Aliases for ARSI Gene
External Ids for ARSI Gene
Previous GeneCards Identifiers for ARSI Gene
This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016]
GeneCards Summary for ARSI Gene
ARSI (Arylsulfatase Family Member I) is a Protein Coding gene. Diseases associated with ARSI include Autosomal Recessive Spastic Paraplegia Type 66 and Louse-Borne Relapsing Fever. Among its related pathways are Metabolism of proteins and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include sulfuric ester hydrolase activity and arylsulfatase activity. An important paralog of this gene is ARSJ.
UniProtKB/Swiss-Prot Summary for ARSI Gene
Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts.