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Aliases for ARSK Gene

Aliases for ARSK Gene

  • Arylsulfatase Family Member K 2 3 5
  • Telethon Sulfatase 3 4
  • Arylsulfatase K 2 3
  • TSULF 3 4
  • ASK 3 4
  • Arylsulfatase Family, Member K 2
  • EC 3.1.6.- 4

External Ids for ARSK Gene

Previous GeneCards Identifiers for ARSK Gene

  • GC05P094917
  • GC05P090081

Summaries for ARSK Gene

Entrez Gene Summary for ARSK Gene

  • Sulfatases (EC, such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARSK Gene

ARSK (Arylsulfatase Family Member K) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include sulfuric ester hydrolase activity and arylsulfatase activity. An important paralog of this gene is IDS.

Additional gene information for ARSK Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARSK Gene

Genomics for ARSK Gene

GeneHancer (GH) Regulatory Elements for ARSK Gene

Promoters and enhancers for ARSK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J095553 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 0.0 -25 3.1 HDGF FOXA2 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TTC37 ARSK RNU6-308P RHOBTB3
GH05J095724 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.2 +175.2 175203 11.6 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 MEF2D GLIS1 RHOBTB3 TTC37 LOC105379096 ENSG00000249545 ARSK SPATA9 GLRX ELL2 ENSG00000250240
GH05J094891 Enhancer 0.9 UCNEbase 20.2 -663.1 -663064 0.2 PKNOX1 ZBTB21 ZNF140 ZNF266 ZNF697 ZNF213 ZNF433 ZNF202 ZNF680 ZNF189 ARSK FAM172A ENSG00000276514 ENSG00000249545 MCTP1
GH05J096197 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.9 +644.1 644068 3.9 FOXA2 MZF1 DMAP1 RAD21 RARA ZNF121 SCRT2 CREM MIXL1 RXRA RIOK2 ARSK PCSK1 GC05M096211 RNU6-524P MIR583 MIR583HG LOC101929710
GH05J095707 Enhancer 0.8 ENCODE 13.2 +152.6 152598 0.2 HDAC1 ATF1 NFRKB TCF12 ZNF766 CAVIN1 ZBTB2 ZBTB11 CEBPB ZEB2 ARSK TTC37 RHOBTB3 SPATA9 ENSG00000250240
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARSK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARSK gene promoter:
  • ATF6
  • GATA-3
  • GATA-2
  • GATA-1
  • HFH-1
  • PPAR-alpha
  • TBP
  • Lmo2
  • E2F-5
  • E2F-4

Genomic Locations for ARSK Gene

Genomic Locations for ARSK Gene
50,029 bases
Plus strand
50,029 bases
Plus strand

Genomic View for ARSK Gene

Genes around ARSK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARSK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARSK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARSK Gene

Proteins for ARSK Gene

  • Protein details for ARSK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arylsulfatase K
    Protein Accession:
    Secondary Accessions:
    • A2BDE3
    • B4E1I4
    • Q3ZCW3
    • Q8N3Q8

    Protein attributes for ARSK Gene

    536 amino acids
    Molecular mass:
    61450 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=AAH36047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ARSK Gene

Post-translational modifications for ARSK Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at posLast=498498, Asn413, Asn375, Asn262, posLast=193193, Asn166, and Asn108
  • Modification sites at PhosphoSitePlus

Other Protein References for ARSK Gene

No data available for DME Specific Peptides for ARSK Gene

Domains & Families for ARSK Gene

Gene Families for ARSK Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for ARSK Gene

Suggested Antigen Peptide Sequences for ARSK Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfatase family.
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with ARSK: view

Function for ARSK Gene

Enzyme Numbers (IUBMB) for ARSK Gene

Gene Ontology (GO) - Molecular Function for ARSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004065 arylsulfatase activity TAS 16174644
GO:0008484 sulfuric ester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARSK: view
genes like me logo Genes that share phenotypes with ARSK: view

Animal Models for ARSK Gene

MGI Knock Outs for ARSK:
  • Arsk Arsk<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ARSK Gene

miRTarBase miRNAs that target ARSK

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARSK

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARSK Gene

Localization for ARSK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARSK Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARSK gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
lysosome 2
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with ARSK: view

Pathways & Interactions for ARSK Gene

genes like me logo Genes that share pathways with ARSK: view

Gene Ontology (GO) - Biological Process for ARSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ARSK: view

No data available for SIGNOR curated interactions for ARSK Gene

Drugs & Compounds for ARSK Gene

(1) Drugs for ARSK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with ARSK: view

Transcripts for ARSK Gene

mRNA/cDNA for ARSK Gene

Unigene Clusters for ARSK Gene

Arylsulfatase family, member K:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARSK

Alternative Splicing Database (ASD) splice patterns (SP) for ARSK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for ARSK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARSK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARSK Gene

Protein differential expression in normal tissues from HIPED for ARSK Gene

This gene is overexpressed in CD8 Tcells (30.1) and Ovary (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARSK Gene

NURSA nuclear receptor signaling pathways regulating expression of ARSK Gene:


SOURCE GeneReport for Unigene cluster for ARSK Gene:


Evidence on tissue expression from TISSUES for ARSK Gene

  • Nervous system(4.2)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with ARSK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARSK Gene

Orthologs for ARSK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARSK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARSK 34 33
  • 99.07 (n)
(Canis familiaris)
Mammalia ARSK 34 33
  • 89.37 (n)
(Bos Taurus)
Mammalia ARSK 34 33
  • 88.81 (n)
(Mus musculus)
Mammalia Arsk 16 34 33
  • 83.8 (n)
(Rattus norvegicus)
Mammalia Arsk 33
  • 83.55 (n)
(Ornithorhynchus anatinus)
Mammalia ARSK 34
  • 77 (a)
(Monodelphis domestica)
Mammalia ARSK 34
  • 67 (a)
(Gallus gallus)
Aves ARSK 34 33
  • 74.98 (n)
(Anolis carolinensis)
Reptilia ARSK 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arsk 33
  • 68.61 (n)
(Danio rerio)
Actinopterygii arsk 34 33
  • 63.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12014 34
  • 20 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00309g 33
  • 39.68 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08364 33
  • 40.78 (n)
Species where no ortholog for ARSK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARSK Gene

Gene Tree for ARSK (if available)
Gene Tree for ARSK (if available)
Evolutionary constrained regions (ECRs) for ARSK: view image

Paralogs for ARSK Gene

Paralogs for ARSK Gene

(1) SIMAP similar genes for ARSK Gene using alignment to 6 proteins:

  • D6R9F9_HUMAN
  • H0Y9F6_HUMAN
  • Q86W75_HUMAN
genes like me logo Genes that share paralogs with ARSK: view

Variants for ARSK Gene

Sequence variations from dbSNP and Humsavar for ARSK Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000093461 -- 95,555,405(+) G/A/T splice_donor_variant
rs1000099574 -- 95,588,107(+) A/G intron_variant
rs1000119287 -- 95,585,107(+) A/G intron_variant
rs1000164381 -- 95,561,890(+) T/G intron_variant
rs1000213811 -- 95,579,940(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARSK Gene

Variant ID Type Subtype PubMed ID
nsv598955 CNV gain 21841781
nsv830408 CNV loss 17160897

Variation tolerance for ARSK Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARSK Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARSK Gene

Disorders for ARSK Gene

Additional Disease Information for ARSK

No disorders were found for ARSK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARSK Gene

Publications for ARSK Gene

  1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PMID: 16174644) Sardiello M … Ballabio A (Human molecular genetics 2005) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. Molecular cloning and initial characterization of three novel human sulfatases. (PMID: 16500042) Obaya AJ (Gene 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ARSK Gene

Sources for ARSK Gene

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