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This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
ASB9 (Ankyrin Repeat And SOCS Box Containing 9) is a Protein Coding gene. Diseases associated with ASB9 include Uterine Corpus Endometrial Carcinoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB11.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ015268 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE CraniofacialAtlas | 616.5 | +0.4 | 423 | 2.5 | HNRNPL CREB1 GATAD2A ZSCAN4 REST SP1 GABPA SOX13 CEBPB RELB | ASB9 RF00017-8172 MOSPD2 | |
GH0XJ015298 | Enhancer | 0.8 | Ensembl ENCODE | 13.1 | -28.4 | -28439 | 3 | CTCF SP1 GABPA SCRT2 MNT RAD21 YY1 SMC3 ATF2 SCRT1 | ASB9 PIGA ASB11 | |
GH0XJ015292 | Enhancer | 0.2 | Ensembl | 13.1 | -22.2 | -22225 | 0.2 | ASB9 PIGA ASB11 | ||
GH0XJ015301 | Enhancer | 0.6 | Ensembl ENCODE | 0.3 | -31.7 | -31725 | 1.6 | MGA ZSCAN5C MYC HLF MAX | PIGA ASB11 ASB9 | |
GH0XJ015309 | Enhancer | 0.6 | Ensembl ENCODE | 0.3 | -40.0 | -40005 | 3 | ZBTB20 MEF2D NFIB PRDM6 RNF2 | ASB11 ASB9 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
.61
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016567 | protein ubiquitination | IDA,IEA | -- |
GO:0035556 | intracellular signal transduction | IEA | -- |
GO:0043687 | post-translational protein modification | TAS | -- |
GO:0045732 | positive regulation of protein catabolic process | IDA | 17148442 |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
LOC100609711 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | ASB9 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ASB9 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Asb9 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Asb9 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ASB9 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ASB9 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ASB9 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | asb9 30 |
|
||
Str.10451 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8986 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4234 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2226e212 | CNV | loss | 25503493 |
dgv2227e212 | CNV | loss | 25503493 |
esv1774504 | CNV | insertion | 17803354 |
esv3573602 | CNV | loss | 25503493 |
nsv528005 | CNV | gain | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
uterine corpus endometrial carcinoma |
|
|