Aliases for ASCC3 Gene
External Ids for ASCC3 Gene
Previous HGNC Symbols for ASCC3 Gene
Previous GeneCards Identifiers for ASCC3 Gene
This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for ASCC3 Gene
ASCC3 (Activating Signal Cointegrator 1 Complex Subunit 3) is a Protein Coding gene. Diseases associated with ASCC3 include Brain Cancer. Among its related pathways are DNA Damage Reversal and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is SNRNP200.
UniProtKB/Swiss-Prot Summary for ASCC3 Gene
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).