External Ids for ARRDC1 Gene
Previous GeneCards Identifiers for ARRDC1 Gene
GeneCards Summary for ARRDC1 Gene
ARRDC1 (Arrestin Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is ARRDC4.
UniProtKB/Swiss-Prot for ARRDC1 Gene
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940).