+) A/G intron_variant
rs1000081099 -- 118,894,852(+) C/T intron_variant
rs1000104029 -- 118,894,157(+) T/G 5_prime_UTR_variant
rs1000202408 -- 118,909,487(+) TTTTTTTT/TTTTTTT downstream_transcript_variant
rs1000266195 -- 118,905,927(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ASF1A Gene

Variant ID Type Subtype PubMed ID
nsv1161446 CNV duplication 26073780
nsv480899 CNV novel sequence insertion 20440878
nsv509151 CNV insertion 20534489
nsv510910 OTHER complex 20534489

Variation tolerance for ASF1A Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASF1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASF1A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASF1A Gene

Disorders for ASF1A Gene

Additional Disease Information for ASF1A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ASF1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASF1A Gene

Publications for ASF1A Gene

  1. Structural basis for the interaction of Asf1 with histone H3 and its functional implications. (PMID: 15840725) Mousson F … Ochsenbein F (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  3. A human homologue of yeast anti-silencing factor has histone chaperone activity. (PMID: 10759893) Munakata T … Horikoshi M (Genes to cells : devoted to molecular & cellular mechanisms 2000) 3 4 22 58
  4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  5. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. (PMID: 22407294) Ask K … Groth A (The EMBO journal 2012) 3 4 58

Products for ASF1A Gene

Sources for ASF1A Gene

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