Aliases for ARR3 Gene
Aliases for ARR3 Gene
External Ids for ARR3 Gene
- HGNC: 710
- Entrez Gene: 407
- Ensembl: ENSG00000120500
- OMIM: 301770
- UniProtKB: P36575
Previous GeneCards Identifiers for ARR3 Gene
- GC0XP065666
- GC0XP066965
- GC0XP067721
- GC0XP068354
- GC0XP069271
- GC0XP069404
- GC0XP069488
- GC0XP063309
Summaries for ARR3 Gene
-
The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]
GeneCards Summary for ARR3 Gene
ARR3 (Arrestin 3) is a Protein Coding gene. Diseases associated with ARR3 include Myopia 26, X-Linked, Female-Limited and Leber Congenital Amaurosis 1. Among its related pathways are Thromboxane A2 receptor signaling and Visual Cycle in Retinal Rods. Gene Ontology (GO) annotations related to this gene include phosphoprotein binding and opsin binding. An important paralog of this gene is ARRB1.
UniProtKB/Swiss-Prot for ARR3 Gene
-
May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARR3 Gene
Genomics for ARR3 Gene
GeneHancer (GH) Regulatory Elements for ARR3 Gene
Promoters and enhancers for ARR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARR3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ARR3 gene promoter:
-
- AP-2alpha isoform 4
- AP-2alpha isoform 3
- AP-2alpha isoform 2
- AP-2alpha
- AP-2alphaA
- ITF-2
- Tal-1beta
- ARP-1
- E2F
- E2F-1
Regulatory Element Products
Genomic Locations for ARR3 Gene
Genomic Locations for ARR3 Gene
- chrX:70,263,503-70,281,840
- (GRCh38/hg38)
- Size:
- 18,338 bases
- Orientation:
- Plus strand
- chrX:69,488,155-69,501,690
- (GRCh37/hg19)
- Size:
- 13,536 bases
- Orientation:
- Plus strand
Genomic View for ARR3 Gene
Genes around ARR3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq13.1 by Entrez Gene
- Xq13.1 by HGNC
- Xq13.1 by Ensembl
ARR3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARR3 Gene
Proteins for ARR3 Gene
-
Protein details for ARR3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P36575-ARRC_HUMAN
- Recommended name:
- Arrestin-C
- Protein Accession:
- P36575
- B5B0B9
- Q5JT23
- Q5JT24
- Q6IBF5
- Q96EN2
Protein attributes for ARR3 Gene
- Size:
- 388 amino acids
- Molecular mass:
- 42778 Da
- Quaternary structure:
-
- Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4.
Protein Expression for ARR3 Gene
Post-translational modifications for ARR3 Gene
Other Protein References for ARR3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ARR3
- Novus Biologicals Antibodies for ARR3
-
Abcam antibodies for ARR3
- Invitrogen Antibodies for ARR3 (AFLGC-ARR3)
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-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for ARR3
Protein Products
-
OriGene Purified Proteins for ARR3
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- Search GeneTex for Proteins for ARR3
-
Abcam proteins for ARR3
Assay Products
- antibodies-online: Search results for available ARR3 related products ranked by validation data
No data available for DME Specific Peptides for ARR3 Gene
Domains & Families for ARR3 Gene
Gene Families for ARR3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ARR3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARR3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P36575- Family:
-
- Belongs to the arrestin family.
Function for ARR3 Gene
Molecular function for ARR3 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.
- GENATLAS Biochemistry:
- X arrestin,expressed in the red-,green-,blue-sensitive cone photoreceptors modulator of cone phototransduction
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002046 | opsin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0051219 | phosphoprotein binding | IEA | -- |
Phenotypes for ARR3 Gene
- MGI mutant phenotypes for ARR3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ARR3:
Animal Models for ARR3 Gene
- MGI Knock Outs for ARR3:
-
- Arr3 Arr3<tm1Chcr>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for ARR3
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- Applied Biological Materials CRISPR for ARR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARR3
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miRNA for ARR3 Gene
- miRTarBase miRNAs that target ARR3
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for ARR3
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- genomics-online: cdna clones - Search results for available ARR3 gene related products
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- Applied Biological Materials Clones for ARR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ARR3
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARR3 Gene
Localization for ARR3 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001750 | photoreceptor outer segment | IEA | -- |
| GO:0001917 | photoreceptor inner segment | IDA | 23704327 |
| GO:0005737 | cytoplasm | TAS | 8224247 |
| GO:0045202 | synapse | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARR3 Gene
Pathways & Interactions for ARR3 Gene
Pathways by source for ARR3 Gene
3 BioSystems pathways for ARR3 Gene
1 Qiagen pathway for ARR3 Gene
Interacting Proteins for ARR3 Gene
Selected Interacting proteins:
ENSP00000311538
P36575-ARRC_HUMAN
for ARR3 Gene via
STRING
MINT
UniProtKB
IID
GPS-Prot Interaction Network for ARR3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001932 | regulation of protein phosphorylation | IEA | -- |
| GO:0006897 | endocytosis | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007601 | visual perception | IEA,TAS | -- |
| GO:0050896 | response to stimulus | IEA | -- |
No data available for SIGNOR curated interactions for ARR3 Gene
Transcripts for ARR3 Gene
mRNA/cDNA for ARR3 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (26) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000374495 1298 bps (uc004dya.4)
- ENST00000477379 425 bps (uc064zsg.1)
- ENST00000480877 549 bps (uc064zsi.1)
- ENST00000307959 1292 bps (uc004dyb.3)
- ENST00000620997 1309 bps (uc064zsh.1)
Unigene Clusters for ARR3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ARR3
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- Applied Biological Materials CRISPR for ARR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARR3
- GenScript: Design CRISPR guide RNA sequences for ARR3
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for ARR3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARR3
- genomics-online: cdna clones - Search results for available ARR3 gene related products
- orf clones - Search results for available ARR3 gene related products
- Applied Biological Materials Clones for ARR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: |
Expression for ARR3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature S Cone Cells Outer Nuclear Layer
- Cone Precursor Cells Outer Nuclear Layer
- Mature L Cone Cells Outer Nuclear Layer
- Mature M Cone Cells Outer Nuclear Layer
- Mature M-S Cone Cells Outer Nuclear Layer
-
Neurons
- Mature S Cone Cells Outer Nuclear Layer
- Cone Precursor Cells Outer Nuclear Layer
- Mature L Cone Cells Outer Nuclear Layer
- Mature M Cone Cells Outer Nuclear Layer
- Mature M-S Cone Cells Outer Nuclear Layer
- NULL (Sensory Organs)
- Epithelial Cells (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for ARR3 Gene
This gene is overexpressed in Small Intestine - Terminal Ileum (x4.8) and Colon - Transverse (x4.2).
This gene is overexpressed in Retina (63.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARR3 Gene
NURSA nuclear receptor signaling pathways regulating expression of ARR3 Gene:
ARR3SOURCE GeneReport for Unigene cluster for ARR3 Gene:
Hs.308mRNA Expression by UniProt/SwissProt for ARR3 Gene:
P36575-ARRC_HUMAN
Tissue specificity:
Inner and outer segments, and the inner plexiform regions of the retina.
Evidence on tissue expression from TISSUES for ARR3 Gene
- Eye(4.7)
Primer Products
-
OriGene qPCR primer pairs for ARR3
-
OriGene qPCR primer pairs and template standards for ARR3
- genomics-online: primer clones - Search results for available ARR3 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARR3 Gene
Orthologs for ARR3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ARR3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ARR3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ARR3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Arr3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Arr3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ARR3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ARR3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ARR3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ARR3 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | arr3a 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Arr1 34 35 |
|
ManyToMany | |
| krz 34 |
|
ManyToMany | |||
| Arr2 34 35 |
|
ManyToMany | |||
| CG32683 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | arr-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10346 34 |
|
OneToMany |
- Species where no ortholog for ARR3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for ARR3 Gene
- ENSEMBL:
- Gene Tree for ARR3 (if available)
- TreeFam:
- Gene Tree for ARR3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARR3: view image
Paralogs for ARR3 Gene
(6) SIMAP similar genes for ARR3 Gene using alignment to 2 proteins:
- ARRC_HUMAN
- D6RCT3_HUMAN
Variants for ARR3 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs140505250 | likely-benign, Anophthalmia - microphthalmia | 70,280,804(+) | C/G/T | coding_sequence_variant, missense_variant | |
| rs765658563 | pathogenic, MYOPIA 26, X-LINKED, FEMALE-LIMITED | 70,278,629(+) | C/A/T | coding_sequence_variant, missense_variant | |
| rs1000410161 | -- | 70,282,104(+) | C/T | downstream_transcript_variant | |
| rs1001150730 | -- | 70,267,503(+) | C/T | upstream_transcript_variant | |
| rs1001267125 | -- | 70,281,398(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1584074 | OTHER | inversion | 17803354 |
| nsv525258 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.92;
19.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARR3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARR3 Gene
Disorders for ARR3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myopia 26, x-linked, female-limited |
|
|
| leber congenital amaurosis 1 |
|
|
| dental pulp necrosis |
|
|
| usher syndrome, type i |
|
|
| myopia |
|
|
Search ARR3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ARR3
No data available for UniProtKB/Swiss-Prot and Genatlas for ARR3 Gene
Publications for ARR3 Gene
- X-arrestin: a new retinal arrestin mapping to the X chromosome. (PMID: 8224247) Murakami A … Inana G (FEBS letters 1993) 2 3 4 22 58
- Isolation and characterization of the human X-arrestin gene. (PMID: 9931451) Sakuma H … Inana G (Gene 1998) 3 4 22 58
- Immunolocalization of X-arrestin in human cone photoreceptors. (PMID: 8612728) Sakuma H … McLaren MJ (FEBS letters 1996) 3 4 22 58
- Cone arrestin identified by targeting expression of a functional family. (PMID: 8308033) Craft CM … Wiechmann AF (The Journal of biological chemistry 1994) 3 4 22 58
- Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PMID: 17620599) Xiao K … Lefkowitz RJ (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 22 58
Products for ARR3 Gene
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- antibodies-online: Search results for 11 available ARR3 Proteins ranked by validation data
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- GeneTex ARR3 Antibody for ARR3
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Sources for ARR3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
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