ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which... See more...

Aliases for ART1 Gene

Aliases for ART1 Gene

  • ADP-Ribosyltransferase 1 2 3 5
  • GPI-Linked NAD(P)(+)--Arginine ADP-Ribosyltransferase 1 3 4
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 1 3 4
  • Mono(ADP-Ribosyl)Transferase 1 3 4
  • ARTC1 3 4
  • CD296 2 3
  • ART2 2 3
  • ADP-Ribosyltransferase 2 3
  • CD296 Antigen 4
  • EC 2.4.2.31 4
  • ART1 5
  • RT6 3

External Ids for ART1 Gene

Previous GeneCards Identifiers for ART1 Gene

  • GC11P004241
  • GC11P003935
  • GC11P003625
  • GC11P003630
  • GC11P003622
  • GC11P003666
  • GC11P003403

Summaries for ART1 Gene

Entrez Gene Summary for ART1 Gene

  • ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]

GeneCards Summary for ART1 Gene

ART1 (ADP-Ribosyltransferase 1) is a Protein Coding gene. Diseases associated with ART1 include Type 1 Diabetes Mellitus 4 and Cholera. Among its related pathways are Defensins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD(P)+-protein-arginine ADP-ribosyltransferase activity. An important paralog of this gene is ART5.

UniProtKB/Swiss-Prot Summary for ART1 Gene

Additional gene information for ART1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ART1 Gene

Genomics for ART1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ART1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J003644 Promoter/Enhancer 0.9 EPDnew ENCODE 600.7 -0.1 -130 1.4 IKZF1 NR2C1 HDAC1 MEF2D TRIM28 TRIM24 ZFHX2 NR2F1 FOXA1 NR2F6 ART1 TRIM21 ART5
GH11J003830 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 +191.4 191427 12.9 GATAD2A CTCF TFE3 ZNF512 LEF1 IKZF1 ZNF692 POLR2A BACH1 ETV6 RHOG NUP98 RRM1 ENSG00000206976 ART1 ART5 CHRNA10 STIM1 PPIAP40 ENSG00000236710
GH11J003377 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 9.8 -265.6 -265609 6.6 BRCA1 ARHGAP35 SP1 CREB1 GATAD2A ATF7 REST ZNF512 LEF1 NFKBIZ TSSC2 ZNF195 lnc-ART1-6 lnc-ART1-9 lnc-MRGPRE-2 NUP98 RRM1 TSSC4 ART5 ART1
GH11J003614 Enhancer 0.9 FANTOM5 ENCODE 12.2 -30.2 -30203 1.7 RELA ZIC2 MTA1 HDAC1 PKNOX1 CTBP1 RUNX3 HES1 RUNX1 MBD2 ART5 ART1 ENSG00000255367 NUP98 RHOG LOC115995503 piR-32214-071 TRPC2 LOC105376526
GH11J003824 Enhancer 1.1 ENCODE dbSUPER 9.8 +181.0 181046 3.2 CTCF TEAD4 ZNF629 IKZF1 POLR2A JUND DDX20 ZNF143 HNRNPUL1 ZNF24 NUP98 OSBPL5 RRM1 ART1 ART5 CHRNA10 lnc-RHOG-1 RHOG PGAP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ART1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ART1

Top Transcription factor binding sites by QIAGEN in the ART1 gene promoter:
  • aMEF-2
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXF2
  • SRF
  • SRF (504 AA)

Genomic Locations for ART1 Gene

Genomic Locations for ART1 Gene
chr11:3,645,110-3,665,516
(GRCh38/hg38)
Size:
20,407 bases
Orientation:
Plus strand
chr11:3,666,358-3,685,646
(GRCh37/hg19)
Size:
19,289 bases
Orientation:
Plus strand

Genomic View for ART1 Gene

Genes around ART1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ART1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ART1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART1 Gene

Proteins for ART1 Gene

  • Protein details for ART1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52961-NAR1_HUMAN
    Recommended name:
    GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
    Protein Accession:
    P52961
    Secondary Accessions:
    • Q6NTD2
    • Q96KT9

    Protein attributes for ART1 Gene

    Size:
    327 amino acids
    Molecular mass:
    36335 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ART1 Gene

Post-translational modifications for ART1 Gene

  • Glycosylation at Asn65 and Asn253
  • Modification sites at PhosphoSitePlus

Other Protein References for ART1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ART1 Gene

Domains & Families for ART1 Gene

Gene Families for ART1 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ART1 Gene

InterPro:
Blocks:
  • NAD:arginine ADP-ribosyltransferase, ART
ProtoNet:

Suggested Antigen Peptide Sequences for ART1 Gene

GenScript: Design optimal peptide antigens:
  • Mono(ADP-ribosyl)transferase 1 (NAR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52961

UniProtKB/Swiss-Prot:

NAR1_HUMAN :
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
Family:
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART1: view

Function for ART1 Gene

Molecular function for ART1 Gene

UniProtKB/Swiss-Prot Function:
Has ADP-ribosyltransferase activity toward GLP1R.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31;.
GENATLAS Biochemistry:
ADP ribosyltransferase 1,expressed in muscle

Enzyme Numbers (IUBMB) for ART1 Gene

Phenotypes From GWAS Catalog for ART1 Gene

Gene Ontology (GO) - Molecular Function for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA,IBA 21873635
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ART1: view
genes like me logo Genes that share phenotypes with ART1: view

Animal Models for ART1 Gene

MGI Knock Outs for ART1:
  • Art1 Art1<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for ART1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ART1

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ART1 Gene

Localization for ART1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART1 Gene

Sarcoplasmic reticulum membrane. Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ART1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
extracellular 3
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS,TAS --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ART1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ART1 Gene

Pathways & Interactions for ART1 Gene

PathCards logo

SuperPathways for ART1 Gene

SuperPathway Contained pathways
1 Defensins
.81
2 Innate Immune System
3 NAD metabolism
.53
genes like me logo Genes that share pathways with ART1: view

Pathways by source for ART1 Gene

1 GeneGo (Thomson Reuters) pathway for ART1 Gene
  • NAD metabolism

Interacting Proteins for ART1 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000250693 P52961-NAR1_HUMAN for ART1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation TAS,IBA 21873635
GO:0018120 peptidyl-arginine ADP-ribosylation IBA 21873635
genes like me logo Genes that share ontologies with ART1: view

No data available for SIGNOR curated interactions for ART1 Gene

Drugs & Compounds for ART1 Gene

(7) Drugs for ART1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 427,427
NADH Approved Nutra 0
5-Bromonicotinamide Experimental Pharma Target 0
NAD Experimental Pharma Agonist, Full agonist, Activator 0
NADP Experimental Pharma 0

(3) Additional Compounds for ART1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ART1: view

Transcripts for ART1 Gene

mRNA/cDNA for ART1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ART1

Alternative Splicing Database (ASD) splice patterns (SP) for ART1 Gene

No ASD Table

Relevant External Links for ART1 Gene

GeneLoc Exon Structure for
ART1

Expression for ART1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ART1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART1 Gene

This gene is overexpressed in Muscle - Skeletal (x47.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ART1

SOURCE GeneReport for Unigene cluster for ART1 Gene:

Hs.382188

Evidence on tissue expression from TISSUES for ART1 Gene

  • Muscle(4.5)
  • Skin(2.3)
  • Nervous system(2.3)
  • Heart(2.2)
  • Pancreas(2.2)
  • Blood(2.2)
  • Intestine(2.1)
  • Kidney(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ART1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ART1 Gene

Orthologs for ART1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ART1 30 31
  • 98.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ART1 30 31
  • 86.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 84 (a)
OneToMany
ART1 30 31
  • 83.74 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Art1 30 17 31
  • 81.68 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Art1 30
  • 80.04 (n)
Oppossum
(Monodelphis domestica)
Mammalia ART1 31
  • 65 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ART1 31
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ART7B 30 31
  • 58.52 (n)
OneToMany
MADPRT 31
  • 45 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
ART1 31
  • 42 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 48 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
-- 31
  • 41 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia art1 30
  • 55.31 (n)
Zebrafish
(Danio rerio)
Actinopterygii CABZ01019905.1 31
  • 38 (a)
ManyToMany
si:ch211-51i16.3 31
  • 33 (a)
ManyToMany
CR846080.3 31
  • 33 (a)
ManyToMany
CABZ01019905.2 31
  • 32 (a)
ManyToMany
CR846080.5 31
  • 31 (a)
ManyToMany
si:ch211-51i16.1 31
  • 31 (a)
ManyToMany
art4 31
  • 30 (a)
ManyToMany
BX908804.1 31
  • 30 (a)
ManyToMany
si:ch73-379f5.5 31
  • 30 (a)
ManyToMany
CABZ01064699.1 31
  • 29 (a)
ManyToMany
CR846080.4 31
  • 27 (a)
ManyToMany
si:ch211-163m16.7 31
  • 26 (a)
ManyToMany
CABZ01019904.1 31
  • 26 (a)
ManyToMany
Species where no ortholog for ART1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ART1 Gene

ENSEMBL:
Gene Tree for ART1 (if available)
TreeFam:
Gene Tree for ART1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ART1: view image

Paralogs for ART1 Gene

Paralogs for ART1 Gene

(3) SIMAP similar genes for ART1 Gene using alignment to 1 proteins:

  • NAR1_HUMAN
genes like me logo Genes that share paralogs with ART1: view

Variants for ART1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ART1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
716968 Benign: not provided 3,659,648(+) G/A SYNONYMOUS_VARIANT
729174 Benign: not provided 3,659,939(+) C/T SYNONYMOUS_VARIANT
rs2280134 - p.Leu257Pro
rs35123761 - p.Pro105Leu
rs35619488 - p.Pro126Arg

Additional dbSNP identifiers (rs#s) for ART1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ART1 Gene

Variant ID Type Subtype PubMed ID
dgv1580n54 CNV loss 21841781
dgv1581n54 CNV loss 21841781
dgv555e59 CNV duplication 20981092
dgv577n106 CNV tandem duplication 24896259
esv2744039 CNV deletion 23290073
esv2744040 CNV deletion 23290073
esv2744041 CNV deletion 23290073
esv2744043 CNV deletion 23290073
esv2744044 CNV deletion 23290073
esv2744045 CNV deletion 23290073
esv2744046 CNV deletion 23290073
esv2759796 CNV gain+loss 17122850
esv2760179 CNV loss 21179565
esv2760300 CNV gain 21179565
esv28322 CNV gain+loss 19812545
esv3625147 CNV gain 21293372
esv3625148 CNV gain 21293372
esv995807 CNV loss 20482838
nsv1046356 CNV gain 25217958
nsv1134083 CNV deletion 24896259
nsv428247 CNV loss 18775914
nsv509385 CNV insertion 20534489
nsv526441 CNV gain 19592680
nsv553142 CNV loss 21841781
nsv553150 CNV loss 21841781
nsv821603 CNV duplication 20802225
nsv832051 CNV gain 17160897
nsv832052 CNV loss 17160897
nsv8776 CNV gain+loss 18304495

Variation tolerance for ART1 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ART1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ART1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ART1 Gene

Disorders for ART1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ART1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
type 1 diabetes mellitus 4
  • diabetes mellitus, insulin-dependent, 4
cholera
  • cholera - vibrio cholerae
retinitis pigmentosa 19
  • rp19
- elite association - COSMIC cancer census association via MalaCards
Search ART1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ART1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ART1 Gene

Publications for ART1 Gene

  1. ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. (PMID: 16627471) Paone G … Moss J (The Journal of biological chemistry 2006) 3 23
  2. Inactivation of platelet-derived growth factor-BB following modification by ADP-ribosyltransferase. (PMID: 11498506) Saxty BA … MacDermot J (British journal of pharmacology 2001) 3 23
  3. Chemotaxin-dependent translocation of immunoreactive ADP-ribosyltransferase-1 to the surface of human neutrophil polymorphs. (PMID: 10092875) Kefalas P … MacDermot J (European journal of biochemistry 1999) 3 23
  4. Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7. (PMID: 8812442) Koch-Nolte F … Thiele HG (Genomics 1996) 2 3
  5. Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. (PMID: 7947688) Okazaki IJ … Moss J (Biochemistry 1994) 3 4

Products for ART1 Gene

Sources for ART1 Gene