The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts ... See more...

Aliases for ART5 Gene

Aliases for ART5 Gene

  • ADP-Ribosyltransferase 5 2 3 5
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 5 3 4
  • NAD(P)(+)--Arginine ADP-Ribosyltransferase 5 3 4
  • Mono(ADP-Ribosyl)Transferase 5 3 4
  • Ecto-ADP-Ribosyltransferase 5 3 4
  • EC 2.4.2.31 4 52
  • ARTC5 3 4

External Ids for ART5 Gene

Previous GeneCards Identifiers for ART5 Gene

  • GC11M004234
  • GC11M003929
  • GC11M003621
  • GC11M003624
  • GC11M003616
  • GC11M003659
  • GC11M003397

Summaries for ART5 Gene

Entrez Gene Summary for ART5 Gene

  • The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for ART5 Gene

ART5 (ADP-Ribosyltransferase 5) is a Protein Coding gene. Diseases associated with ART5 include Spindle Cell Hemangioma. Among its related pathways are NAD metabolism. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD+ nucleosidase activity. An important paralog of this gene is ART3.

Additional gene information for ART5 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ART5 Gene

Genomics for ART5 Gene

GeneHancer (GH) Regulatory Elements for ART5 Gene

Promoters and enhancers for ART5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J003641 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 537.9 -0.2 -185 2.2 POLR2G USF1 NCOR1 PHF8 ZBTB5 ZIC2 POLR2A ZBTB26 TARDBP KLF7 ART5 ART1 piR-30444-044
GH11J004455 Promoter 0.3 EPDnew 500 -813.0 -812964 0.1 ART5 OR52K1 OR52K3P OR52K2
GH11J003830 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 -194.2 -194221 12.9 ZBTB40 CTCF SIN3A NRF1 TCF12 MYC POLR2G USF1 GTF2E2 PHF8 RHOG NUP98 OSBPL5 RRM1 TSSC2 ENSG00000206976 ART1 ART5 CHRNA10 STIM1
GH11J003377 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9.8 +262.8 262815 6.6 ZBTB40 ZNF217 EP300 NRF1 MYC TCF12 USF1 POLR2G SP1 GTF2E2 TSSC2 ZNF195 lnc-ART1-6 lnc-ART1-9 lnc-MRGPRE-2 RRM1 NUP98 ART1 ART5 lnc-ZNF195-2
GH11J003795 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 7.5 -154.9 -154885 4 HNRNPK ZNF217 EP300 NRF1 MYC USF1 POLR2G SP1 NCOR1 GTF2E2 NUP98 PGAP2 RRM1 TRIM68 OSBPL5 TSSC2 ART5 piR-32214-073
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ART5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ART5

Top Transcription factor binding sites by QIAGEN in the ART5 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • FOXF2

Genomic Locations for ART5 Gene

Genomic Locations for ART5 Gene
chr11:3,638,506-3,642,316
(GRCh38/hg38)
Size:
3,811 bases
Orientation:
Minus strand
chr11:3,659,733-3,663,546
(GRCh37/hg19)
Size:
3,814 bases
Orientation:
Minus strand

Genomic View for ART5 Gene

Genes around ART5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ART5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ART5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART5 Gene

Proteins for ART5 Gene

  • Protein details for ART5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L15-NAR5_HUMAN
    Recommended name:
    Ecto-ADP-ribosyltransferase 5
    Protein Accession:
    Q96L15
    Secondary Accessions:
    • C9IYG7
    • Q6UX84
    • Q86W02

    Protein attributes for ART5 Gene

    Size:
    291 amino acids
    Molecular mass:
    32054 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ART5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ART5 Gene

Selected DME Specific Peptides for ART5 Gene

Q96L15:
  • EEMEEKA
  • CSHFNCAYLG

Post-translational modifications for ART5 Gene

  • Glycosylation at Asn101, Asn196, and Asn250
  • Modification sites at PhosphoSitePlus

Domains & Families for ART5 Gene

Gene Families for ART5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ART5 Gene

Blocks:
  • NAD:arginine ADP-ribosyltransferase, ART
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ART5 Gene

GenScript: Design optimal peptide antigens:
  • NAD(P)(+)--arginine ADP-ribosyltransferase 5 (NAR5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96L15

UniProtKB/Swiss-Prot:

NAR5_HUMAN :
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
Family:
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART5: view

Function for ART5 Gene

Molecular function for ART5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31;.

Enzyme Numbers (IUBMB) for ART5 Gene

Gene Ontology (GO) - Molecular Function for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IBA 21873635
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ART5: view
genes like me logo Genes that share phenotypes with ART5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ART5

CRISPR Products

miRNA for ART5 Gene

miRTarBase miRNAs that target ART5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ART5

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ART5 Gene

Localization for ART5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ART5 gene
Compartment Confidence
extracellular 4
mitochondrion 2
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ART5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ART5 Gene

Pathways & Interactions for ART5 Gene

PathCards logo

SuperPathways for ART5 Gene

SuperPathway Contained pathways
1 NAD metabolism
.53
genes like me logo Genes that share pathways with ART5: view

Pathways by source for ART5 Gene

1 GeneGo (Thomson Reuters) pathway for ART5 Gene
  • NAD metabolism

Interacting Proteins for ART5 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000380258 Q96L15-NAR5_HUMAN for ART5 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IBA,IEA 21873635
GO:0018120 peptidyl-arginine ADP-ribosylation IBA 21873635
genes like me logo Genes that share ontologies with ART5: view

No data available for SIGNOR curated interactions for ART5 Gene

Drugs & Compounds for ART5 Gene

(5) Drugs for ART5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 526,526
NADH Approved Nutra 0
NAD Experimental Pharma Full agonist, Agonist, Activator 0
NADP Experimental Pharma 0
Arginine Investigational Nutra Full agonist, Agonist 587
genes like me logo Genes that share compounds with ART5: view

Transcripts for ART5 Gene

mRNA/cDNA for ART5 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ART5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ART5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1:
SP2: -

Relevant External Links for ART5 Gene

GeneLoc Exon Structure for
ART5

Expression for ART5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ART5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART5 Gene

This gene is overexpressed in Testis (x20.2) and Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for ART5 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ART5 Gene



Protein tissue co-expression partners for ART5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ART5

SOURCE GeneReport for Unigene cluster for ART5 Gene:

Hs.125680

Evidence on tissue expression from TISSUES for ART5 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with ART5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ART5 Gene

Orthologs for ART5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ART5 31 30
  • 99.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ART5 31 30
  • 89.4 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Art5 17 31 30
  • 84.19 (n)
rat
(Rattus norvegicus)
Mammalia Art5 30
  • 83.46 (n)
cow
(Bos Taurus)
Mammalia ART5 30
  • 79.23 (n)
-- 31
  • 68 (a)
OneToMany
-- 31
  • 67 (a)
OneToMany
-- 31
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 61 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ART5 31
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 31 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490227 30
  • 51.05 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01019905.1 31
  • 36 (a)
ManyToMany
CR846080.5 31
  • 35 (a)
ManyToMany
CABZ01019905.2 31
  • 34 (a)
ManyToMany
CR846080.3 31
  • 34 (a)
ManyToMany
si:ch211-51i16.3 31
  • 32 (a)
ManyToMany
si:ch73-379f5.5 31
  • 30 (a)
ManyToMany
CABZ01064699.1 31
  • 30 (a)
ManyToMany
art4 31
  • 29 (a)
ManyToMany
BX908804.1 31
  • 28 (a)
ManyToMany
CABZ01019904.1 31
  • 28 (a)
ManyToMany
si:ch211-51i16.1 31
  • 28 (a)
ManyToMany
CR846080.4 31
  • 27 (a)
ManyToMany
si:ch211-163m16.7 31
  • 25 (a)
ManyToMany
Species where no ortholog for ART5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART5 Gene

ENSEMBL:
Gene Tree for ART5 (if available)
TreeFam:
Gene Tree for ART5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ART5: view image

Paralogs for ART5 Gene

Paralogs for ART5 Gene

(4) SIMAP similar genes for ART5 Gene using alignment to 3 proteins:

  • NAR5_HUMAN
  • H7C1W0_HUMAN
  • H7C3U2_HUMAN

Pseudogenes.org Pseudogenes for ART5 Gene

genes like me logo Genes that share paralogs with ART5: view

Variants for ART5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ART5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
722296 Benign: not provided 3,639,012(-) A/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
789615 Benign: not provided 3,639,963(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ART5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ART5 Gene

Variant ID Type Subtype PubMed ID
esv2658889 CNV deletion 23128226
esv2759796 CNV gain+loss 17122850
esv2760179 CNV loss 21179565
esv2760300 CNV gain 21179565
esv28322 CNV gain+loss 19812545
esv3625147 CNV gain 21293372
esv3625148 CNV gain 21293372
esv3625152 CNV loss 21293372
nsv1046356 CNV gain 25217958
nsv428247 CNV loss 18775914
nsv467660 CNV gain 19166990
nsv509385 CNV insertion 20534489
nsv526441 CNV gain 19592680
nsv553140 CNV gain 21841781
nsv832051 CNV gain 17160897
nsv832052 CNV loss 17160897
nsv8775 CNV loss 18304495

Variation tolerance for ART5 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ART5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ART5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ART5 Gene

Disorders for ART5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ART5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spindle cell hemangioma
  • sch
- elite association - COSMIC cancer census association via MalaCards
Search ART5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ART5

genes like me logo Genes that share disorders with ART5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ART5 Gene

Publications for ART5 Gene

  1. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. (PMID: 11587854) Glowacki G … Koch-Nolte F (Gene 2001) 2 3 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  4. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G … Koch-Nolte F (Protein science : a publication of the Protein Society 2002) 3 4 54
  5. Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases. (PMID: 10448534) Okazaki IJ … Moss J (Annual review of nutrition 1999) 2 3 54

Products for ART5 Gene

Sources for ART5 Gene