Aliases for AS3MT Gene
External Ids for AS3MT Gene
Previous GeneCards Identifiers for AS3MT Gene
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
GeneCards Summary for AS3MT Gene
AS3MT (Arsenite Methyltransferase) is a Protein Coding gene. Diseases associated with AS3MT include Myopathy, Myosin Storage, Autosomal Dominant and Hyaline Body Myopathy. Among its related pathways are Cytochrome P450 - arranged by substrate type and arsenate detoxification I (glutaredoxin). Gene Ontology (GO) annotations related to this gene include methyltransferase activity and protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. An important paralog of this gene is METTL7A.
UniProtKB/Swiss-Prot Summary for AS3MT Gene
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed:16407288, PubMed:25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655).