Aliases for ARRDC5 Gene

Aliases for ARRDC5 Gene

  • Arrestin Domain Containing 5 2 3 5
  • Arrestin Domain-Containing Protein 5 3 4
  • ARRDC5 5

External Ids for ARRDC5 Gene

Previous GeneCards Identifiers for ARRDC5 Gene

  • GC19M004843
  • GC19U900462
  • GC19M004844
  • GC19M004652

Summaries for ARRDC5 Gene

GeneCards Summary for ARRDC5 Gene

ARRDC5 (Arrestin Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is ARRDC3.

Additional gene information for ARRDC5 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARRDC5 Gene

Genomics for ARRDC5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARRDC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARRDC5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARRDC5

Top Transcription factor binding sites by QIAGEN in the ARRDC5 gene promoter:
  • AML1a
  • c-Myc
  • CBF(2)
  • CBF-A
  • Egr-3
  • Max1
  • MZF-1
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for ARRDC5 Gene

Genomic Locations for ARRDC5 Gene
chr19:4,867,614-4,915,469
(GRCh38/hg38)
Size:
47,856 bases
Orientation:
Minus strand
chr19:4,890,449-4,902,879
(GRCh37/hg19)
Size:
12,431 bases
Orientation:
Minus strand

Genomic View for ARRDC5 Gene

Genes around ARRDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC5 Gene

Proteins for ARRDC5 Gene

  • Protein details for ARRDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NEK1-ARRD5_HUMAN
    Recommended name:
    Arrestin domain-containing protein 5
    Protein Accession:
    A6NEK1

    Protein attributes for ARRDC5 Gene

    Size:
    342 amino acids
    Molecular mass:
    38383 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW69191.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ARRDC5 Gene

Post-translational modifications for ARRDC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARRDC5 Gene

No data available for DME Specific Peptides for ARRDC5 Gene

Domains & Families for ARRDC5 Gene

Gene Families for ARRDC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARRDC5 Gene

Suggested Antigen Peptide Sequences for ARRDC5 Gene

GenScript: Design optimal peptide antigens:
  • Arrestin domain-containing protein 5 (ARRD5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NEK1

UniProtKB/Swiss-Prot:

ARRD5_HUMAN :
  • Belongs to the arrestin family.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC5: view

Function for ARRDC5 Gene

Phenotypes From GWAS Catalog for ARRDC5 Gene

Gene Ontology (GO) - Molecular Function for ARRDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IBA 21873635
GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination IBA 21873635
genes like me logo Genes that share ontologies with ARRDC5: view
genes like me logo Genes that share phenotypes with ARRDC5: view

Animal Models for ARRDC5 Gene

MGI Knock Outs for ARRDC5:
  • Arrdc5 Arrdc5<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARRDC5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ARRDC5 Gene

Localization for ARRDC5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARRDC5 gene
Compartment Confidence
plasma membrane 2
nucleus 2
endosome 2
cytosol 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for ARRDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with ARRDC5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARRDC5 Gene

Pathways & Interactions for ARRDC5 Gene

PathCards logo

SuperPathways for ARRDC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IBA 21873635
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with ARRDC5: view

No data available for Pathways by source and SIGNOR curated interactions for ARRDC5 Gene

Drugs & Compounds for ARRDC5 Gene

No Compound Related Data Available

Transcripts for ARRDC5 Gene

mRNA/cDNA for ARRDC5 Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARRDC5

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC5 Gene

No ASD Table

Relevant External Links for ARRDC5 Gene

GeneLoc Exon Structure for
ARRDC5

Expression for ARRDC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARRDC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for ARRDC5 Gene

This gene is overexpressed in Testis (x28.7) and Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for ARRDC5 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARRDC5 Gene



Protein tissue co-expression partners for ARRDC5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARRDC5

SOURCE GeneReport for Unigene cluster for ARRDC5 Gene:

Hs.574574
genes like me logo Genes that share expression patterns with ARRDC5: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARRDC5 Gene

Orthologs for ARRDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARRDC5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ARRDC5 30 31
  • 98.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ARRDC5 30 31
  • 84.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ARRDC5 30 31
  • 84.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Arrdc5 30
  • 75 (n)
Mouse
(Mus musculus)
Mammalia Arrdc5 30 17 31
  • 74.68 (n)
OneToOne
Chicken
(Gallus gallus)
Aves LOC101752017 30
  • 58.04 (n)
Species where no ortholog for ARRDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ARRDC5 Gene

ENSEMBL:
Gene Tree for ARRDC5 (if available)
TreeFam:
Gene Tree for ARRDC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARRDC5: view image

Paralogs for ARRDC5 Gene

Paralogs for ARRDC5 Gene

genes like me logo Genes that share paralogs with ARRDC5: view

Variants for ARRDC5 Gene

Additional dbSNP identifiers (rs#s) for ARRDC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARRDC5 Gene

Variant ID Type Subtype PubMed ID
esv25954 CNV gain 19812545
esv3893158 CNV loss 25118596
nsv1065556 CNV loss 25217958
nsv1141946 OTHER inversion 24896259
nsv470117 CNV loss 18288195

Variation tolerance for ARRDC5 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARRDC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARRDC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARRDC5 Gene

Disorders for ARRDC5 Gene

No disorders were found for ARRDC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC5 Gene

Publications for ARRDC5 Gene

  1. YAF2 promotes TP53-mediated genotoxic stress response via stabilization of PDCD5. (PMID: 25603536) Park SY … Yoon HG (Biochimica et biophysica acta 2015) 3
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. (PMID: 20351267) Ying H … DePinho RA (Proceedings of the National Academy of Sciences of the United States of America 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3

Products for ARRDC5 Gene

Sources for ARRDC5 Gene