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Aliases for ARTN Gene

Aliases for ARTN Gene

  • Artemin 2 3 3 5
  • Neublastin 2 3 4
  • EVN 3 4
  • Neurotrophic Factor 2
  • ENOVIN 3
  • Enovin 4
  • ART 3
  • NBN 3

External Ids for ARTN Gene

Previous GeneCards Identifiers for ARTN Gene

  • GC01P044237
  • GC01P043399
  • GC01P043828
  • GC01P043812
  • GC01P044068
  • GC01P044171
  • GC01P044398
  • GC01P042517

Summaries for ARTN Gene

Entrez Gene Summary for ARTN Gene

  • This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016]

GeneCards Summary for ARTN Gene

ARTN (Artemin) is a Protein Coding gene. Diseases associated with ARTN include Hirschsprung Disease 1 and Parkinson Disease, Late-Onset. Among its related pathways are RET signaling and Developmental Biology. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity. An important paralog of this gene is NRTN.

UniProtKB/Swiss-Prot for ARTN Gene

  • Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyers patch-like structures, a major component of the gut-associated lymphoid tissue.

Gene Wiki entry for ARTN Gene

Additional gene information for ARTN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARTN Gene

Genomics for ARTN Gene

GeneHancer (GH) Regulatory Elements for ARTN Gene

Promoters and enhancers for ARTN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J043932 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 668.6 +2.8 2766 4.6 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 GLI4 ZNF2 IRF4 ZNF48 ARTN CCDC24 ATP6V0B ST3GAL3 GC01M043936
GH01J043928 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 668.3 -1.8 -1800 2.3 PKNOX1 ZNF2 RAD21 ZEB1 ZNF335 GLIS2 EGR1 ZSCAN5C SCRT2 ZNF143 ARTN ST3GAL3 ATP6V0B CCDC24 GC01M043857 ENSG00000284989
GH01J044212 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 38.2 +281.6 281585 2.3 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 DMAP1 SZT2 KDM4A-AS1 HYI ARTN RPS8 MED8 HECTD3 PTCH2 KDM4A
GH01J043830 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 40.8 -97.8 -97790 6.3 HDGF PKNOX1 FOXA2 SMAD1 ZNF2 ZNF766 ZNF207 ZNF143 FOS JUNB GC01M043833 ARTN SZT2 LOC101929609 DMAP1 ST3GAL3 IPO13 HYI LOC101929592 KDM4A-AS1
GH01J042949 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.9 -975.1 -975082 15.6 FEZF1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF585B GLIS1 RCOR2 SLC2A1 SLC2A1-AS1 SZT2 ARTN PPIH P3H1 MED8 RNU6-880P ERMAP LOC101929609
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARTN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARTN gene promoter:

Genomic Locations for ARTN Gene

Genomic Locations for ARTN Gene
chr1:43,931,897-43,937,241
(GRCh38/hg38)
Size:
5,345 bases
Orientation:
Plus strand
chr1:44,398,992-44,402,913
(GRCh37/hg19)

Genomic View for ARTN Gene

Genes around ARTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARTN Gene

Proteins for ARTN Gene

  • Protein details for ARTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4W7-ARTN_HUMAN
    Recommended name:
    Artemin
    Protein Accession:
    Q5T4W7
    Secondary Accessions:
    • D3DPY1
    • D3DPY3
    • O95441
    • O96030
    • Q6P6A3

    Protein attributes for ARTN Gene

    Size:
    220 amino acids
    Molecular mass:
    22878 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Binds to RET (By similarity).

    Three dimensional structures from OCA and Proteopedia for ARTN Gene

    Alternative splice isoforms for ARTN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARTN Gene

Post-translational modifications for ARTN Gene

  • Glycosylation at posLast=202202 and posLast=6060
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARTN Gene

Domains & Families for ARTN Gene

Gene Families for ARTN Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ARTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T4W7

UniProtKB/Swiss-Prot:

ARTN_HUMAN :
  • Belongs to the TGF-beta family. GDNF subfamily.
Family:
  • Belongs to the TGF-beta family. GDNF subfamily.
genes like me logo Genes that share domains with ARTN: view

Function for ARTN Gene

Molecular function for ARTN Gene

UniProtKB/Swiss-Prot Function:
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyers patch-like structures, a major component of the gut-associated lymphoid tissue.

Phenotypes From GWAS Catalog for ARTN Gene

Gene Ontology (GO) - Molecular Function for ARTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005102 signaling receptor binding IEA,TAS 9883723
GO:0005515 protein binding IPI 16765900
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with ARTN: view
genes like me logo Genes that share phenotypes with ARTN: view

Animal Models for ARTN Gene

MGI Knock Outs for ARTN:

Animal Model Products

CRISPR Products

miRNA for ARTN Gene

miRTarBase miRNAs that target ARTN

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARTN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARTN Gene

Localization for ARTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARTN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARTN gene
Compartment Confidence
extracellular 5
nucleus 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ARTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARTN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARTN Gene

Pathways & Interactions for ARTN Gene

SuperPathway Contained pathways
1 RET signaling
2 GDNF-Family Ligands and Receptor Interactions
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with ARTN: view

Pathways by source for ARTN Gene

1 Qiagen pathway for ARTN Gene

SIGNOR curated interactions for ARTN Gene

Activates:

Gene Ontology (GO) - Biological Process for ARTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction TAS 9883723
GO:0007405 neuroblast proliferation TAS 9883723
GO:0007411 axon guidance TAS,IEA --
GO:0007422 peripheral nervous system development IEA --
genes like me logo Genes that share ontologies with ARTN: view

Drugs & Compounds for ARTN Gene

(2) Drugs for ARTN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ARTN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARTN: view

Transcripts for ARTN Gene

mRNA/cDNA for ARTN Gene

Unigene Clusters for ARTN Gene

Artemin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARTN

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARTN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for ARTN Gene

GeneLoc Exon Structure for
ARTN
ECgene alternative splicing isoforms for
ARTN

Expression for ARTN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARTN Gene

This gene is overexpressed in Prostate (x4.8).

Protein differential expression in normal tissues from HIPED for ARTN Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARTN Gene



Protein tissue co-expression partners for ARTN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARTN Gene:

ARTN

SOURCE GeneReport for Unigene cluster for ARTN Gene:

Hs.632404

mRNA Expression by UniProt/SwissProt for ARTN Gene:

Q5T4W7-ARTN_HUMAN
Tissue specificity: Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta, pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain.

Evidence on tissue expression from TISSUES for ARTN Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ARTN: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ARTN Gene

Orthologs for ARTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARTN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARTN 34 33
  • 99.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARTN 34 33
  • 88.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Artn 33
  • 80.76 (n)
mouse
(Mus musculus)
Mammalia Artn 16 34 33
  • 80.15 (n)
dog
(Canis familiaris)
Mammalia ARTN 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARTN 34
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARTN 34
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARTN 34
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii artna 34
  • 48 (a)
OneToOne
Species where no ortholog for ARTN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARTN Gene

ENSEMBL:
Gene Tree for ARTN (if available)
TreeFam:
Gene Tree for ARTN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARTN: view image

Paralogs for ARTN Gene

Paralogs for ARTN Gene

(1) SIMAP similar genes for ARTN Gene using alignment to 5 proteins:

  • ARTN_HUMAN
  • D3DPX9_HUMAN
  • E9PIK2_HUMAN
  • E9PLG3_HUMAN
  • E9PN22_HUMAN
genes like me logo Genes that share paralogs with ARTN: view

Variants for ARTN Gene

Sequence variations from dbSNP and Humsavar for ARTN Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000076687 -- 43,935,284(+) G/A intron_variant
rs1000224504 -- 43,934,925(+) T/C intron_variant
rs1000308364 -- 43,932,217(+) C/T upstream_transcript_variant
rs1000402784 -- 43,937,696(+) C/T downstream_transcript_variant
rs1000680304 -- 43,931,930(+) T/G upstream_transcript_variant

Variation tolerance for ARTN Gene

Gene Damage Index Score: 0.18; 3.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARTN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARTN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARTN Gene

Disorders for ARTN Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARTN Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
hirschsprung disease 1
  • hirschsprung disease, susceptibility to, 1
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search ARTN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARTN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ARTN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARTN Gene

Publications for ARTN Gene

  1. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. (PMID: 9883723) Baloh RH … Milbrandt J (Neuron 1998) 2 3 4 22 58
  2. Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease. (PMID: 18970938) Fernandez RM … Borrego S (Journal of pediatric surgery 2008) 3 22 44 58
  3. Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. (PMID: 16765900) Wang X … Garcia KC (Structure (London, England : 1993) 2006) 3 4 22 58
  4. In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin. (PMID: 10673327) Rosenblad C … Johansen TE (Molecular and cellular neurosciences 2000) 3 4 22 58
  5. Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants. (PMID: 10583383) Masure S … Gordon RD (European journal of biochemistry 1999) 3 4 22 58

Products for ARTN Gene

Sources for ARTN Gene

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