Aliases for ASB11 Gene
External Ids for ASB11 Gene
Previous GeneCards Identifiers for ASB11 Gene
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for ASB11 Gene
ASB11 (Ankyrin Repeat And SOCS Box Containing 11) is a Protein Coding gene. Diseases associated with ASB11 include Lacrimal Duct Obstruction. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB5.
UniProtKB/Swiss-Prot Summary for ASB11 Gene
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.