Aliases for ASB11 Gene
Aliases for ASB11 Gene
External Ids for ASB11 Gene
- HGNC: 17186
- Entrez Gene: 140456
- Ensembl: ENSG00000165192
- OMIM: 300626
- UniProtKB: Q8WXH4
Previous GeneCards Identifiers for ASB11 Gene
- GC0XM014746
- GC0XM014127
- GC0XM014503
- GC0XM014663
- GC0XM014661
- GC0XM015061
- GC0XM015211
- GC0XM013060
Summaries for ASB11 Gene
-
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for ASB11 Gene
ASB11 (Ankyrin Repeat And SOCS Box Containing 11) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is ASB5.
UniProtKB/Swiss-Prot for ASB11 Gene
-
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB11 Gene
Genomics for ASB11 Gene
GeneHancer (GH) Regulatory Elements for ASB11 Gene
Promoters and enhancers for ASB11 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ015315 | Promoter | 0.7 | EPDnew | 650.7 | +0.0 | 23 | 0.1 | ZNF664 ZBTB12 TRIM28 | ASB11 ASB9 | |
| GH0XJ015333 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE | 14.6 | -19.7 | -19656 | 2.9 | HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 BRCA1 YY1 POLR2B | PIGA ASB11 ZRSR2 CA5B PIR MOSPD2 GC0XM015327 | |
| GH0XJ015356 | Enhancer | 0.6 | ENCODE | 12.4 | -41.0 | -40977 | 0.1 | FOXA2 RXRA HLF CEBPB RAD21 FOXA1 YY1 MITF SP1 JUND | PIGA ASB11 BMX PIR ACE2 GS1-594A7.3 VEGFD PIR-FIGF | |
| GH0XJ015298 | Enhancer | 0.7 | Ensembl ENCODE | 9.3 | +16.7 | 16723 | 1.3 | SCRT1 SP1 SCRT2 GABPA NR2F2 | ASB9 PIGA ASB11 | |
| GH0XJ015300 | Enhancer | 0.6 | ENCODE | 9 | +15.3 | 15333 | 0.2 | CTCF ZNF654 TAF1 RAD21 YY1 SP1 HNF1A SMC3 | PIGA ASB11 ASB9 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ASB11 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ASB11 gene promoter:
-
- CRE-BP1
- Meis-1a
- ATF-2
- C/EBPalpha
- HOXA9
Regulatory Element Products
Genomic Locations for ASB11 Gene
Genomic Locations for ASB11 Gene
- chrX:15,275,644-15,315,667
- (GRCh38/hg38)
- Size:
- 40,024 bases
- Orientation:
- Minus strand
- chrX:15,298,053-15,333,778
- (GRCh37/hg19)
- Size:
- 35,726 bases
- Orientation:
- Minus strand
Genomic View for ASB11 Gene
Genes around ASB11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by Entrez Gene
- Xp22.2 by HGNC
- Xp22.2 by Ensembl
ASB11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASB11 Gene
Proteins for ASB11 Gene
-
Protein details for ASB11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WXH4-ASB11_HUMAN
- Recommended name:
- Ankyrin repeat and SOCS box protein 11
- Protein Accession:
- Q8WXH4
- E9PEN1
- Q3SYC4
- Q7Z667
Protein attributes for ASB11 Gene
- Size:
- 323 amino acids
- Molecular mass:
- 35367 Da
- Quaternary structure:
- No Data Available
Protein Expression for ASB11 Gene
Post-translational modifications for ASB11 Gene
Other Protein References for ASB11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
-
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- antibodies-online: Search results for 6 available ASB11 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for ASB11
Assay Products
No data available for DME Specific Peptides for ASB11 Gene
Domains & Families for ASB11 Gene
Gene Families for ASB11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ASB11 Gene
Suggested Antigen Peptide Sequences for ASB11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WXH4UniProtKB/Swiss-Prot:
ASB11_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Belongs to the ankyrin SOCS box (ASB) family.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Family:
-
- Belongs to the ankyrin SOCS box (ASB) family.
Function for ASB11 Gene
Molecular function for ASB11 Gene
- UniProtKB/Swiss-Prot Function:
- May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Phenotypes for ASB11 Gene
Animal Model Products
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-
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-
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- Overview of 95 available ASB11 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASB11
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miRNA for ASB11 Gene
- miRTarBase miRNAs that target ASB11
-
- hsa-mir-335-5p (MIRT017058)
- hsa-mir-1277-5p (MIRT503384)
- hsa-mir-297 (MIRT503385)
- hsa-mir-3924 (MIRT503386)
- hsa-mir-190a-3p (MIRT503387)
- hsa-mir-98-3p (MIRT503388)
- hsa-let-7f-1-3p (MIRT503389)
- hsa-let-7b-3p (MIRT503390)
- hsa-let-7a-3p (MIRT503391)
- hsa-mir-567 (MIRT503392)
- hsa-mir-5011-5p (MIRT503393)
- hsa-mir-4666a-3p (MIRT503394)
- hsa-mir-381-3p (MIRT503395)
- hsa-mir-300 (MIRT503396)
- hsa-mir-574-5p (MIRT508361)
- hsa-mir-6867-5p (MIRT508362)
- hsa-mir-223-5p (MIRT508363)
- hsa-mir-4666b (MIRT514701)
- hsa-mir-1909-5p (MIRT514702)
- hsa-mir-3613-3p (MIRT541610)
- hsa-mir-548c-3p (MIRT541611)
- hsa-mir-302c-5p (MIRT716004)
- hsa-mir-210-3p (MIRT716005)
- hsa-mir-3143 (MIRT716006)
- hsa-mir-6820-3p (MIRT716007)
- hsa-mir-3164 (MIRT716008)
- hsa-mir-7157-3p (MIRT716009)
- hsa-mir-6737-3p (MIRT716010)
- hsa-mir-5008-3p (MIRT716011)
- hsa-mir-6889-3p (MIRT716012)
- hsa-mir-4803 (MIRT716013)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for ASB11
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-
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Cell Line Products
-
Horizon Cell Lines for ASB11
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB11 Gene
Localization for ASB11 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| extracellular | 3 |
| plasma membrane | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ASB11 Gene
Pathways & Interactions for ASB11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for ASB11 Gene
4 Reactome pathways for ASB11 Gene
UniProtKB/Swiss-Prot Q8WXH4-ASB11_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ASB11 Gene
GPS-Prot Interaction Network for ASB11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
| GO:0045732 | positive regulation of protein catabolic process | IBA | -- |
No data available for SIGNOR curated interactions for ASB11 Gene
Transcripts for ASB11 Gene
mRNA/cDNA for ASB11 Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000380470 2748 bps (uc010net.3)
- ENST00000344384 2168 bps (uc004cwo.3)
- ENST00000480796 1484 bps (uc004cwp.3)
- ENST00000485437 1089 bps (uc064ych.1)
Unigene Clusters for ASB11 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ASB11
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- Overview of 95 available ASB11 gene related products
- Applied Biological Materials CRISPR for ASB11
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASB11
- GenScript: Design CRISPR guide RNA sequences for ASB11
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ASB11
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- Overview of 95 available ASB11 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ASB11
- Addgene plasmids for ASB11
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- Applied Biological Materials Clones for ASB11
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||
| SP3: | - |
Expression for ASB11 Gene
mRNA differential expression in normal tissues according to GTEx for ASB11 Gene
This gene is overexpressed in Heart - Left Ventricle (x20.3), Muscle - Skeletal (x19.7), and Heart - Atrial Appendage (x9.6).
This gene is overexpressed in Tonsil (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASB11 Gene
NURSA nuclear receptor signaling pathways regulating expression of ASB11 Gene:
ASB11SOURCE GeneReport for Unigene cluster for ASB11 Gene:
Hs.352183Evidence on tissue expression from TISSUES for ASB11 Gene
- Liver(4.2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for ASB11
-
OriGene qPCR primer pairs and template standards for ASB11
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB11 Gene
Orthologs for ASB11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ASB11 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ASB11 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ASB11 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Asb11 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Asb11 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ASB11 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ASB11 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ASB11 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ASB11 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | asb11 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | asb11 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4234 34 |
|
OneToMany |
- Species where no ortholog for ASB11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ASB11 Gene
- ENSEMBL:
- Gene Tree for ASB11 (if available)
- TreeFam:
- Gene Tree for ASB11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ASB11: view image
Paralogs for ASB11 Gene
Paralogs for ASB11 Gene
(59) SIMAP similar genes for ASB11 Gene using alignment to 2 proteins:
- ASB11_HUMAN
- F8WF31_HUMAN
- DKFZp779E2460
- LYRM4
- AURA2
- CTSS
- ZNF547
- DCTN5
- SHANK2
- TMEM44
- RNF217
- ZNF738
- ZNF737
- UTY
- NF2
- FAM175A
- WARS
- FAM210A
- NSRP1
- FKBP3
- DNMT1
- ASB5
- LEPROTL1
- HKR1
- DKFZp313J0816
- ZNF816
- ZNF585B
- USP10
- LINC00596
- TMSB15B
- ZNF28
- ZNF83
- ZNF763
- ZNF283
- SNX31
- EIF3L
- C4orf21
- ZNF564
- SPAG11B
- SPAG11A
- ASB9
- SEPT2
- MED15
- ZNF212
- SPATS2L
- CHID1
- TMEM14B
- DAPL1
- TSEN2
- ZNF461
- QRICH2
- CRCP
- ZNF20
- TCF4
- BECN1
- ASB13
- ZNF468
- APOD
- PLA2G6
- GLT8D2
- TNFRSF17
Variants for ASB11 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000060589 | -- | 15,282,199(-) | A/C/G | 3_prime_UTR_variant | |
| rs1000129205 | -- | 15,289,171(-) | C/T | intron_variant | |
| rs1000244218 | -- | 15,289,589(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs1000599872 | -- | 15,286,871(-) | A/T | intron_variant | |
| rs1000718222 | -- | 15,305,715(-) | A/T | intron_variant |
Residual Variation Intolerance Score:
81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.91;
48.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ASB11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ASB11
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB11 Gene
Disorders for ASB11 Gene
Additional Disease Information for ASB11
No disorders were found for ASB11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB11 Gene
Publications for ASB11 Gene
- Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen CA … Flores-Morales A (The Journal of biological chemistry 2014) 2 3 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J … Vissers LE (The New England journal of medicine 2012) 4 58
- Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
- The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
Products for ASB11 Gene
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Sources for ASB11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
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