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Aliases for ASCL5 Gene

Aliases for ASCL5 Gene

  • Achaete-Scute Family BHLH Transcription Factor 5 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 47 3 4
  • BHLHa47 3 4
  • ASH-5 3 4
  • HASH5 3 4
  • Achaete-Scute Complex Homolog 5 (Drosophila) 2
  • Achaete-Scute Complex Homolog 5 3
  • Achaete-Scute Homolog 5 3
  • BHLHA47 4

External Ids for ASCL5 Gene

Previous GeneCards Identifiers for ASCL5 Gene

  • GC01M199352
  • GC01M201085
  • GC01M201086
  • GC01M172250
  • GC01M201087
  • GC01M201090
  • GC01M201091
  • GC01M201092

Summaries for ASCL5 Gene

GeneCards Summary for ASCL5 Gene

ASCL5 (Achaete-Scute Family BHLH Transcription Factor 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is ASCL3.

Additional gene information for ASCL5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASCL5 Gene

Genomics for ASCL5 Gene

GeneHancer (GH) Regulatory Elements for ASCL5 Gene

Promoters and enhancers for ASCL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J201126 Enhancer 1.2 Ensembl ENCODE dbSUPER 694.4 -0.5 -470 2.2 FOXA2 KLF17 RAD21 RARA SCRT2 FOS RXRA ZNF623 KAT8 ZNF217 ASCL5 TMEM9
GH01J201124 Enhancer 0.6 ENCODE dbSUPER 662.6 +1.6 1596 1.7 ZNF335 DACH1 ASCL5 TMEM9 IGFN1 ENSG00000234132 GPR25 GC01P201114
GH01J201113 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 47.5 +12.8 12817 1.3 PKNOX1 SIN3A ZNF2 ZBTB7B ZNF48 GLIS2 ELK1 ARID2 ZNF143 DEK GC01P201114 CACNA1S ASCL5
GH01J201110 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 42 +15.3 15283 2.2 ZNF263 BHLHE40 MNT ZIC2 ZNF18 CACNA1S ASCL5 IPO9-AS1 ELF3-AS1 TMEM9 GC01M201077
GH01J201153 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.1 -27.2 -27209 1.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 TMEM9 DDX59 RNPEP ENSG00000273478 ELF3-AS1 IGFN1 ASCL5 CACNA1S ENSG00000229821
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ASCL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ASCL5 gene promoter:
  • GR
  • GR-alpha
  • POU2F1
  • POU2F1a
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • GCNF
  • GCNF-1

Genomic Locations for ASCL5 Gene

Genomic Locations for ASCL5 Gene
chr1:201,113,953-201,127,184
(GRCh38/hg38)
Size:
13,232 bases
Orientation:
Minus strand
chr1:201,083,081-201,096,312
(GRCh37/hg19)
Size:
13,232 bases
Orientation:
Minus strand

Genomic View for ASCL5 Gene

Genes around ASCL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASCL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASCL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASCL5 Gene

Proteins for ASCL5 Gene

  • Protein details for ASCL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTU5-ASCL5_HUMAN
    Recommended name:
    Achaete-scute homolog 5
    Protein Accession:
    Q7RTU5

    Protein attributes for ASCL5 Gene

    Size:
    278 amino acids
    Molecular mass:
    29462 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA00301.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ASCL5 Gene

Post-translational modifications for ASCL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASCL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASCL5 Gene

Domains & Families for ASCL5 Gene

Gene Families for ASCL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ASCL5 Gene

Suggested Antigen Peptide Sequences for ASCL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ASCL5: view

No data available for UniProtKB/Swiss-Prot for ASCL5 Gene

Function for ASCL5 Gene

Phenotypes From GWAS Catalog for ASCL5 Gene

Gene Ontology (GO) - Molecular Function for ASCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0003700 contributes_to DNA binding transcription factor activity IBA --
genes like me logo Genes that share ontologies with ASCL5: view

Phenotypes for ASCL5 Gene

genes like me logo Genes that share phenotypes with ASCL5: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASCL5 Gene

Localization for ASCL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASCL5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASCL5 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ASCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0090575 RNA polymerase II transcription factor complex IBA --
genes like me logo Genes that share ontologies with ASCL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ASCL5 Gene

Pathways & Interactions for ASCL5 Gene

SuperPathways for ASCL5 Gene

No Data Available

Interacting Proteins for ASCL5 Gene

Gene Ontology (GO) - Biological Process for ASCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ASCL5: view

No data available for Pathways by source and SIGNOR curated interactions for ASCL5 Gene

Drugs & Compounds for ASCL5 Gene

No Compound Related Data Available

Transcripts for ASCL5 Gene

mRNA/cDNA for ASCL5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASCL5 Gene

Achaete-scute complex homolog 5 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASCL5 Gene

No ASD Table

Relevant External Links for ASCL5 Gene

GeneLoc Exon Structure for
ASCL5
ECgene alternative splicing isoforms for
ASCL5

Expression for ASCL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASCL5 Gene

mRNA differential expression in normal tissues according to GTEx for ASCL5 Gene

This gene is overexpressed in Pancreas (x7.9).

Protein differential expression in normal tissues from HIPED for ASCL5 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASCL5 Gene



Protein tissue co-expression partners for ASCL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASCL5 Gene:

ASCL5

SOURCE GeneReport for Unigene cluster for ASCL5 Gene:

Hs.721460
genes like me logo Genes that share expression patterns with ASCL5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASCL5 Gene

Orthologs for ASCL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASCL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100614803 33
  • 99.19 (n)
mouse
(Mus musculus)
Mammalia Ascl5 16 34 33
  • 82.34 (n)
cow
(Bos Taurus)
Mammalia ASCL5 33
  • 82.22 (n)
rat
(Rattus norvegicus)
Mammalia Ascl5 33
  • 81.62 (n)
dog
(Canis familiaris)
Mammalia ASCL5 33
  • 79.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ASCL5 34
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101887049 33
  • 65.93 (n)
worm
(Caenorhabditis elegans)
Secernentea hlh-6 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
OneToMany
Species where no ortholog for ASCL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASCL5 Gene

ENSEMBL:
Gene Tree for ASCL5 (if available)
TreeFam:
Gene Tree for ASCL5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ASCL5: view image

Paralogs for ASCL5 Gene

Paralogs for ASCL5 Gene

(1) SIMAP similar genes for ASCL5 Gene using alignment to 2 proteins:

  • ASCL5_HUMAN
  • M0R2M9_HUMAN
genes like me logo Genes that share paralogs with ASCL5: view

Variants for ASCL5 Gene

Sequence variations from dbSNP and Humsavar for ASCL5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000533832 -- 201,117,234(-) G/A upstream_transcript_variant
rs1000747570 -- 201,115,661(-) A/G upstream_transcript_variant
rs1000952953 -- 201,115,432(-) C/T upstream_transcript_variant
rs1002153985 -- 201,116,182(-) AAAAA/AAAAAA upstream_transcript_variant
rs1002168881 -- 201,114,785(-) C/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for ASCL5 Gene

Variant ID Type Subtype PubMed ID
nsv428301 CNV gain 18775914

Variation tolerance for ASCL5 Gene

Gene Damage Index Score: 7.31; 81.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASCL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASCL5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASCL5 Gene

Disorders for ASCL5 Gene

Additional Disease Information for ASCL5

No disorders were found for ASCL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASCL5 Gene

Publications for ASCL5 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  2. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PMID: 14516699) McLellan AS … Kealey T (Mechanisms of development 2002) 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ASCL5 Gene

Sources for ASCL5 Gene

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