Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASAP3 Gene

Aliases for ASAP3 Gene

  • ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3 2 3 5
  • Development And Differentiation Enhancing Factor-Like 1 2 3
  • Protein Up-Regulated In Liver Cancer 1 3 4
  • Centaurin, Beta 6 2 3
  • DDEFL1 3 4
  • UPLC1 3 4
  • Arf-GAP With SH3 Domain, ANK Repeat And PH Domain-Containing Protein 3 3
  • ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3 1 3
  • Development And Differentiation-Enhancing Factor-Like 1 4
  • Up-Regulated In Liver Cancer 1 (UPLC1) 3
  • ARF6 GTPase-Activating Protein 3
  • CENTB6 3
  • ACAP4 3

External Ids for ASAP3 Gene

Previous HGNC Symbols for ASAP3 Gene

  • DDEFL1

Previous GeneCards Identifiers for ASAP3 Gene

  • GC01M023628
  • GC01M023755
  • GC01M022006

Summaries for ASAP3 Gene

Entrez Gene Summary for ASAP3 Gene

  • This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for ASAP3 Gene

ASAP3 (ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3) is a Protein Coding gene. Among its related pathways are Endocytosis and Fc gamma R-mediated phagocytosis. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ASAP2.

UniProtKB/Swiss-Prot for ASAP3 Gene

  • Promotes cell proliferation.

Additional gene information for ASAP3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASAP3 Gene

Genomics for ASAP3 Gene

GeneHancer (GH) Regulatory Elements for ASAP3 Gene

Promoters and enhancers for ASAP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I023482 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 585.4 +0.2 243 2.9 HDGF ATF1 ARNT ZNF48 GLIS2 KLF7 ATF7 SP3 NCOA1 REST ASAP3 ZNF436 TCEA3 GC01M023474
GH01I023420 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 43.2 +61.4 61370 5.1 HDGF ATF1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 POLR2B PAF1 TCEA3 ASAP3 ZNF436-AS1 ENSG00000201405 ZNF436 LINC01355 ENSG00000232482
GH01I023478 Enhancer 1.4 Ensembl ENCODE dbSUPER 34.8 +5.2 5249 1.2 PKNOX1 FOXA2 ARID4B DMAP1 YY1 POLR2B ZNF766 DEK SP5 NFYC ASAP3 GC01P023475 GC01M023474 GC01P023474
GH01I023451 Enhancer 1.2 Ensembl ENCODE dbSUPER 30.8 +32.2 32215 2.3 PKNOX1 NFIB NEUROD1 KLF17 GLIS2 GATA2 RCOR1 HCFC1 CEBPB GATAD2B GC01P023453 ASAP3 GC01M023439
GH01I023471 Enhancer 1 Ensembl ENCODE 33.5 +10.2 10210 4.9 PKNOX1 FOXA2 RAD21 RFX5 YY1 SCRT2 RCOR1 RXRA ZNF623 NFIC GC01P023474 GC01P023475 ASAP3 ZNF436-AS1 HNRNPR ZNF436 TCEA3 GC01M023474
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ASAP3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ASAP3 Gene

Genomic Locations for ASAP3 Gene
56,006 bases
Minus strand

Genomic View for ASAP3 Gene

Genes around ASAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASAP3 Gene

Proteins for ASAP3 Gene

  • Protein details for ASAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B3KRW0
    • B4DHH4
    • Q6P9F4
    • Q86UY1
    • Q9NXK2

    Protein attributes for ASAP3 Gene

    903 amino acids
    Molecular mass:
    99155 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ASAP3 Gene

    Alternative splice isoforms for ASAP3 Gene


neXtProt entry for ASAP3 Gene

Post-translational modifications for ASAP3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ASAP3 Gene

Domains & Families for ASAP3 Gene

Suggested Antigen Peptide Sequences for ASAP3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ASAP3: view

No data available for UniProtKB/Swiss-Prot for ASAP3 Gene

Function for ASAP3 Gene

Molecular function for ASAP3 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell proliferation.

Phenotypes From GWAS Catalog for ASAP3 Gene

Gene Ontology (GO) - Molecular Function for ASAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA,IEA 18400762
GO:0005515 protein binding IPI 19380743
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ASAP3: view
genes like me logo Genes that share phenotypes with ASAP3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ASAP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASAP3 Gene

Localization for ASAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASAP3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASAP3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ASAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 18400762
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005925 focal adhesion IEA,IDA 18400762
genes like me logo Genes that share ontologies with ASAP3: view

Pathways & Interactions for ASAP3 Gene

genes like me logo Genes that share pathways with ASAP3: view

Pathways by source for ASAP3 Gene

2 KEGG pathways for ASAP3 Gene

Gene Ontology (GO) - Biological Process for ASAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration IMP,IEA 18400762
GO:0043547 positive regulation of GTPase activity IEA,IDA 18400762
GO:0051492 regulation of stress fiber assembly IMP 18400762
genes like me logo Genes that share ontologies with ASAP3: view

No data available for SIGNOR curated interactions for ASAP3 Gene

Drugs & Compounds for ASAP3 Gene

No Compound Related Data Available

Transcripts for ASAP3 Gene

Unigene Clusters for ASAP3 Gene

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ASAP3

Alternative Splicing Database (ASD) splice patterns (SP) for ASAP3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - -
SP4: -

ExUns: 19b · 19c ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27
SP1: - - - -
SP2: - - - - - - - - - - - -
SP5: - -
SP10: - - -

Relevant External Links for ASAP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASAP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ASAP3 Gene

This gene is overexpressed in Placenta (12.8), Urine (7.9), Pancreas (7.6), and Fetal testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ASAP3 Gene

Protein tissue co-expression partners for ASAP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASAP3 Gene:


SOURCE GeneReport for Unigene cluster for ASAP3 Gene:


mRNA Expression by UniProt/SwissProt for ASAP3 Gene:

Tissue specificity: Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes.

Evidence on tissue expression from TISSUES for ASAP3 Gene

  • Nervous system(4.7)
  • Intestine(4.1)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ASAP3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASAP3 Gene

Orthologs for ASAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASAP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ASAP3 33
  • 98.9 (n)
(Bos Taurus)
Mammalia ASAP3 33 34
  • 90.31 (n)
(Canis familiaris)
Mammalia ASAP3 33 34
  • 88.32 (n)
(Mus musculus)
Mammalia Asap3 33 16 34
  • 82.54 (n)
(Rattus norvegicus)
Mammalia LOC684122 33
  • 81.84 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 22 (a)
(Gallus gallus)
Aves ASAP3 34
  • 68 (a)
(Anolis carolinensis)
Reptilia ASAP3 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia asap3 33
  • 58.34 (n)
(Danio rerio)
Actinopterygii asap3 34
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Asap1 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5006 34
  • 29 (a)
Species where no ortholog for ASAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASAP3 Gene

Gene Tree for ASAP3 (if available)
Gene Tree for ASAP3 (if available)

Paralogs for ASAP3 Gene

Paralogs for ASAP3 Gene

(4) SIMAP similar genes for ASAP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ASAP3: view

Variants for ASAP3 Gene

Sequence variations from dbSNP and Humsavar for ASAP3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035612 A colorectal cancer sample p.Ala617Thr
rs1000007349 -- 23,432,701(-) G/C intron_variant
rs1000163560 -- 23,447,136(-) G/A intron_variant
rs1000186503 -- 23,452,259(-) C/T intron_variant
rs1000210765 -- 23,455,017(-) GAGCCACAAGAGC/GAGC intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ASAP3 Gene

Variant ID Type Subtype PubMed ID
nsv819574 CNV gain 19587683
nsv834435 CNV loss 17160897
nsv1130950 CNV deletion 24896259
nsv1075332 CNV deletion 25765185
esv3585483 CNV loss 21293372
esv3326511 CNV duplication 20981092

Variation tolerance for ASAP3 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ASAP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASAP3 Gene

Disorders for ASAP3 Gene

Additional Disease Information for ASAP3

No disorders were found for ASAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASAP3 Gene

Publications for ASAP3 Gene

  1. Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas. (PMID: 14654939) Okabe H … Nakamura Y (International journal of oncology 2004) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ASAP3 Gene

  • Addgene plasmids for ASAP3

Sources for ASAP3 Gene

Loading form....