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AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
AS3MT (Arsenite Methyltransferase) is a Protein Coding gene. Diseases associated with AS3MT include Myopathy, Myosin Storage, Autosomal Dominant and Hyaline Body Myopathy. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. An important paralog of this gene is COQ5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008168 | methyltransferase activity | IBA | 21873635 |
GO:0016740 | transferase activity | IEA | -- |
GO:0030791 | arsenite methyltransferase activity | TAS | -- |
GO:0030792 | methylarsonite methyltransferase activity | IDA | 25997655 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type |
.01
|
|
2 | Neuropathic Pain-Signaling in Dorsal Horn Neurons |
Aldosterone Signaling in Epithelial Cells
.47
|
|
3 | Metabolism |
.40
|
|
4 | arsenate detoxification I (glutaredoxin) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0009404 | toxin metabolic process | IBA,IDA | 25997655 |
GO:0018872 | arsonoacetate metabolic process | IDA | 25997655 |
GO:0032259 | methylation | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
arsenite |
|
15502-74-6 | ||||
s-adenosylmethionine |
|
485-80-3 | ||||
Arsenic |
|
7440-38-2 |
|
|||
Methylarsonate |
|
124-58-3 |
|
|||
Methylarsonite |
|
25400-23-1 |
|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AS3MT 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AS3MT 30 |
|
||
Cow (Bos Taurus) |
Mammalia | AS3MT 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | As3mt 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | As3mt 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | AS3MT 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | AS3MT 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | AS3MT 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | as3mt 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | as3mt 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9677 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5398 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.12976 30 |
|
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17880345 | Benign: not provided | 102,870,074(+) |
G/T NM_020682.4(AS3MT):c.43-10G>T |
INTRON | |
rs11191439 | - |
p.Met287Thr |
|||
rs34556438 | - |
p.Thr306Ile |
|||
rs35232887 | - |
p.Arg173Trp |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1651901 | CNV | deletion | 17803354 |
esv2489056 | CNV | deletion | 19546169 |
esv2740239 | CNV | deletion | 23290073 |
esv2740251 | CNV | deletion | 23290073 |
esv3546767 | CNV | deletion | 23714750 |
esv3624404 | CNV | loss | 21293372 |
nsv1069070 | CNV | deletion | 25765185 |
nsv1147211 | CNV | deletion | 26484159 |
nsv948172 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
myopathy, myosin storage, autosomal dominant |
|
|
hyaline body myopathy |
|
|
borst-jadassohn intraepidermal carcinoma |
|
|
attention deficit-hyperactivity disorder |
|
|
schizophrenia |
|
|