The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases... See more...

Aliases for ASB6 Gene

Aliases for ASB6 Gene

  • Ankyrin Repeat And SOCS Box Containing 6 2 3 5
  • Ankyrin Repeat And SOCS Box Protein 6 3 4
  • Ankyrin Repeat And SOCS Box-Containing 6 2
  • ASB-6 4
  • ASB6 5

External Ids for ASB6 Gene

Previous GeneCards Identifiers for ASB6 Gene

  • GC09U990201
  • GC09M124043
  • GC09M125852
  • GC09M127772
  • GC09M129476
  • GC09M131436
  • GC09M132396
  • GC09M101995

Summaries for ASB6 Gene

Entrez Gene Summary for ASB6 Gene

  • The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASB6 Gene

ASB6 (Ankyrin Repeat And SOCS Box Containing 6) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot Summary for ASB6 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for ASB6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ASB6 Gene

Genomics for ASB6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ASB6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J129636 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 608.1 +2.1 2059 6.3 CREB1 GATAD2A CTCF HNRNPL PRDM10 ZNF629 TFE3 NFKBIZ ZNF692 POLR2A ASB6 ENSG00000234789 piR-52782 piR-57439 NUP188 FUBP3 SPOUT1 ENSG00000267834 TOR1B NTMT1
GH09J129643 Enhancer 0.2 Ensembl 600.7 -1.6 -1632 0.4 ASB6 PRRX2 RF00017-7987
GH09J129789 Enhancer 1.2 Ensembl ENCODE 23.3 -148.1 -148068 1.7 CREB1 GATAD2A CTCF REST TFE3 ZNF512 LEF1 IKZF1 NFKBIZ ETV6 UBE2V1P4 lnc-TOR1B-1 C9orf78 ASB6 NUP188 USP20 TOR1A EXOSC2 PRRX2-AS1 ENSG00000234789
GH09J129882 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.1 -248.0 -248000 14.6 SP1 GATAD2A CTCF HNRNPL PRDM10 ZNF629 TFE3 IKZF1 KDM1A POLR2A USP20 C9orf78 FNBP1 TOR1A TOR1B FUBP3 EXOSC2 ABL1 ASB6 ENSG00000230684
GH09J129693 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.7 -57.4 -57426 11.8 RNF2 PRDM10 ZNF629 KDM1A ZNF692 ZIC2 PATZ1 BRD9 ZNF24 EZH2 piR-50518 PRRX2 ASB6 ENSG00000234789 PTGES TOR1A C9orf78 USP20 C9orf50 piR-36428-008
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ASB6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ASB6

Top Transcription factor binding sites by QIAGEN in the ASB6 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • E47
  • Egr-3
  • Elk-1
  • Pax-4a
  • Pax-5
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for ASB6 Gene

Genomic Locations for ASB6 Gene
chr9:129,634,604-129,642,169
(GRCh38/hg38)
Size:
7,566 bases
Orientation:
Minus strand
chr9:132,396,883-132,404,448
(GRCh37/hg19)
Size:
7,566 bases
Orientation:
Minus strand

Genomic View for ASB6 Gene

Genes around ASB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB6 Gene

Proteins for ASB6 Gene

  • Protein details for ASB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWX5-ASB6_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 6
    Protein Accession:
    Q9NWX5
    Secondary Accessions:
    • Q5SZB7
    • Q9BV15

    Protein attributes for ASB6 Gene

    Size:
    421 amino acids
    Molecular mass:
    47136 Da
    Quaternary structure:
    • Binds APS. Identified in a complex with ELOB and ELOC (By similarity). Interacts with CUL5 and RNF7.

    Alternative splice isoforms for ASB6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB6 Gene

Post-translational modifications for ASB6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB6 Gene

No data available for DME Specific Peptides for ASB6 Gene

Domains & Families for ASB6 Gene

Gene Families for ASB6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ASB6 Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
  • SOCS protein, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for ASB6 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat and SOCS box protein 6 (ASB6_HUMAN)
  • cDNA FLJ54137, highly similar to Ankyrin repeat and SOCS box protein 6 (ASB-6) (B4DRC4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NWX5

UniProtKB/Swiss-Prot:

ASB6_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with ASB6: view

Function for ASB6 Gene

Molecular function for ASB6 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes From GWAS Catalog for ASB6 Gene

Gene Ontology (GO) - Molecular Function for ASB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16325183
genes like me logo Genes that share ontologies with ASB6: view

Phenotypes for ASB6 Gene

genes like me logo Genes that share phenotypes with ASB6: view

Animal Model Products

CRISPR Products

miRNA for ASB6 Gene

miRTarBase miRNAs that target ASB6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASB6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB6 Gene

Localization for ASB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASB6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB6 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ASB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASB6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ASB6 Gene

Pathways & Interactions for ASB6 Gene

genes like me logo Genes that share pathways with ASB6: view

UniProtKB/Swiss-Prot Q9NWX5-ASB6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ASB6: view

No data available for SIGNOR curated interactions for ASB6 Gene

Drugs & Compounds for ASB6 Gene

No Compound Related Data Available

Transcripts for ASB6 Gene

mRNA/cDNA for ASB6 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASB6

Alternative Splicing Database (ASD) splice patterns (SP) for ASB6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - -
SP2: -
SP3: - - -
SP4:
SP5:

Relevant External Links for ASB6 Gene

GeneLoc Exon Structure for
ASB6

Expression for ASB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ASB6 Gene

Protein differential expression in normal tissues from HIPED for ASB6 Gene

This gene is overexpressed in Cervix (51.9) and Bone (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ASB6 Gene



Protein tissue co-expression partners for ASB6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ASB6

SOURCE GeneReport for Unigene cluster for ASB6 Gene:

Hs.125037

Evidence on tissue expression from TISSUES for ASB6 Gene

  • Nervous system(4.6)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with ASB6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB6 Gene

Orthologs for ASB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ASB6 30 31
  • 99.29 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ASB6 30 31
  • 90.82 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ASB6 30 31
  • 89.31 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ASB6 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ASB6 31
  • 84 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Asb6 30
  • 83.97 (n)
Mouse
(Mus musculus)
Mammalia Asb6 30 17 31
  • 83.74 (n)
OneToOne
Chicken
(Gallus gallus)
Aves ASB6 30 31
  • 70.55 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ASB6 31
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia asb6 30
  • 71.1 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68811 30
Zebrafish
(Danio rerio)
Actinopterygii asb6 30 31
  • 59.72 (n)
OneToOne
Dr.13589 30
Species where no ortholog for ASB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ASB6 Gene

ENSEMBL:
Gene Tree for ASB6 (if available)
TreeFam:
Gene Tree for ASB6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ASB6: view image

Paralogs for ASB6 Gene

(1) SIMAP similar genes for ASB6 Gene using alignment to 2 proteins:

  • ASB6_HUMAN
  • B4DRC4_HUMAN
genes like me logo Genes that share paralogs with ASB6: view

No data available for Paralogs for ASB6 Gene

Variants for ASB6 Gene

Additional dbSNP identifiers (rs#s) for ASB6 Gene

Structural Variations from Database of Genomic Variants (DGV) for ASB6 Gene

Variant ID Type Subtype PubMed ID
nsv1046477 CNV gain 25217958
nsv469901 CNV loss 18288195
nsv831731 CNV gain+loss 17160897
nsv951784 CNV deletion 24416366

Variation tolerance for ASB6 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASB6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ASB6 Gene

Disorders for ASB6 Gene

Additional Disease Information for ASB6

No disorders were found for ASB6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB6 Gene

Publications for ASB6 Gene

  1. ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J … Masuho Y (FEBS letters 2005) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays. (PMID: 29560723) Masschaele D … Tavernier J (Journal of proteome research 2018) 3

Products for ASB6 Gene

Sources for ASB6 Gene