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Aliases for ARRDC4 Gene

Aliases for ARRDC4 Gene

  • Arrestin Domain Containing 4 2 3 5

External Ids for ARRDC4 Gene

Previous GeneCards Identifiers for ARRDC4 Gene

  • GC00U913742
  • GC15P096233
  • GC15P096304
  • GC15P098503
  • GC15P074633

Summaries for ARRDC4 Gene

GeneCards Summary for ARRDC4 Gene

ARRDC4 (Arrestin Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is ARRDC3.

UniProtKB/Swiss-Prot for ARRDC4 Gene

  • Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake (PubMed:19605364).

Additional gene information for ARRDC4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC4 Gene

Genomics for ARRDC4 Gene

GeneHancer (GH) Regulatory Elements for ARRDC4 Gene

Promoters and enhancers for ARRDC4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I097959 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.6 +0.5 509 3.4 PKNOX1 CLOCK SMAD1 FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 ZBTB7B ARRDC4 LINC02251 ENSG00000259478
GH15I098002 Enhancer 1.2 FANTOM5 ENCODE 37.9 +42.9 42924 2.8 PKNOX1 FOXA2 ARID4B YBX1 ZNF48 ZNF207 FOS BCLAF1 YY2 GATAD2B ARRDC4 LINC02251 LOC101927310 LOC105371009
GH15I097976 Enhancer 1.3 FANTOM5 Ensembl ENCODE 28.5 +17.0 17043 2.9 FOXA2 ZBTB40 RAD21 RARA YY1 TCF12 ELK1 FOS RXRA ELF1 ARRDC4 LINC02251 LOC101927310 ENSG00000259478
GH15I097991 Enhancer 1.1 Ensembl ENCODE 28.9 +32.3 32284 2 HDAC1 PKNOX1 ATF1 ZBTB40 RFX5 TCF12 ZNF766 GATA2 FOS ETV6 ENSG00000259478 ARRDC4 LINC02251
GH15I097994 Enhancer 0.8 Ensembl ENCODE 28.4 +35.2 35179 2 CTCF L3MBTL2 TEAD4 RAD21 IKZF1 SMC3 HNF4A ZNF444 MGA ARRDC4 ENSG00000259478 LINC02251 LOC105371009
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARRDC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARRDC4 gene promoter:

Genomic Locations for ARRDC4 Gene

Genomic Locations for ARRDC4 Gene
chr15:97,960,698-97,973,838
(GRCh38/hg38)
Size:
13,141 bases
Orientation:
Plus strand
chr15:98,462,784-98,517,068
(GRCh37/hg19)

Genomic View for ARRDC4 Gene

Genes around ARRDC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC4 Gene

Proteins for ARRDC4 Gene

  • Protein details for ARRDC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCT1-ARRD4_HUMAN
    Recommended name:
    Arrestin domain-containing protein 4
    Protein Accession:
    Q8NCT1
    Secondary Accessions:
    • Q6NSI9

    Protein attributes for ARRDC4 Gene

    Size:
    418 amino acids
    Molecular mass:
    45479 Da
    Quaternary structure:
    • Interacts with ADRB2 (PubMed:21982743, PubMed:23208550). Interacts (via PPxY motifs) with ITCH, NEDD4L and WWP2 (PubMed:23236378). Interacts with AVPR2. Identified in a complex containing at least ARRDC4, AVPR2 and HGS (PubMed:23236378). Interacts with SLC11A2; controls the incorporation of SLC11A2 into extracellular vesicles through an ubiquitination-dependent mechanism (By similarity).

neXtProt entry for ARRDC4 Gene

Post-translational modifications for ARRDC4 Gene

  • Ubiquitination at Lys229
  • Modification sites at PhosphoSitePlus

Other Protein References for ARRDC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARRDC4 Gene

Domains & Families for ARRDC4 Gene

Gene Families for ARRDC4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARRDC4 Gene

Suggested Antigen Peptide Sequences for ARRDC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NCT1

UniProtKB/Swiss-Prot:

ARRD4_HUMAN :
  • Belongs to the arrestin family.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC4: view

Function for ARRDC4 Gene

Molecular function for ARRDC4 Gene

UniProtKB/Swiss-Prot Function:
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake (PubMed:19605364).

Phenotypes From GWAS Catalog for ARRDC4 Gene

Gene Ontology (GO) - Molecular Function for ARRDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23236378
GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination ISS,IEA --
genes like me logo Genes that share ontologies with ARRDC4: view
genes like me logo Genes that share phenotypes with ARRDC4: view

Animal Models for ARRDC4 Gene

MGI Knock Outs for ARRDC4:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARRDC4 Gene

Localization for ARRDC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARRDC4 Gene

Early endosome. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Note=Also found in extracellular vesicles different from exosomes. {ECO:0000250 UniProtKB:A0A0B4J1F4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARRDC4 gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 4
mitochondrion 2
cytosol 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARRDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 23236378
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane IDA 23236378
GO:0016020 membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ARRDC4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARRDC4 Gene

Pathways & Interactions for ARRDC4 Gene

SuperPathways for ARRDC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA,ISS --
GO:0016567 protein ubiquitination IEA,ISS --
GO:0051443 positive regulation of ubiquitin-protein transferase activity IPI 23236378
GO:0140112 extracellular vesicle biogenesis ISS --
genes like me logo Genes that share ontologies with ARRDC4: view

No data available for Pathways by source and SIGNOR curated interactions for ARRDC4 Gene

Drugs & Compounds for ARRDC4 Gene

No Compound Related Data Available

Transcripts for ARRDC4 Gene

mRNA/cDNA for ARRDC4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(125) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARRDC4 Gene

Arrestin domain containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC4 Gene

No ASD Table

Relevant External Links for ARRDC4 Gene

GeneLoc Exon Structure for
ARRDC4
ECgene alternative splicing isoforms for
ARRDC4

Expression for ARRDC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARRDC4 Gene

mRNA differential expression in normal tissues according to GTEx for ARRDC4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.8).

Protein differential expression in normal tissues from HIPED for ARRDC4 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARRDC4 Gene



Protein tissue co-expression partners for ARRDC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARRDC4 Gene:

ARRDC4

SOURCE GeneReport for Unigene cluster for ARRDC4 Gene:

Hs.6093

Evidence on tissue expression from TISSUES for ARRDC4 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with ARRDC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARRDC4 Gene

Orthologs for ARRDC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARRDC4 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARRDC4 33 34
  • 88.83 (n)
cow
(Bos Taurus)
Mammalia ARRDC4 33 34
  • 87.91 (n)
oppossum
(Monodelphis domestica)
Mammalia ARRDC4 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arrdc4 16 34 33
  • 82.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARRDC4 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARRDC4 33 34
  • 75.06 (n)
lizard
(Anolis carolinensis)
Reptilia ARRDC4 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc4 33
  • 63.54 (n)
zebrafish
(Danio rerio)
Actinopterygii arrdc3b 34
  • 48 (a)
ManyToMany
si:dkey-172m14.2 34
  • 29 (a)
ManyToMany
zgc:110353 34
  • 27 (a)
ManyToMany
si:ch211-130m23.2 34
  • 21 (a)
ManyToMany
zgc:110626 34
  • 21 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Vdup1 34
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arrd-16 34
  • 25 (a)
ManyToMany
arrd-12 34
  • 22 (a)
ManyToMany
arrd-6 34
  • 20 (a)
ManyToMany
Species where no ortholog for ARRDC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC4 Gene

ENSEMBL:
Gene Tree for ARRDC4 (if available)
TreeFam:
Gene Tree for ARRDC4 (if available)

Paralogs for ARRDC4 Gene

Paralogs for ARRDC4 Gene

(3) SIMAP similar genes for ARRDC4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARRDC4: view

Variants for ARRDC4 Gene

Sequence variations from dbSNP and Humsavar for ARRDC4 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000098529 -- 97,968,961(+) G/C intron_variant
rs1000359411 -- 97,966,661(+) A/G intron_variant
rs1000711304 -- 97,965,425(+) ACACAC/ACAC intron_variant
rs1000797766 -- 97,963,437(+) T/A intron_variant
rs1001107014 -- 97,970,378(+) T/C intron_variant

Variation tolerance for ARRDC4 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.82; 95.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARRDC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARRDC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARRDC4 Gene

Disorders for ARRDC4 Gene

Additional Disease Information for ARRDC4

No disorders were found for ARRDC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC4 Gene

Publications for ARRDC4 Gene

  1. ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65. (PMID: 28594402) Meng J … Cheng J (Cell death & disease 2017) 2 3 58
  2. Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. (PMID: 23236378) Shea FF … Alvarez CE (PloS one 2012) 3 4 58
  3. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. (PMID: 21982743) Patwari P … Lee RT (Cell metabolism 2011) 3 4 58
  4. A genome-wide association study of neuroticism in a population-based sample. (PMID: 20634892) Calboli FC … Balding DJ (PloS one 2010) 3 44 58
  5. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. (PMID: 19605364) Patwari P … Lee RT (The Journal of biological chemistry 2009) 3 4 58

Products for ARRDC4 Gene

Sources for ARRDC4 Gene

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