Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARRDC5 Gene

Aliases for ARRDC5 Gene

  • Arrestin Domain Containing 5 2 3 5

External Ids for ARRDC5 Gene

Previous GeneCards Identifiers for ARRDC5 Gene

  • GC19M004843
  • GC19U900462
  • GC19M004844
  • GC19M004652

Summaries for ARRDC5 Gene

GeneCards Summary for ARRDC5 Gene

ARRDC5 (Arrestin Domain Containing 5) is a Protein Coding gene.

Additional gene information for ARRDC5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC5 Gene

Genomics for ARRDC5 Gene

GeneHancer (GH) Regulatory Elements for ARRDC5 Gene

Promoters and enhancers for ARRDC5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I004902 Promoter 0.8 EPDnew 557.2 +13.9 13910 0.1 ZBTB21 ZNF629 ATF7 PRDM10 ATF2 ARRDC5 UHRF1 GC19M004863
GH19I004828 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.6 +85.7 85654 4.6 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 POLR2B TICAM1 GC19P004832 SAFB2 PLIN3 SAFB ARRDC5 FEM1A MIR7-3 MIR7-3HG SNRPEP4
GH19I004907 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8 +4.1 4137 9.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF766 E2F8 ZNF143 UHRF1 ENSG00000267030 SAFB SAFB2 KDM4B DPP9-AS1 DUS3L PLIN3 VMAC ENSG00000267769
GH19I004987 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 12 -73.4 -73400 5.9 HDAC1 FOXA2 KLF17 ZNF2 YY1 TCF12 ATF7 RCOR1 EGR2 ZNF148 KDM4B GC19M004987 ARRDC5 PLIN3 PTPRS UHRF1 GC19P005074
GH19I004851 Enhancer 1.1 ENCODE dbSUPER 11.8 +65.0 65046 0.2 HDGF FOXA2 ARID4B ZNF2 ZBTB7B IRF4 ZNF48 TCF12 ARID2 ZNF143 SNRPEP4 DUS3L ARRDC5 CCDC94 ENSG00000267769 GC19M004846 GC19M004858 PIR52015 PLIN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARRDC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARRDC5 gene promoter:

Genomic Locations for ARRDC5 Gene

Genomic Locations for ARRDC5 Gene
chr19:4,890,437-4,916,820
(GRCh38/hg38)
Size:
26,384 bases
Orientation:
Minus strand
chr19:4,890,449-4,902,879
(GRCh37/hg19)

Genomic View for ARRDC5 Gene

Genes around ARRDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC5 Gene

Proteins for ARRDC5 Gene

  • Protein details for ARRDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NEK1-ARRD5_HUMAN
    Recommended name:
    Arrestin domain-containing protein 5
    Protein Accession:
    A6NEK1

    Protein attributes for ARRDC5 Gene

    Size:
    342 amino acids
    Molecular mass:
    38383 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW69191.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ARRDC5 Gene

Post-translational modifications for ARRDC5 Gene

No Post-translational modifications

Other Protein References for ARRDC5 Gene

No data available for DME Specific Peptides for ARRDC5 Gene

Domains & Families for ARRDC5 Gene

Gene Families for ARRDC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARRDC5 Gene

Suggested Antigen Peptide Sequences for ARRDC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NEK1

UniProtKB/Swiss-Prot:

ARRD5_HUMAN :
  • Belongs to the arrestin family.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC5: view

Function for ARRDC5 Gene

Phenotypes From GWAS Catalog for ARRDC5 Gene

Phenotypes for ARRDC5 Gene

GenomeRNAi human phenotypes for ARRDC5:
genes like me logo Genes that share phenotypes with ARRDC5: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARRDC5 Gene

Localization for ARRDC5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARRDC5 gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ARRDC5 Gene

Pathways & Interactions for ARRDC5 Gene

SuperPathways for ARRDC5 Gene

No Data Available

Interacting Proteins for ARRDC5 Gene

Gene Ontology (GO) - Biological Process for ARRDC5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARRDC5 Gene

Drugs & Compounds for ARRDC5 Gene

No Compound Related Data Available

Transcripts for ARRDC5 Gene

mRNA/cDNA for ARRDC5 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARRDC5 Gene

Arrestin domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC5 Gene

No ASD Table

Relevant External Links for ARRDC5 Gene

GeneLoc Exon Structure for
ARRDC5
ECgene alternative splicing isoforms for
ARRDC5

Expression for ARRDC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARRDC5 Gene

mRNA differential expression in normal tissues according to GTEx for ARRDC5 Gene

This gene is overexpressed in Testis (x28.7) and Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for ARRDC5 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARRDC5 Gene



Protein tissue co-expression partners for ARRDC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARRDC5 Gene:

ARRDC5

SOURCE GeneReport for Unigene cluster for ARRDC5 Gene:

Hs.574574
genes like me logo Genes that share expression patterns with ARRDC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARRDC5 Gene

Orthologs for ARRDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARRDC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARRDC5 33 34
  • 98.93 (n)
cow
(Bos Taurus)
Mammalia ARRDC5 33 34
  • 84.56 (n)
dog
(Canis familiaris)
Mammalia ARRDC5 33 34
  • 84.56 (n)
rat
(Rattus norvegicus)
Mammalia Arrdc5 33
  • 75 (n)
mouse
(Mus musculus)
Mammalia Arrdc5 33 16 34
  • 74.68 (n)
chicken
(Gallus gallus)
Aves LOC101752017 33
  • 58.04 (n)
Species where no ortholog for ARRDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARRDC5 Gene

ENSEMBL:
Gene Tree for ARRDC5 (if available)
TreeFam:
Gene Tree for ARRDC5 (if available)

Paralogs for ARRDC5 Gene

No data available for Paralogs for ARRDC5 Gene

Variants for ARRDC5 Gene

Sequence variations from dbSNP and Humsavar for ARRDC5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000199938 -- 4,912,238(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000203050 -- 4,876,402(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000322379 -- 4,907,334(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000345683 -- 4,875,152(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000385468 -- 4,870,588(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARRDC5 Gene

Variant ID Type Subtype PubMed ID
nsv470117 CNV loss 18288195
nsv1141946 OTHER inversion 24896259
nsv1065556 CNV loss 25217958
esv3893158 CNV loss 25118596
esv25954 CNV gain 19812545

Variation tolerance for ARRDC5 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARRDC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARRDC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC5 Gene

Disorders for ARRDC5 Gene

Additional Disease Information for ARRDC5

No disorders were found for ARRDC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC5 Gene

Publications for ARRDC5 Gene

  1. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 58
  2. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. (PMID: 20351267) Ying H … DePinho RA (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  5. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. (PMID: 12886014) Cal S … Lopez-Otin C (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 58

Products for ARRDC5 Gene

Sources for ARRDC5 Gene

Content
Loading form....