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The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]
ARR3 (Arrestin 3) is a Protein Coding gene. Diseases associated with ARR3 include Myopia 26, X-Linked, Female-Limited and Myopia. Among its related pathways are Phototransduction and Visual Cycle in Retinal Rods. Gene Ontology (GO) annotations related to this gene include phosphoprotein binding and opsin binding. An important paralog of this gene is ARRB1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001664 | G protein-coupled receptor binding | IBA | 21873635 |
GO:0002046 | opsin binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0051219 | phosphoprotein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001750 | photoreceptor outer segment | IEA | -- |
GO:0001917 | photoreceptor inner segment | IDA | 23704327 |
GO:0005737 | cytoplasm | TAS | 8224247 |
GO:0042995 | cell projection | IEA | -- |
GO:0045202 | synapse | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Visual Cycle in Retinal Rods |
Visual Cycle in Retinal Rods
-
|
|
2 | CXCR4-mediated signaling events | ||
3 | Thromboxane A2 receptor signaling | ||
4 | Phototransduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001932 | regulation of protein phosphorylation | IEA | -- |
GO:0002031 | G protein-coupled receptor internalization | IBA | 21873635 |
GO:0006897 | endocytosis | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007601 | visual perception | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ARR3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ARR3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ARR3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Arr3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Arr3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | ARR3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ARR3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ARR3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ARR3 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | arr3a 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Arr1 31 32 |
|
ManyToMany | |
krz 31 |
|
ManyToMany | |||
Arr2 31 32 |
|
ManyToMany | |||
CG32683 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | arr-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10346 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710097 | Benign: not provided | 70,278,632(+) | C/G | MISSENSE_VARIANT | |
711141 | Benign: not provided | 70,276,429(+) | C/T | INTRON_VARIANT | |
711142 | Benign: not provided | 70,277,727(+) | C/T | SYNONYMOUS_VARIANT | |
745056 | Likely Benign: not provided | 70,269,910(+) | G/A | INTRON_VARIANT | |
761416 | Likely Benign: not provided | 70,280,782(+) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1584074 | OTHER | inversion | 17803354 |
nsv525258 | CNV | gain | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
myopia 26, x-linked, female-limited |
|
|
myopia |
|
|
oguchi disease 2 |
|
|
refractive error |
|
|
oguchi disease 1 |
|
|