Aliases for ARRDC2 Gene

Aliases for ARRDC2 Gene

  • Arrestin Domain Containing 2 2 3 5
  • Arrestin Domain-Containing Protein 2 3 4
  • CLONE24945 2 3
  • PP2703 2 3
  • ARRDC2 5

External Ids for ARRDC2 Gene

Previous GeneCards Identifiers for ARRDC2 Gene

  • GC19P017979
  • GC19P018111
  • GC19P017677
  • GC19P018123
  • GC19P018180
  • GC19P020487
  • GC19P020629
  • GC19P020734
  • GC19P022243
  • GC19P018300
  • GC19P018332
  • GC19P018706
  • GC19P019015
  • GC19P019333
  • GC19P019669
  • GC19P020031
  • GC19P020345
  • GC19P023320
  • GC19P024462

Summaries for ARRDC2 Gene

GeneCards Summary for ARRDC2 Gene

ARRDC2 (Arrestin Domain Containing 2) is a Protein Coding gene. Diseases associated with ARRDC2 include Ullrich Congenital Muscular Dystrophy 1. An important paralog of this gene is ARRDC3.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARRDC2 Gene

Genomics for ARRDC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARRDC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARRDC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARRDC2

Top Transcription factor binding sites by QIAGEN in the ARRDC2 gene promoter:
  • c-Ets-1
  • c-Myc
  • COMP1
  • E2F
  • E2F-1
  • Max1
  • N-Myc

Genomic Locations for ARRDC2 Gene

Latest Assembly
12,979 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
12,979 bases
Plus strand

(GRCh37/hg19 by Ensembl)
12,971 bases
Plus strand

Genomic View for ARRDC2 Gene

Genes around ARRDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC2 Gene

Proteins for ARRDC2 Gene

  • Protein details for ARRDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arrestin domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RBG9
    • O95895
    • Q6ZRV9
    • Q8WYG6

    Protein attributes for ARRDC2 Gene

    407 amino acids
    Molecular mass:
    44379 Da
    Quaternary structure:
    • Interacts with WWP1 (via WW domains).

    Alternative splice isoforms for ARRDC2 Gene


neXtProt entry for ARRDC2 Gene

Post-translational modifications for ARRDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARRDC2 Gene

No data available for DME Specific Peptides for ARRDC2 Gene

Domains & Families for ARRDC2 Gene

Gene Families for ARRDC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARRDC2 Gene

Suggested Antigen Peptide Sequences for ARRDC2 Gene

GenScript: Design optimal peptide antigens:
  • Arrestin domain-containing protein 2 (ARRD2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the arrestin family.
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC2: view

Function for ARRDC2 Gene

Phenotypes From GWAS Catalog for ARRDC2 Gene

Gene Ontology (GO) - Molecular Function for ARRDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with ARRDC2: view
genes like me logo Genes that share phenotypes with ARRDC2: view

Animal Models for ARRDC2 Gene

MGI Knock Outs for ARRDC2:
  • Arrdc2 Arrdc2<tm1b(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARRDC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARRDC2 Gene

Localization for ARRDC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARRDC2 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
endosome 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARRDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane IDA 23236378
GO:0031410 cytoplasmic vesicle IDA 23236378
genes like me logo Genes that share ontologies with ARRDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARRDC2 Gene

Pathways & Interactions for ARRDC2 Gene

PathCards logo

SuperPathways for ARRDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IBA 21873635
genes like me logo Genes that share ontologies with ARRDC2: view

No data available for Pathways by source and SIGNOR curated interactions for ARRDC2 Gene

Drugs & Compounds for ARRDC2 Gene

No Compound Related Data Available

Transcripts for ARRDC2 Gene

mRNA/cDNA for ARRDC2 Gene

10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARRDC2

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - -

Relevant External Links for ARRDC2 Gene

GeneLoc Exon Structure for

Expression for ARRDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARRDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARRDC2 Gene

This gene is overexpressed in Muscle - Skeletal (x6.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARRDC2

SOURCE GeneReport for Unigene cluster for ARRDC2 Gene:


Evidence on tissue expression from TISSUES for ARRDC2 Gene

  • Nervous system(4.8)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with ARRDC2: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARRDC2 Gene

Orthologs for ARRDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARRDC2 29 30
  • 99.26 (n)
(Canis familiaris)
Mammalia ARRDC2 29 30
  • 87.22 (n)
(Bos Taurus)
Mammalia ARRDC2 29 30
  • 85.67 (n)
(Mus musculus)
Mammalia Arrdc2 29 16 30
  • 79.12 (n)
(Monodelphis domestica)
Mammalia ARRDC2 30
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ARRDC2 30
  • 69 (a)
(Gallus gallus)
Aves ARRDC2 29 30
  • 71.55 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia arrdc2 29
  • 64.1 (n)
(Danio rerio)
Actinopterygii arrdc2 29 30
  • 61.82 (n)
-- 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11055 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001894 29
  • 46.53 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG1105 29
  • 46.02 (n)
Vdup1 30
  • 27 (a)
(Caenorhabditis elegans)
Secernentea arrd-17 29
  • 40.02 (n)
arrd-16 30
  • 25 (a)
arrd-12 30
  • 21 (a)
arrd-6 30
  • 21 (a)
Species where no ortholog for ARRDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ARRDC2 Gene

Gene Tree for ARRDC2 (if available)
Gene Tree for ARRDC2 (if available)
Evolutionary constrained regions (ECRs) for ARRDC2: view image
Alliance of Genome Resources:
Additional Orthologs for ARRDC2

Paralogs for ARRDC2 Gene

Paralogs for ARRDC2 Gene

(3) SIMAP similar genes for ARRDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARRDC2: view

Variants for ARRDC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARRDC2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs17852061 -- p.Arg181His
rs17852062 -- p.Arg192His
rs7259041 -- p.Leu396Pro
rs8110271 -- p.Ala244Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ARRDC2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ARRDC2 Gene

Variant ID Type Subtype PubMed ID
esv3643828 CNV gain 21293372
esv3643829 CNV gain 21293372
nsv2428 CNV insertion 18451855
nsv470130 CNV loss 18288195
nsv833772 CNV gain+loss 17160897

Variation tolerance for ARRDC2 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.03; 84.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARRDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC2 Gene

Disorders for ARRDC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARRDC2 Gene - From: COP

Disorder Aliases PubMed IDs
ullrich congenital muscular dystrophy 1
  • ucmd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARRDC2

genes like me logo Genes that share disorders with ARRDC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARRDC2 Gene

Publications for ARRDC2 Gene

  1. Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding. (PMID: 21191027) Rauch S … Martin-Serrano J (Journal of virology 2011) 3 4
  2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3

Products for ARRDC2 Gene

Sources for ARRDC2 Gene