Aliases for ARRDC3 Gene
External Ids for ARRDC3 Gene
Previous GeneCards Identifiers for ARRDC3 Gene
This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016]
GeneCards Summary for ARRDC3 Gene
ARRDC3 (Arrestin Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include beta-3 adrenergic receptor binding. An important paralog of this gene is ARRDC2.
UniProtKB/Swiss-Prot for ARRDC3 Gene
Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550).