Aliases for ASCL2 Gene
External Ids for ASCL2 Gene
Previous GeneCards Identifiers for ASCL2 Gene
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]
GeneCards Summary for ASCL2 Gene
ASCL2 (Achaete-Scute Family BHLH Transcription Factor 2) is a Protein Coding gene. Diseases associated with ASCL2 include Beckwith-Wiedemann Syndrome and Intracranial Berry Aneurysm. Among its related pathways are Human Early Embryo Development and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ASCL1.
UniProtKB/Swiss-Prot Summary for ASCL2 Gene
AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.