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The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced t... See more...
Aliases for ASB11 Gene
Aliases for ASB11 Gene
External Ids for ASB11 Gene
- HGNC: 17186
- Entrez Gene: 140456
- Ensembl: ENSG00000165192
- OMIM: 300626
- UniProtKB: Q8WXH4
Previous GeneCards Identifiers for ASB11 Gene
- GC0XM014746
- GC0XM014127
- GC0XM014503
- GC0XM014663
- GC0XM014661
- GC0XM015061
- GC0XM015211
- GC0XM013060
Summaries for ASB11 Gene
-
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for ASB11 Gene
ASB11 (Ankyrin Repeat And SOCS Box Containing 11) is a Protein Coding gene. Diseases associated with ASB11 include Lacrimal Duct Obstruction. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB5.
UniProtKB/Swiss-Prot Summary for ASB11 Gene
-
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Additional gene information for ASB11 Gene
- HGNC(17186)
- Entrez Gene(140456)
- Ensembl(ENSG00000165192)
- OMIM(300626)
- UniProtKB(Q8WXH4)
- Open Targets Platform(ENSG00000165192)
- Search for ASB11 at DataMed
- Search for ASB11 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ASB11 Gene
Genomics for ASB11 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ASB11 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ015312 | Promoter | 0.5 | Ensembl | 608.9 | +1.0 | 1039 | 1.6 | ATF2 ATF4 | ASB11 PIGA ASB9 | |
| GH0XJ015315 | Promoter | 0.5 | EPDnew | 600.7 | 0.0 | -4 | 0.1 | ZNF664 ZBTB12 | ASB11 lnc-ASB11-2 PIGA | |
| GH0XJ015317 | Enhancer | 0.2 | Ensembl | 600.7 | -0.7 | -661 | 0.2 | ASB11 lnc-ASB11-2 PIGA | ||
| GH0XJ015333 | Promoter/Enhancer | 2.2 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas | 14.6 | -19.7 | -19660 | 3 | SP1 CREB1 PRDM10 ZNF629 RFX1 POLR2A BACH1 JUND LARP7 PRDM1 | PIGA lnc-ASB11-1 ASB11 ZRSR2 CA5B PIR MOSPD2 lnc-ASB11-2 | |
| GH0XJ015356 | Enhancer | 0.7 | Ensembl ENCODE | 12.4 | -41.1 | -41061 | 1 | SP1 RBAK CEBPB FOXA2 YY1 JUND RAD21 HNF4A RXRA HLF | PIGA ASB11 BMX PIR ACE2 GS1-594A7.3 piR-41405-154 VEGFD PIR-FIGF |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ASB11 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ASB11
- Top Transcription factor binding sites by QIAGEN in the ASB11 gene promoter:
-
- ATF-2
- C/EBPalpha
- CRE-BP1
- HOXA9
- Meis-1a
Genomic Locations for ASB11 Gene
Genomic Locations for ASB11 Gene
- chrX:15,281,697-15,315,640
- (GRCh38/hg38)
- Size:
- 33,944 bases
- Orientation:
- Minus strand
- chrX:15,298,053-15,333,778
- (GRCh37/hg19)
- Size:
- 35,726 bases
- Orientation:
- Minus strand
Genomic View for ASB11 Gene
Genes around ASB11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by HGNC
- Xp22.2 by Entrez Gene
- Xp22.2 by Ensembl
ASB11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASB11 Gene
Proteins for ASB11 Gene
-
Protein details for ASB11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WXH4-ASB11_HUMAN
- Recommended name:
- Ankyrin repeat and SOCS box protein 11
- Protein Accession:
- Q8WXH4
- E9PEN1
- Q3SYC4
- Q7Z667
Protein attributes for ASB11 Gene
- Size:
- 323 amino acids
- Molecular mass:
- 35367 Da
- Quaternary structure:
- No Data Available
Protein Expression for ASB11 Gene
Post-translational modifications for ASB11 Gene
Other Protein References for ASB11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ASB11
- Novus Biologicals Antibodies for ASB11
- Invitrogen Antibodies for ASB11 (AFLGC-ASB11)
-
Biorbyt antibodies for ASB11
Protein Products
-
OriGene Purified Proteins for ASB11
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- antibodies-online: Show 6 available ASB11 Proteins ranked by validation data
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-
Quality Products:
-
Abcam proteins for ASB11
Assay Products
No data available for DME Specific Peptides for ASB11 Gene
Domains & Families for ASB11 Gene
Gene Families for ASB11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ASB11 Gene
- InterPro:
- Blocks:
-
- Ankyrin repeat signature
- SOCS protein, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for ASB11 Gene
- GenScript: Design optimal peptide antigens:
-
- Ankyrin repeat and SOCS box protein 11 (ASB11_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8WXH4UniProtKB/Swiss-Prot:
ASB11_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Belongs to the ankyrin SOCS box (ASB) family.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Family:
-
- Belongs to the ankyrin SOCS box (ASB) family.
Function for ASB11 Gene
Molecular function for ASB11 Gene
- UniProtKB/Swiss-Prot Function:
- May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Phenotypes From GWAS Catalog for ASB11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for ASB11 Gene
Animal Model Products
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CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ASB11 - Select products 50% OFF >
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-
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miRNA for ASB11 Gene
- miRTarBase miRNAs that target ASB11
-
- hsa-miR-335-5p (MIRT017058)
- hsa-miR-1277-5p (MIRT503384)
- hsa-miR-297 (MIRT503385)
- hsa-miR-3924 (MIRT503386)
- hsa-miR-190a-3p (MIRT503387)
- hsa-miR-98-3p (MIRT503388)
- hsa-let-7f-1-3p (MIRT503389)
- hsa-let-7b-3p (MIRT503390)
- hsa-let-7a-3p (MIRT503391)
- hsa-miR-567 (MIRT503392)
- hsa-miR-5011-5p (MIRT503393)
- hsa-miR-4666a-3p (MIRT503394)
- hsa-miR-381-3p (MIRT503395)
- hsa-miR-300 (MIRT503396)
- hsa-miR-574-5p (MIRT508361)
- hsa-miR-6867-5p (MIRT508362)
- hsa-miR-223-5p (MIRT508363)
- hsa-miR-4666b (MIRT514701)
- hsa-miR-1909-5p (MIRT514702)
- hsa-miR-3613-3p (MIRT541610)
- hsa-miR-548c-3p (MIRT541611)
- hsa-miR-302c-5p (MIRT716004)
- hsa-miR-210-3p (MIRT716005)
- hsa-miR-3143 (MIRT716006)
- hsa-miR-6820-3p (MIRT716007)
- hsa-miR-3164 (MIRT716008)
- hsa-miR-7157-3p (MIRT716009)
- hsa-miR-6737-3p (MIRT716010)
- hsa-miR-5008-3p (MIRT716011)
- hsa-miR-6889-3p (MIRT716012)
- hsa-miR-4803 (MIRT716013)
miRNA Products
Inhibitory RNA Products
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for ASB11
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB11 Gene
Localization for ASB11 Gene
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| cytosol | 4 |
| extracellular | 2 |
| cytoskeleton | 1 |
| plasma membrane | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IDA | 24337577 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ASB11 Gene
Pathways & Interactions for ASB11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for ASB11 Gene
4 Reactome pathways for ASB11 Gene
UniProtKB/Swiss-Prot Q8WXH4-ASB11_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ASB11 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| CDK3 | ||
| CUL5 | ||
| ENSG00000272822 | ||
| PRPS1 | ||
| PSMA2 |
GPS-Prot Interaction Network for ASB11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IBA,IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
| GO:0045732 | positive regulation of protein catabolic process | IBA | 21873635 |
No data available for SIGNOR curated interactions for ASB11 Gene
Transcripts for ASB11 Gene
mRNA/cDNA for ASB11 Gene
- 3 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000380470 2748 nts (view in UCSC)
- ENST00000344384 2168 nts (view in UCSC)
- ENST00000480796 2815 nts (view in UCSC)
- ENST00000485437 1089 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ASB11 - Select products 50% OFF >
- * ASB11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ASB11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ASB11
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASB11
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ASB11
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Clone Products
- Applied Biological Materials (abm): Clones for ASB11 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for ASB11
- Addgene plasmids for ASB11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ASB11
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||
| SP3: | - |
Relevant External Links for ASB11 Gene
- GeneLoc Exon Structure for
- ASB11
Expression for ASB11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for ASB11 Gene
This gene is overexpressed in Heart - Left Ventricle (x20.3), Muscle - Skeletal (x19.7), and Heart - Atrial Appendage (x9.6).
This gene is overexpressed in Tonsil (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASB11 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ASB11
SOURCE GeneReport for Unigene cluster for ASB11 Gene:
Hs.352183Evidence on tissue expression from TISSUES for ASB11 Gene
- Liver(4.2)
- Muscle(2.4)
Primer Products
-
OriGene qPCR primer pairs for ASB11
-
OriGene qPCR primer pairs and template standards for ASB11
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB11 Gene
Orthologs for ASB11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ASB11 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ASB11 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ASB11 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Asb11 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Asb11 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ASB11 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ASB11 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ASB11 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ASB11 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | asb11 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | asb11 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4234 31 |
|
OneToMany |
- Species where no ortholog for ASB11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ASB11 Gene
- ENSEMBL:
- Gene Tree for ASB11 (if available)
- TreeFam:
- Gene Tree for ASB11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ASB11: view image
Paralogs for ASB11 Gene
(59) SIMAP similar genes for ASB11 Gene using alignment to 2 proteins:
- ASB11_HUMAN
- F8WF31_HUMAN
- DKFZp779E2460
- LYRM4
- AURA2
- CTSS
- ZNF547
- DCTN5
- SHANK2
- TMEM44
- RNF217
- ZNF738
- ZNF737
- UTY
- NF2
- FAM175A
- WARS
- FAM210A
- NSRP1
- FKBP3
- DNMT1
- ASB5
- LEPROTL1
- HKR1
- DKFZp313J0816
- ZNF816
- ZNF585B
- USP10
- LINC00596
- TMSB15B
- ZNF28
- ZNF83
- ZNF763
- ZNF283
- SNX31
- EIF3L
- C4orf21
- ZNF564
- SPAG11B
- SPAG11A
- ASB9
- SEPT2
- MED15
- ZNF212
- SPATS2L
- CHID1
- TMEM14B
- DAPL1
- TSEN2
- ZNF461
- QRICH2
- CRCP
- ZNF20
- TCF4
- BECN1
- ASB13
- ZNF468
- APOD
- PLA2G6
- GLT8D2
- TNFRSF17
Variants for ASB11 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ASB11 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 782970 | Benign: not provided | 15,289,537(-) | T/A | MISSENSE_VARIANT | |
| 791377 | Benign: not provided | 15,287,983(-) | C/T | MISSENSE_VARIANT | |
| rs144572145 | - | p.Ser165Leu | |||
| rs34025595 | - | p.Asp249Asn | |||
| rs35859007 | - | p.Ser263Gly |
Residual Variation Intolerance Score:
81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.91;
48.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ASB11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ASB11
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB11 Gene
Disorders for ASB11 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lacrimal duct obstruction |
|
|
Search ASB11 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ASB11
No data available for UniProtKB/Swiss-Prot and Genatlas for ASB11 Gene
Publications for ASB11 Gene
- Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen CA … Flores-Morales A (The Journal of biological chemistry 2014) 2 3
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. (PMID: 30759391) Kumar S … Einav S (Cell reports 2019) 3
- BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. (PMID: 31387940) Chen FY … Chen RH (The Journal of cell biology 2019) 3
- Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J … Vissers LE (The New England journal of medicine 2012) 4
ExternalLinks
Products for ASB11 Gene
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- Biorbyt antibodies for ASB11
Sources for ASB11 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
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