Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
ART3 (ADP-Ribosyltransferase 3 (Inactive)) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD(P)+-protein-arginine ADP-ribosyltransferase activity. An important paralog of this gene is ART5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003950 | NAD+ ADP-ribosyltransferase activity | TAS,IBA | 21873635 |
GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031225 | anchored component of membrane | IEA | -- |
GO:0031226 | intrinsic component of plasma membrane | TAS | 9119374 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of proteins | ||
2 | Post-translational modification- synthesis of GPI-anchored proteins | ||
3 | NAD metabolism |
NAD metabolism
.53
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006471 | protein ADP-ribosylation | IEA,TAS | 9119374 |
GO:0018120 | peptidyl-arginine ADP-ribosylation | IBA | 21873635 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ART3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ART3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ART3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Art3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Art3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | ART3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ART3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | art5 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CABZ01019905.1 31 |
|
ManyToMany | |
CR846080.3 31 |
|
ManyToMany | |||
CR846080.5 31 |
|
ManyToMany | |||
si:ch211-51i16.3 31 |
|
ManyToMany | |||
CABZ01019905.2 31 |
|
ManyToMany | |||
CABZ01064699.1 31 |
|
ManyToMany | |||
BX908804.1 31 |
|
ManyToMany | |||
si:ch73-379f5.5 31 |
|
ManyToMany | |||
si:ch211-51i16.1 31 |
|
ManyToMany | |||
CR846080.4 31 |
|
ManyToMany | |||
art4 31 |
|
ManyToMany | |||
si:ch211-163m16.7 31 |
|
ManyToMany | |||
CABZ01019904.1 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11548618 | Benign: not provided | 76,022,794(+) |
G/A NM_001565.4(CXCL10):c.85C>T (p.Arg29Cys) |
MISSENSE_VARIANT,INTRON | |
rs139813823 | Benign: not provided | 76,022,401(+) |
G/T NM_001565.4(CXCL10):c.243C>A (p.Ala81=) |
SYNONYMOUS_VARIANT,INTRON | |
rs1128864 | - |
p.Ser363Leu |
|||
rs143599971 | - |
p.Pro334Ser |
No disorders were found for ART3 Gene.