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Aliases for ASB16 Gene

Aliases for ASB16 Gene

  • Ankyrin Repeat And SOCS Box Containing 16 2 3 5
  • Ankyrin Repeat And SOCS Box-Containing Protein 16 3
  • Ankyrin Repeat And SOCS Box-Containing 16 2
  • Ankyrin Repeat And SOCS Box Protein 16 3
  • ASB-16 4

External Ids for ASB16 Gene

Previous GeneCards Identifiers for ASB16 Gene

  • GC17M041995
  • GC17P044425
  • GC17P042258
  • GC17P042723
  • GC17P039603
  • GC17P038012
  • GC17P042247

Summaries for ASB16 Gene

Entrez Gene Summary for ASB16 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASB16 Gene

ASB16 (Ankyrin Repeat And SOCS Box Containing 16) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is ASB18.

UniProtKB/Swiss-Prot for ASB16 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Additional gene information for ASB16 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB16 Gene

Genomics for ASB16 Gene

GeneHancer (GH) Regulatory Elements for ASB16 Gene

Promoters and enhancers for ASB16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J044168 Enhancer 1.3 FANTOM5 Ensembl ENCODE 668.7 -1.8 -1833 1.1 MLX ARID4B SIN3A ZNF48 ARID2 ZNF143 ATF7 RUNX3 SP5 NCOA1 ASB16 NAGS GC17P044157
GH17J044169 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 650.7 +0.5 457 2.4 MYRF FOXA2 SAP130 FOXA3 RAD21 ZNF48 MEF2D ZGPAT MIER3 ZNF614 GC17M044169 ASB16 NAGS GC17P044157 ASB16-AS1
GH17J044121 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 27.9 -47.2 -47191 3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 HDAC5 ASB16 ENSG00000221044 DCAKD LOC105371789
GH17J044101 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 24.1 -62.8 -62792 12.5 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ASB16-AS1 DHX8 HMGN1P29 LINC00910 ASB16 TMUB2 NAGS G6PC3 C17orf53 ENSG00000267002
GH17J044094 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.9 -73.5 -73544 4.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ASB16 G6PC3 ASB16-AS1 TMEM101 DHX8 LSM12 RNU6-131P C17orf53 HDAC5 TMUB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ASB16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ASB16 gene promoter:

Genomic Locations for ASB16 Gene

Genomic Locations for ASB16 Gene
chr17:44,170,447-44,179,083
(GRCh38/hg38)
Size:
8,637 bases
Orientation:
Plus strand
chr17:42,247,815-42,256,451
(GRCh37/hg19)

Genomic View for ASB16 Gene

Genes around ASB16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB16 Gene

Proteins for ASB16 Gene

  • Protein details for ASB16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NS5-ASB16_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 16
    Protein Accession:
    Q96NS5
    Secondary Accessions:
    • B2RBC0
    • Q8WXK0

    Protein attributes for ASB16 Gene

    Size:
    453 amino acids
    Molecular mass:
    49637 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ASB16 Gene

Post-translational modifications for ASB16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB16 Gene

Domains & Families for ASB16 Gene

Gene Families for ASB16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q96NS5

UniProtKB/Swiss-Prot:

ASB16_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with ASB16: view

Function for ASB16 Gene

Molecular function for ASB16 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes From GWAS Catalog for ASB16 Gene

Gene Ontology (GO) - Molecular Function for ASB16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 17474147
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with ASB16: view
genes like me logo Genes that share phenotypes with ASB16: view

Animal Model Products

CRISPR Products

miRNA for ASB16 Gene

miRTarBase miRNAs that target ASB16

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASB16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB16 Gene

Localization for ASB16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB16 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ASB16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASB16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB16 Gene

Pathways & Interactions for ASB16 Gene

genes like me logo Genes that share pathways with ASB16: view

UniProtKB/Swiss-Prot Q96NS5-ASB16_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ASB16: view

No data available for SIGNOR curated interactions for ASB16 Gene

Drugs & Compounds for ASB16 Gene

No Compound Related Data Available

Transcripts for ASB16 Gene

mRNA/cDNA for ASB16 Gene

(11) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB16 Gene

Ankyrin repeat and SOCS box containing 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ASB16

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB16 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1:
SP2: -
SP3: - -

Relevant External Links for ASB16 Gene

GeneLoc Exon Structure for
ASB16
ECgene alternative splicing isoforms for
ASB16

Expression for ASB16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASB16 Gene

mRNA differential expression in normal tissues according to GTEx for ASB16 Gene

This gene is overexpressed in Muscle - Skeletal (x12.4).

Protein differential expression in normal tissues from HIPED for ASB16 Gene

This gene is overexpressed in Tonsil (40.0), Plasma (14.2), and Liver, secretome (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASB16 Gene



Protein tissue co-expression partners for ASB16 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASB16 Gene:

ASB16

SOURCE GeneReport for Unigene cluster for ASB16 Gene:

Hs.534517

Evidence on tissue expression from TISSUES for ASB16 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ASB16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB16 Gene

Orthologs for ASB16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB16 34 33
  • 99.04 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ASB16 34 33
  • 86.98 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ASB16 34 33
  • 86.83 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb16 33
  • 83.52 (n)
mouse
(Mus musculus)
Mammalia Asb16 16 34 33
  • 82.86 (n)
oppossum
(Monodelphis domestica)
Mammalia ASB16 34
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB16 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb16 33
  • 54.82 (n)
zebrafish
(Danio rerio)
Actinopterygii asb16 34 33
  • 55.39 (n)
OneToOne
Species where no ortholog for ASB16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB16 Gene

ENSEMBL:
Gene Tree for ASB16 (if available)
TreeFam:
Gene Tree for ASB16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ASB16: view image

Paralogs for ASB16 Gene

Paralogs for ASB16 Gene

(7) SIMAP similar genes for ASB16 Gene using alignment to 5 proteins:

  • ASB16_HUMAN
  • K7ELE0_HUMAN
  • K7EM41_HUMAN
  • Q147X6_HUMAN
  • Q6Q622_HUMAN
genes like me logo Genes that share paralogs with ASB16: view

Variants for ASB16 Gene

Sequence variations from dbSNP and Humsavar for ASB16 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000291940 -- 44,168,831(+) G/A/C/T upstream_transcript_variant
rs1000305703 -- 44,175,287(+) A/G intron_variant
rs1000534764 -- 44,174,624(+) C/T intron_variant
rs1000903548 -- 44,173,957(+) G/A intron_variant
rs1001032550 -- 44,178,904(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ASB16 Gene

Variant ID Type Subtype PubMed ID
dgv529n67 CNV gain 20364138
nsv1146669 OTHER inversion 26484159
nsv833455 CNV loss 17160897

Variation tolerance for ASB16 Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.46; 96.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASB16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB16 Gene

Disorders for ASB16 Gene

Additional Disease Information for ASB16

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ASB16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB16 Gene

Publications for ASB16 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile BT … Hilton DJ (Trends in biochemical sciences 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ASB16 Gene

Sources for ASB16 Gene

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