Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
ASB11 (Ankyrin Repeat And SOCS Box Containing 11) is a Protein Coding gene. Diseases associated with ASB11 include Lacrimal Duct Obstruction. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB5.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ015312 | Promoter | 0.5 | Ensembl | 608.9 | +1.0 | 1039 | 1.6 | ATF2 ATF4 | ASB11 PIGA ASB9 | |
GH0XJ015315 | Promoter | 0.5 | EPDnew | 600.7 | 0.0 | -4 | 0.1 | ZNF664 ZBTB12 | ASB11 lnc-ASB11-2 PIGA | |
GH0XJ015317 | Enhancer | 0.2 | Ensembl | 600.7 | -0.7 | -661 | 0.2 | ASB11 lnc-ASB11-2 PIGA | ||
GH0XJ015333 | Promoter/Enhancer | 2.2 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas | 14.6 | -19.7 | -19660 | 3 | SP1 CREB1 PRDM10 ZNF629 RFX1 POLR2A BACH1 JUND LARP7 PRDM1 | PIGA lnc-ASB11-1 ASB11 ZRSR2 CA5B PIR MOSPD2 lnc-ASB11-2 | |
GH0XJ015356 | Enhancer | 0.7 | Ensembl ENCODE | 12.4 | -41.1 | -41061 | 1 | SP1 RBAK CEBPB FOXA2 YY1 JUND RAD21 HNF4A RXRA HLF | PIGA ASB11 BMX PIR ACE2 GS1-594A7.3 piR-41405-154 VEGFD PIR-FIGF |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IDA | 24337577 |
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
.61
|
Symbol | External ID(s) | Details |
---|---|---|
CDK3 | ||
CUL5 | ||
ENSG00000272822 | ||
PRPS1 | ||
PSMA2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016567 | protein ubiquitination | IBA,IEA | -- |
GO:0035556 | intracellular signal transduction | IEA | -- |
GO:0043687 | post-translational protein modification | TAS | -- |
GO:0045732 | positive regulation of protein catabolic process | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||
SP2: | - | - | |||||||||||||||||
SP3: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ASB11 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ASB11 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ASB11 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Asb11 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Asb11 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ASB11 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ASB11 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ASB11 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ASB11 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | asb11 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | asb11 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4234 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
782970 | Benign: not provided | 15,289,537(-) | T/A | MISSENSE_VARIANT | |
791377 | Benign: not provided | 15,287,983(-) | C/T | MISSENSE_VARIANT | |
rs144572145 | - | p.Ser165Leu | |||
rs34025595 | - | p.Asp249Asn | |||
rs35859007 | - | p.Ser263Gly |
Disorder | Aliases | PubMed IDs |
---|---|---|
lacrimal duct obstruction |
|
|