Aliases for AS3MT Gene
Aliases for AS3MT Gene
External Ids for AS3MT Gene
- HGNC: 17452
- Entrez Gene: 57412
- Ensembl: ENSG00000214435
- OMIM: 611806
- UniProtKB: Q9HBK9
Previous GeneCards Identifiers for AS3MT Gene
- GC10P104294
- GC10P104606
- GC10P104621
- GC10P104603
- GC10P104623
- GC10P104624
- GC10P098263
- GC10P104629
Summaries for AS3MT Gene
-
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
GeneCards Summary for AS3MT Gene
AS3MT (Arsenite Methyltransferase) is a Protein Coding gene. Diseases associated with AS3MT include Griscelli Syndrome, Type 3. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and protein-L-isoaspartate (D-aspartate) O-methyltransferase activity.
UniProtKB/Swiss-Prot for AS3MT Gene
-
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).
Additional gene information for AS3MT Gene
- Monarch Initiative
- Search for AS3MT at DataMed
- Search for AS3MT at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AS3MT Gene
Genomics for AS3MT Gene
GeneHancer (GH) Regulatory Elements for AS3MT Gene
Promoters and enhancers for AS3MT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around AS3MT on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for AS3MT Gene
Genomic Locations for AS3MT Gene
- chr10:102,869,453-102,901,899
- (GRCh38/hg38)
- Size:
- 32,447 bases
- Orientation:
- Plus strand
- chr10:104,629,210-104,661,656
- (GRCh37/hg19)
Genomic View for AS3MT Gene
Genes around AS3MT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q24.32 by Ensembl
- 10q24.32 by Entrez Gene
- 10q24.32 by HGNC
AS3MT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AS3MT Gene
Proteins for AS3MT Gene
-
Protein details for AS3MT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HBK9-AS3MT_HUMAN
- Recommended name:
- Arsenite methyltransferase
- Protein Accession:
- Q9HBK9
- A6NP79
- Q0VDK3
- Q0VDK4
- Q5PZ02
Protein attributes for AS3MT Gene
- Size:
- 375 amino acids
- Molecular mass:
- 41748 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAG09731.1; Type=Frameshift; Positions=333; Evidence={ECO:0000305};
Protein Expression for AS3MT Gene
Post-translational modifications for AS3MT Gene
Other Protein References for AS3MT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for AS3MT
- Novus Biologicals Antibodies for AS3MT
-
Abcam antibodies for AS3MT
- GeneTex AS3MT antibody for AS3MT
-
Santa Cruz Biotechnology (SCBT) Antibodies for AS3MT
Protein Products
- R&D Systems Proteins and Enzymes for AS3MT
-
OriGene Purified Proteins for AS3MT
- Search Origene for MassSpec and Protein Over-expression Lysates for AS3MT
- Origene Custom Protein Services for AS3MT
- ProSpec Recombinant Proteins for AS3MT
- antibodies-online: Search results for 7 available AS3MT Proteins ranked by validation data
- Compare Top AS3MT Proteins
-
Quality Products:
- Search GeneTex for Proteins for AS3MT
-
Abcam proteins for AS3MT
Assay Products
-
Cloud-Clone Corp. Assay Kits for AS3MT
No data available for DME Specific Peptides for AS3MT Gene
Domains & Families for AS3MT Gene
Gene Families for AS3MT Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for AS3MT Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for AS3MT Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9HBK9UniProtKB/Swiss-Prot:
AS3MT_HUMAN :- Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.
- Family:
-
- Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.
Function for AS3MT Gene
Molecular function for AS3MT Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=4.6 uM for sodium arsenite {ECO:0000269 PubMed:16407288}; KM=11.8 uM for AdoMet {ECO:0000269 PubMed:16407288};
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.
- UniProtKB/Swiss-Prot Function:
- Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).
Enzyme Numbers (IUBMB) for AS3MT Gene
Phenotypes From GWAS Catalog for AS3MT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0030791 | arsenite methyltransferase activity | TAS | -- |
| GO:0030792 | methylarsonite methyltransferase activity | ISS | -- |
Phenotypes for AS3MT Gene
- MGI mutant phenotypes for AS3MT:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for AS3MT:
-
- Increased viability
- Decreased viability
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Increased transferrin (TF) endocytosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased homologous recombination repair frequency
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for AS3MT Gene
- MGI Knock Outs for AS3MT:
-
- As3mt tm1Djth
Animal Model Products
-
Taconic Biosciences Mouse Models for AS3MT
- Cyagen custom Knockout/knockin (KOKI) mouse models for AS3MT
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AS3MT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AS3MT gene
- Search ViGene Biosciences for AS3MT
CRISPR Products
-
OriGene CRISPR knockouts for AS3MT
- genomics-online: gRNA clones - Search results for available AS3MT gene related products
- Applied Biological Materials CRISPR for AS3MT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AS3MT
- GenScript: Design CRISPR guide RNA sequences for AS3MT
miRNA for AS3MT Gene
- miRTarBase miRNAs that target AS3MT
-
- hsa-mir-640 (MIRT629498)
- hsa-mir-215-5p (MIRT629499)
- hsa-mir-192-5p (MIRT629500)
- hsa-mir-6821-3p (MIRT629501)
- hsa-mir-6790-3p (MIRT629502)
- hsa-mir-150-5p (MIRT629503)
- hsa-mir-1224-3p (MIRT629504)
- hsa-mir-6814-5p (MIRT629505)
- hsa-mir-6513-3p (MIRT629506)
- hsa-mir-4761-5p (MIRT629507)
- hsa-mir-8079 (MIRT629508)
- hsa-mir-1245a (MIRT629509)
- hsa-mir-4735-3p (MIRT629510)
- hsa-mir-18b-5p (MIRT629511)
- hsa-mir-18a-5p (MIRT629512)
- hsa-mir-5006-3p (MIRT631534)
- hsa-mir-4755-5p (MIRT631535)
- hsa-mir-4753-3p (MIRT631536)
- hsa-mir-6873-3p (MIRT631537)
- hsa-mir-211-5p (MIRT631538)
- hsa-mir-204-5p (MIRT631539)
- hsa-mir-623 (MIRT631540)
- hsa-mir-130b-5p (MIRT631541)
- hsa-mir-6817-3p (MIRT631542)
- hsa-mir-6734-3p (MIRT631543)
- hsa-mir-498 (MIRT679941)
- hsa-mir-4279 (MIRT679942)
- hsa-mir-6783-3p (MIRT679943)
- hsa-mir-1343-3p (MIRT679944)
- hsa-mir-23b-5p (MIRT679945)
- hsa-mir-23a-5p (MIRT679946)
- hsa-mir-6778-3p (MIRT679947)
- hsa-mir-1976 (MIRT679948)
- hsa-mir-3653-5p (MIRT679949)
- hsa-mir-138-1-3p (MIRT679950)
- hsa-mir-6742-3p (MIRT679951)
- hsa-mir-6852-5p (MIRT679952)
- hsa-mir-939-3p (MIRT679953)
- hsa-mir-6747-3p (MIRT679954)
- hsa-mir-6727-3p (MIRT679955)
- hsa-mir-4722-3p (MIRT679956)
- hsa-mir-4740-3p (MIRT679957)
- hsa-mir-5571-5p (MIRT679958)
- hsa-mir-665 (MIRT693061)
- hsa-mir-6771-5p (MIRT693062)
- hsa-mir-7160-5p (MIRT693063)
- hsa-mir-4722-5p (MIRT693064)
- hsa-mir-6884-5p (MIRT693065)
- hsa-mir-485-5p (MIRT693066)
- hsa-mir-1827 (MIRT693067)
- hsa-mir-4649-3p (MIRT693068)
- hsa-mir-6787-3p (MIRT693069)
- hsa-mir-6746-5p (MIRT693070)
- hsa-mir-5690 (MIRT693071)
- hsa-mir-6500-3p (MIRT693072)
- hsa-mir-3614-5p (MIRT693073)
- hsa-mir-940 (MIRT693074)
- hsa-mir-6893-5p (MIRT693075)
- hsa-mir-6808-5p (MIRT693076)
- hsa-mir-216b-5p (MIRT693077)
- hsa-mir-216a-5p (MIRT693078)
- hsa-mir-34b-3p (MIRT693079)
- hsa-mir-1267 (MIRT761750)
- hsa-mir-3135b (MIRT764911)
- hsa-mir-3194-3p (MIRT765469)
- hsa-mir-3652 (MIRT766270)
- hsa-mir-367-5p (MIRT766704)
- hsa-mir-4423-5p (MIRT768853)
- hsa-mir-4430 (MIRT768905)
- hsa-mir-5691 (MIRT775005)
- hsa-mir-5693 (MIRT775024)
- hsa-mir-6501-5p (MIRT776517)
- hsa-mir-6805-3p (MIRT779517)
- hsa-mir-744-3p (MIRT781707)
- hsa-mir-129-5p (MIRT783450)
- hsa-mir-3140-3p (MIRT784635)
- hsa-mir-3672 (MIRT785114)
- hsa-mir-4524a-3p (MIRT786099)
- hsa-mir-6864-3p (MIRT789119)
- hsa-mir-6885-3p (MIRT789305)
- hsa-mir-8055 (MIRT789652)
miRNA Products
- Search ViGene Biosciences for AS3MT
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for AS3MT
- Browse OriGene Inhibitory RNA Products For AS3MT
- genomics-online: shRNA clones - Search results for available AS3MT gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for AS3MT gene
Clone Products
- Sino Biological Human cDNA Clone for AS3MT
- VectorBuilder custom plasmid, inducible vectors for AS3MT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AS3MT
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available AS3MT gene related products
- orf clones - Search results for available AS3MT gene related products
- Applied Biological Materials Clones for AS3MT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for AS3MT
-
ViGene Biosciences adenoviral particle packaged cDNA for AS3MT gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AS3MT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AS3MT gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AS3MT Gene
Localization for AS3MT Gene
Subcellular locations from UniProtKB/Swiss-Prot for AS3MT Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| extracellular | 2 |
| mitochondrion | 2 |
- Mitochondria (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for AS3MT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.01
|
|
| 2 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | ||
| 3 | Metabolism |
.37
|
|
| 4 | arsenate detoxification I (glutaredoxin) | ||
Pathways by source for AS3MT Gene
1 BioSystems pathway for AS3MT Gene
4 Reactome pathways for AS3MT Gene
1 Qiagen pathway for AS3MT Gene
Interacting Proteins for AS3MT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009404 | toxin metabolic process | ISS | -- |
| GO:0018872 | arsonoacetate metabolic process | ISS | -- |
| GO:0032259 | methylation | TAS | -- |
No data available for SIGNOR curated interactions for AS3MT Gene
Drugs & Compounds for AS3MT Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| arsenite |
|
15502-74-6 | ||||
| s-adenosylmethionine |
|
29908-03-0 | ||||
| Arsenic |
|
7440-38-2 |
|
|||
| Dimethylarsinate |
|
15132-04-4 |
|
|||
| L-Methionine |
|
63-68-3 |
|
Transcripts for AS3MT Gene
mRNA/cDNA for AS3MT Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (261) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for AS3MT Gene
CRISPR Products
-
OriGene CRISPR knockouts for AS3MT
- genomics-online: gRNA clones - Search results for available AS3MT gene related products
- Applied Biological Materials CRISPR for AS3MT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AS3MT
- GenScript: Design CRISPR guide RNA sequences for AS3MT
miRNA Products
- Search ViGene Biosciences for AS3MT
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for AS3MT
- Browse OriGene Inhibitory RNA Products For AS3MT
- genomics-online: shRNA clones - Search results for available AS3MT gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for AS3MT gene
Clone Products
- Sino Biological Human cDNA Clone for AS3MT
- VectorBuilder custom plasmid, inducible vectors for AS3MT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AS3MT
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available AS3MT gene related products
- orf clones - Search results for available AS3MT gene related products
- Applied Biological Materials Clones for AS3MT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for AS3MT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Periportal Hepatocytes Liver Lobule
- Epiblast (Early Embryonic Tissues)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for AS3MT Gene
This gene is overexpressed in Adrenal Gland (x30.7).
This gene is overexpressed in Adrenal (40.6), Cerebrospinal fluid (7.3), Fetal testis (6.8), and Testis (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AS3MT Gene
NURSA nuclear receptor signaling pathways regulating expression of AS3MT Gene:
AS3MTSOURCE GeneReport for Unigene cluster for AS3MT Gene:
Hs.720370Evidence on tissue expression from TISSUES for AS3MT Gene
- Liver(4.5)
- Urine(2.2)
- Adrenal gland(2)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for AS3MT
- genomics-online: primer clones - Search results for available AS3MT gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AS3MT Gene
Orthologs for AS3MT Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AS3MT 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | AS3MT 33 |
|
||
| cow (Bos Taurus) |
Mammalia | AS3MT 33 34 |
|
||
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | As3mt 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | As3mt 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | AS3MT 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AS3MT 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | AS3MT 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | as3mt 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | as3mt 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9677 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5398 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.12976 33 |
|
- Species where no ortholog for AS3MT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for AS3MT Gene
No data available for Paralogs for AS3MT Gene
Variants for AS3MT Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000054821 | -- | 102,888,219(+) | C/T | intron_variant | |
| rs1000134191 | -- | 102,901,490(+) | G/C | 3_prime_UTR_variant | |
| rs1000168209 | -- | 102,898,160(+) | A/C | intron_variant | |
| rs1000216360 | -- | 102,894,524(+) | A/T | intron_variant | |
| rs1000267314 | -- | 102,894,912(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1651901 | CNV | deletion | 17803354 |
| esv2489056 | CNV | deletion | 19546169 |
| esv2740239 | CNV | deletion | 23290073 |
| esv2740251 | CNV | deletion | 23290073 |
| esv3546767 | CNV | deletion | 23714750 |
| esv3624404 | CNV | loss | 21293372 |
| nsv1069070 | CNV | deletion | 25765185 |
| nsv1147211 | CNV | deletion | 26484159 |
| nsv948172 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.78;
47.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AS3MT Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AS3MT Gene
Disorders for AS3MT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| griscelli syndrome, type 3 |
|
|
Search AS3MT in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for AS3MT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for AS3MT Gene
Publications for AS3MT Gene
- Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic. (PMID: 19896490) Engström KS … Broberg K (Mutation research 2010) 3 22 44 58
- Global analysis of genetic variation in human arsenic (+3 oxidation state) methyltransferase (AS3MT). (PMID: 19932709) Fujihara J … Takeshita H (Toxicology and applied pharmacology 2010) 3 22 44 58
- Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. (PMID: 18682255) Schläwicke Engström K … Broberg K (Mutation research 2009) 3 22 44 58
- Ethnic differences in five intronic polymorphisms associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene. (PMID: 18976679) Fujihara J … Takeshita H (Toxicology and applied pharmacology 2009) 3 22 44 58
- Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions. (PMID: 19538983) Valenzuela OL … Del Razo LM (Toxicology and applied pharmacology 2009) 3 22 44 58
Products for AS3MT Gene
- Browse R&D Systems for Antibodies
- R&D Systems Proteins and Enzymes for AS3MT
- Browse R&D Systems for biochemical assays
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- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
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- Browse Luminex Assays
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for AS3MT
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for AS3MT
- Search Origene for MassSpec and Protein Over-expression Lysates for AS3MT
- Origene Custom Protein Services for AS3MT
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AS3MT
- Browse OriGene Inhibitory RNA Products For AS3MT
- OriGene qPCR primer pairs for AS3MT
- OriGene CRISPR knockouts for AS3MT
- OriGene ORF clones in human for AS3MT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For AS3MT
- GenScript: Next-day shipping of latest version cDNA ORF clones for AS3MT in any vector
- GenScript Custom Purified and Recombinant Proteins Services for AS3MT
- GenScript Custom Assay Services for AS3MT
- GenScript Custom overexpressing Cell Line Services for AS3MT
- GenScript: Design CRISPR guide RNA sequences for AS3MT
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for AS3MT
- Sino Biological Human cDNA Clone for AS3MT
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for AS3MT
- Novus Biologicals lysates and proteins for AS3MT
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for AS3MT
- Abcam proteins for AS3MT
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for AS3MT
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Cloud-Clone Corp. Assay Kits for AS3MT
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for AS3MT
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Cyagen custom Knockout/knockin (KOKI) mouse models for AS3MT
- VectorBuilder custom plasmid, inducible vectors for AS3MT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AS3MT
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 23 available AS3MT Antibodies ranked by validation data
- Compare Top AS3MT Antibodies
- antibodies-online: Search results for 15 available AS3MT Elisa Kits ranked by validation data
- Compare Top AS3MT Elisa Kits
- antibodies-online: Search results for 7 available AS3MT Proteins ranked by validation data
- Compare Top AS3MT Proteins
- Quality Products:
- GeneTex AS3MT antibody for AS3MT
- Search GeneTex for Proteins for AS3MT
- ViGene Biosciences adenoviral particle packaged cDNA for AS3MT gene
- ViGene Biosciences lentiviral particle packaged cDNA for AS3MT gene
- ViGene Biosciences ready-to-package AAV shRNAs for AS3MT gene
- Search ViGene Biosciences for AS3MT
- Santa Cruz Biotechnology (SCBT) Antibodies for AS3MT
- Search Santa Cruz Biotechnology (SCBT) for AS3MT siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AS3MT
- Horizon Cell Lines for AS3MT
- genomics-online: cdna clones - Search results for available AS3MT gene related products
- orf clones - Search results for available AS3MT gene related products
- genomics-online: gRNA clones - Search results for available AS3MT gene related products
- genomics-online: primer clones - Search results for available AS3MT gene related products
- genomics-online: shRNA clones - Search results for available AS3MT gene related products
Sources for AS3MT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
