Aliases for ASCC3 Gene
External Ids for ASCC3 Gene
Previous HGNC Symbols for ASCC3 Gene
Previous GeneCards Identifiers for ASCC3 Gene
This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for ASCC3 Gene
ASCC3 (Activating Signal Cointegrator 1 Complex Subunit 3) is a Protein Coding gene. Among its related pathways are DNA Damage Reversal and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is SNRNP200.
UniProtKB/Swiss-Prot for ASCC3 Gene
3-5 DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation.