Aliases for ARPP21 Gene
This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
GeneCards Summary for ARPP21 Gene
ARPP21 (CAMP Regulated Phosphoprotein 21) is a Protein Coding gene. Diseases associated with ARPP21 include Shoulder Impingement Syndrome and Calcific Tendinitis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and calmodulin binding. An important paralog of this gene is R3HDM1.
UniProtKB/Swiss-Prot for ARPP21 Gene
Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.