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Aliases for ART5 Gene

Aliases for ART5 Gene

  • ADP-Ribosyltransferase 5 2 3 5
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 5 3 4
  • NAD(P)(+)--Arginine ADP-Ribosyltransferase 5 3 4
  • Mono(ADP-Ribosyl)Transferase 5 3 4
  • ARTC5 3 4
  • Ecto-ADP-Ribosyltransferase 5 3
  • EC 2.4.2.31 4

External Ids for ART5 Gene

Previous GeneCards Identifiers for ART5 Gene

  • GC11M004234
  • GC11M003929
  • GC11M003621
  • GC11M003624
  • GC11M003616
  • GC11M003659
  • GC11M003397

Summaries for ART5 Gene

Entrez Gene Summary for ART5 Gene

  • The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for ART5 Gene

ART5 (ADP-Ribosyltransferase 5) is a Protein Coding gene. Among its related pathways are NAD metabolism. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD+ nucleosidase activity. An important paralog of this gene is ART1.

Additional gene information for ART5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART5 Gene

Genomics for ART5 Gene

GeneHancer (GH) Regulatory Elements for ART5 Gene

Promoters and enhancers for ART5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J003641 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 688 -0.2 -189 1.9 FOXA2 ARID4B SIN3A ZNF48 TCF12 POLR2B GLIS2 KLF7 ATF7 SP3 ART5 ART1 GC11M003663 ENSG00000201279
GH11J004455 Promoter 0.5 EPDnew 650 -813.0 -812964 0.1 ART5 OR52K1 OR52K2 OR52K3P
GH11J003830 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 -194.0 -193992 12.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B RHOG NUP98 RRM1 ENSG00000206976 ART1 ART5 CHRNA10 STIM1 PPIAP40 ENSG00000236710
GH11J003783 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 8.4 -143.7 -143678 4.4 HDGF ATF1 PKNOX1 SMAD1 BMI1 BATF KLF5 IRF4 ZNF143 ATF7 NUP98 ART5 GC11P003781 GC11P003794 GC11M003657 GC11M003656
GH11J003614 Enhancer 1.1 FANTOM5 Ensembl ENCODE 12.2 +27.4 27409 1.7 BCOR HDAC1 PKNOX1 MAX ZMYM3 EBF1 ZIC2 IRF4 RELA GATA3 ART1 ART5 ENSG00000255367 NUP98 RHOG TRPC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ART5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ART5 gene promoter:
  • E2F
  • FOXF2
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4

Genomic Locations for ART5 Gene

Genomic Locations for ART5 Gene
chr11:3,638,503-3,642,316
(GRCh38/hg38)
Size:
3,814 bases
Orientation:
Minus strand
chr11:3,659,733-3,663,546
(GRCh37/hg19)
Size:
3,814 bases
Orientation:
Minus strand

Genomic View for ART5 Gene

Genes around ART5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ART5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ART5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART5 Gene

Proteins for ART5 Gene

  • Protein details for ART5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L15-NAR5_HUMAN
    Recommended name:
    Ecto-ADP-ribosyltransferase 5
    Protein Accession:
    Q96L15
    Secondary Accessions:
    • C9IYG7
    • Q6UX84
    • Q86W02

    Protein attributes for ART5 Gene

    Size:
    291 amino acids
    Molecular mass:
    32054 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ART5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ART5 Gene

Post-translational modifications for ART5 Gene

  • Glycosylation at Asn250, posLast=196196, and Asn101
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ART5 Gene

Domains & Families for ART5 Gene

Gene Families for ART5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ART5 Gene

Suggested Antigen Peptide Sequences for ART5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96L15

UniProtKB/Swiss-Prot:

NAR5_HUMAN :
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
Family:
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART5: view

Function for ART5 Gene

Molecular function for ART5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Enzyme Numbers (IUBMB) for ART5 Gene

Gene Ontology (GO) - Molecular Function for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0003953 NAD+ nucleosidase activity IEA --
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ART5: view
genes like me logo Genes that share phenotypes with ART5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ART5

CRISPR Products

miRNA for ART5 Gene

miRTarBase miRNAs that target ART5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ART5

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ART5 Gene

Localization for ART5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ART5 gene
Compartment Confidence
extracellular 4
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ART5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ART5 Gene

Pathways & Interactions for ART5 Gene

SuperPathway Contained pathways
1 NAD metabolism
genes like me logo Genes that share pathways with ART5: view

Pathways by source for ART5 Gene

1 GeneGo (Thomson Reuters) pathway for ART5 Gene

Interacting Proteins for ART5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352992%0d%0a9606.ENSP00000264606%0d%0a
Selected Interacting proteins: Q96L15-NAR5_HUMAN ENSP00000352992 for ART5 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IEA --
genes like me logo Genes that share ontologies with ART5: view

No data available for SIGNOR curated interactions for ART5 Gene

Drugs & Compounds for ART5 Gene

(4) Drugs for ART5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Arginine Approved Nutra Full agonist, Agonist 0
NADH Approved Nutra 0
Nicotinamide Approved, Investigational Nutra 942,946
NAD Pharma Full agonist, Agonist, Activator 0

(1) Additional Compounds for ART5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • beta-Nicotinamide adenine dinucleotide phosphate
  • NADP+
  • Nicotinamide adenine dinucleotide phosphate
  • Oxidized nicotinamide-adenine dinucleotide phosphate
  • TPN
53-59-8
genes like me logo Genes that share compounds with ART5: view

Transcripts for ART5 Gene

mRNA/cDNA for ART5 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ART5 Gene

ADP-ribosyltransferase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ART5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ART5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1:
SP2: -

Relevant External Links for ART5 Gene

GeneLoc Exon Structure for
ART5
ECgene alternative splicing isoforms for
ART5

Expression for ART5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ART5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART5 Gene

This gene is overexpressed in Testis (x20.2) and Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for ART5 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ART5 Gene



Protein tissue co-expression partners for ART5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ART5 Gene:

ART5

SOURCE GeneReport for Unigene cluster for ART5 Gene:

Hs.125680

Evidence on tissue expression from TISSUES for ART5 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with ART5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ART5 Gene

Orthologs for ART5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ART5 34 33
  • 99.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ART5 34 33
  • 89.4 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Art5 16 34 33
  • 84.19 (n)
rat
(Rattus norvegicus)
Mammalia Art5 33
  • 83.46 (n)
cow
(Bos Taurus)
Mammalia ART5 33
  • 79.23 (n)
-- 34
  • 68 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
-- 34
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ART5 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490227 33
  • 51.05 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01019905.1 34
  • 36 (a)
ManyToMany
CR846080.5 34
  • 35 (a)
ManyToMany
CABZ01019905.2 34
  • 34 (a)
ManyToMany
CR846080.3 34
  • 34 (a)
ManyToMany
si:ch211-51i16.3 34
  • 32 (a)
ManyToMany
si:ch73-379f5.5 34
  • 30 (a)
ManyToMany
CABZ01064699.1 34
  • 30 (a)
ManyToMany
art4 34
  • 29 (a)
ManyToMany
BX908804.1 34
  • 28 (a)
ManyToMany
CABZ01019904.1 34
  • 28 (a)
ManyToMany
si:ch211-51i16.1 34
  • 28 (a)
ManyToMany
CR846080.4 34
  • 27 (a)
ManyToMany
si:ch211-163m16.7 34
  • 25 (a)
ManyToMany
Species where no ortholog for ART5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART5 Gene

ENSEMBL:
Gene Tree for ART5 (if available)
TreeFam:
Gene Tree for ART5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ART5: view image

Paralogs for ART5 Gene

Paralogs for ART5 Gene

(4) SIMAP similar genes for ART5 Gene using alignment to 3 proteins:

  • NAR5_HUMAN
  • H7C1W0_HUMAN
  • H7C3U2_HUMAN

Pseudogenes.org Pseudogenes for ART5 Gene

genes like me logo Genes that share paralogs with ART5: view

Variants for ART5 Gene

Sequence variations from dbSNP and Humsavar for ART5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000176092 -- 3,640,829(-) C/T intron_variant
rs1000611646 -- 3,641,035(-) G/A intron_variant
rs1001035551 -- 3,638,999(-) T/C intron_variant
rs1001514578 -- 3,643,931(-) A/T upstream_transcript_variant
rs1001559551 -- 3,643,645(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ART5 Gene

Variant ID Type Subtype PubMed ID
esv2658889 CNV deletion 23128226
esv2759796 CNV gain+loss 17122850
esv2760179 CNV loss 21179565
esv2760300 CNV gain 21179565
esv28322 CNV gain+loss 19812545
esv3625147 CNV gain 21293372
esv3625148 CNV gain 21293372
esv3625152 CNV loss 21293372
nsv1046356 CNV gain 25217958
nsv428247 CNV loss 18775914
nsv467660 CNV gain 19166990
nsv509385 CNV insertion 20534489
nsv526441 CNV gain 19592680
nsv553140 CNV gain 21841781
nsv832051 CNV gain 17160897
nsv832052 CNV loss 17160897
nsv8775 CNV loss 18304495

Variation tolerance for ART5 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ART5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ART5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ART5 Gene

Disorders for ART5 Gene

Additional Disease Information for ART5

No disorders were found for ART5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ART5 Gene

Publications for ART5 Gene

  1. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. (PMID: 11587854) Glowacki G … Koch-Nolte F (Gene 2001) 2 3 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G … Koch-Nolte F (Protein science : a publication of the Protein Society 2002) 3 4 58
  5. Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases. (PMID: 10448534) Okazaki IJ … Moss J (Annual review of nutrition 1999) 2 3 58

Products for ART5 Gene

Sources for ART5 Gene

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