This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq,... See more...

Aliases for ASCC3 Gene

Aliases for ASCC3 Gene

  • Activating Signal Cointegrator 1 Complex Subunit 3 2 3 4 5
  • Helicase, ATP Binding 1 2 3 4
  • ASC1p200 2 3 4
  • ASC-1 Complex Subunit P200 3 4
  • Trip4 Complex Subunit P200 3 4
  • RNA Helicase Family 2 3
  • HELIC1 3 4
  • RNAH 2 3
  • EC 3.6.4.12 4
  • DJ121G13.4 2
  • DJ467N11.1 2
  • ASCC3 5

External Ids for ASCC3 Gene

Previous HGNC Symbols for ASCC3 Gene

  • HELIC1

Previous GeneCards Identifiers for ASCC3 Gene

  • GC06M101063
  • GC06M100956
  • GC06M098395

Summaries for ASCC3 Gene

Entrez Gene Summary for ASCC3 Gene

  • This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for ASCC3 Gene

ASCC3 (Activating Signal Cointegrator 1 Complex Subunit 3) is a Protein Coding gene. Diseases associated with ASCC3 include Brain Cancer. Among its related pathways are DNA Damage Reversal and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is SNRNP200.

UniProtKB/Swiss-Prot Summary for ASCC3 Gene

  • 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).

Gene Wiki entry for ASCC3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ASCC3 Gene

Genomics for ASCC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ASCC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J100877 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 630.8 +4.3 4276 4.8 CEBPG CREB1 GATAD2A PRDM10 ZNF629 ZNF692 POLR2A BACH1 FOXA1 LARP7 ASCC3 GRIK2 ENSG00000260000 LOC107984041 lnc-SIM1-4 piR-32023-211 SIM1
GH06J100883 Enhancer 0.3 Ensembl 619.8 +0.9 854 0.4 CEBPB ASCC3 ENSG00000260000 LOC107984041 SIM1
GH06J100885 Enhancer 0.3 Ensembl 604.6 -1.2 -1246 1 TEAD4 ASCC3 lnc-ASCC3-2 ENSG00000260000 LOC107984041 GRIK2
GH06J100453 Enhancer 1.3 VISTA FANTOM5 ENCODE dbSUPER 18.8 +427.9 427947 6.4 RNF2 POLR2A EZH2 CBX2 BMI1 CBX8 ZNF202 PRDM6 SMARCA4 SP1 ASCC3 ENSG00000228082 RPS3P5 SIM1 lnc-ASCC3-3 lnc-ASCC3-4 MCHR2
GH06J100460 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 11.4 +421.0 421002 5.4 BRCA1 RNF2 SP1 CTCF PRDM10 ZNF692 PRDM1 ZIC2 PKNOX1 POLR2A lnc-ASCC3-3 SIM1 ASCC3 ENSG00000228082 RPS3P5 lnc-ASCC3-4 MCHR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ASCC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ASCC3

Top Transcription factor binding sites by QIAGEN in the ASCC3 gene promoter:
  • aMEF-2
  • Lmo2
  • MEF-2
  • MEF-2A
  • NF-1
  • NF-1/L
  • Olf-1
  • POU2F1
  • POU2F1a
  • SRF (504 AA)

Genomic Locations for ASCC3 Gene

Genomic Locations for ASCC3 Gene
chr6:100,508,194-100,884,455
(GRCh38/hg38)
Size:
376,262 bases
Orientation:
Minus strand
chr6:100,956,070-101,329,248
(GRCh37/hg19)
Size:
373,179 bases
Orientation:
Minus strand

Genomic View for ASCC3 Gene

Genes around ASCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASCC3 Gene

Proteins for ASCC3 Gene

  • Protein details for ASCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3C0-ASCC3_HUMAN
    Recommended name:
    Activating signal cointegrator 1 complex subunit 3
    Protein Accession:
    Q8N3C0
    Secondary Accessions:
    • E7EW23
    • O43738
    • Q4G1A0
    • Q5VTN2
    • Q9H1I9
    • Q9H5A2
    • Q9NTR0

    Protein attributes for ASCC3 Gene

    Size:
    2202 amino acids
    Molecular mass:
    251460 Da
    Quaternary structure:
    • Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3 (PubMed:12077347, PubMed:29144457, PubMed:29997253). Functions as scaffolding subunit that interacts directly with both ASCC1 and ASCC2 (PubMed:29144457, PubMed:29997253). Interacts directly with ALKBH3, and thereby recruits ALKBH3 to the ASCC complex (PubMed:22055184, PubMed:29144457). Part of the ASC-1/TRIP4 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347). Interacts with ZCCHC4 (PubMed:31799605).
    SequenceCaution:
    • Sequence=AAG45474.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA11679.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA11679.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ASCC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASCC3 Gene

Post-translational modifications for ASCC3 Gene

  • Ubiquitination at Lys236, Lys319, Lys423, Lys860, Lys938, Lys1382, and Lys1543
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ASCC3 Gene

Domains & Families for ASCC3 Gene

Gene Families for ASCC3 Gene

Suggested Antigen Peptide Sequences for ASCC3 Gene

GenScript: Design optimal peptide antigens:
  • Trip4 complex subunit p200 (HELC1_HUMAN)
  • ASCC3 protein (Q4G1A0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N3C0

UniProtKB/Swiss-Prot:

ASCC3_HUMAN :
  • Belongs to the helicase family.
Family:
  • Belongs to the helicase family.
genes like me logo Genes that share domains with ASCC3: view

Function for ASCC3 Gene

Molecular function for ASCC3 Gene

UniProtKB/Swiss-Prot Function:
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000269|PubMed:22055184};.

Enzyme Numbers (IUBMB) for ASCC3 Gene

Phenotypes From GWAS Catalog for ASCC3 Gene

Gene Ontology (GO) - Molecular Function for ASCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003678 DNA helicase activity IEA --
GO:0003723 RNA binding IBA 21873635
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with ASCC3: view
genes like me logo Genes that share phenotypes with ASCC3: view

Animal Models for ASCC3 Gene

MGI Knock Outs for ASCC3:
  • Ascc3 Ascc3<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASCC3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASCC3 Gene

Localization for ASCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASCC3 Gene

Nucleus. Nucleus speckle. Note=Colocalizes with ALKBH3 and ASCC2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. {ECO:0000269 PubMed:29144457}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASCC3 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ASCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IBA,TAS 22055184
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with ASCC3: view

Pathways & Interactions for ASCC3 Gene

genes like me logo Genes that share pathways with ASCC3: view

Gene Ontology (GO) - Biological Process for ASCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006307 DNA dealkylation involved in DNA repair IDA,TAS --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0008283 cell proliferation IMP 22055184
GO:0032508 DNA duplex unwinding IDA 22055184
genes like me logo Genes that share ontologies with ASCC3: view

No data available for SIGNOR curated interactions for ASCC3 Gene

Drugs & Compounds for ASCC3 Gene

(3) Drugs for ASCC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for ASCC3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with ASCC3: view

Transcripts for ASCC3 Gene

mRNA/cDNA for ASCC3 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASCC3

Alternative Splicing Database (ASD) splice patterns (SP) for ASCC3 Gene

No ASD Table

Relevant External Links for ASCC3 Gene

GeneLoc Exon Structure for
ASCC3

Expression for ASCC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ASCC3 Gene

Protein differential expression in normal tissues from HIPED for ASCC3 Gene

This gene is overexpressed in Lung (12.5), Brain (10.9), and Peripheral blood mononuclear cells (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ASCC3 Gene



Protein tissue co-expression partners for ASCC3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ASCC3

SOURCE GeneReport for Unigene cluster for ASCC3 Gene:

Hs.486031

mRNA Expression by UniProt/SwissProt for ASCC3 Gene:

Q8N3C0-ASCC3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ASCC3 Gene

  • Skin(4.5)
  • Liver(4.5)
  • Blood(4.4)
  • Intestine(2.5)
  • Muscle(2.3)
  • Kidney(2.3)
  • Lymph node(2.2)
  • Lung(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with ASCC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASCC3 Gene

Orthologs for ASCC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASCC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ASCC3 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ASCC3 30 31
  • 92.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ASCC3 30 31
  • 91.7 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ascc3 30 17 31
  • 88.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ascc3 30
  • 88.02 (n)
Oppossum
(Monodelphis domestica)
Mammalia ASCC3 31
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ASCC3 31
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ASCC3 30 31
  • 79.96 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ASCC3 31
  • 82 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ASCC3 31
  • 84 (a)
OneToMany
ASCC3 (3 of 3) 31
  • 83 (a)
OneToMany
ascc3 30
  • 70.56 (n)
ASCC3 (2 of 3) 31
  • 43 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG5205 30 31
  • 55.54 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001234 30
  • 53.68 (n)
Worm
(Caenorhabditis elegans)
Secernentea CELE_Y54E2A.4 30
  • 52.53 (n)
Y54E2A.4 31
  • 46 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLH1 30
  • 55.11 (n)
BRR2 31
  • 32 (a)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09889g 30
  • 54.35 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABR142W 30
  • 54.02 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G61140 30
  • 55.83 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0213400 30
  • 55.84 (n)
Os.26874 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2602 31
  • 61 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug81 30
  • 55.13 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU08267 30
  • 52.33 (n)
Species where no ortholog for ASCC3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ASCC3 Gene

ENSEMBL:
Gene Tree for ASCC3 (if available)
TreeFam:
Gene Tree for ASCC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ASCC3: view image

Paralogs for ASCC3 Gene

Paralogs for ASCC3 Gene

(2) SIMAP similar genes for ASCC3 Gene using alignment to 3 proteins:

  • ASCC3_HUMAN
  • E5RFZ0_HUMAN
  • J3KNJ4_HUMAN
genes like me logo Genes that share paralogs with ASCC3: view

Variants for ASCC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ASCC3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
716136 Benign: not provided 100,848,409(-) G/A SYNONYMOUS_VARIANT
722060 Benign: not provided 100,631,163(-) A/G SYNONYMOUS_VARIANT
735094 Benign: not provided 100,638,652(-) A/G SYNONYMOUS_VARIANT
746834 Likely Benign: not provided 100,652,878(-) T/C SYNONYMOUS_VARIANT
776143 Benign: not provided 100,650,642(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ASCC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ASCC3 Gene

Variant ID Type Subtype PubMed ID
dgv10862n54 CNV loss 21841781
dgv10863n54 CNV loss 21841781
dgv10864n54 CNV loss 21841781
dgv10865n54 CNV loss 21841781
dgv3597e59 CNV duplication 20981092
dgv6113n100 CNV loss 25217958
esv1007226 CNV insertion 20482838
esv1269345 CNV insertion 17803354
esv2732486 CNV deletion 23290073
esv2763587 CNV loss 21179565
esv28841 CNV gain 19812545
esv3302595 CNV tandem duplication 20981092
esv3309174 CNV mobile element insertion 20981092
esv3336227 CNV insertion 20981092
esv3571321 CNV loss 25503493
esv3576204 CNV gain 25503493
esv3610144 CNV loss 21293372
esv3610145 CNV loss 21293372
esv3610148 CNV gain 21293372
esv3610149 CNV gain 21293372
esv3890916 CNV loss 25118596
nsv1024526 CNV loss 25217958
nsv1027288 CNV loss 25217958
nsv1028122 CNV gain 25217958
nsv1111320 CNV tandem duplication 24896259
nsv463989 CNV loss 19166990
nsv463990 CNV loss 19166990
nsv470848 CNV loss 18288195
nsv474539 CNV novel sequence insertion 20440878
nsv510044 OTHER sequence alteration 20534489
nsv521897 CNV loss 19592680
nsv604268 CNV loss 21841781
nsv604269 CNV loss 21841781
nsv604275 CNV loss 21841781
nsv969431 CNV duplication 23825009
nsv981170 CNV duplication 23825009

Variation tolerance for ASCC3 Gene

Residual Variation Intolerance Score: 0.837% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.26; 97.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASCC3 Gene

Human Gene Mutation Database (HGMD)
ASCC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASCC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASCC3 Gene

Disorders for ASCC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ASCC3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
brain cancer
  • adult brain tumor
- elite association - COSMIC cancer census association via MalaCards
Search ASCC3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ASCC3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ASCC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ASCC3 Gene

Publications for ASCC3 Gene

  1. RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage. (PMID: 29997253) Soll JM … Mosammaparast N (The Journal of biological chemistry 2018) 3 4
  2. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. (PMID: 22055184) Dango S … Shi Y (Molecular cell 2011) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 41

Products for ASCC3 Gene

  • Signalway Proteins for ASCC3

Sources for ASCC3 Gene