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ASAH2B (N-Acylsphingosine Amidohydrolase 2B) is a Protein Coding gene. Diseases associated with ASAH2B include Dermatitis, Atopic, 2 and Alzheimer Disease. An important paralog of this gene is ASAH2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0017040 | N-acylsphingosine amidohydrolase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0042759 | long-chain fatty acid biosynthetic process | IBA | 21873635 |
GO:0046512 | sphingosine biosynthetic process | IBA | 21873635 |
GO:0046514 | ceramide catabolic process | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Palmitic Acid | Approved | Pharma | Agonist, Full agonist | 27 | ||
Stearic acid | Approved, Experimental | Pharma | 0 | |||
Water | Approved | Pharma | 0 | |||
arachidonic acid | Experimental | Pharma | Activator, Agonist, Inhibitor, Activation, Potentiation | 40 | ||
Myristic acid | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
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3-O-Sulfogalactosylceramide (d18:1/12:0) |
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852100-88-0 |
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3-O-Sulfogalactosylceramide (d18:1/14:0) |
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3-O-Sulfogalactosylceramide (d18:1/16:0) |
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862509-48-6 |
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3-O-Sulfogalactosylceramide (d18:1/18:0) |
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244215-65-4 |
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3-O-Sulfogalactosylceramide (d18:1/18:1(9Z)) |
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Compound | Action | Cas Number |
---|---|---|
Ceranib 1 | Ceramidase inhibitor; antiproliferative | 328076-61-5 |
Compound | Action | Cas Number |
---|---|---|
Ceranib 1 | 328076-61-5 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Asah2 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | asah2 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CDase 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3623214 | CNV | loss | 21293372 |
nsv1035197 | CNV | gain | 25217958 |
nsv1069484 | CNV | deletion | 25765185 |
nsv948007 | CNV | duplication | 23825009 |
nsv948008 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dermatitis, atopic, 2 |
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alzheimer disease |
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