This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have... See more...

Aliases for ART3 Gene

Aliases for ART3 Gene

  • ADP-Ribosyltransferase 3 (Inactive) 2 3 5
  • ARTC3 2 3 4
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 3 3 4
  • NAD(P)(+)--Arginine ADP-Ribosyltransferase 3 3 4
  • Mono(ADP-Ribosyl)Transferase 3 3 4
  • Ecto-ADP-Ribosyltransferase 3 3 4
  • Mono-ADP-Ribosyltransferase 3
  • ADP-Ribosyltransferase 3 2
  • EC 4
  • TMART 4
  • ART3 5

External Ids for ART3 Gene

Previous GeneCards Identifiers for ART3 Gene

  • GC04P076891
  • GC04P077186
  • GC04P077325
  • GC04P077454
  • GC04P077353
  • GC04P076932
  • GC04P072684

Summaries for ART3 Gene

Entrez Gene Summary for ART3 Gene

  • This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ART3 Gene

ART3 (ADP-Ribosyltransferase 3 (Inactive)) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD(P)+-protein-arginine ADP-ribosyltransferase activity. An important paralog of this gene is ART5.

Gene Wiki entry for ART3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ART3 Gene

Genomics for ART3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ART3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J076011 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 309.9 +1.1 1116 2.5 BCL11A EBF1 CBFB JUND BATF MAFK STAT5A ZNF24 NRF1 IKZF1 ART3 HSALNG0035292 NAAA NUP54 CXCL10
GH04J076059 Enhancer 1.3 FANTOM5 Ensembl ENCODE 75.2 +49.5 49532 4.6 BCL11A CEBPA FOXA1 HES1 HOMEZ FOXA2 TRIM22 IRF4 GABPA TAL1 ART3 CXCL10 CXCL9 NAAA CXCL11 NUP54 SDAD1 SDAD1-AS1 KR153194-146 piR-58297-350
GH04J076074 Promoter 0.3 EPDnew 261.4 +63.5 63526 0.1 ART3 CXCL9 SDAD1 SDAD1-AS1 CXCL10 PPEF2 KR153194-146 CXCL11 lnc-SCARB2-4 HSALNG0035292
GH04J075980 Promoter 0.3 EPDnew 250.3 -30.4 -30403 0.1 SDAD1-AS1 ART3 lnc-SDAD1-3-001 lnc-SDAD1-3-002 SDAD1 NAAA
GH04J076055 Enhancer 0.9 Ensembl ENCODE 74.8 +44.0 44033 3.2 BCL11A IRF4 TRIM22 EBF1 SOX5 BATF ELF1 NFATC1 BHLHE40 IKZF1 ART3 NAAA NUP54 CXCL10 CXCL9 SDAD1 SDAD1-AS1 piR-58297-350 KR153194-146 CXCL11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ART3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ART3

Top Transcription factor binding sites by QIAGEN in the ART3 gene promoter:
  • AhR
  • AML1a
  • Cdc5
  • FOXO3
  • FOXO3b
  • IRF-1
  • IRF-2
  • p53

Genomic Locations for ART3 Gene

Latest Assembly
101,635 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
101,597 bases
Plus strand

(GRCh37/hg19 by Ensembl)
101,619 bases
Plus strand

Genomic View for ART3 Gene

Genes around ART3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ART3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ART3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART3 Gene

Proteins for ART3 Gene

  • Protein details for ART3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ecto-ADP-ribosyltransferase 3
    Protein Accession:
    Secondary Accessions:
    • Q53XW3
    • Q6FHT7
    • Q8WVJ7
    • Q93069
    • Q96HL1

    Protein attributes for ART3 Gene

    389 amino acids
    Molecular mass:
    43923 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ART3 Gene


neXtProt entry for ART3 Gene

Post-translational modifications for ART3 Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Asn248 and Thr346
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • NAR3_HUMAN (808)

Antibodies for research

  • Abcam antibodies for ART3

No data available for DME Specific Peptides for ART3 Gene

Domains & Families for ART3 Gene

Gene Families for ART3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ART3 Gene

  • NAD:arginine ADP-ribosyltransferase, ART

Suggested Antigen Peptide Sequences for ART3 Gene

GenScript: Design optimal peptide antigens:
  • NAD(P)(+)--arginine ADP-ribosyltransferase 3 (NAR3_HUMAN)
  • Mono-ADP-ribosyltransferase (Q5J1P8_HUMAN)
  • Mono-ADP-ribosyltransferase (Q5J1Q0_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Arg-specific ADP-ribosyltransferase family.
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART3: view

Function for ART3 Gene

Molecular function for ART3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=;.
GENATLAS Biochemistry:
ADP-ribosyltransferase 3,expressed in testis

Enzyme Numbers (IUBMB) for ART3 Gene

Phenotypes From GWAS Catalog for ART3 Gene

Gene Ontology (GO) - Molecular Function for ART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity TAS,IBA 21873635
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ART3: view
genes like me logo Genes that share phenotypes with ART3: view

miRNA for ART3 Gene

miRTarBase miRNAs that target ART3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ART3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ART3 Gene

Localization for ART3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART3 Gene

Cell membrane. Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ART3 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
nucleus 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for ART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0031226 intrinsic component of plasma membrane TAS 9119374
genes like me logo Genes that share ontologies with ART3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ART3 Gene

Pathways & Interactions for ART3 Gene

genes like me logo Genes that share pathways with ART3: view

Pathways by source for ART3 Gene

1 GeneGo (Thomson Reuters) pathway for ART3 Gene
  • NAD metabolism

Gene Ontology (GO) - Biological Process for ART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IEA,TAS 9119374
GO:0018120 peptidyl-arginine ADP-ribosylation IBA 21873635
genes like me logo Genes that share ontologies with ART3: view

No data available for SIGNOR curated interactions for ART3 Gene

Drugs & Compounds for ART3 Gene

(5) Drugs for ART3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 466,466
NADH Approved Nutra 0
NAD Experimental Pharma 0
NADP Experimental Pharma 0
Arginine Investigational Nutra 557

(3) Additional Compounds for ART3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ART3: view

Transcripts for ART3 Gene

mRNA/cDNA for ART3 Gene

27 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ART3

Alternative Splicing Database (ASD) splice patterns (SP) for ART3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP2: - -

Relevant External Links for ART3 Gene

GeneLoc Exon Structure for

Expression for ART3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ART3 Gene

mRNA differential expression in normal tissues according to GTEx for ART3 Gene

This gene is overexpressed in Muscle - Skeletal (x18.2), Heart - Left Ventricle (x7.5), Heart - Atrial Appendage (x6.0), and Testis (x5.4).

Protein differential expression in normal tissues from HIPED for ART3 Gene

This gene is overexpressed in Ovary (29.3), Testis (25.4), and Serum (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ART3 Gene

Protein tissue co-expression partners for ART3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ART3

SOURCE GeneReport for Unigene cluster for ART3 Gene:


mRNA Expression by UniProt/SwissProt for ART3 Gene:

Tissue specificity: Testis specific.

Evidence on tissue expression from TISSUES for ART3 Gene

  • Muscle(4.6)
  • Heart(2.7)
genes like me logo Genes that share expression patterns with ART3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ART3 Gene

Orthologs for ART3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ART3 30 31
  • 98.18 (n)
(Canis familiaris)
Mammalia ART3 30 31
  • 84.68 (n)
(Bos Taurus)
Mammalia ART3 30 31
  • 83.07 (n)
(Mus musculus)
Mammalia Art3 30 17 31
  • 72.39 (n)
(Rattus norvegicus)
Mammalia Art3 30
  • 69.61 (n)
(Monodelphis domestica)
Mammalia ART3 31
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia ART3 31
  • 31 (a)
(Gallus gallus)
Aves -- 31
  • 36 (a)
-- 31
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 31 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia art5 30
  • 51 (n)
(Danio rerio)
Actinopterygii CABZ01019905.1 31
  • 30 (a)
CR846080.3 31
  • 30 (a)
CR846080.5 31
  • 27 (a)
si:ch211-51i16.3 31
  • 27 (a)
CABZ01019905.2 31
  • 27 (a)
CABZ01064699.1 31
  • 25 (a)
BX908804.1 31
  • 24 (a)
si:ch73-379f5.5 31
  • 24 (a)
si:ch211-51i16.1 31
  • 23 (a)
CR846080.4 31
  • 23 (a)
art4 31
  • 23 (a)
si:ch211-163m16.7 31
  • 21 (a)
CABZ01019904.1 31
  • 21 (a)
Species where no ortholog for ART3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ART3 Gene

Gene Tree for ART3 (if available)
Gene Tree for ART3 (if available)
Evolutionary constrained regions (ECRs) for ART3: view image

Paralogs for ART3 Gene

Paralogs for ART3 Gene

(1) SIMAP similar genes for ART3 Gene using alignment to 8 proteins:

  • E7ER42_HUMAN
  • E7EX61_HUMAN
  • Q5J1K9_HUMAN
  • Q5J1P8_HUMAN
  • Q5J1Q0_HUMAN Pseudogenes for ART3 Gene

genes like me logo Genes that share paralogs with ART3: view

Variants for ART3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ART3 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs11548618 Benign: not provided 76,022,794(+) G/A
NM_001565.4(CXCL10):c.85C>T (p.Arg29Cys)
rs139813823 Benign: not provided 76,022,401(+) G/T
NM_001565.4(CXCL10):c.243C>A (p.Ala81=)
rs1128864 - p.Ser363Leu
rs143599971 - p.Pro334Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ART3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ART3 Gene

Variant ID Type Subtype PubMed ID
dgv9135n54 CNV loss 21841781
dgv9136n54 CNV gain 21841781
esv1621359 CNV insertion 17803354
esv2225549 CNV deletion 18987734
esv2427313 CNV deletion 19546169
esv2660008 CNV deletion 23128226
esv2662680 CNV deletion 23128226
esv2676154 CNV deletion 23128226
esv27112 CNV gain 19812545
esv2727841 CNV deletion 23290073
esv2727842 CNV deletion 23290073
esv3305081 CNV mobile element insertion 20981092
esv3308353 CNV mobile element insertion 20981092
esv3338832 CNV insertion 20981092
esv3433677 CNV insertion 20981092
esv3440894 CNV insertion 20981092
esv3443367 CNV insertion 20981092
esv3564101 CNV deletion 23714750
esv3601041 CNV loss 21293372
esv3601042 CNV loss 21293372
esv3601044 CNV loss 21293372
nsv1009047 CNV loss 25217958
nsv292553 CNV deletion 16902084
nsv293489 CNV insertion 16902084
nsv461558 CNV gain 19166990
nsv470047 CNV gain 18288195
nsv513139 CNV loss 21212237
nsv7363 OTHER inversion 18451855
nsv821336 CNV deletion 20802225
nsv955670 CNV deletion 24416366

Variation tolerance for ART3 Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.71; 86.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ART3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ART3 Gene

Disorders for ART3 Gene

Additional Disease Information for ART3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for ART3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ART3 Gene

Publications for ART3 Gene

  1. Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility. (PMID: 18266473) Okada H … Inoue I (PLoS genetics 2008) 3 23 41
  2. Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins. (PMID: 9119374) Koch-Nolte F … Thiele HG (Genomics 1997) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes. (PMID: 16625277) Friedrich M … Hauschildt S (Asian journal of andrology 2006) 3 23

Products for ART3 Gene

Sources for ART3 Gene