Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARRDC5 Gene

Aliases for ARRDC5 Gene

  • Arrestin Domain Containing 5 2 3 5
  • Arrestin Domain-Containing Protein 5 3 4

External Ids for ARRDC5 Gene

Previous GeneCards Identifiers for ARRDC5 Gene

  • GC19M004843
  • GC19U900462
  • GC19M004844
  • GC19M004652

Summaries for ARRDC5 Gene

GeneCards Summary for ARRDC5 Gene

ARRDC5 (Arrestin Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is ARRDC4.

Additional gene information for ARRDC5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC5 Gene

Genomics for ARRDC5 Gene

GeneHancer (GH) Regulatory Elements for ARRDC5 Gene

Promoters and enhancers for ARRDC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J004828 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.6 +85.7 85654 4.6 ZFX ZKSCAN8 ZNF148 NKRF MLLT1 CEBPG POLR2A ZNF687 ZSCAN21 SP7 TICAM1 GC19P004832 SAFB2 PLIN3 SAFB ARRDC5 FEM1A MIR7-3 MIR7-3HG SNRPEP4
GH19J004907 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.9 +4.1 4137 9.5 SP1 CC2D1A CTCF ZNF148 NKRF ZNF121 POLR2A ZNF687 FOS AHR UHRF1 SAFB2 PLIN3 SAFB ENSG00000267769 YJU2 ENSG00000267030 PTPRS ARRDC5
GH19J004987 Enhancer 1.2 Ensembl ENCODE dbSUPER 12 -73.4 -73400 5.9 CBFA2T2 ZNF148 MLLT1 SP1 SMARCA4 MTA1 IKZF1 ZNF600 ZIC2 PATZ1 GC19M004987 KDM4B ENSG00000267030 SAFB YJU2 ENSG00000267769 SAFB2 ARRDC5 PLIN3 RANBP3
GH19J004851 Enhancer 1.1 ENCODE dbSUPER 11.8 +65.0 65046 0.2 CC2D1A ELF3 CTCF TFE3 SP5 KLF14 ZNF384 RAD21 IKZF1 ZNF24 SNRPEP4 DUS3L ARRDC5 YJU2 ENSG00000267769 GC19M004846 GC19M004858 PIR52015 PLIN3
GH19J004860 Enhancer 0.9 ENCODE dbSUPER 12 +55.2 55216 2.5 NFIB MZF1 ZIC2 CTBP1 RUNX3 IKZF1 HDGF ZNF217 DPF2 ZNF423 GC19M004858 PLIN3 TICAM1 ARRDC5 DPP9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARRDC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARRDC5 gene promoter:
  • AML1a
  • c-Myc
  • CBF(2)
  • CBF-A
  • Egr-3
  • Max1
  • MZF-1
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for ARRDC5 Gene

Genomic Locations for ARRDC5 Gene
26,384 bases
Minus strand
12,431 bases
Minus strand

Genomic View for ARRDC5 Gene

Genes around ARRDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC5 Gene

Proteins for ARRDC5 Gene

  • Protein details for ARRDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arrestin domain-containing protein 5
    Protein Accession:

    Protein attributes for ARRDC5 Gene

    342 amino acids
    Molecular mass:
    38383 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAW69191.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ARRDC5 Gene

Post-translational modifications for ARRDC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARRDC5 Gene

Domains & Families for ARRDC5 Gene

Gene Families for ARRDC5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARRDC5 Gene

Suggested Antigen Peptide Sequences for ARRDC5 Gene

GenScript: Design optimal peptide antigens:
  • Arrestin domain-containing protein 5 (ARRD5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the arrestin family.
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC5: view

Function for ARRDC5 Gene

Phenotypes From GWAS Catalog for ARRDC5 Gene

genes like me logo Genes that share phenotypes with ARRDC5: view

Animal Models for ARRDC5 Gene

MGI Knock Outs for ARRDC5:
  • Arrdc5 Arrdc5<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ARRDC5 - Now 50% OFF >
  • * ARRDC5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ARRDC5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ARRDC5 Gene

Localization for ARRDC5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARRDC5 gene
Compartment Confidence
plasma membrane 1
nucleus 1
cytosol 1
cytoskeleton 0
mitochondrion 0
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ARRDC5 Gene

Pathways & Interactions for ARRDC5 Gene

PathCards logo

SuperPathways for ARRDC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC5 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARRDC5 Gene

Drugs & Compounds for ARRDC5 Gene

No Compound Related Data Available

Transcripts for ARRDC5 Gene

mRNA/cDNA for ARRDC5 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ARRDC5 Gene

Arrestin domain containing 5:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ARRDC5 - Now 50% OFF >
  • * ARRDC5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ARRDC5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC5 Gene

No ASD Table

Relevant External Links for ARRDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARRDC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARRDC5 Gene

mRNA differential expression in normal tissues according to GTEx for ARRDC5 Gene

This gene is overexpressed in Testis (x28.7) and Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for ARRDC5 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARRDC5 Gene

Protein tissue co-expression partners for ARRDC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARRDC5 Gene:


SOURCE GeneReport for Unigene cluster for ARRDC5 Gene:

genes like me logo Genes that share expression patterns with ARRDC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARRDC5 Gene

Orthologs for ARRDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARRDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARRDC5 35 34
  • 98.93 (n)
(Canis familiaris)
Mammalia ARRDC5 35 34
  • 84.56 (n)
(Bos Taurus)
Mammalia ARRDC5 35 34
  • 84.56 (n)
(Rattus norvegicus)
Mammalia Arrdc5 34
  • 75 (n)
(Mus musculus)
Mammalia Arrdc5 17 35 34
  • 74.68 (n)
(Gallus gallus)
Aves LOC101752017 34
  • 58.04 (n)
Species where no ortholog for ARRDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARRDC5 Gene

Gene Tree for ARRDC5 (if available)
Gene Tree for ARRDC5 (if available)
Evolutionary constrained regions (ECRs) for ARRDC5: view image

Paralogs for ARRDC5 Gene

Paralogs for ARRDC5 Gene

genes like me logo Genes that share paralogs with ARRDC5: view

Variants for ARRDC5 Gene

Sequence variations from dbSNP and Humsavar for ARRDC5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000199938 -- 4,912,238(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000203050 -- 4,876,402(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000322379 -- 4,907,334(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000345683 -- 4,875,152(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000385468 -- 4,870,588(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARRDC5 Gene

Variant ID Type Subtype PubMed ID
esv25954 CNV gain 19812545
esv3893158 CNV loss 25118596
nsv1065556 CNV loss 25217958
nsv1141946 OTHER inversion 24896259
nsv470117 CNV loss 18288195

Variation tolerance for ARRDC5 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARRDC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC5 Gene

Disorders for ARRDC5 Gene

Additional Disease Information for ARRDC5

No disorders were found for ARRDC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC5 Gene

Publications for ARRDC5 Gene

  1. YAF2 promotes TP53-mediated genotoxic stress response via stabilization of PDCD5. (PMID: 25603536) Park SY … Yoon HG (Biochimica et biophysica acta 2015) 3 58
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 58
  3. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. (PMID: 20351267) Ying H … DePinho RA (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ARRDC5 Gene

Sources for ARRDC5 Gene

Loading form....